Publication Information

{'id': 'https://openalex.org/W4311658426', 'doi': 'https://doi.org/10.1155/2022/3762591', 'title': 'Qu-Yu-Jie-Du Decoction Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulation of Neutrophils and Macrophage Infiltration', 'display_name': 'Qu-Yu-Jie-Du Decoction Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulation of Neutrophils and Macrophage Infiltration', 'publication_year': 2022, 'publication_date': '2022-12-06', 'ids': {'openalex': 'https://openalex.org/W4311658426', 'doi': 'https://doi.org/10.1155/2022/3762591', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36523417'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2022/3762591', 'pdf_url': 'https://downloads.hindawi.com/journals/ecam/2022/3762591.pdf', 'source': {'id': 'https://openalex.org/S15444899', 'display_name': 'Evidence-based Complementary and Alternative Medicine', 'issn_l': '1741-427X', 'issn': ['1741-427X', '1741-4288'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://downloads.hindawi.com/journals/ecam/2022/3762591.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004327591', 'display_name': 'Hong-Wei Zhao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105832', 'display_name': 'First Affiliated Hospital of Guangzhou University of Chinese Medicine', 'ror': 'https://ror.org/01mxpdw03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105832']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongwei Zhao', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China', 'institution_ids': ['https://openalex.org/I4210105832']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043933067', 'display_name': 'Lingling Sun', 'orcid': 'https://orcid.org/0000-0001-7033-1698'}, 'institutions': [{'id': 'https://openalex.org/I4210105832', 'display_name': 'First Affiliated Hospital of Guangzhou University of Chinese Medicine', 'ror': 'https://ror.org/01mxpdw03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105832']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lingling Sun', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China', 'institution_ids': ['https://openalex.org/I4210105832']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101600503', 'display_name': 'Xi Xiao', 'orcid': 'https://orcid.org/0000-0003-1521-9542'}, 'institutions': [{'id': 'https://openalex.org/I4210105832', 'display_name': 'First Affiliated Hospital of Guangzhou University of Chinese Medicine', 'ror': 'https://ror.org/01mxpdw03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105832']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xi Xiao', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China', 'institution_ids': ['https://openalex.org/I4210105832']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024092359', 'display_name': 'Jietao Lin', 'orcid': 'https://orcid.org/0000-0002-5507-3499'}, 'institutions': [{'id': 'https://openalex.org/I4210105832', 'display_name': 'First Affiliated Hospital of Guangzhou University of Chinese Medicine', 'ror': 'https://ror.org/01mxpdw03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105832']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jietao Lin', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China', 'institution_ids': ['https://openalex.org/I4210105832']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042171373', 'display_name': 'Cui Shao', 'orcid': 'https://orcid.org/0000-0002-5651-5252'}, 'institutions': [{'id': 'https://openalex.org/I4210105832', 'display_name': 'First Affiliated Hospital of Guangzhou University of Chinese Medicine', 'ror': 'https://ror.org/01mxpdw03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105832']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cui Shao', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China', 'institution_ids': ['https://openalex.org/I4210105832']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100690637', 'display_name': 'Lizhu Lin', 'orcid': 'https://orcid.org/0000-0002-5396-3033'}, 'institutions': [{'id': 'https://openalex.org/I4210105832', 'display_name': 'First Affiliated Hospital of Guangzhou University of Chinese Medicine', 'ror': 'https://ror.org/01mxpdw03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105832']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Lizhu Lin', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China', 'institution_ids': ['https://openalex.org/I4210105832']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5100690637'], 'corresponding_institution_ids': ['https://openalex.org/I4210105832'], 'apc_list': {'value': 2400, 'currency': 'USD', 'value_usd': 2400, 'provenance': 'doaj'}, 'apc_paid': {'value': 2400, 'currency': 'USD', 'value_usd': 2400, 'provenance': 'doaj'}, 'fwci': 0.228, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.492478, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 60, 'max': 70}, 'biblio': {'volume': '2022', 'issue': None, 'first_page': '1', 'last_page': '10'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10134', 'display_name': 'Inflammatory Bowel Disease', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10134', 'display_name': 'Inflammatory Bowel Disease', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10066', 'display_name': 'Gut microbiota and health', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/decoction', 'display_name': 'Decoction', 'score': 0.61296374}, {'id': 'https://openalex.org/keywords/infiltration', 'display_name': 'Infiltration (HVAC)', 'score': 0.60551023}], 'concepts': [{'id': 'https://openalex.org/C190409667', 'wikidata': 'https://www.wikidata.org/wiki/Q1136912', 'display_name': 'Decoction', 'level': 2, 'score': 0.61296374}, {'id': 'https://openalex.org/C153400128', 'wikidata': 'https://www.wikidata.org/wiki/Q3150731', 'display_name': 'Infiltration (HVAC)', 'level': 2, 'score': 0.60551023}, {'id': 'https://openalex.org/C2775862500', 'wikidata': 'https://www.wikidata.org/wiki/Q2453464', 'display_name': 'Colitis', 'level': 2, 'score': 0.59512633}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4897926}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.4786414}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.29520413}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.26156372}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.2155768}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.112635136}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.06490788}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.06354213}, {'id': 'https://openalex.org/C159985019', 'wikidata': 'https://www.wikidata.org/wiki/Q181790', 'display_name': 'Composite material', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2022/3762591', 'pdf_url': 'https://downloads.hindawi.com/journals/ecam/2022/3762591.pdf', 'source': {'id': 'https://openalex.org/S15444899', 'display_name': 'Evidence-based Complementary and Alternative Medicine', 'issn_l': '1741-427X', 'issn': ['1741-427X', '1741-4288'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/efaafd07256b4effb81e8679f0b1f734', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747316', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36523417', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2022/3762591', 'pdf_url': 'https://downloads.hindawi.com/journals/ecam/2022/3762591.pdf', 'source': {'id': 'https://openalex.org/S15444899', 'display_name': 'Evidence-based Complementary and Alternative Medicine', 'issn_l': '1741-427X', 'issn': ['1741-427X', '1741-4288'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.7, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [{'funder': 'https://openalex.org/F4320326685', 'funder_display_name': 'Guangzhou Science, Technology and Innovation Commission', 'award_id': '201904010396'}], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1502093553', 'https://openalex.org/W1596258860', 'https://openalex.org/W181283657', 'https://openalex.org/W1855226200', 'https://openalex.org/W1954354169', 'https://openalex.org/W1956258286', 'https://openalex.org/W1965037168', 'https://openalex.org/W1977644273', 'https://openalex.org/W1978136857', 'https://openalex.org/W1986079650', 'https://openalex.org/W1998737485', 'https://openalex.org/W2013637937', 'https://openalex.org/W2015336843', 'https://openalex.org/W2030411262', 'https://openalex.org/W2047595952', 'https://openalex.org/W2056882652', 'https://openalex.org/W2062626858', 'https://openalex.org/W2068885672', 'https://openalex.org/W2072907428', 'https://openalex.org/W2087048554', 'https://openalex.org/W2099613681', 'https://openalex.org/W2128593833', 'https://openalex.org/W2132879755', 'https://openalex.org/W2137272926', 'https://openalex.org/W2151826099', 'https://openalex.org/W2400851843', 'https://openalex.org/W2565789746', 'https://openalex.org/W2604974488', 'https://openalex.org/W2791016534', 'https://openalex.org/W2894767183', 'https://openalex.org/W2947257267', 'https://openalex.org/W2958912900', 'https://openalex.org/W3004377487', 'https://openalex.org/W3005327708', 'https://openalex.org/W4230297249', 'https://openalex.org/W4244626580'], 'related_works': ['https://openalex.org/W4387497383', 'https://openalex.org/W2948807893', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2527526854', 'https://openalex.org/W2078814861', 'https://openalex.org/W2062208111', 'https://openalex.org/W1986764834', 'https://openalex.org/W1976181487', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'Background.': [0], 'Inflammatory': [1], 'bowel': [2], 'disease': [3], '(IBD)': [4], 'is': [5, 28, 52, 302], 'becoming': [6], 'a': [7, 29, 247, 305], 'global': [8], 'disease.': [9], 'A': [10], 'percentage': [11], 'of': [12, 65, 152, 177, 193, 218, 228, 240, 265, 273, 280], 'IBD': [13], 'patients': [14], 'will': [15, 21], 'not': [16, 53], 'react': [17], 'to': [18, 83, 162, 173, 187, 199, 257], 'therapy': [19], 'or': [20, 124], 'lose': [22], 'their': [23, 84], 'response.': [24], 'Qu-Yu-Jie-Du': [25], 'Decoction': [26], '(QYJD)': [27], 'traditional': [30], 'Chinese': [31], 'medicine': [32], 'formula': [33], 'commonly': [34], 'used': [35, 161, 172, 186], 'for': [36, 148], 'intestinal': [37, 241], 'diseases.': [38], 'It': [39], 'has': [40, 45], 'been': [41], 'reported': [42], 'that': [43, 234], 'QYJD': [44, 66, 100, 104, 125, 210, 223, 268, 292], 'an': [46], 'anti-inflammatory': [47, 63], 'effect,': [48], 'but': [49], 'the': [50, 62, 69, 88, 91, 97, 103, 116, 139, 142, 153, 164, 168, 175, 189, 212, 226, 229, 238, 271, 278, 300], 'mechanism': [51, 301], 'fully': [54], 'understood.': [55], 'In': [56], 'this': [57], 'study,': [58], 'we': [59], 'mainly': [60], 'evaluated': [61], 'effect': [64, 249], 'and': [67, 102, 114, 132, 146, 181, 204, 215, 245, 260, 277, 286, 299, 309], 'explored': [68], 'possible': [70], 'mechanisms.': [71], 'Methods.': [72], 'Twenty-four': [73], 'BALB/c': [74], 'mice': [75, 119, 143, 154, 219, 244, 298], 'were': [76, 107, 120, 134, 144, 255], 'randomly': [77], 'divided': [78], 'into': [79], '4': [80], 'groups': [81], 'according': [82], 'body': [85], 'weight,': [86], 'namely,': [87], 'control': [89], 'group,': [90, 96, 101], 'dextran': [92], 'sulfate': [93], 'sodium': [94], '(DSS)': [95], 'DSS': [98, 110], '+': [99], 'group.': [105], 'Mice': [106], 'given': [108, 121], '3%': [109], 'drinking': [111], 'water': [112], 'freely,': [113], 'at': [115], 'same': [117], 'time,': [118], 'normal': [122], 'saline': [123], '(4.44': [126], 'mg/g/d),': [127], 'respectively.': [128], 'Mental': [129], 'state,': [130], 'faeces,': [131], 'weight': [133, 213], 'recorded': [135], 'every': [136], 'day.': [137], 'On': [138], '10th': [140], 'day,': [141], 'sacrificed': [145], 'collected': [147], 'investigation.': [149], 'The': [150, 253], 'length': [151], 'colon': [155, 194, 207, 251, 263, 289], 'was': [156, 160, 171, 185, 197], 'measured.': [157], 'Histological': [158], 'analysis': [159], 'detect': [163, 188, 200], 'morphological': [165], 'changes': [166], 'in': [167, 206, 243, 262, 288, 297, 307], 'colon.': [169], 'Immunohistochemistry': [170], 'measure': [174], 'infiltration': [176], 'macrophages': [178, 259], '(F4/80,': [179], 'CD163)': [180], 'neutrophils': [182, 261], '(Ly6G).': [183], 'Colorimetry': [184], 'myeloperoxidase': [190, 274], '(MPO)': [191, 276], 'activity': [192, 272, 275], 'tissues.': [195, 208, 252, 290], 'ELISA': [196], 'utilized': [198], 'associated': [201], 'inflammatory': [202], 'cytokines': [203], 'chemokines': [205], 'Results.': [209], 'alleviated': [211], 'loss': [214], 'colitis': [216, 296], 'symptoms': [217], 'caused': [220, 231], 'by': [221, 232], 'DSS.': [222], 'fought': [224], 'against': [225], 'shortening': [227], 'intestine': [230], 'DSS;': [233], 'is,': [235], 'it': [236], 'improved': [237], 'decline': [239], 'compliance': [242], 'had': [246], 'protective': [248], 'on': [250], 'mechanisms': [254], 'related': [256], 'downregulating': [258], 'tissues': [264], 'infiltration.': [266, 311], 'Besides,': [267], 'simultaneously': [269], 'reduced': [270], 'contents': [279], 'IL-1β,': [281], 'IL-6,': [282], 'TNF-α,': [283], 'TGF-β,': [284], 'CCL2,': [285], 'CXCL2': [287], 'Conclusions.': [291], 'can': [293], 'ameliorate': [294], 'DSS-induced': [295], 'connected': [303], 'with': [304], 'reduction': [306], 'neutrophil': [308], 'macrophage': [310]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4311658426', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-15T15:02:15.849599', 'created_date': '2022-12-27'}