Title: Method development and validation of solifenacin succinate in pharmaceutical dosage form using first order derivative UV spectrophotometry
Abstract: A new simple, accurate and precise first order derivative assay method was developed and validated for the quantitative determination of solifenacin succinate in bulk and tablets dosage form using UV-visible spectrophotometer.In this method, water was used as solvent, with the absorption maxima of 294 nm.The developed method obeyed Beer's law in the concentration range of 100-500 µg/ml with correlation coefficient of 0.999.The method showed good reproducibility and precision in this concentration range.The % recovery and % RSD values were found to be within the limits, indicating the method to be accurate and precise, respectively.The LOD and LOQ values were found to be 6.4 µg/ml and 19.4 µg/ml.The validation parameters tested in accordance with the requirements of ICH guidelines, prove the suitability of this method.The proposed method can be used for routine quality control analysis for the estimation of solifenacin succinate in bulk and tablet dosage form.