Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4289515481', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs21-pd4-04', 'title': 'Abstract PD4-04: Updated results of tucatinib vs placebo added to trastuzumab and capecitabine for patients with previously treated HER2-positive metastatic breast cancer with brain metastases (HER2CLIMB)', 'display_name': 'Abstract PD4-04: Updated results of tucatinib vs placebo added to trastuzumab and capecitabine for patients with previously treated HER2-positive metastatic breast cancer with brain metastases (HER2CLIMB)', 'publication_year': 2022, 'publication_date': '2022-02-15', 'ids': {'openalex': 'https://openalex.org/W4289515481', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs21-pd4-04'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs21-pd4-04', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049174232', 'display_name': 'Nancy U. Lin', 'orcid': 'https://orcid.org/0000-0003-2263-5413'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nancy U Lin', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, MA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, MA', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027764647', 'display_name': 'Rashmi K. Murthy', 'orcid': 'https://orcid.org/0000-0002-0103-4718'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rashmi K Murthy', 'raw_affiliation_strings': ['University of Texas MD Anderson Cancer Center, Houston, TX'], 'affiliations': [{'raw_affiliation_string': 'University of Texas MD Anderson Cancer Center, Houston, TX', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075889627', 'display_name': 'Vandana G. Abramson', 'orcid': 'https://orcid.org/0000-0002-6855-1322'}, 'institutions': [{'id': 'https://openalex.org/I901861585', 'display_name': 'Vanderbilt University Medical Center', 'ror': 'https://ror.org/05dq2gs74', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162197', 'https://openalex.org/I901861585']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vandana Abramson', 'raw_affiliation_strings': ['Vanderbilt University Medical Center, Nashville, TN'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt University Medical Center, Nashville, TN', 'institution_ids': ['https://openalex.org/I901861585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013557141', 'display_name': 'Carey K. Anders', 'orcid': 'https://orcid.org/0000-0001-9165-4074'}, 'institutions': [{'id': 'https://openalex.org/I4390039326', 'display_name': 'Duke Cancer Institute', 'ror': 'https://ror.org/04vt65461', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876', 'https://openalex.org/I4390039326']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carey Anders', 'raw_affiliation_strings': ['Duke Cancer Institute, Durham, NC'], 'affiliations': [{'raw_affiliation_string': 'Duke Cancer Institute, Durham, NC', 'institution_ids': ['https://openalex.org/I4390039326', 'https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107343489', 'display_name': 'Thomas Bachelot', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105738', 'display_name': 'Centre Léon Bérard', 'ror': 'https://ror.org/01cmnjq37', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105738']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Thomas Bachelot', 'raw_affiliation_strings': ['Centre Léon Bérard, Lyon, France'], 'affiliations': [{'raw_affiliation_string': 'Centre Léon Bérard, Lyon, France', 'institution_ids': ['https://openalex.org/I4210105738']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041145711', 'display_name': 'Philippe L. Bédard', 'orcid': 'https://orcid.org/0000-0002-6771-2999'}, 'institutions': [{'id': 'https://openalex.org/I1325899441', 'display_name': 'University Health Network', 'ror': 'https://ror.org/042xt5161', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441']}, {'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Philippe Bedard', 'raw_affiliation_strings': ['University Health Network, Princess Margaret Cancer Centre,, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'University Health Network, Princess Margaret Cancer Centre,, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001562050', 'display_name': 'Virginia F. Borges', 'orcid': 'https://orcid.org/0000-0003-1158-7524'}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}, {'id': 'https://openalex.org/I4210134151', 'display_name': 'University of Colorado Cancer Center', 'ror': 'https://ror.org/04cqn7d42', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210134151']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Virginia Borges', 'raw_affiliation_strings': ['University of Colorado Cancer Center, Aurora, CO'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado Cancer Center, Aurora, CO', 'institution_ids': ['https://openalex.org/I921990950', 'https://openalex.org/I4210134151']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007286394', 'display_name': 'David Cameron', 'orcid': 'https://orcid.org/0000-0002-2717-7979'}, 'institutions': [{'id': 'https://openalex.org/I2802581871', 'display_name': 'Edinburgh Cancer Research', 'ror': 'https://ror.org/05a7t9b67', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I2802581871', 'https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Cameron', 'raw_affiliation_strings': ['Edinburgh Cancer Research Centre, Edinburgh, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Edinburgh Cancer Research Centre, Edinburgh, United Kingdom', 'institution_ids': ['https://openalex.org/I2802581871']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007286394', 'display_name': 'David Cameron', 'orcid': 'https://orcid.org/0000-0002-2717-7979'}, 'institutions': [{'id': 'https://openalex.org/I2802581871', 'display_name': 'Edinburgh Cancer Research', 'ror': 'https://ror.org/05a7t9b67', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I2802581871', 'https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Cameron', 'raw_affiliation_strings': ['Edinburgh Cancer Research Centre, Edinburgh, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Edinburgh Cancer Research Centre, Edinburgh, United Kingdom', 'institution_ids': ['https://openalex.org/I2802581871']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052268581', 'display_name': 'Lisa A. Carey', 'orcid': 'https://orcid.org/0000-0003-2388-4649'}, 'institutions': [{'id': 'https://openalex.org/I4390039329', 'display_name': 'UNC Lineberger Comprehensive Cancer Center', 'ror': 'https://ror.org/043ehm030', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I114027177', 'https://openalex.org/I4390039329']}], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lisa Carey', 'raw_affiliation_strings': ['UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC'], 'affiliations': [{'raw_affiliation_string': 'UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC', 'institution_ids': ['https://openalex.org/I4390039329']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069610642', 'display_name': 'A Jo Chien', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A Jo Chien', 'raw_affiliation_strings': ['University of California at San Francisco, San Francisco, CA'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Francisco, San Francisco, CA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003897511', 'display_name': 'Giuseppe Curigliano', 'orcid': 'https://orcid.org/0000-0003-1781-2518'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Curigliano', 'raw_affiliation_strings': ['Istituto Europeo di Oncologia, IRCCS, University of Milano, Milan, Italy'], 'affiliations': [{'raw_affiliation_string': 'Istituto Europeo di Oncologia, IRCCS, University of Milano, Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I189158943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023226233', 'display_name': 'Michael P. DiGiovanna', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802730090', 'display_name': 'Yale Cancer Center', 'ror': 'https://ror.org/03j7sze86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2802730090', 'https://openalex.org/I4210117499', 'https://openalex.org/I4210165192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael DiGiovanna', 'raw_affiliation_strings': ['Yale Cancer Center, New Haven, CT'], 'affiliations': [{'raw_affiliation_string': 'Yale Cancer Center, New Haven, CT', 'institution_ids': ['https://openalex.org/I2802730090']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067468792', 'display_name': 'Karen A. Gelmon', 'orcid': 'https://orcid.org/0000-0003-4111-2757'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Karen Gelmon', 'raw_affiliation_strings': ['British Columbia Cancer - Vancouver Centre, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'British Columbia Cancer - Vancouver Centre, Vancouver, BC, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021577928', 'display_name': 'Gabriel Hortobagyi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gabriel Hortobagyi', 'raw_affiliation_strings': ['University of Texas MD Anderson Cancer Center, Houston, TX'], 'affiliations': [{'raw_affiliation_string': 'University of Texas MD Anderson Cancer Center, Houston, TX', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068059897', 'display_name': 'Sara A. Hurvitz', 'orcid': 'https://orcid.org/0000-0001-7808-7191'}, 'institutions': [{'id': 'https://openalex.org/I4390039293', 'display_name': 'UCLA Jonsson Comprehensive Cancer Center', 'ror': 'https://ror.org/0599cs764', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799798094', 'https://openalex.org/I4390039293']}, {'id': 'https://openalex.org/I2801403999', 'display_name': 'UCLA Medical Center', 'ror': 'https://ror.org/04vq5kb54', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799798094', 'https://openalex.org/I2801403999']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sara Hurvitz', 'raw_affiliation_strings': ['UCLA Medical Center/Jonsson Comprehensive Cancer Center,, Los Angeles, CA'], 'affiliations': [{'raw_affiliation_string': 'UCLA Medical Center/Jonsson Comprehensive Cancer Center,, Los Angeles, CA', 'institution_ids': ['https://openalex.org/I4390039293', 'https://openalex.org/I2801403999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032785430', 'display_name': 'Ian E. Krop', 'orcid': 'https://orcid.org/0000-0002-6380-5944'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ian Krop', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, MA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, MA', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010278367', 'display_name': 'Sherene Loi', 'orcid': 'https://orcid.org/0000-0001-6137-9171'}, 'institutions': [{'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Sherene Loi', 'raw_affiliation_strings': ['Peter MacCallum Cancer Centre, Melbourne, Australia'], 'affiliations': [{'raw_affiliation_string': 'Peter MacCallum Cancer Centre, Melbourne, Australia', 'institution_ids': ['https://openalex.org/I2800555584']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087559224', 'display_name': 'Sibylle Loibl', 'orcid': 'https://orcid.org/0000-0001-6488-4958'}, 'institutions': [], 'countries': ['GU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Sibylle Loibl', 'raw_affiliation_strings': ['German Breast Group, Neu-Isenburg, Guam'], 'affiliations': [{'raw_affiliation_string': 'German Breast Group, Neu-Isenburg, Guam', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088637879', 'display_name': 'Volkmar Mueller', 'orcid': 'https://orcid.org/0000-0003-4231-7906'}, 'institutions': [{'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}, {'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Volkmar Mueller', 'raw_affiliation_strings': ['Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany', 'institution_ids': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053983312', 'display_name': 'Mafalda Oliveira', 'orcid': 'https://orcid.org/0000-0001-9152-8799'}, 'institutions': [{'id': 'https://openalex.org/I4210127641', 'display_name': "Vall d'Hebron Hospital Universitari", 'ror': 'https://ror.org/03ba28x55', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127641']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Mafalda Oliveira', 'raw_affiliation_strings': ["Hospital Universitario Vall D'Hebron,, Barcelona, Spain"], 'affiliations': [{'raw_affiliation_string': "Hospital Universitario Vall D'Hebron,, Barcelona, Spain", 'institution_ids': ['https://openalex.org/I4210127641']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110656542', 'display_name': 'Elisavet Paplomata', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210103341', 'display_name': 'University of Wisconsin Carbone Cancer Center', 'ror': 'https://ror.org/01e4byj08', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799905417', 'https://openalex.org/I4210103341', 'https://openalex.org/I4210132596']}, {'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elisavet Paplomata', 'raw_affiliation_strings': ['Carbone Cancer Center/University of Wisconsin, Madison, WI'], 'affiliations': [{'raw_affiliation_string': 'Carbone Cancer Center/University of Wisconsin, Madison, WI', 'institution_ids': ['https://openalex.org/I4210103341', 'https://openalex.org/I135310074']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030502460', 'display_name': 'Mark D. Pegram', 'orcid': 'https://orcid.org/0000-0002-9743-8118'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mark Pegram', 'raw_affiliation_strings': ['Stanford Comprehensive Cancer Institute, Palo Alto, CA'], 'affiliations': [{'raw_affiliation_string': 'Stanford Comprehensive Cancer Institute, Palo Alto, CA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015491002', 'display_name': 'Dennis J. Slamon', 'orcid': 'https://orcid.org/0000-0002-6330-498X'}, 'institutions': [{'id': 'https://openalex.org/I4390039293', 'display_name': 'UCLA Jonsson Comprehensive Cancer Center', 'ror': 'https://ror.org/0599cs764', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799798094', 'https://openalex.org/I4390039293']}, {'id': 'https://openalex.org/I2801403999', 'display_name': 'UCLA Medical Center', 'ror': 'https://ror.org/04vq5kb54', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799798094', 'https://openalex.org/I2801403999']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dennis Slamon', 'raw_affiliation_strings': ['UCLA Medical Center/Jonsson Comprehensive Cancer Center, Los Angeles, CA'], 'affiliations': [{'raw_affiliation_string': 'UCLA Medical Center/Jonsson Comprehensive Cancer Center, Los Angeles, CA', 'institution_ids': ['https://openalex.org/I4390039293', 'https://openalex.org/I2801403999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038095983', 'display_name': 'Amelia Zelnak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I101890099', 'display_name': 'Northside Hospital', 'ror': 'https://ror.org/01g63ab19', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I101890099']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amelia Zelnak', 'raw_affiliation_strings': ['Northside Hospital, Sandy Springs, GA'], 'affiliations': [{'raw_affiliation_string': 'Northside Hospital, Sandy Springs, GA', 'institution_ids': ['https://openalex.org/I101890099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033085910', 'display_name': 'Jorge Ramos', 'orcid': 'https://orcid.org/0000-0002-3377-1683'}, 'institutions': [{'id': 'https://openalex.org/I99319750', 'display_name': 'Seagen (United States)', 'ror': 'https://ror.org/01vwesc15', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I99319750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jorge Ramos', 'raw_affiliation_strings': ['Seagen, Bothell, WA'], 'affiliations': [{'raw_affiliation_string': 'Seagen, Bothell, WA', 'institution_ids': ['https://openalex.org/I99319750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063479774', 'display_name': 'Wentao Feng', 'orcid': 'https://orcid.org/0000-0001-8109-5117'}, 'institutions': [{'id': 'https://openalex.org/I99319750', 'display_name': 'Seagen (United States)', 'ror': 'https://ror.org/01vwesc15', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I99319750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wentao Feng', 'raw_affiliation_strings': ['Seagen, Bothell, WA'], 'affiliations': [{'raw_affiliation_string': 'Seagen, Bothell, WA', 'institution_ids': ['https://openalex.org/I99319750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070245248', 'display_name': 'Eric P. Winer', 'orcid': 'https://orcid.org/0000-0002-8819-1723'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric Winer', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, MA'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, MA', 'institution_ids': ['https://openalex.org/I4210117453']}]}], 'institution_assertions': [], 'countries_distinct_count': 9, 'institutions_distinct_count': 25, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.769, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.748334, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '82', 'issue': '4_Supplement', 'first_page': 'PD4', 'last_page': '04'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11600', 'display_name': 'Brain Metastases and Treatment', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11600', 'display_name': 'Brain Metastases and Treatment', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12829', 'display_name': 'Advanced Breast Cancer Therapies', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/regimen', 'display_name': 'Regimen', 'score': 0.67833066}], 'concepts': [{'id': 'https://openalex.org/C2777909004', 'wikidata': 'https://www.wikidata.org/wiki/Q420207', 'display_name': 'Capecitabine', 'level': 4, 'score': 0.83415425}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8207344}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.6819328}, {'id': 'https://openalex.org/C2781413609', 'wikidata': 'https://www.wikidata.org/wiki/Q7308373', 'display_name': 'Regimen', 'level': 2, 'score': 0.67833066}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6608208}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.59009475}, {'id': 'https://openalex.org/C2779786085', 'wikidata': 'https://www.wikidata.org/wiki/Q412616', 'display_name': 'Trastuzumab', 'level': 4, 'score': 0.5644307}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.50323766}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.49234498}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.42574698}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4103397}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.18743867}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.09760621}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs21-pd4-04', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4253790588', 'https://openalex.org/W4250720993', 'https://openalex.org/W3006658735', 'https://openalex.org/W2597946808', 'https://openalex.org/W2588276706', 'https://openalex.org/W2364043314', 'https://openalex.org/W2356101927', 'https://openalex.org/W2130207808', 'https://openalex.org/W2096251760', 'https://openalex.org/W2042663917'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Tucatinib': [2], 'is': [3, 14], 'an': [4, 95], 'oral': [5], 'tyrosine': [6], 'kinase': [7], 'inhibitor': [8], 'highly': [9], 'specific': [10], 'for': [11, 16, 422, 466, 580], 'HER2': [12], 'that': [13], 'approved': [15], 'use': [17], 'in': [18, 24, 47, 67, 78, 114, 131, 139, 174, 207, 240, 247, 273, 295, 312, 331, 352, 369, 388, 404, 458, 482, 501], 'combination': [19, 175], 'with': [20, 26, 35, 69, 80, 133, 147, 176, 209, 250, 275, 298, 314, 333, 355, 371, 390, 424, 469, 484, 493, 504, 582, 589], 'trastuzumab': [21, 177, 577], 'and': [22, 63, 84, 112, 152, 178, 194, 237, 325, 382, 427, 461, 474, 487, 578], 'capecitabine': [23, 579], 'adults': [25], 'advanced': [27], 'or': [28, 42, 158, 172, 243], 'metastatic': [29, 49, 71, 471, 586], 'HER2+': [30, 70, 470], 'breast': [31, 72, 472, 587], 'cancer,': [32], 'including': [33, 77], 'patients': [34, 68, 79, 132, 138, 208, 249, 274, 297, 313, 332, 354, 370, 389, 423, 468, 483, 581], 'brain': [36, 87, 134, 144, 148, 210, 231, 242, 251, 262, 299, 317, 336, 356, 374, 393, 425, 475, 490, 590], 'metastases,': [37, 426], 'who': [38], 'have': [39], 'received': [40], 'one': [41], 'more': [43], 'prior': [44], 'anti-HER2-based': [45], 'regimens': [46], 'the': [48, 52, 55, 115, 181, 184, 198, 202, 221, 230, 241, 260, 405, 414, 454, 505, 597], 'setting.': [50], 'In': [51], 'HER2CLIMB': [53, 140], 'trial,': [54], 'tucatinib': [56, 103, 167, 203, 406, 494, 572], 'regimen': [57, 200, 456], 'significantly': [58], 'prolonged': [59], 'progression-free': [60], 'survival': [61, 65], '(PFS)': [62], 'overall': [64], '(OS)': [66], 'cancer': [73, 473, 588], '(Murthy,': [74], 'NEJM': [75], '2020),': [76], 'untreated,': [81, 155], 'treated': [82, 85, 156, 159, 334, 391, 488, 584], 'stable,': [83, 157], 'progressing': [86, 316, 373, 486], 'metastases': [88, 149, 211, 300, 318, 337, 357, 375, 394, 591], '(Lin,': [89], 'J': [90], 'Clin': [91], 'Oncol,': [92], '2020).': [93], 'With': [94, 448], 'additional': [96, 452], '15.6': [97, 449], 'months': [98, 291, 294, 308, 311, 327, 330, 348, 351, 365, 368, 384, 387, 435, 442, 450], 'of': [99, 102, 110, 127, 284, 430, 451, 464, 571, 596], 'follow-up,': [100, 453], 'addition': [101], 'continued': [104, 495], 'to': [105, 165, 188, 191, 201, 229, 496, 576], 'show': [106, 497], 'clinically': [107, 498], 'meaningful': [108, 499], 'prolongation': [109, 463], 'PFS': [111], 'OS': [113, 236, 288, 465], 'total': [116], 'study': [117], 'population': [118], '(Curigliano,': [119], 'ASCO': [120], 'Meeting,': [121], '2021).': [122], 'We': [123], 'report': [124], 'updated': [125], 'results': [126, 570], 'exploratory': [128], 'efficacy': [129], 'analyses': [130, 206], 'metastases.': [135, 252, 476, 491], 'Methods:': [136], 'All': [137], 'had': [141], 'a': [142, 281, 459], 'baseline': [143, 213], 'MRI.': [145, 263], 'Patients': [146, 161, 253], 'were': [150, 162, 214, 245, 257], 'eligible': [151], 'classified': [153], 'as': [154], 'progressing.': [160], 'randomized': [163, 224], '2:1': [164], 'receive': [166], '300': [168], 'mg': [169], 'twice': [170], 'daily': [171], 'placebo,': [173], 'capecitabine.': [179], 'Following': [180], 'primary': [182, 506], 'analysis,': [183], 'protocol': [185], 'was': [186, 271, 289, 346, 402, 433, 480], 'amended': [187], 'unblind': [189], 'sites': [190], 'treatment': [192], 'assignment': [193], 'allowed': [195], 'crossover': [196], 'from': [197, 220], 'placebo': [199, 415, 574], 'regimen.': [204], 'Efficacy': [205], 'at': [212, 216, 259], 'performed': [215], 'approximately': [217], '2': [218], 'years': [219], 'last': [222, 261], 'patient': [223], 'by': [225], 'applying': [226], 'RECIST': [227], '1.1': [228], 'based': [232], 'on': [233], 'investigator': [234], 'evaluation.': [235], 'CNS-PFS': [238, 255, 345, 502], '(progression': [239], 'death)': [244], 'evaluated': [246, 272], 'all': [248, 296, 353, 467], 'without': [254], 'events': [256], 'censored': [258], 'Confirmed': [264], 'intracranial': [265], '(IC)': [266], 'objective': [267], 'response': [268, 431], 'rate': [269], '(ORR-IC)': [270], 'measurable': [276], 'IC': [277], 'disease.': [278], 'Results:': [279], 'At': [280], 'median': [282, 287, 428], 'follow-up': [283], '29.6': [285], 'months,': [286], '21.6': [290, 326], 'vs': [292, 309, 328, 349, 366, 385, 413, 440, 573], '12.5': [293], '(HR:': [301, 319, 338, 358, 376, 395], '0.60;': [302], '95%': [303, 321, 340, 360, 378, 397, 409, 418], 'CI:': [304, 322, 341, 361, 379, 398, 410, 419, 437, 444], '0.44,': [305], '0.81),': [306], '21.4': [307], '11.8': [310], 'untreated/treated': [315, 372, 485], '0.52;': [320], '0.36,': [323], '0.77),': [324], '16.4': [329], 'stable': [335, 392, 489], '0.70;': [339], '0.42,': [342], '1.16).': [343], 'Median': [344], '9.9': [347], '4.2': [350], '0.39;': [359], '0.27,': [362], '0.56),': [363], '9.6': [364], '4.0': [367], '0.34;': [377], '0.22,': [380], '0.54),': [381], '13.9': [383], '5.6': [386], '0.41;': [396], '0.19,': [399], '0.85).': [400], 'ORR-IC': [401], 'higher': [403], 'arm': [407, 416], '(47.3%;': [408], '33.7,': [411], '61.2)': [412], '(20.0%;': [417], '5.7,': [420], '43.7)': [421], 'duration': [429], '(DOR)': [432], '8.6': [434], '(95%': [436, 443], '5.5,': [438], '10.3)': [439], '3.0': [441], '3.0,': [445], '10.3).': [446], 'Conclusions:': [447], 'tucatinib-trastuzumab-capecitabine': [455], 'resulted': [457], 'robust': [460], 'durable': [462], 'Additionally,': [477], 'this': [478], 'benefit': [479, 500], 'maintained': [481], 'Treatment': [492], 'consistent': [503], 'analysis.': [507], 'Citation': [508], 'Format:': [509], 'Nancy': [510], 'U': [511], 'Lin,': [512], 'Rashmi': [513], 'K': [514], 'Murthy,': [515], 'Vandana': [516], 'Abramson,': [517], 'Carey': [518], 'Anders,': [519], 'Thomas': [520], 'Bachelot,': [521], 'Philippe': [522], 'Bedard,': [523], 'Virginia': [524], 'Borges,': [525], 'David': [526, 528], 'Cameron,': [527, 529], 'Lisa': [530], 'Carey,': [531], 'A': [532], 'Jo': [533], 'Chien,': [534], 'Giuseppe': [535], 'Curigliano,': [536], 'Michael': [537], 'DiGiovanna,': [538], 'Karen': [539], 'Gelmon,': [540], 'Gabriel': [541], 'Hortobagyi,': [542], 'Sara': [543], 'Hurvitz,': [544], 'Ian': [545], 'Krop,': [546], 'Sherene': [547], 'Loi,': [548], 'Sibylle': [549], 'Loibl,': [550], 'Volkmar': [551], 'Mueller,': [552], 'Mafalda': [553], 'Oliveira,': [554], 'Elisavet': [555], 'Paplomata,': [556], 'Mark': [557], 'Pegram,': [558], 'Dennis': [559], 'Slamon,': [560], 'Amelia': [561], 'Zelnak,': [562], 'Jorge': [563], 'Ramos,': [564], 'Wentao': [565], 'Feng,': [566], 'Eric': [567], 'Winer.': [568], 'Updated': [569], 'added': [575], 'previously': [583], 'HER2-positive': [585], '(HER2CLIMB)': [592], '[abstract].': [593], 'In:': [594], 'Proceedings': [595], '2021': [598, 604], 'San': [599, 607], 'Antonio': [600], 'Breast': [601], 'Cancer': [602, 613], 'Symposium;': [603], 'Dec': [605], '7-10;': [606], 'Antonio,': [608], 'TX.': [609], 'Philadelphia': [610], '(PA):': [611], 'AACR;': [612], 'Res': [614], '2022;82(4': [615], 'Suppl):Abstract': [616], 'nr': [617], 'PD4-04.': [618]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4289515481', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}], 'updated_date': '2025-01-12T10:34:31.545977', 'created_date': '2022-08-03'}