Sactipeptide Engineering by Probing the Substrate Tolerance of a Thioether‐Bond‐Forming Sactisynthase

Name: Work Video:
Duration: 3 min 30 s
Ataurehman Ali; Dominic Happel; Jan Habermann; Katrin Schoenfeld; Arturo Macarrón Palacios; Sebastian Bitsch; Simon Englert; Hendrik Schneider; Olga Avrutina; Sebastian Fabritz; Harald Kolmar
{'id': 'https://openalex.org/W4294215054', 'doi': 'https://doi.org/10.1002/anie.202210883', 'title': 'Sactipeptide Engineering by Probing the Substrate Tolerance of a Thioether‐Bond‐Forming Sactisynthase', 'display_name': 'Sactipeptide Engineering by Probing the Substrate Tolerance of a Thioether‐Bond‐Forming Sactisynthase', 'publication_year': 2022, 'publication_date': '2022-09-01', 'ids': {'openalex': 'https://openalex.org/W4294215054', 'doi': 'https://doi.org/10.1002/anie.202210883', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36049110'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/anie.202210883', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202210883', 'source': {'id': 'https://openalex.org/S67393510', 'display_name': 'Angewandte Chemie International Edition', 'issn_l': '1433-7851', 'issn': ['1433-7851', '1521-3773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202210883', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010886478', 'display_name': 'Ataurehman Ali', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ataurehman Ali', 'raw_affiliation_strings': ['Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078443135', 'display_name': 'Dominic Happel', 'orcid': 'https://orcid.org/0009-0002-9065-8262'}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Dominic Happel', 'raw_affiliation_strings': ['Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066683989', 'display_name': 'Jan Habermann', 'orcid': 'https://orcid.org/0009-0001-2628-7164'}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jan Habermann', 'raw_affiliation_strings': ['Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046692002', 'display_name': 'Katrin Schoenfeld', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Katrin Schoenfeld', 'raw_affiliation_strings': ['Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004073520', 'display_name': 'Arturo Macarrón Palacios', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Arturo Macarrón Palacios', 'raw_affiliation_strings': ['Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018385428', 'display_name': 'Sebastian Bitsch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sebastian Bitsch', 'raw_affiliation_strings': ['Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013666449', 'display_name': 'Simon Englert', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Simon Englert', 'raw_affiliation_strings': ['Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012177825', 'display_name': 'Hendrik Schneider', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hendrik Schneider', 'raw_affiliation_strings': ['Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049874639', 'display_name': 'Olga Avrutina', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Olga Avrutina', 'raw_affiliation_strings': ['Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt  Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062406135', 'display_name': 'Sebastian Fabritz', 'orcid': 'https://orcid.org/0000-0001-5453-1323'}, 'institutions': [{'id': 'https://openalex.org/I4210087042', 'display_name': 'Max Planck Institute for Medical Research', 'ror': 'https://ror.org/000bxzc63', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210087042']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sebastian Fabritz', 'raw_affiliation_strings': ['Department of Chemical Biology Max Planck Institute for Medical Research  Jahnstraße 29 69120 Heidelberg Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Biology Max Planck Institute for Medical Research  Jahnstraße 29 69120 Heidelberg Germany', 'institution_ids': ['https://openalex.org/I4210087042']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061848625', 'display_name': 'Harald Kolmar', 'orcid': 'https://orcid.org/0000-0002-8210-1993'}, 'institutions': [{'id': 'https://openalex.org/I31512782', 'display_name': 'Technical University of Darmstadt', 'ror': 'https://ror.org/05n911h24', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I31512782']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Harald Kolmar', 'raw_affiliation_strings': ['Centre for Synthetic Biology Technical University of Darmstadt  64283 Damstadt Germany', 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt Alarich-Weiß-Straße 4 64287 Darmstadt Germany'], 'affiliations': [{'raw_affiliation_string': 'Centre for Synthetic Biology Technical University of Darmstadt  64283 Damstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}, {'raw_affiliation_string': 'Department for Organic Chemistry and Biochemistry Technische Universität Darmstadt Alarich-Weiß-Straße 4 64287 Darmstadt Germany', 'institution_ids': ['https://openalex.org/I31512782']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5061848625'], 'corresponding_institution_ids': ['https://openalex.org/I31512782'], 'apc_list': {'value': 5250, 'currency': 'USD', 'value_usd': 5250, 'provenance': 'doaj'}, 'apc_paid': {'value': 5250, 'currency': 'USD', 'value_usd': 5250, 'provenance': 'doaj'}, 'fwci': 0.514, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 80, 'max': 83}, 'biblio': {'volume': '61', 'issue': '45', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural Characterization', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural Characterization', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10252', 'display_name': 'Microbial Natural Products and Biosynthesis', 'score': 0.982, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11966', 'display_name': 'Silk-based biomaterials and applications', 'score': 0.9767, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thioether', 'display_name': 'Thioether', 'score': 0.99739915}, {'id': 'https://openalex.org/keywords/molecular-engineering', 'display_name': 'Molecular engineering', 'score': 0.47110894}], 'concepts': [{'id': 'https://openalex.org/C2779444094', 'wikidata': 'https://www.wikidata.org/wiki/Q727732', 'display_name': 'Thioether', 'level': 2, 'score': 0.99739915}, {'id': 'https://openalex.org/C2777289219', 'wikidata': 'https://www.wikidata.org/wiki/Q7632154', 'display_name': 'Substrate (aquarium)', 'level': 2, 'score': 0.5851514}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.50024295}, {'id': 'https://openalex.org/C65604355', 'wikidata': 'https://www.wikidata.org/wiki/Q3523861', 'display_name': 'Molecular engineering', 'level': 2, 'score': 0.47110894}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.4686054}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.41004416}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.32278466}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.24078682}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.22416922}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13149083}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.091141194}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013440', 'descriptor_name': 'Sulfides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/anie.202210883', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202210883', 'source': {'id': 'https://openalex.org/S67393510', 'display_name': 'Angewandte Chemie International Edition', 'issn_l': '1433-7851', 'issn': ['1433-7851', '1521-3773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://tuprints.ulb.tu-darmstadt.de/22904', 'pdf_url': 'https://tuprints.ulb.tu-darmstadt.de/22904/1/ANIE_ANIE202210883.pdf', 'source': {'id': 'https://openalex.org/S4377196390', 'display_name': 'TUbilio (Technical University of Darmstadt)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I31512782', 'host_organization_name': 'Technical University of Darmstadt', 'host_organization_lineage': ['https://openalex.org/I31512782'], 'host_organization_lineage_names': ['Technical University of Darmstadt'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828075', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://tuprints.ulb.tu-darmstadt.de/22904/3/anie202210883-sup-0001-misc_information.pdf', 'pdf_url': 'https://tuprints.ulb.tu-darmstadt.de/22904/3/anie202210883-sup-0001-misc_information.pdf', 'source': {'id': 'https://openalex.org/S4306401590', 'display_name': 'Technischen Universität Darmstadt', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I31512782', 'host_organization_name': 'Technical University of Darmstadt', 'host_organization_lineage': ['https://openalex.org/I31512782'], 'host_organization_lineage_names': ['Technical University of Darmstadt'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36049110', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/anie.202210883', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202210883', 'source': {'id': 'https://openalex.org/S67393510', 'display_name': 'Angewandte Chemie International Edition', 'issn_l': '1433-7851', 'issn': ['1433-7851', '1521-3773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.45, 'display_name': 'Clean water and sanitation'}], 'grants': [{'funder': 'https://openalex.org/F4320320879', 'funder_display_name': 'Deutsche Forschungsgemeinschaft', 'award_id': 'KO1390/13-1'}], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1865024295', 'https://openalex.org/W1893358185', 'https://openalex.org/W2008790942', 'https://openalex.org/W2011730713', 'https://openalex.org/W2017512654', 'https://openalex.org/W2069812362', 'https://openalex.org/W2070989924', 'https://openalex.org/W2071127741', 'https://openalex.org/W2079285243', 'https://openalex.org/W2116279935', 'https://openalex.org/W2125637695', 'https://openalex.org/W2135827613', 'https://openalex.org/W2146939730', 'https://openalex.org/W2160259785', 'https://openalex.org/W2171173788', 'https://openalex.org/W2315964119', 'https://openalex.org/W2324131361', 'https://openalex.org/W2339786511', 'https://openalex.org/W2343711127', 'https://openalex.org/W2395693131', 'https://openalex.org/W2467914015', 'https://openalex.org/W2471857557', 'https://openalex.org/W2519129667', 'https://openalex.org/W2621442359', 'https://openalex.org/W2734461206', 'https://openalex.org/W2735730838', 'https://openalex.org/W2755025259', 'https://openalex.org/W2767680811', 'https://openalex.org/W2768059482', 'https://openalex.org/W2783701887', 'https://openalex.org/W2943305525', 'https://openalex.org/W2944229994', 'https://openalex.org/W2963332926', 'https://openalex.org/W2975466304', 'https://openalex.org/W2978513174', 'https://openalex.org/W3000260492', 'https://openalex.org/W3084236163', 'https://openalex.org/W3088837322', 'https://openalex.org/W3108635724', 'https://openalex.org/W3131568000', 'https://openalex.org/W3164404232', 'https://openalex.org/W3186636267', 'https://openalex.org/W3190134834', 'https://openalex.org/W3198452085', 'https://openalex.org/W4232436811', 'https://openalex.org/W4234309976', 'https://openalex.org/W4245161407', 'https://openalex.org/W4294215054'], 'related_works': ['https://openalex.org/W4395048337', 'https://openalex.org/W4387697957', 'https://openalex.org/W4294215054', 'https://openalex.org/W4205708008', 'https://openalex.org/W2958691256', 'https://openalex.org/W2952411060', 'https://openalex.org/W2500981667', 'https://openalex.org/W2165896740', 'https://openalex.org/W2068198467', 'https://openalex.org/W2054051158'], 'abstract_inverted_index': {'Sactipeptides': [0], 'are': [1], 'ribosomally': [2], 'synthesized': [3], 'peptides': [4], 'containing': [5], 'a': [6, 63, 104, 112], 'unique': [7], 'sulfur': [8], 'to': [9, 52, 91, 111], 'α-carbon': [10], 'crosslink.': [11], 'Catalyzed': [12], 'by': [13], 'sactisynthases,': [14], 'this': [15], 'thioether': [16, 57, 80, 97], 'pattern': [17], 'endows': [18], 'sactipeptides': [19, 88], 'with': [20], 'enhanced': [21], 'structural,': [22], 'thermal,': [23], 'and': [24, 86], 'proteolytic': [25], 'stability,': [26], 'which': [27, 99], 'makes': [28], 'them': [29], 'attractive': [30], 'scaffolds': [31], 'for': [32, 73, 121], 'the': [33, 41, 45, 49, 54, 68, 93, 119, 122], 'development': [34], 'of': [35, 48, 56, 79, 84, 96, 125], 'novel': [36], 'biotherapeutics.': [37], 'Herein,': [38], 'we': [39, 107], 'report': [40], 'in-depth': [42], 'study': [43, 92], 'on': [44], 'substrate': [46], 'tolerance': [47], 'sactisynthase': [50], 'AlbA': [51], 'catalyze': [53], 'formation': [55, 78, 95], 'bridges': [58], 'in': [59], 'sactipeptides.': [60, 126], 'We': [61], 'identified': [62, 101], 'possible': [64], 'modification': [65], 'site': [66], 'within': [67], 'sactipeptide': [69], 'subtilosin': [70, 109], 'A': [71, 82, 110], 'allowing': [72], 'peptide': [74], 'engineering': [75, 124], 'without': [76], 'compromising': [77], 'bridges.': [81], 'panel': [83], 'natural': [85], 'hybrid': [87], 'was': [89], 'produced': [90], 'AlbA-mediated': [94], 'bridges,': [98], 'were': [100], 'mass-spectrometrically.': [102], 'In': [103], 'proof-of-principle': [105], 'study,': [106], 're-engineered': [108], 'thioether-bridged,': [113], 'specific': [114], 'streptavidin': [115], 'targeting': [116], 'peptide,': [117], 'opening': [118], 'door': [120], 'functional': [123]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4294215054', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-21T15:07:32.911419', 'created_date': '2022-09-02'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
