Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4289028828', 'doi': 'https://doi.org/10.1172/jci157765', 'title': 'IgE-neutralizing UB-221 mAb, distinct from omalizumab and ligelizumab, exhibits CD23-mediated IgE downregulation and relieves urticaria symptoms', 'display_name': 'IgE-neutralizing UB-221 mAb, distinct from omalizumab and ligelizumab, exhibits CD23-mediated IgE downregulation and relieves urticaria symptoms', 'publication_year': 2022, 'publication_date': '2022-08-01', 'ids': {'openalex': 'https://openalex.org/W4289028828', 'doi': 'https://doi.org/10.1172/jci157765', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35912861'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci157765', 'pdf_url': 'http://www.jci.org/articles/view/157765/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.jci.org/articles/view/157765/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053681085', 'display_name': 'B S Kuo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140213', 'display_name': 'United Biomedical (United States)', 'ror': 'https://ror.org/044bp3769', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210140213']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Be-Sheng Kuo', 'raw_affiliation_strings': ['UBI Asia, Hsinchu, Taiwan.', 'United BioPharma, Inc., Hsinchu, Taiwan.', 'United Biomedical, Inc., Hauppauge, New York, USA.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}, {'raw_affiliation_string': 'UBI Asia, Hsinchu, Taiwan.', 'institution_ids': []}, {'raw_affiliation_string': 'United Biomedical, Inc., Hauppauge, New York, USA.', 'institution_ids': ['https://openalex.org/I4210140213']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036102077', 'display_name': 'Chao-Hung Li', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chao-Hung Li', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072214339', 'display_name': 'Jiun-Bo Chen', 'orcid': 'https://orcid.org/0000-0002-8866-8552'}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Jiun-Bo Chen', 'raw_affiliation_strings': ['UBI Asia, Hsinchu, Taiwan.', 'United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}, {'raw_affiliation_string': 'UBI Asia, Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010682149', 'display_name': 'Yu-Yu Shiung', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yu-Yu Shiung', 'raw_affiliation_strings': ['UBI Asia, Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'UBI Asia, Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062947819', 'display_name': 'Chia‐Yu Chu', 'orcid': 'https://orcid.org/0000-0002-9370-3279'}, 'institutions': [{'id': 'https://openalex.org/I4210131804', 'display_name': 'National Taiwan University Hospital', 'ror': 'https://ror.org/03nteze27', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210131804']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chia-Yu Chu', 'raw_affiliation_strings': ['Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.', 'institution_ids': ['https://openalex.org/I4210131804']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067058550', 'display_name': 'Chih‐Hung Lee', 'orcid': 'https://orcid.org/0000-0001-9804-3874'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chih-Hung Lee', 'raw_affiliation_strings': ['Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036362168', 'display_name': 'Yaw‐Jen Liu', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yaw-Jen Liu', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000616659', 'display_name': 'Je-Hung Kuo', 'orcid': 'https://orcid.org/0000-0002-5499-8027'}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Je-Hung Kuo', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008211557', 'display_name': 'Cindy H. Hsu', 'orcid': 'https://orcid.org/0000-0002-8192-6969'}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Cindy Hsu', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052784117', 'display_name': 'Hsiao-Wen Su', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018075036', 'display_name': 'Sanofi (France)', 'ror': 'https://ror.org/02n6c9837', 'country_code': 'FR', 'type': 'company', 'lineage': ['https://openalex.org/I3018075036']}, {'id': 'https://openalex.org/I189718659', 'display_name': 'Pfizer (United Kingdom)', 'ror': 'https://ror.org/04x4v8p40', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I189718659']}, {'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}, {'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}, {'id': 'https://openalex.org/I4210123153', 'display_name': 'Sanofi (Belgium)', 'ror': 'https://ror.org/02wnz8673', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I3018075036', 'https://openalex.org/I4210123153']}, {'id': 'https://openalex.org/I4210092929', 'display_name': 'Novartis (France)', 'ror': 'https://ror.org/00geypp27', 'country_code': 'FR', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996', 'https://openalex.org/I4210092929']}, {'id': 'https://openalex.org/I2948539688', 'display_name': 'AbbVie (United States)', 'ror': 'https://ror.org/02g5p4n58', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2948539688']}], 'countries': ['BE', 'CH', 'FR', 'GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Hsiao-Wen Su', 'raw_affiliation_strings': [' Novartis, Pfizer, Roche, Sanofi, and UBP;', ' consultant for AbbVie, Lilly,', ' speaker for AbbVie, Lilly, Novartis, Pfizer, Roche,', 'One-ness Biotech, Pfizer, Regeneron, Roche, Sanofi, and UBP;'], 'affiliations': [{'raw_affiliation_string': 'One-ness Biotech, Pfizer, Regeneron, Roche, Sanofi, and UBP;', 'institution_ids': ['https://openalex.org/I3018075036', 'https://openalex.org/I189718659', 'https://openalex.org/I118019719', 'https://openalex.org/I186523950']}, {'raw_affiliation_string': ' Novartis, Pfizer, Roche, Sanofi, and UBP;', 'institution_ids': ['https://openalex.org/I4210123153', 'https://openalex.org/I4210092929', 'https://openalex.org/I189718659', 'https://openalex.org/I118019719']}, {'raw_affiliation_string': ' speaker for AbbVie, Lilly, Novartis, Pfizer, Roche,', 'institution_ids': ['https://openalex.org/I4210092929', 'https://openalex.org/I189718659', 'https://openalex.org/I118019719', 'https://openalex.org/I2948539688']}, {'raw_affiliation_string': ' consultant for AbbVie, Lilly,', 'institution_ids': ['https://openalex.org/I2948539688']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035930943', 'display_name': 'Ywan-Feng Li', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ywan-Feng Li', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001155293', 'display_name': 'Annie Lai', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Annie Lai', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038760054', 'display_name': 'Yueh-Feng Ho', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yueh-Feng Ho', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061786508', 'display_name': 'Yi-Ning Cheng', 'orcid': 'https://orcid.org/0000-0002-0525-8874'}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yi-Ning Cheng', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014268511', 'display_name': 'Hong-Xuan Huang', 'orcid': 'https://orcid.org/0000-0002-9055-9849'}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Hong-Xuan Huang', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031557805', 'display_name': 'Meng-Chung Lung', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Meng-Chung Lung', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079331579', 'display_name': 'Ming-Syue Wu', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ming-Syue Wu', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104039397', 'display_name': 'Fu-Hong Yang', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Fu-Hong Yang', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103576193', 'display_name': 'Chen-Han Lin', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chen-Han Lin', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077840738', 'display_name': 'William W. Tseng', 'orcid': 'https://orcid.org/0000-0002-0360-6871'}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'William Tseng', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089724061', 'display_name': 'Jasper B. Yang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210123153', 'display_name': 'Sanofi (Belgium)', 'ror': 'https://ror.org/02wnz8673', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I3018075036', 'https://openalex.org/I4210123153']}, {'id': 'https://openalex.org/I4210092929', 'display_name': 'Novartis (France)', 'ror': 'https://ror.org/00geypp27', 'country_code': 'FR', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996', 'https://openalex.org/I4210092929']}, {'id': 'https://openalex.org/I189718659', 'display_name': 'Pfizer (United Kingdom)', 'ror': 'https://ror.org/04x4v8p40', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I180857899', 'https://openalex.org/I189718659']}, {'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}, {'id': 'https://openalex.org/I2948539688', 'display_name': 'AbbVie (United States)', 'ror': 'https://ror.org/02g5p4n58', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I2948539688']}, {'id': 'https://openalex.org/I3018075036', 'display_name': 'Sanofi (France)', 'ror': 'https://ror.org/02n6c9837', 'country_code': 'FR', 'type': 'company', 'lineage': ['https://openalex.org/I3018075036']}, {'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['BE', 'CH', 'FR', 'GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jasper Yang', 'raw_affiliation_strings': [' Novartis, Pfizer, Roche, Sanofi, and UBP;', ' consultant for AbbVie, Lilly,', ' speaker for AbbVie, Lilly, Novartis, Pfizer, Roche,', 'One-ness Biotech, Pfizer, Regeneron, Roche, Sanofi, and UBP;'], 'affiliations': [{'raw_affiliation_string': ' Novartis, Pfizer, Roche, Sanofi, and UBP;', 'institution_ids': ['https://openalex.org/I4210123153', 'https://openalex.org/I4210092929', 'https://openalex.org/I189718659', 'https://openalex.org/I118019719']}, {'raw_affiliation_string': ' speaker for AbbVie, Lilly, Novartis, Pfizer, Roche,', 'institution_ids': ['https://openalex.org/I4210092929', 'https://openalex.org/I189718659', 'https://openalex.org/I118019719', 'https://openalex.org/I2948539688']}, {'raw_affiliation_string': 'One-ness Biotech, Pfizer, Regeneron, Roche, Sanofi, and UBP;', 'institution_ids': ['https://openalex.org/I3018075036', 'https://openalex.org/I189718659', 'https://openalex.org/I118019719', 'https://openalex.org/I186523950']}, {'raw_affiliation_string': ' consultant for AbbVie, Lilly,', 'institution_ids': ['https://openalex.org/I2948539688']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088409694', 'display_name': 'Chia‐Yin Lin', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chia-Yin Lin', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048247506', 'display_name': 'Pei-Hua Tsai', 'orcid': 'https://orcid.org/0000-0002-4266-4046'}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Pei-Hua Tsai', 'raw_affiliation_strings': ['UBI Asia, Hsinchu, Taiwan.', 'United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}, {'raw_affiliation_string': 'UBI Asia, Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037970876', 'display_name': 'Heng-Kwei Chang', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Heng-Kwei Chang', 'raw_affiliation_strings': ['UBI Asia, Hsinchu, Taiwan.', 'United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}, {'raw_affiliation_string': 'UBI Asia, Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102742836', 'display_name': 'Yi-Jen Wang', 'orcid': 'https://orcid.org/0000-0001-5494-4611'}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yi-Jen Wang', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024797391', 'display_name': 'Techeng Chen', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Techeng Chen', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059479723', 'display_name': 'Shugene Lynn', 'orcid': None}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Shugene Lynn', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042723278', 'display_name': 'Liao Ming-yang', 'orcid': 'https://orcid.org/0000-0003-0496-0191'}, 'institutions': [], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Mei-June Liao', 'raw_affiliation_strings': ['United BioPharma, Inc., Hsinchu, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100337614', 'display_name': 'C. M. Wang', 'orcid': 'https://orcid.org/0000-0002-7604-1744'}, 'institutions': [{'id': 'https://openalex.org/I4210140213', 'display_name': 'United Biomedical (United States)', 'ror': 'https://ror.org/044bp3769', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210140213']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chang Yi Wang', 'raw_affiliation_strings': ['UBI Asia, Hsinchu, Taiwan.', 'United BioPharma, Inc., Hsinchu, Taiwan.', 'United Biomedical, Inc., Hauppauge, New York, USA.'], 'affiliations': [{'raw_affiliation_string': 'United BioPharma, Inc., Hsinchu, Taiwan.', 'institution_ids': []}, {'raw_affiliation_string': 'UBI Asia, Hsinchu, Taiwan.', 'institution_ids': []}, {'raw_affiliation_string': 'United Biomedical, Inc., Hauppauge, New York, USA.', 'institution_ids': ['https://openalex.org/I4210140213']}]}], 'countries_distinct_count': 6, 'institutions_distinct_count': 11, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'fwci': 11.072, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 32, 'citation_normalized_percentile': {'value': 0.999908, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '132', 'issue': '15', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12438', 'display_name': 'Diagnosis and Management of Urticaria', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12438', 'display_name': 'Diagnosis and Management of Urticaria', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11346', 'display_name': 'Role of Mast Cells in Immunoregulation and Disease', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd23', 'display_name': 'CD23', 'score': 0.82338893}, {'id': 'https://openalex.org/keywords/omalizumab', 'display_name': 'Omalizumab', 'score': 0.483016}], 'concepts': [{'id': 'https://openalex.org/C2778564945', 'wikidata': 'https://www.wikidata.org/wiki/Q415392', 'display_name': 'Omalizumab', 'level': 4, 'score': 0.9873997}, {'id': 'https://openalex.org/C141105273', 'wikidata': 'https://www.wikidata.org/wiki/Q79455', 'display_name': 'Immunoglobulin E', 'level': 3, 'score': 0.9063034}, {'id': 'https://openalex.org/C34814297', 'wikidata': 'https://www.wikidata.org/wiki/Q4845302', 'display_name': 'CD23', 'level': 4, 'score': 0.82338893}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.6107317}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.567119}, {'id': 'https://openalex.org/C49802076', 'wikidata': 'https://www.wikidata.org/wiki/Q5251810', 'display_name': 'Degranulation', 'level': 3, 'score': 0.53959596}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.50055575}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.46991768}, {'id': 'https://openalex.org/C2777456892', 'wikidata': 'https://www.wikidata.org/wiki/Q107988', 'display_name': 'Basophil', 'level': 4, 'score': 0.43764395}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32597217}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.10321626}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.09427041}], 'mesh': [{'descriptor_ui': 'D000069444', 'descriptor_name': 'Omalizumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014581', 'descriptor_name': 'Urticaria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007073', 'descriptor_name': 'Immunoglobulin E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069444', 'descriptor_name': 'Omalizumab', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000069444', 'descriptor_name': 'Omalizumab', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014581', 'descriptor_name': 'Urticaria', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D014581', 'descriptor_name': 'Urticaria', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci157765', 'pdf_url': 'http://www.jci.org/articles/view/157765/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337824', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35912861', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci157765', 'pdf_url': 'http://www.jci.org/articles/view/157765/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 69, 'referenced_works': ['https://openalex.org/W1494211513', 'https://openalex.org/W1494659642', 'https://openalex.org/W1696337576', 'https://openalex.org/W1855016645', 'https://openalex.org/W1892361499', 'https://openalex.org/W1910182345', 'https://openalex.org/W1946894882', 'https://openalex.org/W1988028493', 'https://openalex.org/W1991012007', 'https://openalex.org/W2008931469', 'https://openalex.org/W2009968823', 'https://openalex.org/W2010416354', 'https://openalex.org/W2010919000', 'https://openalex.org/W2013511927', 'https://openalex.org/W2025712675', 'https://openalex.org/W2040640809', 'https://openalex.org/W2041477351', 'https://openalex.org/W2042588031', 'https://openalex.org/W2043003756', 'https://openalex.org/W2043497590', 'https://openalex.org/W2044692976', 'https://openalex.org/W2052428579', 'https://openalex.org/W2056069273', 'https://openalex.org/W2062209413', 'https://openalex.org/W2066962548', 'https://openalex.org/W2070334379', 'https://openalex.org/W2079440940', 'https://openalex.org/W2084016153', 'https://openalex.org/W2085071459', 'https://openalex.org/W2091689358', 'https://openalex.org/W2093460937', 'https://openalex.org/W2094303364', 'https://openalex.org/W2099512139', 'https://openalex.org/W2100955722', 'https://openalex.org/W2102629488', 'https://openalex.org/W2118347957', 'https://openalex.org/W2119256134', 'https://openalex.org/W2120948675', 'https://openalex.org/W2125248316', 'https://openalex.org/W2136060598', 'https://openalex.org/W2138814764', 'https://openalex.org/W2139618618', 'https://openalex.org/W2144712546', 'https://openalex.org/W2147110025', 'https://openalex.org/W2148159422', 'https://openalex.org/W2155051645', 'https://openalex.org/W2156168777', 'https://openalex.org/W2163792469', 'https://openalex.org/W2272318635', 'https://openalex.org/W2402139063', 'https://openalex.org/W2598514439', 'https://openalex.org/W2605134986', 'https://openalex.org/W2609560535', 'https://openalex.org/W2786694607', 'https://openalex.org/W2810475021', 'https://openalex.org/W2884094674', 'https://openalex.org/W2901343691', 'https://openalex.org/W2969582750', 'https://openalex.org/W2970651795', 'https://openalex.org/W2978592627', 'https://openalex.org/W2999840425', 'https://openalex.org/W3006039641', 'https://openalex.org/W3014820779', 'https://openalex.org/W3084248603', 'https://openalex.org/W3117764278', 'https://openalex.org/W3127207093', 'https://openalex.org/W3136454416', 'https://openalex.org/W4210773038', 'https://openalex.org/W4313305986'], 'related_works': ['https://openalex.org/W4289028828', 'https://openalex.org/W4205790605', 'https://openalex.org/W3135743637', 'https://openalex.org/W3083341846', 'https://openalex.org/W2999288820', 'https://openalex.org/W2911898790', 'https://openalex.org/W2421625876', 'https://openalex.org/W2134003380', 'https://openalex.org/W2054139100', 'https://openalex.org/W1596224569'], 'abstract_inverted_index': {'Over': [0], 'the': [1, 7, 28, 56], 'last': [2], '2': [3], 'decades,': [4], 'omalizumab': [5, 44, 72, 98, 112, 162], 'is': [6, 69], 'only': [8, 29], 'anti-IgE': [9, 25, 62], 'antibody': [10], 'that': [11, 42, 68, 138], 'has': [12], 'been': [13], 'approved': [14], 'for': [15], 'asthma': [16], 'and': [17, 27, 73, 97, 111, 131, 142, 147, 173], 'chronic': [18], 'spontaneous': [19], 'urticaria': [20], '(CSU).': [21], 'Ligelizumab,': [22], 'a': [23, 65, 123, 195, 206], 'higher-affinity': [24], 'mAb': [26, 63], 'rival': [30], 'viable': [31], 'candidate': [32], 'in': [33, 45, 50, 76, 85, 113, 151, 194, 203, 209], 'late-stage': [34], 'clinical': [35], 'trials,': [36], 'showed': [37], 'anti-CSU': [38], 'efficacy': [39], 'superior': [40, 134], 'to': [41, 81, 126, 137, 170, 190], 'of': [43, 59, 64, 116, 139, 153], 'phase': [46, 51], 'IIb': [47], 'but': [48], 'not': [49], 'III.': [52], 'This': [53], 'report': [54], 'features': [55], 'antigenic-functional': [57], 'characteristics': [58], 'UB-221,': [60, 75], 'an': [61], 'newer': [66], 'class': [67], 'distinct': [70], 'from': [71], 'ligelizumab.': [74], 'free': [77], 'form,': [78], 'bound': [79, 120, 144], 'abundantly': [80], 'CD23-occupied': [82], 'IgE': [83, 117, 121, 146, 150, 175], 'and,': [84], 'oligomeric': [86], 'mAb-IgE': [87], 'complex': [88], 'forms,': [89], 'freely': [90], 'engaged': [91], 'CD23,': [92], 'while': [93, 161], 'ligelizumab': [94, 110, 143], 'reacted': [95], 'limitedly': [96], 'stayed': [99], 'inert': [100], 'toward': [101], 'CD23;': [102], 'these': [103], 'observations': [104], 'are': [105], 'consistent': [106], 'with': [107, 122, 155, 158, 192, 205], 'UB-221': [108, 119, 141, 167, 187], 'outperforming': [109], 'CD23-mediated': [114], 'downregulation': [115], 'production.': [118], 'strong': [124], 'affinity': [125], 'prevent': [127], 'FcԑRI-mediated': [128], 'basophil': [129], 'activation': [130], 'degranulation,': [132], 'exhibiting': [133], 'IgE-neutralizing': [135], 'activity': [136], 'omalizumab.': [140], 'cellular': [145], 'effectively': [148], 'neutralized': [149], 'sera': [152], 'patients': [154, 191], 'atopic': [156], 'dermatitis': [157], 'equal': [159], 'strength,': [160], 'lagged': [163], 'behind.': [164], 'A': [165, 185], 'single': [166, 186], 'dose': [168, 188], 'administered': [169, 189], 'cynomolgus': [171], 'macaques': [172], 'human': [174], '(ε,': [176], 'κ)–knockin': [177], 'mice': [178], 'could': [179], 'induce': [180], 'rapid,': [181], 'pronounced': [182], 'serum-IgE': [183], 'reduction.': [184], 'CSU': [193], 'first-in-human': [196], 'trial': [197], 'exhibited': [198], 'durable': [199], 'disease': [200], 'symptom': [201], 'relief': [202], 'parallel': [204], 'rapid': [207], 'reduction': [208], 'serum': [210], 'free-IgE': [211], 'level.': [212]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4289028828', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 3}], 'updated_date': '2024-08-31T06:46:46.865076', 'created_date': '2022-07-31'}