Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4307887061', 'doi': 'https://doi.org/10.1186/s10020-022-00559-5', 'title': 'Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications', 'display_name': 'Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications', 'publication_year': 2022, 'publication_date': '2022-10-31', 'ids': {'openalex': 'https://openalex.org/W4307887061', 'doi': 'https://doi.org/10.1186/s10020-022-00559-5', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36316651'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s10020-022-00559-5', 'pdf_url': 'https://molmed.biomedcentral.com/counter/pdf/10.1186/s10020-022-00559-5', 'source': {'id': 'https://openalex.org/S6769275', 'display_name': 'Molecular Medicine', 'issn_l': '1076-1551', 'issn': ['1076-1551', '1528-3658'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://molmed.biomedcentral.com/counter/pdf/10.1186/s10020-022-00559-5', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037037283', 'display_name': 'Mitko Mladenov', 'orcid': 'https://orcid.org/0000-0003-3475-2131'}, 'institutions': [{'id': 'https://openalex.org/I76245029', 'display_name': 'Saints Cyril and Methodius University of Skopje', 'ror': 'https://ror.org/02wk2vx54', 'country_code': 'MK', 'type': 'education', 'lineage': ['https://openalex.org/I76245029']}], 'countries': ['MK'], 'is_corresponding': False, 'raw_author_name': 'Mitko Mladenov', 'raw_affiliation_strings': ['Faculty of Natural Sciences and Mathematics, Institute of Biology, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Natural Sciences and Mathematics, Institute of Biology, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia', 'institution_ids': ['https://openalex.org/I76245029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012723358', 'display_name': 'Jane Bogdanov', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I76245029', 'display_name': 'Saints Cyril and Methodius University of Skopje', 'ror': 'https://ror.org/02wk2vx54', 'country_code': 'MK', 'type': 'education', 'lineage': ['https://openalex.org/I76245029']}], 'countries': ['MK'], 'is_corresponding': False, 'raw_author_name': 'Jane Bogdanov', 'raw_affiliation_strings': ['Faculty of Natural Sciences and Mathematics, Institute of Chemistry, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Natural Sciences and Mathematics, Institute of Chemistry, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia', 'institution_ids': ['https://openalex.org/I76245029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004334738', 'display_name': 'B. Bogdanov', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I76245029', 'display_name': 'Saints Cyril and Methodius University of Skopje', 'ror': 'https://ror.org/02wk2vx54', 'country_code': 'MK', 'type': 'education', 'lineage': ['https://openalex.org/I76245029']}], 'countries': ['MK'], 'is_corresponding': False, 'raw_author_name': 'Bogdan Bogdanov', 'raw_affiliation_strings': ['Faculty of Natural Sciences and Mathematics, Institute of Chemistry, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Natural Sciences and Mathematics, Institute of Chemistry, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia', 'institution_ids': ['https://openalex.org/I76245029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073267151', 'display_name': 'Nikola Hadzi‐Petrushev', 'orcid': 'https://orcid.org/0000-0002-4498-7359'}, 'institutions': [{'id': 'https://openalex.org/I76245029', 'display_name': 'Saints Cyril and Methodius University of Skopje', 'ror': 'https://ror.org/02wk2vx54', 'country_code': 'MK', 'type': 'education', 'lineage': ['https://openalex.org/I76245029']}], 'countries': ['MK'], 'is_corresponding': False, 'raw_author_name': 'Nikola Hadzi-Petrushev', 'raw_affiliation_strings': ['Faculty of Natural Sciences and Mathematics, Institute of Biology, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Natural Sciences and Mathematics, Institute of Biology, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia', 'institution_ids': ['https://openalex.org/I76245029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110532157', 'display_name': 'Andre Kamkin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I337778094', 'display_name': 'Pirogov Russian National Research Medical University', 'ror': 'https://ror.org/018159086', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I337778094', 'https://openalex.org/I4210117042']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Andre Kamkin', 'raw_affiliation_strings': ['Department of Physiology, Pirogov Russian National Research Medical University, Ostrovityanova Street 1, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, Pirogov Russian National Research Medical University, Ostrovityanova Street 1, Moscow, Russia', 'institution_ids': ['https://openalex.org/I337778094']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015915229', 'display_name': 'Radoslav Stojchevski', 'orcid': 'https://orcid.org/0000-0002-5942-1622'}, 'institutions': [{'id': 'https://openalex.org/I2800628709', 'display_name': 'Lenox Hill Hospital', 'ror': 'https://ror.org/0231d2y50', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I2800628709']}, {'id': 'https://openalex.org/I1302444339', 'display_name': 'Northwell Health', 'ror': 'https://ror.org/02bxt4m23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Radoslav Stojchevski', 'raw_affiliation_strings': ['Friedman Diabetes Institute at Lenox Hill Hospital, Northwell Health, 110 E 59th Street, Suite 8B, Room 837, 10022, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Friedman Diabetes Institute at Lenox Hill Hospital, Northwell Health, 110 E 59th Street, Suite 8B, Room 837, 10022, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2800628709', 'https://openalex.org/I1302444339']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076949477', 'display_name': 'Dimiter Avtanski', 'orcid': 'https://orcid.org/0000-0002-4479-6448'}, 'institutions': [{'id': 'https://openalex.org/I2800628709', 'display_name': 'Lenox Hill Hospital', 'ror': 'https://ror.org/0231d2y50', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I2800628709']}, {'id': 'https://openalex.org/I1302444339', 'display_name': 'Northwell Health', 'ror': 'https://ror.org/02bxt4m23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dimiter Avtanski', 'raw_affiliation_strings': ['Friedman Diabetes Institute at Lenox Hill Hospital, Northwell Health, 110 E 59th Street, Suite 8B, Room 837, 10022, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Friedman Diabetes Institute at Lenox Hill Hospital, Northwell Health, 110 E 59th Street, Suite 8B, Room 837, 10022, New York, NY, USA', 'institution_ids': ['https://openalex.org/I2800628709', 'https://openalex.org/I1302444339']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1990, 'currency': 'GBP', 'value_usd': 2440, 'provenance': 'doaj'}, 'apc_paid': {'value': 1990, 'currency': 'GBP', 'value_usd': 2440, 'provenance': 'doaj'}, 'fwci': 0.462, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.284024, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '28', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11319', 'display_name': "Curcumin's Biomedical Applications", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11319', 'display_name': "Curcumin's Biomedical Applications", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13254', 'display_name': 'Macrophage Migration Inhibitory Factor', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13551', 'display_name': 'Biochemical effects in animals', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.7790094}, {'id': 'https://openalex.org/C2778250585', 'wikidata': 'https://www.wikidata.org/wiki/Q312266', 'display_name': 'Curcumin', 'level': 2, 'score': 0.6661792}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5952688}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.48613593}, {'id': 'https://openalex.org/C67082663', 'wikidata': 'https://www.wikidata.org/wiki/Q3523816', 'display_name': 'Molecular medicine', 'level': 4, 'score': 0.47128338}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4200503}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.36754182}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.2915187}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.083716154}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s10020-022-00559-5', 'pdf_url': 'https://molmed.biomedcentral.com/counter/pdf/10.1186/s10020-022-00559-5', 'source': {'id': 'https://openalex.org/S6769275', 'display_name': 'Molecular Medicine', 'issn_l': '1076-1551', 'issn': ['1076-1551', '1528-3658'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/d57bba6f185144f1850b50f988e985b8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620630', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36316651', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s10020-022-00559-5', 'pdf_url': 'https://molmed.biomedcentral.com/counter/pdf/10.1186/s10020-022-00559-5', 'source': {'id': 'https://openalex.org/S6769275', 'display_name': 'Molecular Medicine', 'issn_l': '1076-1551', 'issn': ['1076-1551', '1528-3658'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.82, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 132, 'referenced_works': ['https://openalex.org/W1487479750', 'https://openalex.org/W1515160621', 'https://openalex.org/W1535475758', 'https://openalex.org/W1544633776', 'https://openalex.org/W1566119822', 'https://openalex.org/W1858846386', 'https://openalex.org/W1965940007', 'https://openalex.org/W1971441087', 'https://openalex.org/W1971444224', 'https://openalex.org/W1974633849', 'https://openalex.org/W1975652164', 'https://openalex.org/W1975770667', 'https://openalex.org/W1981774142', 'https://openalex.org/W1983401069', 'https://openalex.org/W1986125636', 'https://openalex.org/W1987712541', 'https://openalex.org/W1988943265', 'https://openalex.org/W1991327193', 'https://openalex.org/W1991389049', 'https://openalex.org/W1991451322', 'https://openalex.org/W1992564227', 'https://openalex.org/W1992888962', 'https://openalex.org/W1996854381', 'https://openalex.org/W1997676435', 'https://openalex.org/W1997784491', 'https://openalex.org/W1997863391', 'https://openalex.org/W2002073588', 'https://openalex.org/W2002804439', 'https://openalex.org/W2004840945', 'https://openalex.org/W2009621510', 'https://openalex.org/W2009912257', 'https://openalex.org/W2013744555', 'https://openalex.org/W2013821641', 'https://openalex.org/W2017754734', 'https://openalex.org/W2018797572', 'https://openalex.org/W2022617421', 'https://openalex.org/W2029305679', 'https://openalex.org/W2029661871', 'https://openalex.org/W2030339637', 'https://openalex.org/W2031439970', 'https://openalex.org/W2033043158', 'https://openalex.org/W2034123367', 'https://openalex.org/W2040081799', 'https://openalex.org/W2040459007', 'https://openalex.org/W2041019655', 'https://openalex.org/W2042338705', 'https://openalex.org/W2049154089', 'https://openalex.org/W2058046287', 'https://openalex.org/W2061166531', 'https://openalex.org/W2063187946', 'https://openalex.org/W2065238738', 'https://openalex.org/W2065612142', 'https://openalex.org/W2070426078', 'https://openalex.org/W2073588035', 'https://openalex.org/W2074740965', 'https://openalex.org/W2077069398', 'https://openalex.org/W2077166822', 'https://openalex.org/W2077895811', 'https://openalex.org/W2080419804', 'https://openalex.org/W2081272963', 'https://openalex.org/W2081408570', 'https://openalex.org/W2081476178', 'https://openalex.org/W2081876939', 'https://openalex.org/W2084780635', 'https://openalex.org/W2087854103', 'https://openalex.org/W2090303371', 'https://openalex.org/W2092490963', 'https://openalex.org/W2093009907', 'https://openalex.org/W2093234844', 'https://openalex.org/W2096693165', 'https://openalex.org/W2096931514', 'https://openalex.org/W2097374264', 'https://openalex.org/W2099295261', 'https://openalex.org/W2112486282', 'https://openalex.org/W2116087305', 'https://openalex.org/W2120535614', 'https://openalex.org/W2123684526', 'https://openalex.org/W2124122523', 'https://openalex.org/W2133174050', 'https://openalex.org/W2135140753', 'https://openalex.org/W2135399983', 'https://openalex.org/W2135684059', 'https://openalex.org/W2137605946', 'https://openalex.org/W2141103901', 'https://openalex.org/W2143966947', 'https://openalex.org/W2146378769', 'https://openalex.org/W2146558971', 'https://openalex.org/W2146749576', 'https://openalex.org/W2147173545', 'https://openalex.org/W2148119611', 'https://openalex.org/W2148489323', 'https://openalex.org/W2154111720', 'https://openalex.org/W2155022036', 'https://openalex.org/W2156562672', 'https://openalex.org/W2158200096', 'https://openalex.org/W2158497176', 'https://openalex.org/W2159706204', 'https://openalex.org/W2167543749', 'https://openalex.org/W2171392415', 'https://openalex.org/W2173064381', 'https://openalex.org/W2173107455', 'https://openalex.org/W2253579948', 'https://openalex.org/W2267800268', 'https://openalex.org/W2342967374', 'https://openalex.org/W2405183840', 'https://openalex.org/W2418609627', 'https://openalex.org/W2517809404', 'https://openalex.org/W2529079020', 'https://openalex.org/W2560098666', 'https://openalex.org/W2579340176', 'https://openalex.org/W2606221454', 'https://openalex.org/W2611502890', 'https://openalex.org/W2612172075', 'https://openalex.org/W2620079766', 'https://openalex.org/W2788488823', 'https://openalex.org/W2791011305', 'https://openalex.org/W2800659616', 'https://openalex.org/W2803636650', 'https://openalex.org/W2807835895', 'https://openalex.org/W2890923113', 'https://openalex.org/W2896858448', 'https://openalex.org/W2897075077', 'https://openalex.org/W2902644392', 'https://openalex.org/W2952397590', 'https://openalex.org/W2964485240', 'https://openalex.org/W2971456522', 'https://openalex.org/W3007488940', 'https://openalex.org/W3081169663', 'https://openalex.org/W3122741988', 'https://openalex.org/W3159217912', 'https://openalex.org/W3160651125', 'https://openalex.org/W3199284064'], 'related_works': ['https://openalex.org/W4379468034', 'https://openalex.org/W4360797513', 'https://openalex.org/W2899084033', 'https://openalex.org/W2887769962', 'https://openalex.org/W2589512255', 'https://openalex.org/W2117116660', 'https://openalex.org/W2055583675', 'https://openalex.org/W2047540814', 'https://openalex.org/W1984122016', 'https://openalex.org/W1971462710'], 'abstract_inverted_index': {'Abstract': [0], 'Curcumin': [1], 'is': [2, 20, 30, 123, 156, 234], 'a': [3, 188, 236], 'polyphenolic': [4], 'compound': [5], 'derived': [6], 'from': [7], 'turmeric': [8], 'that': [9], 'has': [10], 'potential': [11], 'beneficial': [12], 'properties': [13], 'for': [14, 240], 'cardiovascular': [15, 108, 147, 242], 'and': [16, 19, 23, 38, 48, 80, 89, 109, 129, 135, 143, 178, 201, 203, 211, 219, 243], 'renal': [17, 110, 141, 244], 'diseases': [18], 'relatively': [21], 'safe': [22], 'inexpensive.': [24], 'However,': [25], 'the': [26, 98, 101, 118, 125, 133, 181, 205, 230], 'application': [27, 102], 'of': [28, 51, 53, 67, 84, 103, 127, 139, 150, 169, 183, 207, 225], 'curcumin': [29], 'rather': [31], 'problematic': [32], 'due': [33], 'to': [34], 'its': [35, 54, 70], 'chemical': [36, 46, 76], 'instability': [37], 'low': [39], 'bioavailability.': [40], 'The': [41, 146], 'experimental': [42], 'results': [43], 'showed': [44], 'improved': [45, 75], 'stability': [47, 77], 'potent': [49], 'pharmacokinetics': [50], 'one': [52], 'analogs': [55], '–': [56], '(2': [57], 'E': [58, 60], ',6': [59], ')-2,6-bis[(2-trifluoromethyl)benzylidene]cyclohexanone': [61], '(C66).': [62], 'There': [63], 'are': [64], 'several': [65], 'advantages': [66], 'C66,': [68], 'like': [69], 'synthetic': [71], 'accessibility,': [72], 'structural': [73], 'simplicity,': [74], '(in': [78], 'vitro': [79], 'in': [81, 105, 112, 132, 136, 180, 222], 'vivo),': [82], 'presence': [83], 'two': [85], 'reactive': [86], 'electrophilic': [87], 'centers,': [88], 'good': [90], 'electron-accepting': [91], 'capacity.': [92], 'Considering': [93], 'these': [94], 'characteristics,': [95], 'we': [96], 'reviewed': [97], 'literature': [99], 'on': [100, 162, 229], 'C66': [104, 122, 151, 166, 186, 233], 'resolving': [106], 'diabetes-associated': [107], 'complications': [111], 'animal': [113, 223], 'models.': [114], 'We': [115], 'also': [116], 'summarized': [117], 'mechanisms': [119], 'by': [120, 192], 'which': [121, 171], 'preventing': [124], 'release': [126], 'pro-oxidative': [128], 'pro-inflammatory': [130], 'molecules': [131], 'priming': [134], 'activation': [137], 'stage': [138], 'cardiomyopathy,': [140], 'fibrosis,': [142, 175], 'diabetic': [144, 184, 226], 'nephropathy.': [145, 227], 'protective': [148], 'effect': [149, 191], 'against': [152], 'diabetes-induced': [153], 'oxidative': [154, 176], 'damage': [155], 'Nrf2': [157], 'mediated': [158], 'but': [159], 'mainly': [160], 'dependent': [161], 'JNK2.': [163], 'In': [164], 'general,': [165], 'causes': [167], 'inhibition': [168], 'JNK2,': [170], 'reduces': [172], 'cardiac': [173], 'inflammation,': [174], 'stress,': [177], 'apoptosis': [179], 'settings': [182], 'cardiomyopathy.': [185], 'exerts': [187], 'powerful': [189], 'antifibrotic': [190], 'reducing': [193], 'inflammation-related': [194], 'factors': [195, 209], '(MCP-1,': [196], 'NF-κB,': [197], 'TNF-α,': [198], 'IL-1β,': [199], 'COX-2,': [200], 'CAV-1)': [202], 'inducing': [204], 'expression': [206], 'anti-inflammatory': [208], '(HO-1': [210], 'NEDD4),': [212], 'as': [213, 215], 'well': [214], 'targeting': [216], 'TGF-β/SMADs,': [217], 'MAPK/ERK,': [218], 'PPAR-γ': [220], 'pathways': [221], 'models': [224], 'Based': [228], 'available': [231], 'evidence,': [232], 'becoming': [235], 'promising': [237], 'drug': [238], 'candidate': [239], 'improving': [241], 'health.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4307887061', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 5}], 'updated_date': '2024-12-16T03:34:11.790699', 'created_date': '2022-11-06'}