Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4308738493', 'doi': 'https://doi.org/10.1016/j.toxlet.2022.11.001', 'title': '20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-β1/Smad3 signaling pathway', 'display_name': '20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-β1/Smad3 signaling pathway', 'publication_year': 2023, 'publication_date': '2023-01-01', 'ids': {'openalex': 'https://openalex.org/W4308738493', 'doi': 'https://doi.org/10.1016/j.toxlet.2022.11.001', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36368619'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.toxlet.2022.11.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205878144', 'display_name': 'Toxicology Letters', 'issn_l': '0378-4274', 'issn': ['0378-4274', '1879-3169'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100334863', 'display_name': 'Biao Li', 'orcid': 'https://orcid.org/0000-0002-0493-2062'}, 'institutions': [{'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Biao Li', 'raw_affiliation_strings': ['Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I4210136596', 'https://openalex.org/I197869895']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004116649', 'display_name': 'Yuchen Ma', 'orcid': 'https://orcid.org/0000-0002-9990-5023'}, 'institutions': [{'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuchen Ma', 'raw_affiliation_strings': ['Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I4210136596', 'https://openalex.org/I197869895']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041860678', 'display_name': 'Lina Tan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lina Tan', 'raw_affiliation_strings': ['Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I4210136596', 'https://openalex.org/I197869895']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062104326', 'display_name': 'Huan Ren', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huan Ren', 'raw_affiliation_strings': ['Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I4210136596', 'https://openalex.org/I197869895']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046749591', 'display_name': 'Lifang Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lifang Wu', 'raw_affiliation_strings': ['Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I4210136596', 'https://openalex.org/I197869895']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101309013', 'display_name': 'Qian Su', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}, {'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qian Su', 'raw_affiliation_strings': ['Department of Infectious Disease, The First Hospital of Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Disease, The First Hospital of Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I197869895', 'https://openalex.org/I4210136596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081861875', 'display_name': 'Jue Song', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}, {'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jue Song', 'raw_affiliation_strings': ['Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I197869895', 'https://openalex.org/I4210136596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100344588', 'display_name': 'Wei Chen', 'orcid': 'https://orcid.org/0000-0003-4044-5058'}, 'institutions': [{'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Chen', 'raw_affiliation_strings': ['School of Public Health, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'School of Public Health, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I197869895']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059264917', 'display_name': 'Peng Gong', 'orcid': 'https://orcid.org/0000-0003-1513-3765'}, 'institutions': [{'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}, {'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Peng Gong', 'raw_affiliation_strings': ['Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I197869895', 'https://openalex.org/I4210136596']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102770636', 'display_name': 'Yong Jin', 'orcid': 'https://orcid.org/0000-0003-3133-7952'}, 'institutions': [{'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yong Jin', 'raw_affiliation_strings': ['Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Department of Pharmacy, The First Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I4210136596', 'https://openalex.org/I197869895']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5059264917', 'https://openalex.org/A5102770636'], 'corresponding_institution_ids': ['https://openalex.org/I197869895', 'https://openalex.org/I4210136596', 'https://openalex.org/I4210136596', 'https://openalex.org/I197869895'], 'apc_list': {'value': 3990, 'currency': 'USD', 'value_usd': 3990, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.389, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.999324, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 87, 'max': 90}, 'biblio': {'volume': '373', 'issue': None, 'first_page': '1', 'last_page': '12'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12910', 'display_name': 'Metabolism and Function of Arachidonic Acid Derivatives', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12910', 'display_name': 'Metabolism and Function of Arachidonic Acid Derivatives', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Epidemiology and Management of NAFLD', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10337', 'display_name': 'Liver Cirrhosis and Associated Complications', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hepatic-fibrosis', 'display_name': 'Hepatic fibrosis', 'score': 0.8925952}, {'id': 'https://openalex.org/keywords/hepatic-stellate-cell', 'display_name': 'Hepatic stellate cell', 'score': 0.8191405}, {'id': 'https://openalex.org/keywords/ccl4', 'display_name': 'CCL4', 'score': 0.59113306}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.52062505}, {'id': 'https://openalex.org/keywords/hepatic-steatosis', 'display_name': 'Hepatic Steatosis', 'score': 0.503797}, {'id': 'https://openalex.org/keywords/hepatic-encephalopathy', 'display_name': 'Hepatic Encephalopathy', 'score': 0.501816}], 'concepts': [{'id': 'https://openalex.org/C2993667909', 'wikidata': 'https://www.wikidata.org/wiki/Q147778', 'display_name': 'Hepatic fibrosis', 'level': 3, 'score': 0.8925952}, {'id': 'https://openalex.org/C176891718', 'wikidata': 'https://www.wikidata.org/wiki/Q1997459', 'display_name': 'Hepatic stellate cell', 'level': 2, 'score': 0.8191405}, {'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.73132}, {'id': 'https://openalex.org/C2777359374', 'wikidata': 'https://www.wikidata.org/wiki/Q225045', 'display_name': 'Carbon tetrachloride', 'level': 2, 'score': 0.61620826}, {'id': 'https://openalex.org/C102124568', 'wikidata': 'https://www.wikidata.org/wiki/Q5009626', 'display_name': 'CCL4', 'level': 3, 'score': 0.59113306}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.52062505}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.44284356}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42388323}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.38544425}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.34761584}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34149694}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.105900586}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D055166', 'descriptor_name': 'Hepatic Stellate Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053773', 'descriptor_name': 'Transforming Growth Factor beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002251', 'descriptor_name': 'Carbon Tetrachloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002251', 'descriptor_name': 'Carbon Tetrachloride', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D055166', 'descriptor_name': 'Hepatic Stellate Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008103', 'descriptor_name': 'Liver Cirrhosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008103', 'descriptor_name': 'Liver Cirrhosis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D008103', 'descriptor_name': 'Liver Cirrhosis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053773', 'descriptor_name': 'Transforming Growth Factor beta1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.toxlet.2022.11.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205878144', 'display_name': 'Toxicology Letters', 'issn_l': '0378-4274', 'issn': ['0378-4274', '1879-3169'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36368619', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.53}], 'grants': [{'funder': 'https://openalex.org/F4320316314', 'funder_display_name': 'Key Technologies Research and Development Program of Anhui Province', 'award_id': '2022e07020040'}, {'funder': 'https://openalex.org/F4320321603', 'funder_display_name': 'Anhui Medical University', 'award_id': '2020xkj179'}], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1061159978', 'https://openalex.org/W1574423401', 'https://openalex.org/W1913730804', 'https://openalex.org/W1993614561', 'https://openalex.org/W1995378781', 'https://openalex.org/W2003577377', 'https://openalex.org/W2005296614', 'https://openalex.org/W2022545669', 'https://openalex.org/W2035653659', 'https://openalex.org/W2092103925', 'https://openalex.org/W2095279903', 'https://openalex.org/W2096314064', 'https://openalex.org/W2121853618', 'https://openalex.org/W2163358442', 'https://openalex.org/W2182635476', 'https://openalex.org/W2316493884', 'https://openalex.org/W2322915906', 'https://openalex.org/W2342679639', 'https://openalex.org/W2411064109', 'https://openalex.org/W2594846471', 'https://openalex.org/W2598044185', 'https://openalex.org/W2613180696', 'https://openalex.org/W2617302805', 'https://openalex.org/W2735790845', 'https://openalex.org/W2742925410', 'https://openalex.org/W2777882786', 'https://openalex.org/W2780314928', 'https://openalex.org/W2791818671', 'https://openalex.org/W2800261814', 'https://openalex.org/W2805635722', 'https://openalex.org/W2881438881', 'https://openalex.org/W2897557611', 'https://openalex.org/W2946202071', 'https://openalex.org/W2965888264', 'https://openalex.org/W2970290812', 'https://openalex.org/W3003998150', 'https://openalex.org/W3110665170', 'https://openalex.org/W3118464984', 'https://openalex.org/W3129783784', 'https://openalex.org/W3182179813', 'https://openalex.org/W4224882447', 'https://openalex.org/W4248328427', 'https://openalex.org/W983032067'], 'related_works': ['https://openalex.org/W4387646365', 'https://openalex.org/W2917795919', 'https://openalex.org/W2419131078', 'https://openalex.org/W2382895565', 'https://openalex.org/W2359831249', 'https://openalex.org/W2355939533', 'https://openalex.org/W2347377923', 'https://openalex.org/W2288620160', 'https://openalex.org/W2042520936', 'https://openalex.org/W1988454503'], 'abstract_inverted_index': {'Hepatic': [0, 16], 'fibrosis': [1, 67, 98, 113, 154, 168, 189], 'is': [2, 114, 123], 'caused': [3], 'by': [4, 69, 93], 'excessive': [5], 'accumulation': [6], 'of': [7, 29, 79, 84, 88, 109, 119, 129, 135, 145, 158, 200], 'extracellular': [8], 'matrix': [9], '(ECM)': [10], 'due': [11], 'to': [12, 75, 126], 'repeated': [13], 'liver': [14, 66, 153], 'injury.': [15], 'stellate': [17], 'cells': [18, 58, 137], '(HSCs)': [19], 'play': [20], 'a': [21, 193], 'key': [22], 'role': [23, 186], 'in': [24, 151, 187], 'the': [25, 44, 77, 85, 107, 127, 143, 171, 178, 197], 'pathogenesis': [26], 'and': [27, 63, 99, 122, 138, 156, 190], 'progression': [28], 'hepatic': [30, 41, 55, 97, 112, 163, 167, 188, 201], 'fibrosis.': [31, 130, 164, 202], 'A': [32], 'study': [33, 76], 'showed': [34, 105], 'that': [35, 106, 118, 181], 'CYP4A14': [36], 'gene': [37], 'defect': [38], 'can': [39], 'inhibit': [40, 142], 'fibrosis,': [42, 56], 'but': [43], 'specific': [45], 'mechanism': [46], 'was': [47, 148], 'not': [48], 'clear.': [49], 'In': [50, 176], 'this': [51], 'experiment,': [52], 'patients': [53, 110], 'with': [54, 65, 111], 'LX-2': [57, 136], '(a': [59], 'human': [60], 'HSCs': [61], 'line),': [62], 'mice': [64, 155], 'induced': [68, 166], 'carbon': [70], 'tetrachloride': [71], '(CCl4)': [72], 'were': [73], 'used': [74], 'effect': [78], '20-Hydroxytetraenoic': [80], 'acid': [81, 90], '(20-HETE),': [82], 'one': [83], 'main': [86], 'metabolites': [87], 'arachidonic': [89], '(AA)': [91], 'catalyzed': [92], 'CYP4A': [94], 'enzyme,': [95], 'on': [96], 'its': [100], 'mechanism.': [101], 'Our': [102], 'experimental': [103], 'results': [104, 179], '20-HETE': [108, 131, 139, 147, 159, 165, 182], 'significantly': [115, 149], 'higher': [116], 'than': [117], 'normal': [120], 'people': [121], 'closely': [124], 'related': [125], 'degree': [128], 'could': [132, 141, 161], 'induce': [133], 'activation': [134], 'antagonist': [140], 'induction': [144], '20-HETE.': [146], 'increased': [150], 'CCl4-induced': [152], 'inhibition': [157], 'production': [160], 'attenuate': [162], 'mainly': [169], 'via': [170], 'TGF-': [172], 'β1/Smad3': [173], 'signal': [174], 'pathway.': [175], 'conclusion,': [177], 'suggest': [180], 'plays': [183], 'an': [184], 'important': [185], 'may': [191], 'be': [192], 'possible': [194], 'target': [195], 'for': [196], 'clinical': [198], 'treatment': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4308738493', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}], 'updated_date': '2024-09-13T21:10:38.691991', 'created_date': '2022-11-15'}