Publication Information

{'id': 'https://openalex.org/W4312018395', 'doi': 'https://doi.org/10.1021/acs.chemrestox.2c00239', 'title': 'Perfluorooctanoic Acid-Disturbed Serum and Liver Lipidome in C57BL/6 Mice', 'display_name': 'Perfluorooctanoic Acid-Disturbed Serum and Liver Lipidome in C57BL/6 Mice', 'publication_year': 2022, 'publication_date': '2022-12-09', 'ids': {'openalex': 'https://openalex.org/W4312018395', 'doi': 'https://doi.org/10.1021/acs.chemrestox.2c00239', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36484463'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.chemrestox.2c00239', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S152840809', 'display_name': 'Chemical Research in Toxicology', 'issn_l': '0893-228X', 'issn': ['0893-228X', '1520-5010'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056546567', 'display_name': 'Bei Gao', 'orcid': 'https://orcid.org/0000-0002-3321-2339'}, 'institutions': [{'id': 'https://openalex.org/I200845125', 'display_name': 'Nanjing University of Information Science and Technology', 'ror': 'https://ror.org/02y0rxk19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200845125']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bei Gao', 'raw_affiliation_strings': ['Key Laboratory of Hydrometeorological Disaster Mechanism and Warning of Ministry of Water Resources, Nanjing University of Information Science and Technology, Nanjing 210044, China', 'School of Marine Sciences, Nanjing University of Information Science and Technology, Nanjing 210044, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Hydrometeorological Disaster Mechanism and Warning of Ministry of Water Resources, Nanjing University of Information Science and Technology, Nanjing 210044, China', 'institution_ids': ['https://openalex.org/I200845125']}, {'raw_affiliation_string': 'School of Marine Sciences, Nanjing University of Information Science and Technology, Nanjing 210044, China', 'institution_ids': ['https://openalex.org/I200845125']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011203043', 'display_name': 'Pengcheng Tu', 'orcid': 'https://orcid.org/0000-0001-8920-7478'}, 'institutions': [{'id': 'https://openalex.org/I4210136416', 'display_name': 'Zhejiang Center for Disease Control and Prevention', 'ror': 'https://ror.org/03f015z81', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210136416']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'PengCheng Tu', 'raw_affiliation_strings': ['Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China', 'institution_ids': ['https://openalex.org/I4210136416']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101902480', 'display_name': 'Liang Chi', 'orcid': 'https://orcid.org/0000-0002-3769-4144'}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Liang Chi', 'raw_affiliation_strings': ['Metaorganism Immunity Section, Laboratory of Immune Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States'], 'affiliations': [{'raw_affiliation_string': 'Metaorganism Immunity Section, Laboratory of Immune Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States', 'institution_ids': ['https://openalex.org/I4210134534', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029616299', 'display_name': 'Weishou Shen', 'orcid': 'https://orcid.org/0000-0001-9452-5665'}, 'institutions': [{'id': 'https://openalex.org/I200845125', 'display_name': 'Nanjing University of Information Science and Technology', 'ror': 'https://ror.org/02y0rxk19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200845125']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weishou Shen', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative In-novation Center of Atmospheric Environment and Equipment Technology, Nanjing 210044, China', 'School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing 210044, China'], 'affiliations': [{'raw_affiliation_string': 'School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing 210044, China', 'institution_ids': ['https://openalex.org/I200845125']}, {'raw_affiliation_string': 'Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative In-novation Center of Atmospheric Environment and Equipment Technology, Nanjing 210044, China', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055461945', 'display_name': 'Nan Gao', 'orcid': 'https://orcid.org/0000-0002-3903-6866'}, 'institutions': [{'id': 'https://openalex.org/I134687103', 'display_name': 'Nanjing Tech University', 'ror': 'https://ror.org/03sd35x91', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I134687103']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Nan Gao', 'raw_affiliation_strings': ['School of Biological and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China'], 'affiliations': [{'raw_affiliation_string': 'School of Biological and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China', 'institution_ids': ['https://openalex.org/I134687103']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5055461945'], 'corresponding_institution_ids': ['https://openalex.org/I134687103'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.421, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.572916, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 80}, 'biblio': {'volume': '35', 'issue': '12', 'first_page': '2252', 'last_page': '2259'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11869', 'display_name': 'Per- and polyfluoroalkyl substances research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11869', 'display_name': 'Per- and polyfluoroalkyl substances research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11629', 'display_name': 'Birth, Development, and Health', 'score': 0.9794, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9736, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/perfluorooctanoic-acid', 'display_name': 'Perfluorooctanoic acid', 'score': 0.9984846}, {'id': 'https://openalex.org/keywords/lipidome', 'display_name': 'Lipidome', 'score': 0.9634832}], 'concepts': [{'id': 'https://openalex.org/C2775979320', 'wikidata': 'https://www.wikidata.org/wiki/Q418348', 'display_name': 'Perfluorooctanoic acid', 'level': 2, 'score': 0.9984846}, {'id': 'https://openalex.org/C2780241833', 'wikidata': 'https://www.wikidata.org/wiki/Q6556375', 'display_name': 'Lipidome', 'level': 3, 'score': 0.9634832}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7284117}, {'id': 'https://openalex.org/C61322309', 'wikidata': 'https://www.wikidata.org/wiki/Q423143', 'display_name': 'Sphingomyelin', 'level': 3, 'score': 0.57954544}, {'id': 'https://openalex.org/C58017582', 'wikidata': 'https://www.wikidata.org/wiki/Q6556376', 'display_name': 'Lipidomics', 'level': 2, 'score': 0.5432216}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5003376}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.46949795}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.20106947}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.09248483}], 'mesh': [{'descriptor_ui': 'D002210', 'descriptor_name': 'Caprylates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000081362', 'descriptor_name': 'Lipidomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002210', 'descriptor_name': 'Caprylates', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D050356', 'descriptor_name': 'Lipid Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010713', 'descriptor_name': 'Phosphatidylcholines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010713', 'descriptor_name': 'Phosphatidylcholines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010713', 'descriptor_name': 'Phosphatidylcholines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.chemrestox.2c00239', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S152840809', 'display_name': 'Chemical Research in Toxicology', 'issn_l': '0893-228X', 'issn': ['0893-228X', '1520-5010'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36484463', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.49, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320324849', 'funder_display_name': 'Nanjing University of Information Science and Technology', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1543068333', 'https://openalex.org/W17199539', 'https://openalex.org/W1964373436', 'https://openalex.org/W2000476420', 'https://openalex.org/W2019544391', 'https://openalex.org/W2023502440', 'https://openalex.org/W2030507620', 'https://openalex.org/W2114233282', 'https://openalex.org/W2117859857', 'https://openalex.org/W2134776160', 'https://openalex.org/W2163064437', 'https://openalex.org/W2207469885', 'https://openalex.org/W2318476459', 'https://openalex.org/W2343937560', 'https://openalex.org/W2565498582', 'https://openalex.org/W2590499380', 'https://openalex.org/W2607311572', 'https://openalex.org/W2766501219', 'https://openalex.org/W2775592096', 'https://openalex.org/W2899672621', 'https://openalex.org/W2901829216', 'https://openalex.org/W2908438579', 'https://openalex.org/W2910596005', 'https://openalex.org/W2919002166', 'https://openalex.org/W2941270373', 'https://openalex.org/W2943267700', 'https://openalex.org/W2965123746', 'https://openalex.org/W2973241362', 'https://openalex.org/W2985934863', 'https://openalex.org/W2994186404', 'https://openalex.org/W3006450495', 'https://openalex.org/W3008469335', 'https://openalex.org/W3037751133', 'https://openalex.org/W3048632356', 'https://openalex.org/W3103752265', 'https://openalex.org/W3122022461', 'https://openalex.org/W3131898516', 'https://openalex.org/W3178734264', 'https://openalex.org/W3194762766', 'https://openalex.org/W3197617982', 'https://openalex.org/W3199820739', 'https://openalex.org/W3217045809', 'https://openalex.org/W4200282167', 'https://openalex.org/W4206372026', 'https://openalex.org/W4280531562', 'https://openalex.org/W4283017342', 'https://openalex.org/W4308346882', 'https://openalex.org/W625964156', 'https://openalex.org/W756447442'], 'related_works': ['https://openalex.org/W4317479263', 'https://openalex.org/W3209610556', 'https://openalex.org/W3207725197', 'https://openalex.org/W2986402841', 'https://openalex.org/W2810768141', 'https://openalex.org/W2768723747', 'https://openalex.org/W2746999282', 'https://openalex.org/W2732317838', 'https://openalex.org/W2091512523', 'https://openalex.org/W1988727893'], 'abstract_inverted_index': {'Perfluorooctanoic': [0, 76], 'acid': [1, 19, 29, 43, 67, 77, 122], 'is': [2, 30], 'a': [3, 14, 87, 150], 'manufactured': [4], 'material': [5], 'extensively': [6], 'utilized': [7], 'in': [8, 36, 72, 82, 98, 111, 147, 157, 188], 'industrial': [9], 'and': [10, 84, 119, 130, 139, 183], 'consumer': [11], 'products.': [12], 'As': [13], 'persistent': [15], 'organic': [16], 'pollutant,': [17], 'perfluorooctanoic': [18, 28, 42, 66, 121, 162, 177, 184], 'has': [20, 48], 'raised': [21], 'increasing': [22], 'public': [23], 'health': [24, 186], 'concerns': [25], 'recently.': [26], 'Although': [27], 'known': [31], 'to': [32, 61, 172], 'induce': [33], 'lipid': [34, 46, 70, 80, 90, 109, 181], 'accumulation': [35], 'the': [37, 39, 63, 69, 79, 99, 103, 112, 125, 131, 148, 158, 174], 'liver,': [38, 85, 149], 'impact': [40, 64], 'of': [41, 65, 89, 127, 133, 152, 160, 176, 180], 'on': [44, 68], 'different': [45], 'classes': [47, 91], 'not': [49], 'been': [50], 'fully': [51], 'evaluated.': [52], 'In': [53, 106, 142], 'this': [54, 168], 'study,': [55], 'we': [56], 'performed': [57], 'untargeted': [58], 'lipidomics': [59], 'analysis': [60], 'investigate': [62], 'homeostasis': [71], 'C57BL/6': [73], 'male': [74], 'mice.': [75, 164], 'disturbed': [78], 'profiles': [81], 'serum': [83, 104, 159], 'with': [86, 144], 'variety': [88], 'significantly': [92], 'altered.': [93], 'Greater': [94], 'impacts': [95], 'were': [96, 114], 'observed': [97], 'liver': [100, 113], 'lipidome': [101], 'than': [102], 'lipidome.': [105], 'particular,': [107], 'some': [108], 'clusters': [110], 'altered': [115], 'by': [116], 'both': [117], 'high-': [118], 'low-dose': [120], 'exposure,': [123], 'including': [124], 'increase': [126, 146], 'unsaturated': [128], 'triglycerides': [129], 'decrease': [132, 151], 'sphingomyelins,': [134], 'saturated': [135, 137, 153], 'phosphatidylcholines,': [136], 'lysophosphatidylcholines,': [138], 'phospholipid': [140], 'ethers.': [141], 'parallel': [143], 'an': [145], 'phosphatidylcholines': [154], 'was': [155], 'found': [156], 'high-dose': [161], 'acid-treated': [163], 'The': [165], 'findings': [166], 'from': [167], 'study': [169], 'are': [170], 'helpful': [171], 'improve': [173], 'understanding': [175], 'acid-induced': [178], 'dysregulation': [179], 'metabolism': [182], 'acid-associated': [185], 'effects': [187], 'liver.': [189]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4312018395', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-12-13T14:40:56.582583', 'created_date': '2023-01-03'}