Edge-to-Edge Transcatheter Mitral Valve Repair Versus Optimal Medical Treatment in Nonresponders to Cardiac Resynchronization Therapy: The MITRA-CRT Trial

Name: Work Video:
Duration: 3 min 30 s
Xavier Freixa; José Marı́a Tolosana; Pedro Cepas‐Guillén; Marco Hernández‐Enríquez; Laura Sanchís; Eduardo Flores‐Umanzor; Marta Farrero; Rut Andrea; Mercè Roqué; Maria José Carretero; Ander Regueiro; Salvatore Brugaletta; Josep Rodés‐Cabau; Lluı́s Mont; Marta Sitges; Manel Sabaté; M. Castel
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1124, 1132, 1140, 1195, 1206, 1225, 1253, 1257, 1262, 1270, 1279, 1296, 1306, 1318, 1332, 1340, 1347, 1513, 1525, 2016, 2026, 2051, 2055, 2060, 2117, 2125, 2129, 2134, 2167, 2183, 2189, 2199, 2211, 2218, 2230, 2235, 2286, 2467, 2571, 2589], 'most': [723, 1354], 'recent': [724], 'version': [725], 'article.': [728], 'Previous': [729, 1444, 1451, 1508, 2602], 'versions:': [730], 'September': [731], '20,': [732, 2625], '2022:': [733], 'Ahead': [734], 'Print': [736], 'mitral': [738, 776, 1085, 1969, 2000, 2423, 2456, 2504], 'valve': [739, 2001, 2457], 'repair': [740, 2379, 2417, 2458], '(TMVr)': [741], 'with': [742, 751, 774, 837, 862, 926, 959, 992, 999, 1014, 1024, 1063, 1091, 1173, 1624, 2143, 2159, 2163, 2229, 2263, 2382, 2461], '"edge-to-edge"': [743, 2155], 'systems': [744], 'have': [745, 780], 'shown': [746, 781, 1345], 'promising': [747], 'results': [748], 'patients': [750, 773, 818, 836, 861, 914, 953, 998, 1241, 1248, 1266, 1294, 1322, 1356, 2022, 2049, 2086, 2142, 2228, 2381, 2460], 'dilated': [752], 'cardiomyopathy': [753], '(DCM)': [754], 'reduced': [756, 807, 933, 2054], 'left': [757, 874, 934, 1361, 1940, 1943, 1946, 1950, 1955, 1960, 1964, 2095, 2130], 'ventricular': [758], 'ejection': [759, 1957], 'fraction': [760], '(LVEF).1': [761], 'Recent': [762], 'randomized': [763, 1099, 1275, 2008], 'trials': [764], 'comparing': [765, 987], 'optimal': [766], 'medical': [767, 1082, 1539, 2419], 'therapy': [768, 842, 1026, 2511], '(OMT)': [769], 'versus': [770, 949, 989, 2041], 'TMVr': [771, 820, 851, 911, 991, 1090, 1263, 1277, 1307, 2021, 2052, 2085, 2118], 'functional': [775, 928, 2069], 'regurgitation': [777, 2505], '(FMR)': [778], '>2': [779, 961], 'divergent': [782], 'results.': [783], 'One': [784, 2005], 'them,': [786, 1246], 'COAPT': [788, 2376, 2468], 'trial': [789, 908, 967, 986], '(Cardiovascular': [790], 'Outcomes': [791, 1411], 'Assessment': [792], 'Mitraclip': [795, 994], 'Percutaneous': [796], 'Therapy': [797], 'for': [798, 1067, 1089, 1337, 1510, 1522, 2251, 2298, 2421, 2558, 2560], 'Failure': [800, 2573, 2638], 'Patients': [801, 1623], 'With': [802], 'Functional': [803], 'Regurgitation),': [805], 'reported': [806, 1167, 1180], 'mortality': [808], 'heart': [810, 1034, 1044, 1211, 1690, 1937, 2032, 2174, 2383], 'failure': [811, 1045], '(HF)': [812], 'admissions': [813, 1336], 'after': [814, 878, 1386, 1658], '2': [815], 'years': [816], 'undergoing': [819], 'on': [821, 835, 1799], 'top': [822, 2605], 'OMT.1,2': [824], 'In': [825], 'addition,': [826], 'a': [827, 857, 979, 1052, 1064, 1185, 1237, 1289, 1300, 2111, 2114, 2164, 2180, 2282, 2556], 'subgroup': [828], 'analysis': [829], 'latter': [832], 'study': [833, 944, 1106, 1136, 2247, 2274], 'focusing': [834], 'without': [839, 2463], 'cardiac': [840, 1923, 2464, 2509, 2553], 'resynchronization': [841, 1924, 2465, 2510, 2554], '(CRT)': [843], 'also': [844, 2066], 'revealed': [845], 'improved': [846, 927, 2068], '2-year': [847], 'prognosis': [848], 'group.3': [852], 'Auricchio': [853, 2477, 2530], 'et': [854, 2374, 2413, 2453, 2499, 2548], 'al4': [855], 'analyzed': [856], 'cohort': [858], 'DCM': [860, 952, 997, 1013, 2144, 2219], 'CRT': [863, 899, 916, 956, 966, 1000, 1020, 1464, 1476, 2146], 'FMR': [865, 919, 960, 1008, 2153], '>2,': [866, 2154], 'showing': [867], 'significant': [868, 918, 1364], 'clinical': [869, 1420, 2222, 2252], 'improvement,': [870], 'LVEF': [871, 930, 1015, 1349, 2099], 'recovery,': [872, 931], 'ventricle': [875, 935, 1947, 1951, 1956, 1961, 1965, 2096, 2131], 'volume': [876, 1371, 1607, 1610, 1613, 1869, 1876], 'reduction': [877, 2024, 2115, 2165, 2181], 'TMVr.': [879, 1104], 'Nonetheless,': [880], 'post': [882], 'hoc': [883], 'retrospective': [885], 'nature': [886], 'aforementioned': [889, 2231], 'studies': [890, 2262], 'absence': [893], 'stratification': [895], 'according': [896], 'response': [900], 'represent': [901], 'major': [902], 'limitations.': [903], 'hypothesis': [905], 'our': [907], 'was': [909, 945, 978, 1087, 1098, 1107, 1156, 1203, 1312, 1350, 1379, 2007, 2161, 2271], 'that': [910, 1130], 'nonresponder': [913], '(grade': [920, 1579, 1584, 1590], '≥2,': [921], '100%)': [922], 'would': [923], 'be': [924, 2257], 'associated': [925, 2162], 'class,': [929], 'volumes.': [936], 'Thus,': [937], 'objective': [939], 'present': [942, 2152], 'pilot': [943, 2246], 'compare': [947], 'OMT': [948, 988], 'OMT+TMVr': [950], 'who': [954, 1001, 2147], 'received': [955, 1269, 2281], 'remained': [958], 'advanced': [963, 1043, 1314, 2126], 'HF.The': [964], 'MITRA': [965], '(Transcatheter': [968], 'non-Responders': [973], 'Therapy)': [977], 'pilot,': [980], 'single-center,': [981], 'randomized,': [982], 'controlled': [983], 'open-label': [985], 'OMT+"edge-to-edge"': [990], 'device': [995, 2010], 'were': [1002, 1171, 1190, 1242, 1249, 1403, 2100, 2148, 2208], 'clinically': [1003, 2149], 'symptomatic': [1004], '(nonresponders)': [1005], 'had': [1007, 1012], '>2.': [1009], 'Clinical': [1010, 1152, 1310], 'candidates': [1011], 'between': [1016, 1192, 2102], '15%': [1017], '40%,': [1019], 'implantation': [1021, 1388, 1465, 1660], '>6': [1022], 'months': [1023, 2019, 2078], 'effective': [1025, 1929], 'defined': [1027, 1047, 1204], 'as': [1028, 1168, 1181, 1184, 1205, 1315, 1892, 2157, 2259], 'biventricular': [1029, 1475], 'stimulation': [1030], '>95%': [1032], 'beats5': [1035], 'moderate-to-severe3': [1037], 'severe4': [1039], 'MR.': [1040], 'Inclusion': [1041], 'required': [1042], 'symptoms': [1046, 2515], 'by': [1048, 1109, 1317, 2276, 2512], 'presence': [1050], 'New': [1053, 1324, 1980], 'York': [1054, 1325, 1981], 'Association': [1056, 1327, 2574, 2579, 2583], 'class': [1057, 1328, 1495, 2070], 'III': [1058], 'IV': [1060, 1504], 'II': [1062, 1329], 'hospital': [1065], 'admission': [1066], 'HF': [1068, 1214, 1338, 1511, 1523, 1538, 1688, 1732, 1748, 2035, 2058], 'within': [1069, 1339], 'previous': [1071, 1341], 'year': [1072, 1342, 1527], 'despite': [1073], 'use': [1075], 'stable': [1077], 'maximal': [1078], 'doses': [1079], 'guideline-directed': [1081], 'therapy.': [1083], 'If': [1084], 'anatomy': [1086], 'suitable': [1088], 'Mitraclip,': [1092], 'patient': [1094, 1274, 2006], 'signed': [1095], 'consent': [1096], '1:1': [1100], 'control': [1102, 1258, 1297], 'approved': [1108], 'Ethics': [1111], 'Committee': [1112], 'Clinic': [1115], 'Barcelona': [1116], 'consistent': [1118], 'principles': [1121], 'outlined': [1122], 'Declaration': [1125], 'Helsinki.': [1127], 'data': [1129, 1165, 1178], 'support': [1131], 'findings': [1133], 'available': [1138], 'from': [1139, 1801, 2285, 2308, 2570], 'corresponding': [1141], 'author': [1142], 'upon': [1143], 'reasonable': [1144], 'request.': [1145], 'All': [1146, 1265], 'participants': [1147], 'gave': [1148], 'written': [1149], 'informed': [1150], 'consent.': [1151], 'echocardiographic': [1154, 1574, 2224], 'follow-up': [1155, 1679, 1834], 'performed': [1157], 'at': [1158, 1216, 1412, 1680, 1835, 2076, 2195], '1,': [1159], '3,': [1160], '12': [1162, 1217, 1681, 1836, 2018, 2077, 2612], 'months.': [1163, 1218], 'Categorical': [1164], 'percentages': [1169], '(percentages)': [1170], 'compared': [1172, 2158], 'Fisher': [1174], 'exact': [1175], 'test.': [1176, 1197], 'Continuous': [1177], 'means±SD': [1182], 'median': [1186, 1897], '(interquartile': [1187], 'range)': [1188], 'tested': [1191], 'groups': [1193, 1287, 1368], 'using': [1194, 2249], 'Kruskal-Wallis': [1196], 'primary': [1199], 'efficacy': [1200], 'end': [1201, 1222, 1684, 2169, 2201], 'point': [1202, 1223, 1685, 2170], 'combined': [1207, 2027, 2168], 'CV': [1209, 2030, 2172], 'death,': [1210, 1687, 2031, 2173], 'transplantation,': [1212, 2033, 2175], 'hospitalizations': [1215, 1521, 2036, 2178, 2187], 'A': [1219, 2566], 'secondary': [1220, 2422], 'safety': [1221, 2200], 'included': [1224, 1251, 2138], 'number': [1226, 2056, 2136, 2184], 'procedure-': [1228, 1625], 'device-related': [1230, 1399, 1627], 'serious': [1231, 1400, 1985, 2205], 'adverse': [1232, 1401, 1986, 2206], 'events.From': [1233], '2015': [1234], '2019,': [1236], 'total': [1238], '53': [1240], 'initially': [1243], 'screened.': [1244], 'Among': [1245], '31': [1247, 1761], 'finally': [1250, 2014], 'study:': [1254], '15': [1255], '16': [1260], 'group.': [1264, 2213], 'but': [1267, 1288, 2012, 2104], 'one': [1268], 'allocated': [1271], 'treatment': [1272, 1540, 2193, 2420], '(a': [1273], 'refused': [1278, 2015], 'intervention).': [1280], 'Baseline': [1281, 1405], 'characteristics': [1282, 1421, 1575], 'showed': [1283, 1389, 2023, 2067, 2079], 'no': [1284, 1396, 2203], 'differences': [1285, 2093], 'among': [1286], 'higher': [1290], 'prevalence': [1291], 'COPD': [1293], 'group': [1298, 1308, 1416, 1418, 1674, 1676, 1813, 1815, 2053, 2119], 'trend': [1301, 2112], 'toward': [1302, 2113], 'older': [1303], 'age': [1304], '(Table).': [1309, 2120], 'status': [1311, 2127, 2216], 'relatively': [1313], 'depicted': [1316], 'small': [1319], 'percentage': [1320, 1334], '(13%)': [1330], 'high': [1333], '(60%).': [1343], 'As': [1344], 'Table,': [1348], 'very': [1351], 'low': [1352], '(median': [1357], '21%)': [1359], 'ventricles': [1362], 'exhibited': [1363, 2110], 'enlargements': [1365], 'both': [1367, 2221], '(mean': [1369], 'LVED': [1370, 1609, 1875, 1880], '136.8±40.6': [1373], 'mL/m2).': [1374], 'Technical': [1375], 'procedural': [1377], 'success': [1378, 1620], 'achieved': [1380], 'all': [1382, 1393], 'patients.': [1383], 'Transesophageal': [1384], 'echocardiography': [1385, 2075], 'clip': [1387, 1659], 'residual': [1390, 2080], 'MR≤2': [1391, 2081], 'patients,': [1394], 'procedural-': [1397], 'events': [1402, 2207], 'registered.Table.': [1404], 'Characteristics': [1406], 'Procedural': [1408, 1655], 'Follow-Up': [1410], '1': [1413, 2196], 'YearTotal': [1414], '(n=31)TMVr': [1415, 1673, 1812], '(n=16)Control': [1417, 1675, 1814], '(n=15)Baseline': [1419], 'Age,': [1422], 'y69.7±772.1±767.2±6': [1423], 'Male': [1424], 'sex25': [1425], '(81)13': [1426, 1501, 1554], '(81)12': [1427, 1502, 1555], '(80)': [1428, 1503, 1556], 'Body': [1429], 'mass': [1430], 'index26': [1431], '(23–30)27.5': [1432], '(23–30)25.4': [1433], '(23–31)': [1434], 'Diabetes7': [1435], '(23)2': [1436], '(13)5': [1437], '(33)': [1438, 1463, 1544, 1588, 1753], 'Ischemic': [1439], 'cardiomyopathy14': [1440], '(45)8': [1441], '(50)6': [1442], '(40)': [1443], 'stroke': [1445], 'TIA2': [1447], '(7)1': [1448, 1449], '(7)': [1450, 1757, 1760, 1763, 1766], 'NVAF': [1452], 'flutter19': [1454], '(61)11': [1455], '(69)8': [1456], '(53)': [1457], 'Persistent': [1458], 'atrial': [1459, 1977], 'fibrillation14': [1460], '(45)9': [1461], '(56)5': [1462], 'time': [1466], 'before': [1467], 'inclusion,': [1468], 'd1510': [1469], '(700–2555)1699': [1470], '(829–2829)1012': [1471], '(268–2555)': [1472], 'Percentage': [1473], 'stimulation,': [1477], '%98': [1478], '(95–99)98': [1479], '(94.5–99)99': [1480], '(95–100)': [1481], 'Anterior': [1482], 'LV': [1483], 'lead': [1484], 'position000': [1485], 'Mean': [1486], 'GFR,': [1487, 1932], 'mL/min59±1856.4±1861.7±19': [1488], 'EUROSCORE': [1489], 'II3.96': [1490], '(3.1–7)4.23': [1491], '(3.2–7.5)3.75': [1492], '(2.7–6.1)': [1493], 'NYHA': [1494, 1777], 'II4': [1496], '(13)1': [1497, 1558, 1562], '(6)3': [1498, 1559, 1563], '(20)': [1499, 1560, 1564], 'III25': [1500], '(ambulatory)2': [1505], '(7)2': [1506, 1780], '(13)0': [1507], 'hospitalization': [1509], 'last': [1514, 1526], 'year19': [1515], '(61)12': [1516], '(75)7': [1517], '(47)': [1518], 'Number': [1519, 1746], '(median)2': [1528], '(1–3)1.5': [1529], '(1–3)2': [1530], '(1–3)': [1531], 'BNP667': [1532], '(373–1183)623': [1533], '(373–1341)711': [1534], '(433–1176)': [1535], '6MWT,': [1536], 'm384±96353±99407±90': [1537], 'ACEI/ARB11': [1541], '(35)5': [1542, 1543], 'ARNI10': [1545], '(32)6': [1546, 1847], '(38)4': [1547], '(27)': [1548], 'Beta-blockers29': [1549], '(94)15': [1550], '(94)14': [1551], '(93)': [1552, 1663], 'MRA25': [1553], 'Hydralazine4': [1557], 'Nitrates4': [1561], 'Digoxin3': [1565], '(10)1': [1566], '(6)2': [1567], '(13)': [1568], 'Loop': [1569], 'diuretics30': [1570], '(97)16': [1571], '(100)14': [1572], '(93)Baseline': [1573], 'MR': [1576, 1656, 1838], 'severity': [1577, 1657, 1839], 'Moderate': [1578, 1664, 1667, 1845], '2)1': [1580], '(3)1': [1581], '(6)0': [1582], 'Moderate-severe': [1583], '3)8': [1585], '(26)3': [1586], '(19)5': [1587], 'Severe': [1589, 1671, 1855], '4)22': [1591], '(71)12': [1592], '(75)10': [1593], '(67)': [1594], 'ERO': [1595], 'area*0.51±0.120.54±0.460.46±0.10': [1596], 'LVEF,': [1597, 1859, 1866, 1954], '%21': [1598], '(17–25)20': [1599], '(16.5–27)22': [1600], '(19–25)': [1601], 'LVESD,': [1602, 1963], 'mm58.4±8.7258.8±8.0157.9±9.68': [1603], 'LVEDD,': [1604, 1949], 'mm70.0±7.7871.2±8.0168.8±7.61': [1605], 'LVES': [1606, 1868, 1873], '(indexed)107.3±37.0107.1±40.9107.6±33.7': [1608], '(indexed)136.8±40.6136.3±43.1137.4±39.0': [1611], 'LA': [1612], '(indexed)74.4±5.476.5±27.972.4±30.8': [1614], 'Spap48.5±14.649.6±12.447.5±16.6Procedural': [1615], 'outcomes': [1616], '(TMVr': [1617], 'group)': [1618], 'Implant': [1619], 'rate15': [1621], '(100)†': [1622], 'SAEs0': [1628], 'Vascular': [1629], 'complication0': [1630], 'Atrial': [1631], 'septum': [1632], 'lesion0': [1633], 'Cardiogenic': [1634], 'shock': [1635], 'resulting': [1636], 'intravenous': [1638], 'inotropic': [1639], 'support0': [1640], 'embolism0': [1642], 'tamponade0': [1644], 'Urgent': [1645], 'conversion': [1646], 'hear': [1648], 'surgery0': [1649], 'Admission': [1650], 'days': [1651], 'related': [1652], 'procedure2.93±1.7': [1654], 'Mild': [1661, 1840], '(1)14': [1662], '(2)7': [1665], '(1)': [1666], 'severe': [1669], '(3)0': [1670], '(4)0Total': [1672], '(n=15)P': [1677, 1816], 'valueClinical': [1678], 'mo': [1682, 1837], 'Combined': [1683], '(CV': [1686], 'rehospitalization,': [1689], 'transplant)12': [1691], '(39;': [1692], '95%': [1693, 1697, 1701, 1707, 1711, 1715, 1721, 1725, 1729, 1735, 1739, 1743, 1770, 1774, 1823, 1827, 1831], 'CI,': [1694, 1698, 1702, 1708, 1712, 1716, 1722, 1726, 1730, 1736, 1740, 1744, 1771, 1775, 1824, 1828, 1832, 2039, 2044], '21.8–57.8)2': [1695], '(13;': [1696, 1710, 1728, 1773], '1.6–38.3)10': [1699], '(67;': [1700, 1742], '38.8–88.2)0.003': [1703], 'All-cause': [1704], 'mortality5': [1705], '(16;': [1706], '5.5–33.8)2': [1709], '1.6–38.4)3': [1713], '(20;': [1714], '4.3–48.1)0.65': [1717], 'mortality3': [1719], '(10;': [1720], '5.5–33.8)1': [1723], '(7;': [1724, 1738, 1769], '0.15–30.2)2': [1727], '1.7–40.5)0.60': [1731], 'rehospitalization11': [1733], '(37;': [1734], '19.9–56.1)1': [1737], '0.1–32.9)10': [1741], '38.4–88.2)0.002': [1745], 'hospitalizations0.003': [1749], '019': [1750], '(63)14': [1751], '(93)5': [1752], '18': [1754], '(27)1': [1755], '(7)7': [1756], '21': [1758], '(3)01': [1759, 1762, 1765], '41': [1764], 'transplant2': [1768], '0.79–21.4)02': [1772], '1.7–40.5)0.23': [1776], 'class<0.001': [1778], 'I2': [1779], '(14)0': [1781], 'II11': [1782], '(41)10': [1783], '(72)1': [1784], '(8)': [1785], 'III9': [1786], '(33)2': [1787], '(14)7': [1788], '(54)': [1789], 'IV5': [1790], '(19)015': [1791], '(38)': [1792], '6MWT': [1793, 1800, 1899, 2072], 'distance,': [1794], 'm402.7±89.1410.4±97.8393.7±86.10.75': [1795], 'Change': [1796, 1808, 1864, 1871, 1878, 1885], 'distance': [1798], 'baseline19.33±77.282.5±57.5−31.2±47.50.014': [1802], 'BNP': [1803, 1810], 'level457': [1804], '(280–992)543': [1805], '(280–1889)385.5': [1806], '(254–550)0.35': [1807], 'level−130.2±1329.9−186±1719.6−46.5±455.10.85Total': [1811], 'value': [1817], 'Increase': [1818], 'diuretic': [1820, 2063, 2192], 'treatment14': [1821], '(50;': [1822], '30.7–69.4)2': [1825], '(14;': [1826], '1.8–42.8)12': [1829], '(86;': [1830], '57.2–98.2)<0.001Echocardiographic': [1833], '(1)6': [1841], '(24)5': [1842], '(39)1': [1843], '(8)0.005': [1844], '(2)8': [1846], '(46)2': [1848], '(17)': [1849, 1854], 'Moderate-to-severe': [1850], '(3)4': [1851], '(16)2': [1852], '(15)2': [1853], '(4)7': [1856], '(28)07': [1857], '(58)': [1858], '%20': [1860], '(18–25)22': [1861], '(19–25)20': [1862], '(16–25)0.23': [1863], '%−0.28±5.810±7.12−0.58±4.360.81': [1867], '(indexed)103.7±40.1111.5±43.295.9±37.10.38': [1870], 'volume2.48±19.48.8±16.7−3.8±20.50.13': [1874], '(indexed)134.7±45.4144±48.6126.2±42.80.39': [1877], 'volume3.97±21.579.29±16.65−0.87±25.040.29': [1881], 'sPAP,': [1882, 1887, 1988], 'mm': [1883, 1888], 'Hg45.9±10.946.6±10.445.1±12.20.81': [1884], 'Hg−2.94±14.4−7.44±14.32.86±13.30.16Values': [1889], 'expressed': [1891], 'n': [1893], '(%),': [1894], "mean±SD'": [1895], '(IQR).': [1898], 'indicates': [1900], '6-minute': [1901], 'walking': [1902], 'test;': [1903], 'BNP,': [1904], 'B-type': [1905], 'natriuretic': [1906], 'peptide': [1907], 'level;': [1908], 'ACEI,': [1909], 'angiotensin': [1910, 1915, 1919], 'convertering': [1911], 'enzyme': [1912], 'inhibitor;': [1913, 1921], 'ARB,': [1914], 'receptor': [1916, 1973], 'blocker;': [1917], 'ARNI,': [1918], 'receptor-neprilysin': [1920], 'CRT,': [1922], 'therapy;': [1925], 'CV,': [1926], 'cardiovascular;': [1927], 'ERO,': [1928], 'regurgitant': [1930], 'orifice;': [1931], 'glomerular': [1933], 'filtration': [1934], 'rate;': [1935], 'HF,': [1936], 'failure;': [1938], 'LA,': [1939], 'atrium;': [1941], 'LV,': [1942], 'ventricle;': [1944], 'LVED,': [1945], 'end-diastolic;': [1948], 'end-diastolic': [1952], 'diameter;': [1953, 1967], 'fraction;': [1958], 'LVES,': [1959], 'end-systolic;': [1962], 'end-systolic': [1966], 'MR,': [1968, 2537], 'regurgitation;': [1970], 'MRA,': [1971], 'mineralocorticoid': [1972], 'antagonist;': [1974], 'NVAF,': [1975], 'nonvalvular': [1976], 'fibrillation;': [1978], 'NYHA,': [1979], 'Association;': [1983], 'SAE,': [1984], 'event;': [1987], 'systolic': [1989, 2105], 'pulmonary': [1990, 2106], 'artery': [1991, 2107], 'pressure;': [1992], 'TIA,': [1993], 'transient': [1994], 'ischemic': [1995], 'attack;': [1996], 'TMVr,': [1998, 2156], 'transcatheter': [1999], 'repair.*Five': [2002], 'missing': [2003], 'values.†': [2004], 'group,': [2011], 'he': [2013], 'intervention.At': [2017], 'follow-up,': [2020], 'end-point': [2028], '(13%': [2037], '[95%': [2038, 2043], '1.6–38.3]': [2040], '67%': [2042], '38.8–88.2];': [2045], 'P=0.003;': [2046], 'Table).': [2047], 'Additionally,': [2048], 'hospitalizations,': [2059], 'need': [2061, 2190, 2236], 'scalation': [2064, 2194], 'distance.': [2073], 'Transthoracic': [2074], '85%': [2083], '25%': [2088], 'controls': [2090], '(P=0.005).': [2091], 'No': [2092], 'dimensions,': [2097], 'observed': [2101, 2209], 'groups,': [2103], 'pressure': [2108], 'values': [2109], 'This': [2121], 'observation': [2122], 'may': [2123], 'reflect': [2124], 'dilatation/dysfunction': [2132], 'limited': [2135], 'patients.In': [2139], 'conclusion,': [2140], 'nonresponders': [2150, 2507], 'OMT,': [2160], 'CHF': [2177, 2186], 'year.': [2197], 'Regarding': [2198], 'point,': [2202], 'procedure-related': [2204], 'TVMr': [2212], 'advance': [2215], 'parameters': [2225], 'referred': [2227], 'inclusion': [2232], 'criteria': [2233], 'highlight': [2234], 'anticipate': [2238], 'more': [2239], 'preventive': [2240], 'strategies.': [2241], 'limitations': [2243], 'preclude': [2248], 'it': [2250], 'decision-making,': [2253], 'they': [2255], 'should': [2256], 'considered': [2258], 'hypothesis-generating.': [2260], 'Further': [2261], 'larger': [2264], 'samples': [2265], 'warranted.Article': [2267], 'InformationSources': [2268], 'FundingThis': [2270], 'an': [2272, 2304], 'investigator-initiated': [2273], 'supported': [2275], 'Abbott': [2277, 2299], 'Medical.': [2278, 2300], 'Dr': [2279, 2301], 'formation': [2283], 'grant': [2284, 2307], 'Spanish': [2287], 'Society': [2288, 2591], 'Cardiology.Disclosures': [2290], 'Drs': [2291], 'proctors': [2297], 'has': [2303], 'institutional': [2305], 'research': [2306], 'Boston': [2309], 'Scientific.Footnotes*X.': [2310], 'J.M.': [2313], 'contributed': [2315], 'equally.For': [2316], 'Sources': [2317], 'Funding': [2319], 'Disclosures,': [2321], 'see': [2322], 'page': [2323], '1159.Registration:': [2324], 'URL:': [2325], 'https://www.clinicaltrials.gov;': [2326], 'Unique': [2327], 'Identifier:': [2328], 'NCT02592889.Correspondence': [2329], 'protected]cat': [2350], 'protected]catReferences1.': [2353], 'Stone': [2354], 'GW,': [2355], 'Lindenfeld': [2356, 2435], 'J,': [2357, 2436, 2494], 'Abraham': [2358, 2437], 'WT,': [2359, 2438], 'Kar': [2360, 2439], 'S,': [2361, 2440, 2482, 2496], 'Lim': [2362, 2441], 'DS,': [2363, 2442], 'Mishell': [2364, 2443], 'JM,': [2365, 2444], 'Whisenant': [2366, 2445], 'B,': [2367, 2400, 2452], 'Grayburn': [2368], 'PA,': [2369], 'Rinaldi': [2370], 'M,': [2371], 'Kapadia': [2372], 'SR,': [2373], 'al;': [2375, 2414, 2500], 'Investigators.Transcatheter': [2377], 'mitral-valve': [2378], 'failure.N': [2384], 'Engl': [2385, 2425], 'J': [2386, 2426, 2594], 'Med.': [2387, 2427], '2018;': [2388, 2428], '379:2307–2318.': [2389], 'doi:': [2390, 2430, 2474, 2525, 2599], '10.1056/NEJMoa1806640CrossrefMedlineGoogle': [2391], 'Scholar2.': [2392], 'Obadia': [2393], 'JF,': [2394], 'Messika-Zeitoun': [2395], 'D,': [2396, 2412], 'Leurent': [2397], 'G,': [2398, 2402], 'Iung': [2399], 'Bonnet': [2401], 'Piriou': [2403], 'N,': [2404], 'Lefèvre': [2405], 'T,': [2406], 'Piot': [2407], 'C,': [2408, 2498, 2543], 'Rouleau': [2409], 'F,': [2410, 2484, 2547], 'Carrié': [2411], 'MITRA-FR': [2415], 'Investigators.Percutaneous': [2416], 'regurgitation.N': [2424], '379:2297–2306.': [2429], '10.1056/NEJMoa1805374CrossrefMedlineGoogle': [2431], 'Scholar3.': [2432], 'Kosmidou': [2433], 'I,': [2434], 'BK,': [2446], 'Kipperman': [2447], 'RM,': [2448], 'Boudoulas': [2449], 'KD,': [2450], 'Redfors': [2451], 'al.': [2454, 2549], 'therapy:': [2466, 2555], 'trial.Circ': [2469], 'Fail.': [2471, 2596], '2020;': [2472, 2597], '13:e007293.': [2473], '10.1161/CIRCHEARTFAILURE.120.007293LinkGoogle': [2475], 'Scholar4.': [2476], 'A,': [2478, 2531], 'Schillinger': [2479], 'W,': [2480, 2529], 'Meyer': [2481], 'Maisano': [2483], 'Hoffmann': [2485], 'R,': [2486], 'Ussia': [2487], 'GP,': [2488], 'Pedrazzini': [2489], 'GB,': [2490], 'van': [2491], 'der': [2492], 'Heyden': [2493], 'Fratini': [2495], 'Klersy': [2497], 'PERMIT-CARE': [2501], 'Investigators.Correction': [2502], 'MitraClip': [2513], 'improves': [2514], 'promotes': [2517], 'reverse': [2518], 'remodeling.J': [2519], 'Am': [2520], 'Coll': [2521], 'Cardiol.': [2522], '2011;': [2523], '58:2183–2189.': [2524], '10.1016/j.jacc.2011.06.061CrossrefMedlineGoogle': [2526], 'Scholar5.': [2527], 'Mullens': [2528], 'Martens': [2532], 'P,': [2533], 'Witte': [2534], 'K,': [2535, 2541, 2545], 'Cowie': [2536], 'Delgado': [2538], 'V,': [2539], 'Dickstein': [2540], 'Linde': [2542], 'Vernooy': [2544], 'Leyva': [2546], 'Optimized': [2550], 'implementation': [2551], 'call': [2557], 'action': [2559], 'referral': [2561], 'optimization': [2563], 'care:': [2565], 'joint': [2567], 'position': [2568], 'statement': [2569], '(HFA),': [2575], 'European': [2576, 2582, 2590], 'Rhythm': [2578], '(EHRA),': [2580], 'Imaging': [2586], '(EACVI)': [2587], 'Cardiology.Eur': [2593], '22:2349–2369.': [2598], '10.1002/ejhf.2046CrossrefMedlineGoogle': [2600], 'Scholar': [2601], 'Back': [2603], 'Next': [2606], 'FiguresReferencesRelatedDetails': [2607], 'December': [2608], '2022Vol': [2609], 'Issue': [2611], 'Advertisement': [2613, 2632], 'Article': [2614], 'InformationMetrics': [2615], '©': [2616], '2022': [2617, 2626], 'American': [2618], 'Association,': [2620], 'Inc.https://doi.org/10.1161/CIRCHEARTFAILURE.121.009501PMID:': [2621], '36124767': [2622], 'publishedSeptember': [2624], 'Keywordsretrospectiveprognosisheart': [2627], 'failuremitral': [2628], 'valvecardiomyopathy,': [2629], 'dilatedPDF': [2630], 'download': [2631], 'SubjectsCatheter-Based': [2633], 'Coronary': [2634], 'Valvular': [2636], 'InterventionsHeart': [2637]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4297855476', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-12-13T21:38:16.216233', 'created_date': '2022-10-01'}
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