Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4285400617', 'doi': 'https://doi.org/10.1016/j.cej.2022.138086', 'title': 'Injectable Tumor Microenvironment-Modulated Hydrogels with Enhanced Chemosensitivity and Osteogenesis for Tumor-Associated Bone Defects Closed-Loop Management', 'display_name': 'Injectable Tumor Microenvironment-Modulated Hydrogels with Enhanced Chemosensitivity and Osteogenesis for Tumor-Associated Bone Defects Closed-Loop Management', 'publication_year': 2022, 'publication_date': '2022-07-14', 'ids': {'openalex': 'https://openalex.org/W4285400617', 'doi': 'https://doi.org/10.1016/j.cej.2022.138086'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cej.2022.138086', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S149937609', 'display_name': 'Chemical Engineering Journal', 'issn_l': '1385-8947', 'issn': ['1385-8947', '1873-3212'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.cej.2022.138086', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101783737', 'display_name': 'Min Cai', 'orcid': 'https://orcid.org/0000-0002-9017-0753'}, 'institutions': [{'id': 'https://openalex.org/I4210132950', 'display_name': 'Stomatology Hospital', 'ror': 'https://ror.org/041yj5753', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132950']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min Cai', 'raw_affiliation_strings': ['Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China'], 'affiliations': [{'raw_affiliation_string': 'Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China', 'institution_ids': ['https://openalex.org/I4210132950', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100335651', 'display_name': 'Xiaojun Li', 'orcid': 'https://orcid.org/0000-0002-5136-8660'}, 'institutions': [{'id': 'https://openalex.org/I139024713', 'display_name': 'Guangdong University of Technology', 'ror': 'https://ror.org/04azbjn80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139024713']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaojun Li', 'raw_affiliation_strings': ['School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China'], 'affiliations': [{'raw_affiliation_string': 'School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China', 'institution_ids': ['https://openalex.org/I139024713']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074806890', 'display_name': 'Meng Xu', 'orcid': 'https://orcid.org/0000-0002-2218-6737'}, 'institutions': [{'id': 'https://openalex.org/I4210132950', 'display_name': 'Stomatology Hospital', 'ror': 'https://ror.org/041yj5753', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132950']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Meng Xu', 'raw_affiliation_strings': ['Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China'], 'affiliations': [{'raw_affiliation_string': 'Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China', 'institution_ids': ['https://openalex.org/I4210132950', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007665864', 'display_name': 'Shiqi Zhou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132950', 'display_name': 'Stomatology Hospital', 'ror': 'https://ror.org/041yj5753', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132950']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shiqi Zhou', 'raw_affiliation_strings': ['Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China'], 'affiliations': [{'raw_affiliation_string': 'Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China', 'institution_ids': ['https://openalex.org/I4210132950', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007472221', 'display_name': 'Lei Fan', 'orcid': 'https://orcid.org/0000-0002-7161-1277'}, 'institutions': [{'id': 'https://openalex.org/I90610280', 'display_name': 'South China University of Technology', 'ror': 'https://ror.org/0530pts50', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I90610280']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Fan', 'raw_affiliation_strings': ['School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China'], 'affiliations': [{'raw_affiliation_string': 'School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China', 'institution_ids': ['https://openalex.org/I90610280']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032624256', 'display_name': 'Jingyan Huang', 'orcid': 'https://orcid.org/0000-0003-4023-5501'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210132950', 'display_name': 'Stomatology Hospital', 'ror': 'https://ror.org/041yj5753', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132950']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jingyan Huang', 'raw_affiliation_strings': ['Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China'], 'affiliations': [{'raw_affiliation_string': 'Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210132950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066775548', 'display_name': 'Cairong Xiao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90610280', 'display_name': 'South China University of Technology', 'ror': 'https://ror.org/0530pts50', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I90610280']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cairong Xiao', 'raw_affiliation_strings': ['School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China'], 'affiliations': [{'raw_affiliation_string': 'School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China', 'institution_ids': ['https://openalex.org/I90610280']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061466702', 'display_name': 'Yichen Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132950', 'display_name': 'Stomatology Hospital', 'ror': 'https://ror.org/041yj5753', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132950']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yichen Lee', 'raw_affiliation_strings': ['Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China'], 'affiliations': [{'raw_affiliation_string': 'Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China', 'institution_ids': ['https://openalex.org/I4210132950', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101875670', 'display_name': 'Bo Yang', 'orcid': 'https://orcid.org/0009-0002-2946-9200'}, 'institutions': [{'id': 'https://openalex.org/I4210132950', 'display_name': 'Stomatology Hospital', 'ror': 'https://ror.org/041yj5753', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132950']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bo Yang', 'raw_affiliation_strings': ['Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China'], 'affiliations': [{'raw_affiliation_string': 'Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China', 'institution_ids': ['https://openalex.org/I4210132950', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100350790', 'display_name': 'Le Wang', 'orcid': 'https://orcid.org/0000-0002-2726-2655'}, 'institutions': [{'id': 'https://openalex.org/I4210092091', 'display_name': 'Third Affiliated Hospital of Guangzhou Medical University', 'ror': 'https://ror.org/00fb35g87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092091']}, {'id': 'https://openalex.org/I92039509', 'display_name': 'Guangzhou Medical University', 'ror': 'https://ror.org/00zat6v61', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I92039509']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Le Wang', 'raw_affiliation_strings': ['Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, Department of Spine Surgery, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China'], 'affiliations': [{'raw_affiliation_string': 'Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, Department of Spine Surgery, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China', 'institution_ids': ['https://openalex.org/I4210092091', 'https://openalex.org/I92039509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006427323', 'display_name': 'Ross Crawford', 'orcid': 'https://orcid.org/0000-0001-6079-1316'}, 'institutions': [{'id': 'https://openalex.org/I160993911', 'display_name': 'Queensland University of Technology', 'ror': 'https://ror.org/03pnv4752', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I160993911']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Ross William Crawford', 'raw_affiliation_strings': ['Institute of Health and Biomedical Innovation & Australia-China Centre for Tissue Engineering and Regenerative Medicine, Centre for Biomedical Technologies, Queensland University of Technology, Brisbane 4059, Australia'], 'affiliations': [{'raw_affiliation_string': 'Institute of Health and Biomedical Innovation & Australia-China Centre for Tissue Engineering and Regenerative Medicine, Centre for Biomedical Technologies, Queensland University of Technology, Brisbane 4059, Australia', 'institution_ids': ['https://openalex.org/I160993911']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051762810', 'display_name': 'Yin Xiao', 'orcid': 'https://orcid.org/0000-0003-1785-3491'}, 'institutions': [{'id': 'https://openalex.org/I160993911', 'display_name': 'Queensland University of Technology', 'ror': 'https://ror.org/03pnv4752', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I160993911']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Yin Xiao', 'raw_affiliation_strings': ['Institute of Health and Biomedical Innovation & Australia-China Centre for Tissue Engineering and Regenerative Medicine, Centre for Biomedical Technologies, Queensland University of Technology, Brisbane 4059, Australia'], 'affiliations': [{'raw_affiliation_string': 'Institute of Health and Biomedical Innovation & Australia-China Centre for Tissue Engineering and Regenerative Medicine, Centre for Biomedical Technologies, Queensland University of Technology, Brisbane 4059, Australia', 'institution_ids': ['https://openalex.org/I160993911']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100325659', 'display_name': 'Lei Zhou', 'orcid': 'https://orcid.org/0000-0001-8056-9464'}, 'institutions': [{'id': 'https://openalex.org/I4210092091', 'display_name': 'Third Affiliated Hospital of Guangzhou Medical University', 'ror': 'https://ror.org/00fb35g87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092091']}, {'id': 'https://openalex.org/I92039509', 'display_name': 'Guangzhou Medical University', 'ror': 'https://ror.org/00zat6v61', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I92039509']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Lei Zhou', 'raw_affiliation_strings': ['Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, Department of Spine Surgery, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China'], 'affiliations': [{'raw_affiliation_string': 'Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, Department of Spine Surgery, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China', 'institution_ids': ['https://openalex.org/I4210092091', 'https://openalex.org/I92039509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044131040', 'display_name': 'Chengyun Ning', 'orcid': 'https://orcid.org/0000-0003-3293-4716'}, 'institutions': [{'id': 'https://openalex.org/I90610280', 'display_name': 'South China University of Technology', 'ror': 'https://ror.org/0530pts50', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I90610280']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Chengyun Ning', 'raw_affiliation_strings': ['School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China'], 'affiliations': [{'raw_affiliation_string': 'School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China', 'institution_ids': ['https://openalex.org/I90610280']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100322620', 'display_name': 'Yan Wang', 'orcid': 'https://orcid.org/0000-0002-1490-7450'}, 'institutions': [{'id': 'https://openalex.org/I4210132950', 'display_name': 'Stomatology Hospital', 'ror': 'https://ror.org/041yj5753', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132950']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yan Wang', 'raw_affiliation_strings': ['Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China'], 'affiliations': [{'raw_affiliation_string': 'Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China', 'institution_ids': ['https://openalex.org/I4210132950', 'https://openalex.org/I157773358']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5100325659', 'https://openalex.org/A5044131040', 'https://openalex.org/A5100322620'], 'corresponding_institution_ids': ['https://openalex.org/I4210092091', 'https://openalex.org/I92039509', 'https://openalex.org/I90610280', 'https://openalex.org/I4210132950', 'https://openalex.org/I157773358'], 'apc_list': {'value': 4180, 'currency': 'USD', 'value_usd': 4180, 'provenance': 'doaj'}, 'apc_paid': {'value': 4180, 'currency': 'USD', 'value_usd': 4180, 'provenance': 'doaj'}, 'fwci': 1.508, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.619412, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '450', 'issue': None, 'first_page': '138086', 'last_page': '138086'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10782', 'display_name': 'Nanotechnology and Imaging for Cancer Therapy and Diagnosis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10782', 'display_name': 'Nanotechnology and Imaging for Cancer Therapy and Diagnosis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11221', 'display_name': 'Bisphosphonates in Cancer Treatment and Bone Health', 'score': 0.9873, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tumor-microenvironment', 'display_name': 'Tumor Microenvironment', 'score': 0.639134}, {'id': 'https://openalex.org/keywords/tumor-targeting', 'display_name': 'Tumor Targeting', 'score': 0.525876}, {'id': 'https://openalex.org/keywords/gelatin', 'display_name': 'Gelatin', 'score': 0.47414678}], 'concepts': [{'id': 'https://openalex.org/C108586683', 'wikidata': 'https://www.wikidata.org/wiki/Q17164826', 'display_name': 'Self-healing hydrogels', 'level': 2, 'score': 0.7590306}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.72416025}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5852322}, {'id': 'https://openalex.org/C2778823387', 'wikidata': 'https://www.wikidata.org/wiki/Q179254', 'display_name': 'Gelatin', 'level': 2, 'score': 0.47414678}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.45300403}, {'id': 'https://openalex.org/C2777529286', 'wikidata': 'https://www.wikidata.org/wiki/Q337231', 'display_name': 'Hyaluronic acid', 'level': 2, 'score': 0.442505}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.38867128}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15681908}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.10801846}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.068956256}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.066877246}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C3020616263', 'wikidata': 'https://www.wikidata.org/wiki/Q1216998', 'display_name': 'Tumor cells', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cej.2022.138086', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S149937609', 'display_name': 'Chemical Engineering Journal', 'issn_l': '1385-8947', 'issn': ['1385-8947', '1873-3212'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10072/418409', 'pdf_url': 'https://research-repository.griffith.edu.au/bitstream/10072/418409/2/Xiao2993424-Published.pdf', 'source': {'id': 'https://openalex.org/S4306402548', 'display_name': 'Griffith Research Online (Griffith University, Queensland, Australia)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I11701301', 'host_organization_name': 'Griffith University', 'host_organization_lineage': ['https://openalex.org/I11701301'], 'host_organization_lineage_names': ['Griffith University'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cej.2022.138086', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S149937609', 'display_name': 'Chemical Engineering Journal', 'issn_l': '1385-8947', 'issn': ['1385-8947', '1873-3212'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.59}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W1495320094', 'https://openalex.org/W19745091', 'https://openalex.org/W1976516525', 'https://openalex.org/W1976532810', 'https://openalex.org/W1979545270', 'https://openalex.org/W2042474003', 'https://openalex.org/W2042507692', 'https://openalex.org/W2049306818', 'https://openalex.org/W2061819254', 'https://openalex.org/W2092514440', 'https://openalex.org/W2094346703', 'https://openalex.org/W2123517195', 'https://openalex.org/W2137656352', 'https://openalex.org/W2157928968', 'https://openalex.org/W2159182678', 'https://openalex.org/W2181778634', 'https://openalex.org/W2262513754', 'https://openalex.org/W2374374054', 'https://openalex.org/W2539792805', 'https://openalex.org/W2581608583', 'https://openalex.org/W2596045267', 'https://openalex.org/W2602016219', 'https://openalex.org/W2754432248', 'https://openalex.org/W2767616074', 'https://openalex.org/W2772425736', 'https://openalex.org/W2786389638', 'https://openalex.org/W2792294729', 'https://openalex.org/W2888554684', 'https://openalex.org/W2890123883', 'https://openalex.org/W2892650455', 'https://openalex.org/W2895644927', 'https://openalex.org/W2895914201', 'https://openalex.org/W2897397780', 'https://openalex.org/W2899865898', 'https://openalex.org/W2901519930', 'https://openalex.org/W2914161462', 'https://openalex.org/W2921396831', 'https://openalex.org/W2940447007', 'https://openalex.org/W2944543271', 'https://openalex.org/W2966791866', 'https://openalex.org/W2970486242', 'https://openalex.org/W2971163117', 'https://openalex.org/W2988615195', 'https://openalex.org/W2995088215', 'https://openalex.org/W2996833538', 'https://openalex.org/W3010512985', 'https://openalex.org/W3023233752', 'https://openalex.org/W3028148512', 'https://openalex.org/W3083551875', 'https://openalex.org/W3092306588', 'https://openalex.org/W3134361008', 'https://openalex.org/W3145688605', 'https://openalex.org/W3160305387', 'https://openalex.org/W3162361934', 'https://openalex.org/W3170322213', 'https://openalex.org/W3205951426', 'https://openalex.org/W3212224588', 'https://openalex.org/W4211210519'], 'related_works': ['https://openalex.org/W4367461411', 'https://openalex.org/W3172701770', 'https://openalex.org/W3114707268', 'https://openalex.org/W3019696165', 'https://openalex.org/W2995521903', 'https://openalex.org/W2914578840', 'https://openalex.org/W2894369394', 'https://openalex.org/W2383888215', 'https://openalex.org/W2041289204', 'https://openalex.org/W1574682962'], 'abstract_inverted_index': {'Patients': [0], 'with': [1, 78], 'postoperative': [2, 189], 'tumor-associated': [3, 60, 190], 'bone': [4, 10, 24, 61, 179, 191], 'defects': [5, 62], 'need': [6], 'both': [7], 'chemotherapy': [8, 18], 'and': [9, 22, 30, 38, 54, 71, 86, 90, 130, 140, 152, 181], 'repair': [11, 180], 'in': [12, 27, 96], 'the': [13, 97, 108, 123, 144, 156, 161, 173], 'shifted': [14, 163], 'disease': [15], 'states,': [16], 'but': [17], 'resistance,': [19, 89], 'severe': [20], 'side-effects,': [21], 'poor': [23], 'regeneration': [25], 'result': [26], 'tumor': [28, 39, 76, 120, 146, 183], 'recurrence': [29], 'therapy': [31], 'failure.': [32], 'Herein,': [33], 'we': [34], 'develop': [35], 'an': [36], 'injectable': [37], 'microenvironment': [40], '(TME)-modulated': [41], 'hydrogel': [42], 'composed': [43], 'of': [44, 100, 104, 113, 133, 159, 188], 'bio-responsive': [45], 'drug-loaded': [46, 117, 134], 'mesoporous': [47], 'bioactive': [48], 'glass': [49], 'nanoparticles': [50, 118, 135], '(MBGN),': [51], 'gelatin': [52], '(Gel),': [53], 'oxidized': [55], 'chondroitin': [56], 'sulfate': [57], '(OCS)': [58], 'for': [59], 'closed-loop': [63, 186], 'management.': [64], 'The': [65], 'TME-modulated': [66, 174], 'hydrogels': [67, 162, 175], 'can': [68, 136, 176], 'deplete': [69], 'protons': [70], 'glutathione': [72], '(GSH)': [73], 'within': [74], 'residual': [75], 'tissues': [77], 'sustained': [79], 'drug': [80], 'responsive-release': [81], 'capability,': [82], 'therefore': [83], 'interfering': [84], 'TME': [85, 105], 'overcoming': [87], 'cancer': [88], 'also': [91], 'reducing': [92], 'off-target': [93], 'effects.': [94, 171], 'Mechanistically,': [95], 'early': [98], 'state': [99, 158], 'treatment,': [101, 160], 'acidic': [102], 'environment': [103], 'will': [106], 'break': [107], 'Schiff’s': [109], 'base': [110], 'bond': [111], 'network': [112], 'hydrogels,': [114], 'thus': [115], 'deliver': [116], 'into': [119, 164], 'cells.': [121], 'Subsequently,': [122], 'pH-responsive': [124], 'amide': [125], 'bonds,': [126], 'GSH-responsive': [127], 'disulfide': [128], 'bonds': [129], 'acidity-degradable': [131], 'nanocarriers': [132], 'induce': [137, 150], 'ROS': [138], 'stress': [139], 'mitochondrial-related': [141], 'damage,': [142], 'activating': [143], 'p16-CYLD': [145], 'suppressor': [147], 'pathway': [148], 'to': [149, 167], 'apoptosis': [151], 'inhibit': [153], 'metastasis.': [154], 'In': [155], 'late': [157], 'regenerative': [165], 'scaffolds': [166], 'exert': [168], 'long-lasting': [169], 'osteogenesis': [170], 'Overall,': [172], 'orchestrate': [177], 'steady': [178], 'avoid': [182], 'recurrence,': [184], 'achieving': [185], 'management': [187], 'defects.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4285400617', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 10}], 'updated_date': '2024-09-18T18:42:19.957516', 'created_date': '2022-07-14'}