Title: Metal‐Cyclic Dinucleotide Nanomodulator‐Stimulated STING Signaling for Strengthened Radioimmunotherapy of Large Tumor (Small 41/2022)
Abstract: SmallVolume 18, Issue 41 2270219 FrontispieceFree Access Metal-Cyclic Dinucleotide Nanomodulator-Stimulated STING Signaling for Strengthened Radioimmunotherapy of Large Tumor (Small 41/2022) Duo Wang, Duo Wang The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorTianqi Nie, Tianqi Nie Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107 ChinaSearch for more papers by this authorCuiqing Huang, Cuiqing Huang The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorZerong Chen, Zerong Chen The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorXiaocong Ma, Xiaocong Ma The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorWeiming Fang, Weiming Fang The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorYanyu Huang, Yanyu Huang Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA, 95817 USASearch for more papers by this authorLiangping Luo, Liangping Luo The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 China Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, 510317 ChinaSearch for more papers by this authorZeyu Xiao, Zeyu Xiao The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this author Duo Wang, Duo Wang The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorTianqi Nie, Tianqi Nie Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107 ChinaSearch for more papers by this authorCuiqing Huang, Cuiqing Huang The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorZerong Chen, Zerong Chen The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorXiaocong Ma, Xiaocong Ma The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorWeiming Fang, Weiming Fang The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this authorYanyu Huang, Yanyu Huang Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA, 95817 USASearch for more papers by this authorLiangping Luo, Liangping Luo The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 China Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, 510317 ChinaSearch for more papers by this authorZeyu Xiao, Zeyu Xiao The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, 510632 ChinaSearch for more papers by this author First published: 13 October 2022 https://doi.org/10.1002/smll.202270219AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Large Tumor Therapy In article number 2203227, Yanyu Huang, Liangping Luo, Zeyu Xiao, and co-workers report a localized radioimmunotherapeutic regimen by using X-ray irradiation and a metal-cyclic dinucleotide-containing nanomodulator for the treatment of large tumors. This combined paradigm amplifies the STING signaling pathway by elevating the production of 2′,3′-cGAMP and activating both localized and systematic anti-tumor immunity. Volume18, Issue41October 13, 20222270219 RelatedInformation