Publication Information

{'id': 'https://openalex.org/W4290263427', 'doi': None, 'title': 'Oncogenesis by mutations in anti-oncogenes: a view.', 'display_name': 'Oncogenesis by mutations in anti-oncogenes: a view.', 'publication_year': 1990, 'publication_date': '1990-03-01', 'ids': {'openalex': 'https://openalex.org/W4290263427', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2190526'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2190526', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5015355496', 'display_name': 'Willem Den Otter', 'orcid': None}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'W Den Otter', 'raw_affiliation_strings': ['Department of Pathology, Academisch Ziekenhuis, Utrecht, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Academisch Ziekenhuis, Utrecht, The Netherlands.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051407672', 'display_name': 'Jan Willem Koten', 'orcid': 'https://orcid.org/0000-0003-3661-9238'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J W Koten', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002338400', 'display_name': 'B J Van der Vegt', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'B J Van der Vegt', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081577994', 'display_name': 'Frits A. Beemer', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'F A Beemer', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079187321', 'display_name': 'O J Boxma', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'O J Boxma', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056004711', 'display_name': 'D. J. Derkinderen', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D J Derkinderen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010833803', 'display_name': 'P W De Graaf', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P W De Graaf', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026833302', 'display_name': 'J Huber', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Huber', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085329305', 'display_name': 'C J Lips', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C J Lips', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109957362', 'display_name': 'Paul Roholl', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P J Roholl', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.048, 'has_fulltext': False, 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.618784, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 78}, 'biblio': {'volume': '10', 'issue': '2B', 'first_page': '475', 'last_page': '87'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10754', 'display_name': 'Neuroendocrine Tumor Research Advances', 'score': 0.9302, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10754', 'display_name': 'Neuroendocrine Tumor Research Advances', 'score': 0.9302, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proto-oncogenes', 'display_name': 'Proto-Oncogenes', 'score': 0.5518306}], 'concepts': [{'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.94376075}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.69687206}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.5903717}, {'id': 'https://openalex.org/C2911062167', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Proto-Oncogenes', 'level': 5, 'score': 0.5518306}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.52233565}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5177754}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.48555872}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.4272217}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4265229}, {'id': 'https://openalex.org/C93304396', 'wikidata': 'https://www.wikidata.org/wiki/Q14763008', 'display_name': 'Mitosis', 'level': 2, 'score': 0.4103312}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.2711618}], 'mesh': [{'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D009857', 'descriptor_name': 'Oncogenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013489', 'descriptor_name': 'Suppression, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012075', 'descriptor_name': 'Remission, Spontaneous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2190526', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.77, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W76548452', 'https://openalex.org/W2808352915', 'https://openalex.org/W2756973355', 'https://openalex.org/W2586385055', 'https://openalex.org/W2482590614', 'https://openalex.org/W2302306110', 'https://openalex.org/W2283593345', 'https://openalex.org/W2266852516', 'https://openalex.org/W2167484872', 'https://openalex.org/W2064378035'], 'abstract_inverted_index': {'Oncogenesis': [0, 156], 'is': [1, 47, 128, 157, 260, 355], 'the': [2, 41, 44, 51, 69, 81, 87, 132, 174, 184, 199, 219, 223, 230, 279, 284, 294, 315, 349, 371, 379, 386, 389], 'result': [3], 'of': [4, 6, 12, 43, 71, 83, 89, 136, 138, 176, 198, 222, 288, 291, 296, 307, 318, 351, 366, 391], 'accumulation': [5], 'specific': [7, 13], 'gene': [8], 'mutations.': [9], 'Two': [10], 'classes': [11], 'cancer': [14], 'mutations': [15, 118, 243, 253, 331, 354], 'are': [16, 27, 30, 56, 121, 152, 254], 'distinguished:': [17], 'namely': [18], 'those': [19, 23], 'affecting': [20], 'anti-oncogenes': [21, 84, 120, 245], 'and': [22, 105, 165, 178, 196, 209, 229, 378], 'in': [24, 48, 62, 86, 119, 125, 129, 154, 160, 168, 183, 191, 215, 237, 244, 256, 266, 282, 303, 344], 'which': [25, 140, 283], 'oncogenes': [26], 'involved.': [28], 'Anti-oncogenes': [29], 'thought': [31], 'to': [32, 79, 108, 131, 341], 'regulate': [33], 'normal': [34, 337], 'growth': [35, 166, 334], 'by': [36], 'encoding': [37], 'proteins': [38], 'that': [39, 53, 115, 189, 250, 262, 301, 323], 'inhibit': [40], 'expression': [42, 70], 'oncogenes.': [45], 'This': [46, 127, 339], 'line': [49], 'with': [50, 310, 313, 326], 'observation': [52], 'tumor': [54], 'cells': [55, 150, 300], 'often': [57], 'homozygous': [58], 'for': [59, 103, 123, 247], 'a': [60, 90, 100, 270, 304, 308, 320, 324, 333, 345, 362], 'defect': [61], 'an': [63, 72, 263, 267], 'anti-oncogene,': [64], 'as': [65], 'this': [66, 75], 'will': [67, 234, 381], 'allow': [68], 'oncogene.': [73], 'In': [74, 187, 217], 'paper': [76], 'we': [77], 'attempt': [78], 'calculate': [80], 'number': [82, 295], 'involved': [85, 255], 'genesis': [88], 'malignant': [91, 297, 374], 'tumour': [92, 149, 179, 275, 299, 375], 'cell.': [93], 'These': [94, 112], 'calculations': [95, 113, 292], 'were': [96], 'initially': [97], 'performed': [98], 'using': [99], 'simplified': [101], 'model': [102, 135], 'oncogenesis': [104, 124, 137, 177, 248], 'later': [106], 'applied': [107], 'more': [109, 145], 'complicated': [110], 'situations.': [111], 'indicate': [114], 'usually': [116], 'four': [117, 241, 352], 'required': [122, 246], 'adults.': [126, 239], 'contradiction': [130], 'well-known': [133], '2-hit': [134], 'Knudson': [139], 'predicts': [141], 'about': [142, 293, 367], '10(9)': [143], 'times': [144], 'de': [146], 'novo': [147], 'arising': [148], 'than': [151], 'observed': [153, 159], 'reality.': [155], 'only': [158, 213], 'proliferating': [161], 'cells.': [162, 338], 'Cell': [163], 'proliferation': [164, 343], 'kinetics': [167], 'various': [169, 280], 'organs': [170, 188, 281], 'differ': [171], 'greatly.': [172], 'Therefore': [173], 'time': [175], 'manifestation': [180], 'also': [181], 'varies': [182], 'different': [185, 274], 'organs.': [186], 'develop': [190], 'early': [192, 214], 'life': [193], '(e.g.': [194], 'retina': [195], 'neurons': [197], 'brain)': [200], 'mitotic': [201], 'activity': [202], 'ceases': [203], 'soon': [204], 'after': [205, 227], 'birth.': [206], 'Consequently': [207], 'neural': [208], 'retinal': [210], 'tumours': [211, 233, 285], 'emerge': [212], 'life.': [216], 'contrast,': [218], 'main': [220], 'development': [221], 'female': [224], 'breast': [225, 232], 'occurs': [226], 'puberty,': [228], 'earliest': [231], 'become': [235], 'apparent': [236], 'young': [238], 'The': [240, 357], 'recessive': [242, 252], 'imply': [249], 'probably': [251, 382], 'two': [257, 327], 'loci.': [258], 'It': [259], 'clear': [261], 'inherited': [264, 311], 'mutation': [265], 'anti-oncogene': [268], 'at': [269], 'particular': [271], 'locus': [272], 'causes': [273], 'types': [276], 'depending': [277], 'on': [278], 'arise.': [286], 'Comparison': [287], '(a)': [289], 'results': [290], 'neuroendocrine': [298], 'arise': [302], 'pancreatic': [305], 'islet': [306], 'patient': [309], 'MEN1-syndrome': [312], '(b)': [314], 'pathological': [316], 'anatomy': [317], 'such': [319], 'patient,': [321], 'suggests': [322], 'cell': [325, 342, 376], 'or': [328], 'three': [329], 'oncogenic': [330, 353], 'has': [332, 388], 'advantage': [335], 'over': [336], 'leads': [340], 'premalignant': [346, 359], 'lesion': [347, 387], 'until': [348], 'set': [350], 'complete.': [356], 'clinically': [358], 'lesions': [360], 'have': [361], 'maximal': [363], 'mean': [364], 'diameter': [365], '0.4': [368], 'cm': [369], 'when': [370, 385], 'first': [372], 'true': [373], 'develops,': [377], 'pathologist': [380], 'note': [383], 'malignancy': [384], 'size': [390], '1-2': [392], 'cm.(ABSTRACT': [393], 'TRUNCATED': [394], 'AT': [395], '400': [396], 'WORDS)': [397]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4290263427', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-15T22:42:41.493007', 'created_date': '2022-08-07'}