Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4289109525', 'doi': 'https://doi.org/10.3390/biomedicines10081847', 'title': 'A Brominated Furanone Inhibits Pseudomonas aeruginosa Quorum Sensing and Type III Secretion, Attenuating Its Virulence in a Murine Cutaneous Abscess Model', 'display_name': 'A Brominated Furanone Inhibits Pseudomonas aeruginosa Quorum Sensing and Type III Secretion, Attenuating Its Virulence in a Murine Cutaneous Abscess Model', 'publication_year': 2022, 'publication_date': '2022-07-31', 'ids': {'openalex': 'https://openalex.org/W4289109525', 'doi': 'https://doi.org/10.3390/biomedicines10081847', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36009394'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biomedicines10081847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2737005842', 'display_name': 'Biomedicines', 'issn_l': '2227-9059', 'issn': ['2227-9059'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.3390/biomedicines10081847', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082139151', 'display_name': 'Naybi Muñoz-Cázares', 'orcid': 'https://orcid.org/0000-0002-6243-7983'}, 'institutions': [{'id': 'https://openalex.org/I4210097172', 'display_name': 'Colegio de Postgraduados', 'ror': 'https://ror.org/00qfnf017', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I4210097172']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Naybi Muñoz-Cázares', 'raw_affiliation_strings': ['Laboratorio de Fitoquímica, Posgrado en Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Fitoquímica, Posgrado en Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico', 'institution_ids': ['https://openalex.org/I4210097172']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034717584', 'display_name': 'Israel Castillo‐Juárez', 'orcid': 'https://orcid.org/0000-0001-6983-5565'}, 'institutions': [{'id': 'https://openalex.org/I4210097172', 'display_name': 'Colegio de Postgraduados', 'ror': 'https://ror.org/00qfnf017', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I4210097172']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Israel Castillo-Juárez', 'raw_affiliation_strings': ['Laboratorio de Fitoquímica, Posgrado en Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Fitoquímica, Posgrado en Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico', 'institution_ids': ['https://openalex.org/I4210097172']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024219837', 'display_name': 'Rodolfo García‐Contreras', 'orcid': 'https://orcid.org/0000-0001-8475-2282'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Rodolfo García-Contreras', 'raw_affiliation_strings': ['Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006838889', 'display_name': 'Víctor Alberto Castro‐Torres', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Víctor Alberto Castro-Torres', 'raw_affiliation_strings': ['Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047536179', 'display_name': 'Miguel Díaz‐Guerrero', 'orcid': 'https://orcid.org/0000-0002-7498-8117'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Miguel Díaz-Guerrero', 'raw_affiliation_strings': ['Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico', 'Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}, {'raw_affiliation_string': 'Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026291302', 'display_name': 'José S. Rodríguez‐Zavala', 'orcid': 'https://orcid.org/0000-0002-7094-5523'}, 'institutions': [{'id': 'https://openalex.org/I4210157394', 'display_name': 'Instituto Nacional de Cardiología', 'ror': 'https://ror.org/046e90j34', 'country_code': 'MX', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157394']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'José S. Rodríguez-Zavala', 'raw_affiliation_strings': ['Departamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico', 'institution_ids': ['https://openalex.org/I4210157394']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052005910', 'display_name': 'Héctor Quezada', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097267', 'display_name': 'Hospital Infantil de México Federico Gómez', 'ror': 'https://ror.org/00nzavp26', 'country_code': 'MX', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097267']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Héctor Quezada', 'raw_affiliation_strings': ['Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico', 'institution_ids': ['https://openalex.org/I4210097267']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046915974', 'display_name': 'Bertha González‐Pedrajo', 'orcid': 'https://orcid.org/0000-0002-2125-2157'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': True, 'raw_author_name': 'Bertha González-Pedrajo', 'raw_affiliation_strings': ['Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088228537', 'display_name': 'Mariano Martínez‐Vázquez', 'orcid': 'https://orcid.org/0000-0003-0954-2765'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': True, 'raw_author_name': 'Mariano Martínez-Vázquez', 'raw_affiliation_strings': ['Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5046915974', 'https://openalex.org/A5088228537'], 'corresponding_institution_ids': ['https://openalex.org/I8961855', 'https://openalex.org/I8961855'], 'apc_list': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'apc_paid': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'fwci': 0.899, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '10', 'issue': '8', 'first_page': '1847', 'last_page': '1847'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10593', 'display_name': 'Bacterial biofilms and quorum sensing', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10593', 'display_name': 'Bacterial biofilms and quorum sensing', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides and Activities', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pyocyanin', 'display_name': 'Pyocyanin', 'score': 0.9536373}, {'id': 'https://openalex.org/keywords/swarming-motility', 'display_name': 'Swarming motility', 'score': 0.70426244}, {'id': 'https://openalex.org/keywords/chromobacterium-violaceum', 'display_name': 'Chromobacterium violaceum', 'score': 0.5960066}, {'id': 'https://openalex.org/keywords/pathogenic-bacteria', 'display_name': 'Pathogenic bacteria', 'score': 0.42445627}], 'concepts': [{'id': 'https://openalex.org/C60987743', 'wikidata': 'https://www.wikidata.org/wiki/Q1460232', 'display_name': 'Virulence', 'level': 3, 'score': 0.9655732}, {'id': 'https://openalex.org/C2781427627', 'wikidata': 'https://www.wikidata.org/wiki/Q410503', 'display_name': 'Pyocyanin', 'level': 5, 'score': 0.9536373}, {'id': 'https://openalex.org/C118687296', 'wikidata': 'https://www.wikidata.org/wiki/Q905754', 'display_name': 'Quorum sensing', 'level': 4, 'score': 0.8980571}, {'id': 'https://openalex.org/C2777637488', 'wikidata': 'https://www.wikidata.org/wiki/Q31856', 'display_name': 'Pseudomonas aeruginosa', 'level': 3, 'score': 0.8786912}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.81472576}, {'id': 'https://openalex.org/C58123911', 'wikidata': 'https://www.wikidata.org/wiki/Q467410', 'display_name': 'Biofilm', 'level': 3, 'score': 0.79653907}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.79651594}, {'id': 'https://openalex.org/C186380895', 'wikidata': 'https://www.wikidata.org/wiki/Q2258085', 'display_name': 'Swarming motility', 'level': 5, 'score': 0.70426244}, {'id': 'https://openalex.org/C130211564', 'wikidata': 'https://www.wikidata.org/wiki/Q21199165', 'display_name': 'Type three secretion system', 'level': 4, 'score': 0.63179314}, {'id': 'https://openalex.org/C2777916119', 'wikidata': 'https://www.wikidata.org/wiki/Q3498295', 'display_name': 'Chromobacterium violaceum', 'level': 5, 'score': 0.5960066}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.58223563}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5547317}, {'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.5086249}, {'id': 'https://openalex.org/C2781463711', 'wikidata': 'https://www.wikidata.org/wiki/Q131143', 'display_name': 'Pseudomonas', 'level': 3, 'score': 0.45079333}, {'id': 'https://openalex.org/C2778883795', 'wikidata': 'https://www.wikidata.org/wiki/Q804517', 'display_name': 'Pathogenic bacteria', 'level': 3, 'score': 0.42445627}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12747821}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07013491}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biomedicines10081847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2737005842', 'display_name': 'Biomedicines', 'issn_l': '2227-9059', 'issn': ['2227-9059'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/b6a25e4afee345da8d461c4b24b53d0a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://dx.doi.org/10.3390/biomedicines10081847', 'pdf_url': 'https://www.mdpi.com/2227-9059/10/8/1847/pdf?version=1659269768', 'source': {'id': 'https://openalex.org/S4306400947', 'display_name': 'MDPI (MDPI AG)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210097602', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute (Switzerland)', 'host_organization_lineage': ['https://openalex.org/I4210097602'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute (Switzerland)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36009394', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biomedicines10081847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2737005842', 'display_name': 'Biomedicines', 'issn_l': '2227-9059', 'issn': ['2227-9059'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321739', 'funder_display_name': 'Consejo Nacional de Ciencia y Tecnología', 'award_id': '284081'}], 'datasets': [], 'versions': [], 'referenced_works_count': 61, 'referenced_works': ['https://openalex.org/W1526205344', 'https://openalex.org/W1526476826', 'https://openalex.org/W1539392213', 'https://openalex.org/W1703657909', 'https://openalex.org/W1710549082', 'https://openalex.org/W1991428108', 'https://openalex.org/W2001179836', 'https://openalex.org/W2001330381', 'https://openalex.org/W2005009733', 'https://openalex.org/W2007002493', 'https://openalex.org/W2015059535', 'https://openalex.org/W2025413688', 'https://openalex.org/W2030096585', 'https://openalex.org/W2040605556', 'https://openalex.org/W2042500078', 'https://openalex.org/W2044876834', 'https://openalex.org/W2052037206', 'https://openalex.org/W2055613435', 'https://openalex.org/W2061520106', 'https://openalex.org/W2065799084', 'https://openalex.org/W2069136665', 'https://openalex.org/W2069286409', 'https://openalex.org/W2077627110', 'https://openalex.org/W2104198286', 'https://openalex.org/W2105668062', 'https://openalex.org/W2108954105', 'https://openalex.org/W2112814507', 'https://openalex.org/W2113771246', 'https://openalex.org/W2117479122', 'https://openalex.org/W2118992559', 'https://openalex.org/W2119410664', 'https://openalex.org/W2125268958', 'https://openalex.org/W2132629607', 'https://openalex.org/W2133231650', 'https://openalex.org/W2133425351', 'https://openalex.org/W2146292204', 'https://openalex.org/W2152710136', 'https://openalex.org/W2155700027', 'https://openalex.org/W2165526004', 'https://openalex.org/W2267420900', 'https://openalex.org/W2306122989', 'https://openalex.org/W2423271305', 'https://openalex.org/W2499128788', 'https://openalex.org/W2518739676', 'https://openalex.org/W2536440917', 'https://openalex.org/W2593872179', 'https://openalex.org/W2598898392', 'https://openalex.org/W2606365851', 'https://openalex.org/W2606692795', 'https://openalex.org/W2737953146', 'https://openalex.org/W2747637465', 'https://openalex.org/W2750701124', 'https://openalex.org/W2912470012', 'https://openalex.org/W2921340540', 'https://openalex.org/W2946119776', 'https://openalex.org/W2951068392', 'https://openalex.org/W2966539757', 'https://openalex.org/W2983568473', 'https://openalex.org/W3002619197', 'https://openalex.org/W3127930028', 'https://openalex.org/W3138235143'], 'related_works': ['https://openalex.org/W4384023626', 'https://openalex.org/W4308570572', 'https://openalex.org/W4292953748', 'https://openalex.org/W4220917978', 'https://openalex.org/W3164659769', 'https://openalex.org/W2997230984', 'https://openalex.org/W2753650496', 'https://openalex.org/W2736007284', 'https://openalex.org/W2594120191', 'https://openalex.org/W2129003991'], 'abstract_inverted_index': {'Quorum': [0], 'sensing': [1], '(QS)': [2], 'and': [3, 55, 62, 73, 83, 110, 143, 162], 'type': [4, 70], 'III': [5, 71], 'secretion': [6, 68, 127], 'systems': [7, 45], '(T3SSs)': [8], 'are': [9], 'among': [10], 'the': [11, 40, 67, 114, 126, 151, 159, 163, 179, 190, 194, 203, 213], 'most': [12], 'attractive': [13], 'anti-virulence': [14, 218], 'targets': [15], 'for': [16, 189], 'combating': [17], 'multidrug-resistant': [18], 'pathogenic': [19], 'bacteria.': [20], 'Some': [21], 'halogenated': [22, 51], 'furanones': [23, 52, 124], 'reduce': [24], 'QS-associated': [25], 'virulence,': [26], 'but': [27], 'their': [28, 63, 88], 'role': [29], 'in': [30, 79, 96, 113, 134, 158, 184], 'T3SS': [31], 'inhibition': [32, 41], 'remains': [33], 'unclear.': [34], 'This': [35], 'study': [36], 'aimed': [37], 'to': [38, 65, 90, 146], 'assess': [39], 'of': [42, 69, 128, 140, 166, 182, 193, 215], 'these': [43], 'two': [44, 84], 'on': [46], 'Pseudomonas': [47], 'aeruginosa': [48, 81], 'virulence.': [49], 'The': [50, 102, 138], '(Z)-4-bromo-5-(bromomethylene)-2(5H)': [53], '(C-30)': [54], '5-(dibromomethylene)-2(5H)': [56], '(named': [57], 'hereafter': [58], 'GBr)': [59], 'were': [60], 'synthesized,': [61], 'ability': [64, 89], 'inhibit': [66], 'exoenzymes': [72], 'QS-controlled': [74], 'virulence': [75], 'factors': [76], 'was': [77, 94], 'analyzed': [78], 'P.': [80], 'PA14': [82, 152], 'clinical': [85], 'isolates.': [86], 'Furthermore,': [87], 'prevent': [91], 'bacterial': [92], 'establishment': [93], 'determined': [95], 'a': [97], 'murine': [98], 'cutaneous': [99], 'abscess': [100], 'model.': [101], 'GBr': [103, 141, 185, 204], 'furanone': [104, 205], 'reduced': [105], 'pyocyanin': [106], 'production,': [107], 'biofilm': [108], 'formation,': [109], 'swarming': [111], 'motility': [112], 'same': [115], 'manner': [116], 'or': [117, 131], 'more': [118, 168, 216], 'effectively': [119], 'than': [120, 170], 'C-30.': [121], 'Moreover,': [122], 'both': [123], 'inhibited': [125], 'ExoS,': [129], 'ExoT,': [130], 'ExoU': [132], 'effectors': [133], 'all': [135], 'tested': [136], 'strains.': [137], 'administration': [139], '(25': [142], '50': [144], 'µM)': [145], 'CD1': [147], 'mice': [148], 'infected': [149], 'with': [150], 'strain': [153], 'significantly': [154], 'decreased': [155], 'necrosis': [156], 'formation': [157], 'inoculation': [160], 'zone': [161], 'systemic': [164], 'spread': [165], 'bacteria': [167], 'efficiently': [169], 'C-30': [171], '(50': [172], 'µM).': [173], 'Molecular': [174], 'docking': [175], 'analysis': [176], 'suggested': [177], 'that': [178, 202, 210], 'gem': [180], 'position': [181], 'bromine': [183], 'increases': [186], 'its': [187], 'affinity': [188], 'active': [191], 'site': [192], 'QS': [195], 'LasR': [196], 'regulator.': [197], 'Overall,': [198], 'our': [199], 'findings': [200], 'showed': [201], 'displayed': [206], 'efficient': [207], 'multi-target': [208], 'properties': [209], 'may': [211], 'favor': [212], 'development': [214], 'effective': [217], 'therapies.': [219]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4289109525', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2025-01-07T19:37:33.742721', 'created_date': '2022-08-01'}