Title: Synthesis and Antimicrobial Evaluation of Some New Pyrazole Derivatives Containing Thiazole Scaffolds
Abstract: In present work, one-pot synthesis of some new 2,4-disubstitued thiazolyl pyrazole derivatives was carried out. The reaction of different pyrazole 4-carbalaldehydes, thiosemicarbazides and α-haloketones in one pot afforded the target molecules. The synthesis was carried out via two methods: one conventional method, whereby pyrazole 4-carbaldehydes, thiosemicarbazides, and α-haloketones were refluxed in ethanol; and a second way, where the reaction mixture was ground at RT. The rate of the reaction, yield of the products, and purity of the products were compared for both methods. All of the synthesized compounds were tested for their antimicrobial activities. It was found that most of the compounds showed good-to-moderate antibacterial as well as antifungal activities.