Publication Information

{'id': 'https://openalex.org/W4289827876', 'doi': 'https://doi.org/10.2174/1381612801666220524192103', 'title': 'DNA Minor-Groove Binding Drugs', 'display_name': 'DNA Minor-Groove Binding Drugs', 'publication_year': 1995, 'publication_date': '1995-06-01', 'ids': {'openalex': 'https://openalex.org/W4289827876', 'doi': 'https://doi.org/10.2174/1381612801666220524192103'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/1381612801666220524192103', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55674637', 'display_name': 'Current Pharmaceutical Design', 'issn_l': '1381-6128', 'issn': ['1381-6128', '1873-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033312783', 'display_name': 'Franco Zunino', 'orcid': 'https://orcid.org/0000-0002-1895-2742'}, 'institutions': [{'id': 'https://openalex.org/I4210156707', 'display_name': 'Fondazione IRCCS Istituto Nazionale dei Tumori', 'ror': 'https://ror.org/05dwj7825', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I4210156707']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'F. Zunino', 'raw_affiliation_strings': ['Division of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': 'Division of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy', 'institution_ids': ['https://openalex.org/I4210156707']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042622420', 'display_name': 'Fabio Animati', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210108499', 'display_name': 'Menarini Group (Italy)', 'ror': 'https://ror.org/02h1wg091', 'country_code': 'IT', 'type': 'company', 'lineage': ['https://openalex.org/I4210108499']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'F. Animati', 'raw_affiliation_strings': ['Menarini Ricerche Sud S.p.A., Via Tito Speri 10, 00040 Pomezia, Roma, Italy'], 'affiliations': [{'raw_affiliation_string': 'Menarini Ricerche Sud S.p.A., Via Tito Speri 10, 00040 Pomezia, Roma, Italy', 'institution_ids': ['https://openalex.org/I4210108499']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089156584', 'display_name': 'Giovanni Capranico', 'orcid': 'https://orcid.org/0000-0002-8708-6454'}, 'institutions': [{'id': 'https://openalex.org/I4210156707', 'display_name': 'Fondazione IRCCS Istituto Nazionale dei Tumori', 'ror': 'https://ror.org/05dwj7825', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I4210156707']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'G. Capranico', 'raw_affiliation_strings': ['Division of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': 'Division of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy', 'institution_ids': ['https://openalex.org/I4210156707']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5033312783'], 'corresponding_institution_ids': ['https://openalex.org/I4210156707'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.777, 'has_fulltext': False, 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.571002, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '1', 'issue': '1', 'first_page': '83', 'last_page': '94'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9845, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9845, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'DNA and Nucleic Acid Chemistry', 'score': 0.9699, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9687, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neoplastic-transformation', 'display_name': 'Neoplastic transformation', 'score': 0.4421773}], 'concepts': [{'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.8115343}, {'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.77366924}, {'id': 'https://openalex.org/C3019303373', 'wikidata': 'https://www.wikidata.org/wiki/Q60535862', 'display_name': 'Minor groove', 'level': 3, 'score': 0.71218836}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.59787685}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.51891303}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.5075458}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.46530396}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.44744685}, {'id': 'https://openalex.org/C2993273003', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Neoplastic transformation', 'level': 4, 'score': 0.4421773}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44158694}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.2900902}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.083034545}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/1381612801666220524192103', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55674637', 'display_name': 'Current Pharmaceutical Design', 'issn_l': '1381-6128', 'issn': ['1381-6128', '1873-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.7, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3152230514', 'https://openalex.org/W3147138563', 'https://openalex.org/W3092521730', 'https://openalex.org/W2796949944', 'https://openalex.org/W2395219877', 'https://openalex.org/W2366562690', 'https://openalex.org/W2145675608', 'https://openalex.org/W2141064514', 'https://openalex.org/W2045299745', 'https://openalex.org/W1996910582'], 'abstract_inverted_index': {'Since': [0], 'neoplastic': [1], 'transformation': [2], 'is': [3, 15, 179], 'likely': [4], 'related': [5], 'to': [6, 38, 42, 126], 'oncogene': [7], 'activation': [8], 'or': [9, 120, 151], 'alterations': [10], 'in': [11, 18, 88, 108, 142, 168], 'specific': [12, 25, 163], 'genes,': [13], 'there': [14], 'much': [16], 'interest': [17], 'the': [19, 44], 'development': [20], 'of': [21, 24, 46, 58, 63, 69, 116, 148, 161, 175], 'drugs': [22, 33], 'capable': [23], 'gene': [26, 47], 'inactivation.': [27], 'In': [28, 112], 'particular,': [29], 'DNA': [30, 103, 121, 144, 149], 'minor-groove': [31, 102, 177], 'binding': [32, 130], 'have': [34, 52, 139], 'been': [35, 53], 'extensively': [36], 'studied': [37], 'determine': [39], 'their': [40], 'ability': [41], 'influence': [43], 'regulation': [45], 'expression.': [48], 'Sequence-selective': [49], 'groove': [50, 129], 'binders': [51], 'designed': [54], '·': [55], 'as': [56], 'carriers': [57], 'alkylating': [59, 67], 'moieties.': [60], 'Prototypical': [61], 'agents': [62, 98, 119], 'this': [64], 'class': [65], 'are': [66, 94, 124], 'derivatives': [68], 'distamycin.': [70], 'These': [71], 'compounds': [72], 'exhibit': [73], 'a': [74, 84, 109, 114, 140, 155, 158], 'markedly': [75], 'enhanced': [76], 'cytotoxicity': [77], 'over': [78], 'conventional': [79], 'benzoyl': [80], 'N\xad': [81], 'mustards': [82], 'and': [83, 171], 'significant': [85], 'antitumor': [86, 97, 166], 'activity': [87], 'preclinical': [89, 169], 'evaluation': [90, 170], '.': [91], 'Cyclopropylpyrroloindole': [92], 'analogs': [93], 'very': [95], 'potent': [96], 'which': [99], 'interact': [100], 'with': [101], 'favoring': [104], 'an': [105], 'alkylation': [106], 'reaction': [107], 'sequence-selective': [110], 'manner.': [111], 'addition,': [113], 'number': [115], 'DNA-damaging': [117], 'cytotoxic': [118], 'topoisomerase': [122], 'inhibitors': [123], 'known': [125], 'contain': [127], 'minor\xad': [128], 'elements.': [131], 'The': [132, 165], 'identification': [133], 'of.': [134], 'drug': [135], 'structural': [136], 'factors': [137], 'that': [138], 'role': [141], 'promoting': [143], 'recognition': [145], 'during': [146], 'formatiOn': [147], 'cleavage': [150], 'covalent': [152], 'modificatwn': [153], 'represents': [154], 'basis': [156], 'for': [157], 'rational': [159], 'design': [160], 'more': [162], 'inhibitors.': [164], 'efficacy': [167], 'early': [172], 'clinical': [173], 'studies': [174], 'sequence-specific': [176], 'alkylators': [178], 'described.': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4289827876', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T03:04:14.575534', 'created_date': '2022-08-05'}