Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4293237642', 'doi': 'https://doi.org/10.21203/rs.3.rs-1962158/v1', 'title': 'Macrophage polarity and wound age determination', 'display_name': 'Macrophage polarity and wound age determination', 'publication_year': 2022, 'publication_date': '2022-08-26', 'ids': {'openalex': 'https://openalex.org/W4293237642', 'doi': 'https://doi.org/10.21203/rs.3.rs-1962158/v1'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-1962158/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-1962158/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.researchsquare.com/article/rs-1962158/latest.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025184711', 'display_name': 'Yumi Kuninaka', 'orcid': 'https://orcid.org/0000-0002-2743-2626'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}, {'id': 'https://openalex.org/I4210159520', 'display_name': 'Mizuho (Japan)', 'ror': 'https://ror.org/05e34ra63', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210159520']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yumi Kuninaka', 'raw_affiliation_strings': ['Wakayama Medical University', 'Wakayama Medical University Mizuho Nosaka', 'Wakayama Medical University Toshikazu Kondo'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021']}, {'raw_affiliation_string': 'Wakayama Medical University Mizuho Nosaka', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I4210159520']}, {'raw_affiliation_string': 'Wakayama Medical University Toshikazu Kondo', 'institution_ids': ['https://openalex.org/I190805021']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049130878', 'display_name': 'Yuko Ishida', 'orcid': 'https://orcid.org/0000-0001-6104-7599'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}, {'id': 'https://openalex.org/I4210159520', 'display_name': 'Mizuho (Japan)', 'ror': 'https://ror.org/05e34ra63', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210159520']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuko Ishida', 'raw_affiliation_strings': ['Wakayama Medical University', 'Wakayama Medical University Mizuho Nosaka', 'Wakayama Medical University Toshikazu Kondo'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021']}, {'raw_affiliation_string': 'Wakayama Medical University Mizuho Nosaka', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I4210159520']}, {'raw_affiliation_string': 'Wakayama Medical University Toshikazu Kondo', 'institution_ids': ['https://openalex.org/I190805021']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029496020', 'display_name': 'Akiko Ishigami', 'orcid': 'https://orcid.org/0000-0002-8393-5092'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}, {'id': 'https://openalex.org/I4210159520', 'display_name': 'Mizuho (Japan)', 'ror': 'https://ror.org/05e34ra63', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210159520']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akiko Ishigami', 'raw_affiliation_strings': ['Wakayama Medical University', 'Wakayama Medical University Mizuho Nosaka', 'Wakayama Medical University Toshikazu Kondo'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021']}, {'raw_affiliation_string': 'Wakayama Medical University Mizuho Nosaka', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I4210159520']}, {'raw_affiliation_string': 'Wakayama Medical University Toshikazu Kondo', 'institution_ids': ['https://openalex.org/I190805021']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017023363', 'display_name': 'Mizuho Nosaka', 'orcid': 'https://orcid.org/0000-0002-6330-4963'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mizuho Nosaka', 'raw_affiliation_strings': ['Wakayama Medical University'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077057848', 'display_name': 'Jumpei Matsuki', 'orcid': 'https://orcid.org/0000-0003-4602-7412'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}, {'id': 'https://openalex.org/I4210159520', 'display_name': 'Mizuho (Japan)', 'ror': 'https://ror.org/05e34ra63', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210159520']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jumpei Matsuki', 'raw_affiliation_strings': ['Wakayama Medical University', 'Wakayama Medical University Mizuho Nosaka', 'Wakayama Medical University Toshikazu Kondo'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021']}, {'raw_affiliation_string': 'Wakayama Medical University Mizuho Nosaka', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I4210159520']}, {'raw_affiliation_string': 'Wakayama Medical University Toshikazu Kondo', 'institution_ids': ['https://openalex.org/I190805021']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078045557', 'display_name': 'Haruki Yasuda', 'orcid': 'https://orcid.org/0000-0003-2936-3131'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}, {'id': 'https://openalex.org/I4210159520', 'display_name': 'Mizuho (Japan)', 'ror': 'https://ror.org/05e34ra63', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210159520']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Haruki Yasuda', 'raw_affiliation_strings': ['Wakayama Medical University', 'Wakayama Medical University Mizuho Nosaka', 'Wakayama Medical University Toshikazu Kondo'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021']}, {'raw_affiliation_string': 'Wakayama Medical University Mizuho Nosaka', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I4210159520']}, {'raw_affiliation_string': 'Wakayama Medical University Toshikazu Kondo', 'institution_ids': ['https://openalex.org/I190805021']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071077523', 'display_name': 'Ayumi Kofuna', 'orcid': 'https://orcid.org/0000-0001-5891-3601'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}, {'id': 'https://openalex.org/I4210159520', 'display_name': 'Mizuho (Japan)', 'ror': 'https://ror.org/05e34ra63', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210159520']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ayumi Kofuna', 'raw_affiliation_strings': ['Wakayama Medical University', 'Wakayama Medical University Mizuho Nosaka', 'Wakayama Medical University Toshikazu Kondo'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021']}, {'raw_affiliation_string': 'Wakayama Medical University Mizuho Nosaka', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I4210159520']}, {'raw_affiliation_string': 'Wakayama Medical University Toshikazu Kondo', 'institution_ids': ['https://openalex.org/I190805021']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040849525', 'display_name': 'Akihiko Kimura', 'orcid': 'https://orcid.org/0000-0001-6157-3011'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}, {'id': 'https://openalex.org/I4210159520', 'display_name': 'Mizuho (Japan)', 'ror': 'https://ror.org/05e34ra63', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210159520']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akihiko Kimura', 'raw_affiliation_strings': ['Wakayama Medical University', 'Wakayama Medical University Mizuho Nosaka', 'Wakayama Medical University Toshikazu Kondo'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021']}, {'raw_affiliation_string': 'Wakayama Medical University Mizuho Nosaka', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I4210159520']}, {'raw_affiliation_string': 'Wakayama Medical University Toshikazu Kondo', 'institution_ids': ['https://openalex.org/I190805021']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011164372', 'display_name': 'Fukumi Furukawa', 'orcid': 'https://orcid.org/0000-0002-9205-3745'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}, {'id': 'https://openalex.org/I4210159520', 'display_name': 'Mizuho (Japan)', 'ror': 'https://ror.org/05e34ra63', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210159520']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fukumi Furukawa', 'raw_affiliation_strings': ['Wakayama Medical University', 'Wakayama Medical University Mizuho Nosaka', 'Wakayama Medical University Toshikazu Kondo'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021', 'https://openalex.org/I190805021']}, {'raw_affiliation_string': 'Wakayama Medical University Mizuho Nosaka', 'institution_ids': ['https://openalex.org/I190805021', 'https://openalex.org/I4210159520']}, {'raw_affiliation_string': 'Wakayama Medical University Toshikazu Kondo', 'institution_ids': ['https://openalex.org/I190805021']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000365632', 'display_name': 'Toshikazu Kondo', 'orcid': 'https://orcid.org/0000-0002-5059-8309'}, 'institutions': [{'id': 'https://openalex.org/I190805021', 'display_name': 'Wakayama Medical University', 'ror': 'https://ror.org/005qv5373', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I190805021']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshikazu Kondo', 'raw_affiliation_strings': ['Wakayama Medical University'], 'affiliations': [{'raw_affiliation_string': 'Wakayama Medical University', 'institution_ids': ['https://openalex.org/I190805021']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 60}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10771', 'display_name': 'Wound Healing and Treatments', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2742', 'display_name': 'Rehabilitation'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10771', 'display_name': 'Wound Healing and Treatments', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2742', 'display_name': 'Rehabilitation'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11313', 'display_name': 'Immune cells in cancer', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11670', 'display_name': 'Pressure Ulcer Prevention and Management', 'score': 0.9805, 'subfield': {'id': 'https://openalex.org/subfields/3609', 'display_name': 'Occupational Therapy'}, 'field': {'id': 'https://openalex.org/fields/36', 'display_name': 'Health Professions'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd163', 'display_name': 'CD163', 'score': 0.92965555}, {'id': 'https://openalex.org/keywords/m2-macrophage', 'display_name': 'M2 Macrophage', 'score': 0.75037396}, {'id': 'https://openalex.org/keywords/macrophage-polarization', 'display_name': 'Macrophage polarization', 'score': 0.6683004}, {'id': 'https://openalex.org/keywords/immunofluorescence', 'display_name': 'Immunofluorescence', 'score': 0.46875596}, {'id': 'https://openalex.org/keywords/macrophage-inflammatory-protein', 'display_name': 'Macrophage inflammatory protein', 'score': 0.4575147}, {'id': 'https://openalex.org/keywords/cd80', 'display_name': 'CD80', 'score': 0.42025477}], 'concepts': [{'id': 'https://openalex.org/C2775858924', 'wikidata': 'https://www.wikidata.org/wiki/Q18034009', 'display_name': 'CD163', 'level': 4, 'score': 0.92965555}, {'id': 'https://openalex.org/C2910375186', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'M2 Macrophage', 'level': 4, 'score': 0.75037396}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.7322681}, {'id': 'https://openalex.org/C2780269544', 'wikidata': 'https://www.wikidata.org/wiki/Q1509074', 'display_name': 'Wound healing', 'level': 2, 'score': 0.67760175}, {'id': 'https://openalex.org/C2776682551', 'wikidata': 'https://www.wikidata.org/wiki/Q21072584', 'display_name': 'Macrophage polarization', 'level': 4, 'score': 0.6683004}, {'id': 'https://openalex.org/C2778236600', 'wikidata': 'https://www.wikidata.org/wiki/Q592324', 'display_name': 'Immunofluorescence', 'level': 3, 'score': 0.46875596}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.46201032}, {'id': 'https://openalex.org/C170217031', 'wikidata': 'https://www.wikidata.org/wiki/Q6725509', 'display_name': 'Macrophage inflammatory protein', 'level': 4, 'score': 0.4575147}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42361614}, {'id': 'https://openalex.org/C2778297628', 'wikidata': 'https://www.wikidata.org/wiki/Q5009843', 'display_name': 'CD80', 'level': 5, 'score': 0.42025477}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3877915}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37645948}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.32822382}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.31918025}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.281336}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.17186949}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.14937046}, {'id': 'https://openalex.org/C39347974', 'wikidata': 'https://www.wikidata.org/wiki/Q21135811', 'display_name': 'CD40', 'level': 4, 'score': 0.08274773}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-1962158/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-1962158/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-1962158/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-1962158/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.79, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 84, 'referenced_works': ['https://openalex.org/W141565801', 'https://openalex.org/W1563235390', 'https://openalex.org/W1916893403', 'https://openalex.org/W1949832432', 'https://openalex.org/W1967958218', 'https://openalex.org/W1972747140', 'https://openalex.org/W1976141939', 'https://openalex.org/W1977289462', 'https://openalex.org/W1983217518', 'https://openalex.org/W1987408673', 'https://openalex.org/W1989070304', 'https://openalex.org/W1989790028', 'https://openalex.org/W2005751554', 'https://openalex.org/W2006960578', 'https://openalex.org/W2010087085', 'https://openalex.org/W2018860353', 'https://openalex.org/W2027065592', 'https://openalex.org/W2030592653', 'https://openalex.org/W2032879966', 'https://openalex.org/W2038425716', 'https://openalex.org/W2038689279', 'https://openalex.org/W2042585249', 'https://openalex.org/W2046480364', 'https://openalex.org/W2050772679', 'https://openalex.org/W2064110387', 'https://openalex.org/W2064603017', 'https://openalex.org/W2065108573', 'https://openalex.org/W2065577291', 'https://openalex.org/W2067973973', 'https://openalex.org/W2068933459', 'https://openalex.org/W2093705034', 'https://openalex.org/W2102010912', 'https://openalex.org/W2104782188', 'https://openalex.org/W2108723188', 'https://openalex.org/W2109483577', 'https://openalex.org/W2110315161', 'https://openalex.org/W2118654016', 'https://openalex.org/W2119297186', 'https://openalex.org/W2141063357', 'https://openalex.org/W2159442019', 'https://openalex.org/W2159560463', 'https://openalex.org/W2163912530', 'https://openalex.org/W2174617543', 'https://openalex.org/W2238909991', 'https://openalex.org/W2247338536', 'https://openalex.org/W2296430932', 'https://openalex.org/W2323233305', 'https://openalex.org/W2325727928', 'https://openalex.org/W2353982544', 'https://openalex.org/W2419316064', 'https://openalex.org/W2516952220', 'https://openalex.org/W2605242173', 'https://openalex.org/W2608213449', 'https://openalex.org/W2609179980', 'https://openalex.org/W2613737538', 'https://openalex.org/W2734365706', 'https://openalex.org/W2748417030', 'https://openalex.org/W2765168756', 'https://openalex.org/W2765550546', 'https://openalex.org/W2767972305', 'https://openalex.org/W2768709220', 'https://openalex.org/W2782685575', 'https://openalex.org/W2793011605', 'https://openalex.org/W2794217634', 'https://openalex.org/W2799932713', 'https://openalex.org/W2807906301', 'https://openalex.org/W2891771349', 'https://openalex.org/W2901831182', 'https://openalex.org/W2913590717', 'https://openalex.org/W2955275274', 'https://openalex.org/W2970718184', 'https://openalex.org/W2977184583', 'https://openalex.org/W2989599122', 'https://openalex.org/W2990592352', 'https://openalex.org/W3011276968', 'https://openalex.org/W3020707688', 'https://openalex.org/W3167118224', 'https://openalex.org/W3168732619', 'https://openalex.org/W3176899844', 'https://openalex.org/W3185382019', 'https://openalex.org/W4200272612', 'https://openalex.org/W4205928601', 'https://openalex.org/W4210889227', 'https://openalex.org/W4299524280'], 'related_works': ['https://openalex.org/W4310057555', 'https://openalex.org/W4296251420', 'https://openalex.org/W4293237642', 'https://openalex.org/W4285992386', 'https://openalex.org/W4220966087', 'https://openalex.org/W3138502727', 'https://openalex.org/W3011360742', 'https://openalex.org/W2978368290', 'https://openalex.org/W2062526438', 'https://openalex.org/W1978630124'], 'abstract_inverted_index': {'Abstract': [0], 'We': [1], 'investigated': [2], 'the': [3, 6, 137, 145, 150, 156], 'dynamics': [4], 'of': [5, 9, 22, 49, 122, 144, 153, 158, 172], 'gene': [7], 'expression': [8], 'M1': [10, 79, 124, 179], 'and': [11, 32, 38, 47, 59, 95, 180], 'M2': [12, 86, 97, 128, 181], 'macrophage': [13, 113], 'markers': [14, 51], 'during': [15], 'skin': [16, 185], 'wound': [17, 93, 117, 170, 186, 193], 'healing': [18], 'in': [19, 91, 102, 108, 155, 183], 'mice.': [20], 'Expression': [21], 'M1-macrophage': [23], 'markers,': [24], 'such': [25, 52], 'as': [26, 53], 'Il12a,': [27], 'Tnf,': [28], 'Il6,': [29], 'Il1b': [30], ',': [31, 58, 61], 'Nos2': [33], 'was': [34], 'upregulated': [35], 'after': [36, 45, 66], 'wounding': [37], 'peaked': [39, 62], 'at': [40, 63], '1': [41], 'or': [42], '3': [43, 90], 'days': [44, 65], 'injury,': [46], 'that': [48, 77, 96, 178], 'M2-macrophage': [50], 'Mrc1,': [54], 'Cd163,': [55], 'Ccl17,': [56], 'Arg': [57], 'Tgfb1': [60], '6': [64, 104], 'injury.': [67], 'Consistent': [68], 'with': [69], 'these': [70], 'findings,': [71], 'using': [72, 115], 'double-color': [73], 'immunofluorescence': [74], 'analysis': [75], 'revealed': [76], 'CD80-positive': [78], 'macrophages': [80, 87, 98, 125, 129, 182], 'were': [81, 99, 132], 'more': [82], 'abundant': [83], 'than': [84, 134], 'CD206-positive': [85], 'on': [88], 'day': [89, 103], 'mouse': [92], 'specimens,': [94], 'prominently': [100], 'detected': [101], 'wounds.': [105], 'For': [106], 'application': [107], 'forensic': [109], 'practice,': [110], 'we': [111], 'examined': [112], 'polarization': [114], 'human': [116, 184], 'specimens.': [118], 'The': [119], 'average': [120], 'ratios': [121], 'HLA-DRα-positive': [123], 'to': [126], 'CD163-positive': [127], '(M1/M2': [130], 'ratios)': [131], 'greater': [133], '2.0': [135, 154, 166], 'for': [136, 192], 'wounds': [138], 'aged': [139], '2–5': [140, 173], 'days.': [141, 174], 'Furthermore,': [142], 'six': [143], 'eight': [146], 'samples': [147], 'individually': [148], 'exceeded': [149], 'M1/M2': [151, 162], 'ratio': [152, 163], 'range': [157], '1.88–4.30.': [159], 'Therefore,': [160], 'an': [161], 'significantly': [164], 'above': [165], 'strongly': [167], 'indicates': [168], 'a': [169, 189], 'age': [171, 194], 'This': [175], 'study': [176], 'showed': [177], 'might': [187], 'be': [188], 'promising': [190], 'marker': [191], 'determination.': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4293237642', 'counts_by_year': [], 'updated_date': '2024-12-07T20:35:05.794348', 'created_date': '2022-08-27'}