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'Medical': [179], 'the': [182, 310, 323, 333, 370, 383, 403, 409, 461, 466, 490, 505, 528, 569, 593, 602, 609, 628, 638, 655, 666, 670, 678, 716, 724, 746, 1053, 1073, 1077, 1127, 1133, 1137, 1139, 1146, 1152, 1167, 1182, 1211, 1333, 1480, 1660], 'Johannes': [183], 'Gutenberg': [184], 'Mainz,': [186, 187], 'Germany': [188], 'Published': [189], 'Online:September': [190], '05,': [191], '2022https://doi.org/10.1024/0301-1526/a001018PDF': [192], 'ToolsAdd': [193], 'to': [194, 304, 361, 498, 527, 621, 1063, 1089, 1109, 1173, 1199, 1235], 'favoritesDownload': [195], 'CitationsTrack': [196], 'Citations': [197], 'ShareShare': [198], 'onFacebookTwitterLinkedInReddit': [199], 'SectionsMoreThe': [200], 'prevalence': [201], 'nutrition': [205, 243, 1257, 1525], '(HPN)': [206], 'Europe': [208], 'is': [209, 222, 267, 341, 380, 884], '0.65–12.7/1,000,000': [210], 'adult': [211, 1217], 'population': [212, 378, 680, 1232], '[1].': [213], 'The': [214, 510, 584, 643, 686, 705, 763, 821, 881, 1425, 1554], 'risk': [215, 293, 1481], 'thromboembolic': [217, 236, 797, 1298], 'complications': [218, 547, 798, 1097], 'among': [219, 256, 1188], 'HPN': [220, 257, 275, 424, 442, 463, 481, 672, 696, 713, 733, 802, 1059, 1086, 1111, 1157, 1189], 'patients': [221, 258, 276, 422, 440, 457, 482, 500, 697, 714, 734, 1060, 1087, 1115, 1190, 1218, 1417, 1487], 'high': [223], 'an': [225, 429, 782, 1102, 1236], 'estimated': [226], 'annualized': [227], 'incidence': [228, 579, 764, 783, 882, 1021, 1026, 1030, 1037], 'approximately': [230], '11.4%': [231], '[2].': [232], 'Risk': [233], 'factors': [234], 'events': [237, 556, 775, 889], 'include': [238, 1126], 'permanent': [239], 'venous': [240, 397, 551, 1484, 1590], 'catheters,': [241], 'hyperosmolar': [242], 'solutions,': [244], 'endothelial': [245], 'damage,': [246], 'pre-existing': [248], 'prothrombotic': [249], 'diseases.The': [250], 'prevalent': [251], 'use': [252], 'long-term': [254, 1493], 'ranges': [259], 'between': [260, 1149], '22%': [261], '66%': [263], '[3].': [264], 'Currently,': [265], 'there': [266, 832], 'no': [268, 1637], 'firm': [269], 'evidence': [270], 'optimal': [272], 'prescriptions': [278], 'necessarily': [279], 'rely': [280], 'individual': [282], 'characteristics.': [283], 'Extended': [284], 'may': [287, 319, 1191], 'be': [288, 305, 1090, 1225], 'associated': [289, 348, 973, 1234], 'poor': [291, 1174], 'compliance,': [292], 'heparin-induced': [295], 'thrombocytopenia': [296], '(HIT),': [297], 'osteoporosis.': [299], 'Direct': [300], 'oral': [301, 327, 344], 'anticoagulants': [302], 'seem': [303], 'a': [306, 435, 495, 766, 807, 811, 814, 818, 824, 1121, 1260, 1304, 1347, 1454, 1592], 'feasible': [307], 'option': [308], 'primary': [311], 'secondary': [313], 'thrombosis': [314, 398, 1339, 1485], 'prevention,': [315], 'although': [316], 'their': [317, 326, 478], 'bioavailability': [318], 'vary': [320], 'depending': [321], 'degree': [324], 'absorption': [328], '[4,': [329], '5,': [330], '6].': [331], 'Finally,': [332], 'quality': [334, 410, 511, 1054, 1184, 1212], 'vitamin': [336, 354, 363, 873], 'K': [337, 355, 364, 874], 'antagonists': [338], '(VKA)': [339], 'treatment': [340, 1187, 1336], 'influenced': [342], 'by': [343, 382, 568, 1092, 1101], 'absorption,': [345], 'hepatic': [346], 'impairment': [347], 'abnormal': [350], 'INR': [351, 522, 1175], 'values,': [352], 'routine': [353], 'supplementation,': [356], 'bacterial': [358], 'overgrowth': [359], 'leading': [360], 'impaired': [362], 'metabolism.': [365], 'Despite': [366], 'this,': [367], 'VKA': [368, 412, 502, 513, 603, 613, 626, 751, 981, 1056, 1161, 1186, 1214, 1223], 'remains': [369], 'most': [371, 706], 'widely': [372], 'used': [373, 653, 708], 'drug': [374], 'class': [375], 'this': [377, 420, 1230], 'recommended': [381], 'European': [384], 'Society': [385, 558], 'Nutrition': [388, 972, 1268], 'Metabolism': [390], '(ESPEN)': [391], 'guidelines': [392], 'case': [394], 'catheter-related': [396, 819, 1338, 1483], '[7,': [399], '8].In': [400], 'light': [401], 'substantial': [404], 'paucity': [405], 'data': [407, 474, 631, 1209], 'HPN,': [417, 1220], 'we': [418, 1206], 'studied': [419], 'matched': [426, 484], 'controls': [427, 831, 1067, 1099], 'indication': [430, 491], 'VKA.We': [432], 'retrospectively': [433], 'analyzed': [434, 541], 'cohort': [436, 1305, 1494], '12': [438], 'consecutive': [439], 'who': [445], 'have': [446, 1192], 'been': [447, 1193], 'followed': [448], 'more': [450], 'than': [451, 1098], '3': [452, 748, 1169], 'months': [453, 694, 702, 749], 'during': [454], 'follow-up.': [455, 622], 'All': [456], 'were': [458, 475, 483, 540, 564, 606, 619, 633, 833], 'managed': [459, 1227], 'at': [460, 599, 608, 627, 661, 669, 1195, 1646], 'reference': [462], 'center': [464, 663], '(2004–2015).': [472], 'Patient': [473], 'retrieved': [476], 'from': [477, 1076, 1649], 'medical': [479, 571, 1203], 'records.': [480], 'based': [485, 648], 'sex,': [487], 'age,': [488], '1:8': [496], 'ratio': [497, 784], '96': [499], 'enrolled': [503], 'Italian': [506, 1555], 'START': [507], 'register': [508], '[9].': [509], 'was': [514, 590, 597, 652, 659, 690, 715, 728, 754, 776, 799, 1162], 'measured': [515], 'as': [516, 534, 566, 575, 886, 1046, 1107, 1373], 'time': [517, 585, 610, 629, 689, 877, 1585], 'therapeutic': [519, 879, 1587], 'range': [520, 1588], '(TTR;': [521], 'range:': [523], '2–3)': [524], 'calculated': [525, 722], 'according': [526], 'interpolated': [529], 'Rosendaal′s': [530], 'formula': [531], 'expressed': [533, 574], 'percentual': [535], 'in-rage': [537], 'days.Baseline': [538], 'characteristics': [539, 676, 860, 1042, 1148], 'using': [542], 'appropriate': [543], 'descriptive': [544], 'statistics.': [545], 'Thromboembolic': [546], '(i.e.,': [548, 1165], 'arterial': [549, 846], 'thromboembolism)': [552], 'major': [554, 770, 948], 'bleeding': [555, 794, 809, 816, 1300], '(International': [557], 'Haemostasis': [562], 'criteria)': [563], 'recorded': [565], 'reported': [567, 800], 'treating': [570], 'staff': [572], 'absolute': [576], 'number': [577, 887, 1122], '(number': [580], 'events/100': [582], 'patient-years).': [583], 'unit': [586], 'statistical': [588], 'analysis': [589], 'patient-year': [591], 'start': [594], 'observation': [596], 'set': [598], 'onset': [600], 'therapy.': [604], 'Individuals': [605, 623], 'right-censored': [607, 634], 'event,': [612], 'discontinuation,': [614], 'death': [615, 774, 854], 'or': [616, 942], 'if': [617], 'they': [618], 'lost': [620], 'still': [624], 'receiving': [625], 'collection': [632], 'accordance': [636], 'latest': [639], 'available': [640], 'follow-up': [641, 688, 726], 'visit.': [642], 'software': [644], 'Jamovi': [645], '(version': [646], '1.6)': [647], 'R': [650], 'language': [651], 'analysis.': [656], 'Ethical': [657], 'approval': [658], 'obtained': [660], 'each': [662], 'participating': [664], 'START-registry': [667], 'aforementioned': [671], 'referral': [673], 'center.The': [674], 'baseline': [675, 1147], 'study': [679, 1119, 1141, 1306], 'are': [681], 'depicted': [682], 'Table': [684], 'I.': [685], 'median': [687, 826, 999, 1006], '48': [691], '(Q1–Q3:': [692, 700, 730, 737, 756, 760], '23–89)': [693], '30': [699], '19–43)': [701], 'controls.': [704, 740], 'frequently': [707], 'central': [709], 'vein': [710], 'catheter': [711, 718], 'Groshong': [717], '(n=8).': [719], 'Median': [720], 'TTR': [721, 753, 827], 'over': [723], 'entire': [725], 'period': [727], '62%': [729], '47–73)': [731], '68%': [736], '55–78)': [738], 'During': [741], 'stable': [742], 'anticoagulation,': [743], 'namely': [744], 'excluding': [745], 'initial': [747, 1208], 'therapy,': [752], '63%': [755], '46–77)': [757], '69%': [759], '55-78),': [761], 'respectively.': [762], 'composite': [767], 'thromboembolic,': [769], 'bleeding,': [771, 949], 'anticoagulation-related': [773, 853], 'similar': [777, 1062, 1093], 'both': [779], 'groups': [780], '0.9': [786], '(95%': [787, 893], 'CI:': [788], '0.2–3.0).': [789], 'A': [790, 1492], 'total': [791], 'two': [793], 'one': [796, 804, 1178], 'patients:': [803], 'patient': [805, 1231, 1455], 'had': [806, 813, 823], 'gastrointestinal': [808, 815], 'second': [812], 'thrombosis.': [820], 'latter': [822], 'low': [825, 1134], '44.5%.': [829], 'Among': [830], '11': [834], 'bleedings': [835], '(6': [836], 'gastrointestinal,': [837], '2': [838, 843], 'hematuria,': [839], '1': [840, 845, 852], 'cranial': [841], 'unknown),': [844], 'thromboembolism': [847], '(transient': [848], 'ischemic': [849, 940], 'attack),': [850], '(fatal': [855], 'intracerebral': [856], 'hemorrhage).Table': [857], 'I': [858, 1040], 'Baseline': [859, 1041], 'clinical': [862, 1044], 'outcomesPatients': [863], 'HPNPatients': [865], 'not': [866], 'HPNN=12N=96Notes.': [868], 'BMI:': [869], 'body-mass': [870], 'index;': [871], 'VKA:': [872], 'antagonist;': [875], 'TTR:': [876], 'range.': [880], 'rate': [883, 1094, 1238], 'provided': [885, 1207], 'per': [890], '100': [891], 'person-years': [892], 'CI).Age': [894], '(median±IQR)70±772±9Women': [895], '(%)50%42%BMI': [896], '(median±IQR)': [897], '23±527±5Active': [898], 'cancer,': [899], 'n': [900, 907], '(%)05': [901], '(6%)Inflammatory': [902], 'disease': [904], '(Crohn': [905], 'disease),': [906], '(%)2': [908, 930, 937, 951, 977], '(17%)0Autoimmune': [909], 'diseases,': [910], 'n.': [911, 916, 921, 924, 929, 936, 945, 950, 957, 964, 969, 976, 985, 991], '(%)06': [912], '(7%)Chronic': [913], 'kidney': [914], 'disease,': [915, 975], '(%)4': [917], '(33%)8': [918], '(9%)Hepatic': [919], 'dysfunction,': [920], '(%)1': [922, 925], '(8%)0Diabetes,': [923], '(8%)9': [926], '(10%)Heart': [927], 'failure,': [928], '(17%)6': [931], '(7%)Prior': [932], 'acute': [933], 'coronary': [934], 'syndrome,': [935, 956], '(17%)15': [938], '(17%)Prior': [939], 'stroke': [941], 'systemic': [943], 'embolism,': [944], '(%)04': [946], '(6%)Prior': [947], '(18%)2': [952], '(2%)Therapy': [953], 'Short': [954], '(%)100%0': [958], 'Cause': [959], 'resection': [961], 'Intestinal': [962], 'ischemia,': [963], '(%)': [965], '7': [966], '(58%)–': [967], 'Peritonitis,': [968], '(%)5': [970, 992], '(42%)–': [971], 'liver': [974], '(17%)–': [978], 'Indication': [979], 'Venous': [983, 1024], 'thromboembolism,': [984, 1020, 1025], '(%)7': [986], '(58%)58': [987], '(60%)': [988], 'Atrial': [989, 1562], 'fibrillation,': [990], '(42%)38': [993], '(40%)': [994], 'Months': [995], 'follow': [997], 'up,': [998], '(25th–75th': [1000, 1007], 'percentiles)48': [1001], '(23–89)30': [1002], '(19–43)Outcomes': [1003], 'Overall': [1004], 'TTR,': [1005], 'percentiles)62%': [1008], '(47–73)68%': [1009], '(55–78)': [1010], 'Total': [1011, 1014], 'events,': [1012, 1015], 'n.313': [1013], 'incidence5.1': [1016], '(1.0–14.9)5.5': [1017], '(2.9–9.4)': [1018], 'Arterial': [1019], 'rate00.4': [1022, 1038], '(0.005–2.2)': [1023], 'rate2.0': [1027], '(0.03–11.1)0': [1028], 'Bleeding,': [1029], 'rate3.4': [1031], '(0.4–12.3)5.1': [1032], '(2.6–8.8)': [1033], 'Anticoagulation': [1034, 1558], 'related': [1035], 'death,': [1036], '(0.005–2.3)Table': [1039], 'outcomesView': [1045], 'image': [1047], 'HTML': [1048], 'Our': [1049], 'findings': [1050], 'indicate': [1051], 'that': [1052, 1064, 1181, 1222], 'appeared': [1061], 'observed': [1065], '(62%': [1068], 'vs.': [1069], '68%),': [1070], 'exceeding': [1072], '60%': [1074], 'limit': [1075], 'literature': [1078], 'defining': [1079], 'adequate': [1080], '[10].': [1082], 'This': [1083, 1118], 'group': [1084], 'seemed': [1088], 'characterized': [1091], 'anticoagulant-related': [1096], 'overall': [1103], 'lower': [1104], 'event': [1105], 'rates': [1106], 'compared': [1108], 'other': [1110], 'cohorts': [1112], 'unselected': [1114], '[2,': [1116], '7].': [1117], 'has': [1120], 'limitations': [1124], 'which': [1125], 'small': [1128], 'sample': [1129], 'size': [1130], 'consequently': [1132], 'precision': [1135], 'estimates,': [1138], 'retrospective': [1140], 'design,': [1142], 'unaccounted': [1143], 'differences': [1144], 'groups,': [1150], 'lack': [1153], 'information': [1155], 'concerning': [1156], 'cases': [1158], 'whom': [1160], 'discontinued': [1163], 'early': [1164], 'first': [1168], 'months)': [1170], 'possibly': [1171], 'due': [1172], 'control.': [1176], 'Moreover,': [1177], 'cannot': [1179], 'exclude': [1180], 'good': [1183], 'due,': [1194], 'least': [1196], 'part,': [1198], 'higher': [1200], 'intensity': [1201], 'care.In': [1204], 'conclusion,': [1205], 'selected': [1216], 'suggesting': [1221], 'might': [1224], 'adequately': [1226], 'also': [1228], 'acceptable': [1237], 'complications.References1': [1240], 'Bakker': [1241], 'H,': [1242, 1578], 'Bozzetti': [1243, 1513], 'F,': [1244, 1514], 'Staun': [1245], 'M,': [1246, 1248, 1252, 1326, 1446], 'Leon-Sanz': [1247], 'Hebuterne': [1249], 'X,': [1250], 'Pertkiewicz': [1251], 'et': [1253, 1293, 1408, 1519, 1552], 'al.': [1254, 1294, 1409, 1520, 1553], 'Home': [1255, 1295], 'adults:': [1259], 'european': [1261], 'multicentre': 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[1313], 'Scholar3': [1320], 'Atema': [1323], 'JJ,': [1324], 'Coppens': [1325], 'S.': [1330], 'Anticoagulants': [1331, 1478], 'prevention': [1334], 'children': [1343], 'nutrition:': [1346, 1424], 'systematic': [1348, 1593], 'review': [1349, 1594], 'critical': [1351], 'appraisal.': [1352], 'Blood': [1353], 'Transfus.': [1354], '2017;15(4):369–77.': [1355], 'articleMedline,': [1359, 1466, 1504], 'Scholar4': [1361], 'Christensen': [1362], 'LD,': [1363], 'Vinter-Jensen': [1364], 'L,': [1365, 1442, 1510, 1516], 'Rasmussen': [1366], 'HH,': [1367], 'Kristensen': [1368], 'SR,': [1369], 'Larsen': [1370], 'TB.': [1371], 'Rivaroxaban': [1372], 'anticoagulant': [1374], 'therapy': [1375], 'syndrome.': [1379, 1459], 'Report': [1380], 'three': [1382], 'cases.': [1383], 'Res.': [1385, 1430], '2015;135(3):568–70.': [1386], 'Scholar5': [1393], 'Cheung': [1394], 'YW,': [1395], 'Mathot': [1398], 'RAA,': [1399], 'van': [1400, 1471], 'den': [1401], 'Dool': [1402], 'EJ,': [1403], 'Stroobants': [1404], 'AK,': 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