Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4308112307', 'doi': 'https://doi.org/10.1016/j.cmet.2022.10.001', 'title': 'The past, present, and future physiology and pharmacology of glucagon', 'display_name': 'The past, present, and future physiology and pharmacology of glucagon', 'publication_year': 2022, 'publication_date': '2022-11-01', 'ids': {'openalex': 'https://openalex.org/W4308112307', 'doi': 'https://doi.org/10.1016/j.cmet.2022.10.001', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36323234'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cmet.2022.10.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S177533077', 'display_name': 'Cell Metabolism', 'issn_l': '1550-4131', 'issn': ['1550-4131', '1932-7420'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1016/j.cmet.2022.10.001', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022558489', 'display_name': 'Megan E. Capozzi', 'orcid': 'https://orcid.org/0000-0002-7587-0663'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Megan E. Capozzi', 'raw_affiliation_strings': ['Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA'], 'affiliations': [{'raw_affiliation_string': 'Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA', 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071074041', 'display_name': 'David A. D’Alessio', 'orcid': 'https://orcid.org/0000-0003-4155-4870'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David A. D’Alessio', 'raw_affiliation_strings': ['Department of Medicine, Endocrinology Division, Duke University Medical Center, Durham, NC 27701, USA', 'Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA'], 'affiliations': [{'raw_affiliation_string': 'Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA', 'institution_ids': ['https://openalex.org/I4210126298']}, {'raw_affiliation_string': 'Department of Medicine, Endocrinology Division, Duke University Medical Center, Durham, NC 27701, USA', 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103123633', 'display_name': 'Jonathan E. Campbell', 'orcid': 'https://orcid.org/0000-0003-4358-6331'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210153043', 'display_name': 'Duke University Hospital', 'ror': 'https://ror.org/04bct7p84', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876', 'https://openalex.org/I4210153043']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Jonathan E. Campbell', 'raw_affiliation_strings': ['Department of Medicine, Endocrinology Division, Duke University Medical Center, Durham, NC 27701, USA', 'Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27701, USA', 'Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27701, USA', 'institution_ids': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210153043']}, {'raw_affiliation_string': 'Department of Medicine, Endocrinology Division, Duke University Medical Center, Durham, NC 27701, USA', 'institution_ids': ['https://openalex.org/I4210126298']}, {'raw_affiliation_string': 'Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA', 'institution_ids': ['https://openalex.org/I4210126298']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5103123633'], 'corresponding_institution_ids': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210153043'], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.512, 'has_fulltext': False, 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.523548, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '34', 'issue': '11', 'first_page': '1654', 'last_page': '1674'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10401', 'display_name': 'Management of Diabetes Mellitus and Cardiovascular Risk', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10560', 'display_name': 'Management of Diabetes Mellitus and Hypoglycemia', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hyperglucagonemia', 'display_name': 'Hyperglucagonemia', 'score': 0.98036706}, {'id': 'https://openalex.org/keywords/glucagon-receptor', 'display_name': 'Glucagon receptor', 'score': 0.8317835}, {'id': 'https://openalex.org/keywords/catabolism', 'display_name': 'Catabolism', 'score': 0.5665486}, {'id': 'https://openalex.org/keywords/continuous-glucose-monitoring', 'display_name': 'Continuous Glucose Monitoring', 'score': 0.550149}, {'id': 'https://openalex.org/keywords/glucose-control', 'display_name': 'Glucose Control', 'score': 0.533161}, {'id': 'https://openalex.org/keywords/diabetes', 'display_name': 'Diabetes', 'score': 0.528824}, {'id': 'https://openalex.org/keywords/glucose-homeostasis', 'display_name': 'Glucose Homeostasis', 'score': 0.514517}, {'id': 'https://openalex.org/keywords/type-2-diabetes', 'display_name': 'Type 2 Diabetes', 'score': 0.503322}], 'concepts': [{'id': 'https://openalex.org/C2908748658', 'wikidata': 'https://www.wikidata.org/wiki/Q776790', 'display_name': 'Hyperglucagonemia', 'level': 4, 'score': 0.98036706}, {'id': 'https://openalex.org/C2778563252', 'wikidata': 'https://www.wikidata.org/wiki/Q170617', 'display_name': 'Glucagon', 'level': 3, 'score': 0.95372343}, {'id': 'https://openalex.org/C2778542361', 'wikidata': 'https://www.wikidata.org/wiki/Q14904911', 'display_name': 'Glucagon receptor', 'level': 4, 'score': 0.8317835}, {'id': 'https://openalex.org/C96942376', 'wikidata': 'https://www.wikidata.org/wiki/Q21130714', 'display_name': 'Catabolism', 'level': 3, 'score': 0.5665486}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5375933}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4846659}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.44860414}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.44121}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.43209547}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3791258}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3204733}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.2541382}], 'mesh': [{'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D050416', 'descriptor_name': 'Glucagon-Secreting Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005934', 'descriptor_name': 'Glucagon', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005934', 'descriptor_name': 'Glucagon', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005934', 'descriptor_name': 'Glucagon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050416', 'descriptor_name': 'Glucagon-Secreting Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018027', 'descriptor_name': 'Receptors, Glucagon', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018027', 'descriptor_name': 'Receptors, Glucagon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cmet.2022.10.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S177533077', 'display_name': 'Cell Metabolism', 'issn_l': '1550-4131', 'issn': ['1550-4131', '1932-7420'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641554', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36323234', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cmet.2022.10.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S177533077', 'display_name': 'Cell Metabolism', 'issn_l': '1550-4131', 'issn': ['1550-4131', '1932-7420'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.67, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 235, 'referenced_works': ['https://openalex.org/W1522924058', 'https://openalex.org/W1535643256', 'https://openalex.org/W1569090915', 'https://openalex.org/W1592686897', 'https://openalex.org/W1594189146', 'https://openalex.org/W1613677910', 'https://openalex.org/W1773084519', 'https://openalex.org/W1802476941', 'https://openalex.org/W1940160448', 'https://openalex.org/W1964812502', 'https://openalex.org/W1965705224', 'https://openalex.org/W1967442749', 'https://openalex.org/W1971639453', 'https://openalex.org/W1971651709', 'https://openalex.org/W1975432012', 'https://openalex.org/W1975758863', 'https://openalex.org/W1982094574', 'https://openalex.org/W1986861420', 'https://openalex.org/W1987808520', 'https://openalex.org/W1988784323', 'https://openalex.org/W1988801692', 'https://openalex.org/W1988860334', 'https://openalex.org/W1989188472', 'https://openalex.org/W1991584810', 'https://openalex.org/W1993186449', 'https://openalex.org/W1994867775', 'https://openalex.org/W1995329674', 'https://openalex.org/W1999532186', 'https://openalex.org/W2003983489', 'https://openalex.org/W2006859748', 'https://openalex.org/W2007561446', 'https://openalex.org/W2008479890', 'https://openalex.org/W2010787940', 'https://openalex.org/W2012020918', 'https://openalex.org/W2012460673', 'https://openalex.org/W2013438463', 'https://openalex.org/W2013974905', 'https://openalex.org/W2014554878', 'https://openalex.org/W2015463169', 'https://openalex.org/W2019950804', 'https://openalex.org/W2026640914', 'https://openalex.org/W2027083357', 'https://openalex.org/W2028287235', 'https://openalex.org/W2030386197', 'https://openalex.org/W2035095846', 'https://openalex.org/W2036141586', 'https://openalex.org/W2039911916', 'https://openalex.org/W2041539328', 'https://openalex.org/W2045325331', 'https://openalex.org/W2046912474', 'https://openalex.org/W2050103781', 'https://openalex.org/W2050636523', 'https://openalex.org/W2050915207', 'https://openalex.org/W2050946651', 'https://openalex.org/W2053234614', 'https://openalex.org/W2054111620', 'https://openalex.org/W2054564814', 'https://openalex.org/W2055721182', 'https://openalex.org/W2057346406', 'https://openalex.org/W2057500552', 'https://openalex.org/W2059531482', 'https://openalex.org/W2059719062', 'https://openalex.org/W2059802140', 'https://openalex.org/W2060932265', 'https://openalex.org/W2061258998', 'https://openalex.org/W2061574308', 'https://openalex.org/W2061865038', 'https://openalex.org/W2065212828', 'https://openalex.org/W2065571876', 'https://openalex.org/W2067102849', 'https://openalex.org/W2068732838', 'https://openalex.org/W2069337786', 'https://openalex.org/W2070303853', 'https://openalex.org/W2073158702', 'https://openalex.org/W2078229355', 'https://openalex.org/W2079078137', 'https://openalex.org/W2084766474', 'https://openalex.org/W2085330452', 'https://openalex.org/W2088773716', 'https://openalex.org/W2092465444', 'https://openalex.org/W2092700428', 'https://openalex.org/W2094544071', 'https://openalex.org/W2095482123', 'https://openalex.org/W2101814428', 'https://openalex.org/W2102597208', 'https://openalex.org/W2103920106', 'https://openalex.org/W2104523229', 'https://openalex.org/W2105748867', 'https://openalex.org/W2106971468', 'https://openalex.org/W2112871433', 'https://openalex.org/W2113278846', 'https://openalex.org/W2113527429', 'https://openalex.org/W2113530540', 'https://openalex.org/W2119612859', 'https://openalex.org/W2122367003', 'https://openalex.org/W2122905319', 'https://openalex.org/W2125591445', 'https://openalex.org/W2126411608', 'https://openalex.org/W2127167047', 'https://openalex.org/W2128251681', 'https://openalex.org/W2136764645', 'https://openalex.org/W2140141005', 'https://openalex.org/W2140978079', 'https://openalex.org/W2141771305', 'https://openalex.org/W2144387356', 'https://openalex.org/W2144576542', 'https://openalex.org/W2144640781', 'https://openalex.org/W2146415791', 'https://openalex.org/W2146466098', 'https://openalex.org/W2146534889', 'https://openalex.org/W2147903228', 'https://openalex.org/W2148175667', 'https://openalex.org/W2149712400', 'https://openalex.org/W2150399183', 'https://openalex.org/W2150622862', 'https://openalex.org/W2153585915', 'https://openalex.org/W2154785285', 'https://openalex.org/W2155450095', 'https://openalex.org/W2156443031', 'https://openalex.org/W2159459646', 'https://openalex.org/W2161741963', 'https://openalex.org/W2162418500', 'https://openalex.org/W2162440711', 'https://openalex.org/W2164739927', 'https://openalex.org/W2166913319', 'https://openalex.org/W2199891677', 'https://openalex.org/W2207556001', 'https://openalex.org/W2319284560', 'https://openalex.org/W2321801510', 'https://openalex.org/W2328089478', 'https://openalex.org/W2329149299', 'https://openalex.org/W2335041533', 'https://openalex.org/W2339874459', 'https://openalex.org/W2340464977', 'https://openalex.org/W2342294330', 'https://openalex.org/W2346764160', 'https://openalex.org/W2391083005', 'https://openalex.org/W2410646263', 'https://openalex.org/W2414002317', 'https://openalex.org/W2416488997', 'https://openalex.org/W2514133655', 'https://openalex.org/W2521730099', 'https://openalex.org/W2528810881', 'https://openalex.org/W2549302673', 'https://openalex.org/W2563394258', 'https://openalex.org/W2583125779', 'https://openalex.org/W2583338414', 'https://openalex.org/W2591832038', 'https://openalex.org/W2592871963', 'https://openalex.org/W2595853302', 'https://openalex.org/W2597198656', 'https://openalex.org/W2598676152', 'https://openalex.org/W2604759438', 'https://openalex.org/W2604852286', 'https://openalex.org/W2606401765', 'https://openalex.org/W2612316600', 'https://openalex.org/W2618137606', 'https://openalex.org/W2622785186', 'https://openalex.org/W2623137383', 'https://openalex.org/W2734127146', 'https://openalex.org/W2754928426', 'https://openalex.org/W2758956409', 'https://openalex.org/W2779666226', 'https://openalex.org/W2781547740', 'https://openalex.org/W2783721053', 'https://openalex.org/W2786903684', 'https://openalex.org/W2789611122', 'https://openalex.org/W2792395170', 'https://openalex.org/W2795481136', 'https://openalex.org/W2802042026', 'https://openalex.org/W2804855734', 'https://openalex.org/W2807927825', 'https://openalex.org/W2808030638', 'https://openalex.org/W2886911834', 'https://openalex.org/W2889408384', 'https://openalex.org/W2899339394', 'https://openalex.org/W2911935607', 'https://openalex.org/W2914141586', 'https://openalex.org/W2914783967', 'https://openalex.org/W2918858243', 'https://openalex.org/W2921138268', 'https://openalex.org/W2927163824', 'https://openalex.org/W2940492200', 'https://openalex.org/W2941039646', 'https://openalex.org/W2945339474', 'https://openalex.org/W2948394616', 'https://openalex.org/W2963266978', 'https://openalex.org/W2967453995', 'https://openalex.org/W2981706918', 'https://openalex.org/W2982363774', 'https://openalex.org/W2994879170', 'https://openalex.org/W3001720309', 'https://openalex.org/W3003663516', 'https://openalex.org/W3007650583', 'https://openalex.org/W3015267091', 'https://openalex.org/W3024746822', 'https://openalex.org/W3027292275', 'https://openalex.org/W3033451567', 'https://openalex.org/W3034529715', 'https://openalex.org/W3036314870', 'https://openalex.org/W3082270698', 'https://openalex.org/W3083878863', 'https://openalex.org/W3085056884', 'https://openalex.org/W3087889571', 'https://openalex.org/W3092115529', 'https://openalex.org/W3104261746', 'https://openalex.org/W3107959946', 'https://openalex.org/W3118955581', 'https://openalex.org/W3130443851', 'https://openalex.org/W3134075201', 'https://openalex.org/W3139973230', 'https://openalex.org/W3147643344', 'https://openalex.org/W3154496344', 'https://openalex.org/W3155770573', 'https://openalex.org/W3157453693', 'https://openalex.org/W3158732985', 'https://openalex.org/W3160773731', 'https://openalex.org/W3177122952', 'https://openalex.org/W3177270616', 'https://openalex.org/W3177393241', 'https://openalex.org/W3189887832', 'https://openalex.org/W3196916730', 'https://openalex.org/W3198244591', 'https://openalex.org/W3212938293', 'https://openalex.org/W3213821887', 'https://openalex.org/W3214082775', 'https://openalex.org/W4200085837', 'https://openalex.org/W4212972020', 'https://openalex.org/W4220747142', 'https://openalex.org/W4221069978', 'https://openalex.org/W4225916730', 'https://openalex.org/W4226050738', 'https://openalex.org/W4243679099', 'https://openalex.org/W4281947100', 'https://openalex.org/W4301495556'], 'related_works': ['https://openalex.org/W4308112307', 'https://openalex.org/W4205979504', 'https://openalex.org/W3034529715', 'https://openalex.org/W2948991480', 'https://openalex.org/W2549302673', 'https://openalex.org/W2529231790', 'https://openalex.org/W2168726045', 'https://openalex.org/W2140141005', 'https://openalex.org/W2057500552', 'https://openalex.org/W2030479607'], 'abstract_inverted_index': {'The': [0], 'evolution': [1], 'of': [2, 14, 19, 52, 67, 72, 82, 88, 112, 136, 151], 'glucagon': [3, 20, 33, 53, 73, 83, 96, 113, 137], 'has': [4, 114], 'seen': [5], 'the': [6, 12, 17, 49, 60, 70, 79, 86, 110, 134, 139, 142, 149], 'transition': [7], 'from': [8, 138], 'an': [9], 'impurity': [10], 'in': [11, 25, 62], 'preparation': [13], 'insulin': [15], 'to': [16, 39, 43, 58, 97, 122, 127, 141, 148], 'development': [18], 'receptor': [21, 34], 'agonists': [22], 'for': [23, 95], 'use': [24], 'type': [26, 30], '1': [27], 'diabetes.': [28], 'In': [29], '2': [31], 'diabetes,': [32, 68], 'antagonists': [35], 'have': [36], 'been': [37], 'explored': [38], 'reduce': [40], 'glycemia': [41], 'thought': [42], 'be': [44], 'induced': [45], 'by': [46], 'hyperglucagonemia.': [47], 'However,': [48], 'catabolic': [50], 'actions': [51], 'are': [54], 'currently': [55], 'being': [56], 'leveraged': [57], 'target': [59], 'rise': [61], 'obesity': [63], 'that': [64, 66, 109, 118], 'paralleled': [65], 'bringing': [69], 'pharmacology': [71], 'full': [74], 'circle.': [75], 'During': [76], 'this': [77, 124, 152], 'evolution,': [78], 'physiological': [80], 'importance': [81], 'advanced': [84], 'beyond': [85], 'control': [87], 'hepatic': [89], 'glucose': [90], 'production,': [91], 'incorporating': [92], 'critical': [93], 'roles': [94], 'regulate': [98], 'both': [99], 'lipid': [100], 'and': [101, 144], 'amino': [102], 'acid': [103], 'metabolism.': [104], 'Thus,': [105], 'it': [106, 120], 'is': [107], 'unsurprising': [108], 'study': [111], 'left': [115], 'several': [116], 'paradoxes': [117], 'make': [119], 'difficult': [121], 'distill': [123], 'hormone': [125], 'down': [126], 'a': [128], 'simplified': [129], 'action.': [130], 'Here,': [131], 'we': [132], 'describe': [133], 'history': [135], 'past': [140], 'present': [143], 'suggest': [145], 'some': [146], 'direction': [147], 'future': [150], 'field.': [153]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4308112307', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 22}], 'updated_date': '2024-09-12T10:14:30.175695', 'created_date': '2022-11-08'}