Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4285097145', 'doi': 'https://doi.org/10.1016/j.celrep.2022.111080', 'title': 'Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude', 'display_name': 'Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude', 'publication_year': 2022, 'publication_date': '2022-07-01', 'ids': {'openalex': 'https://openalex.org/W4285097145', 'doi': 'https://doi.org/10.1016/j.celrep.2022.111080', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35830815'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.celrep.2022.111080', 'pdf_url': 'http://www.cell.com/article/S2211124722008786/pdf', 'source': {'id': 'https://openalex.org/S169236886', 'display_name': 'Cell Reports', 'issn_l': '2211-1247', 'issn': ['2211-1247', '2639-1856'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.cell.com/article/S2211124722008786/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5069486856', 'display_name': 'Jeong-Min Ju', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210101891', 'display_name': 'Korea Institute of Brain Science', 'ror': 'https://ror.org/017stnw60', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101891']}, {'id': 'https://openalex.org/I58716616', 'display_name': 'Korea Institute of Science and Technology', 'ror': 'https://ror.org/05kzfa883', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I58716616']}, {'id': 'https://openalex.org/I4210140519', 'display_name': 'Korean Association Of Science and Technology Studies', 'ror': 'https://ror.org/04qh86j58', 'country_code': 'KR', 'type': 'other', 'lineage': ['https://openalex.org/I4210140519']}, {'id': 'https://openalex.org/I88761825', 'display_name': 'Korea University of Science and Technology', 'ror': 'https://ror.org/000qzf213', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I88761825']}, {'id': 'https://openalex.org/I4210145660', 'display_name': 'Bio-Medical Science (South Korea)', 'ror': 'https://ror.org/046p12h21', 'country_code': 'KR', 'type': 'company', 'lineage': ['https://openalex.org/I4210145660']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jeongmin Ju', 'raw_affiliation_strings': ['Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea', 'Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210101891', 'https://openalex.org/I58716616', 'https://openalex.org/I4210140519']}, {'raw_affiliation_string': 'Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea', 'institution_ids': ['https://openalex.org/I88761825', 'https://openalex.org/I4210145660']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028443948', 'display_name': 'Hae Nim Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}, {'id': 'https://openalex.org/I4210101891', 'display_name': 'Korea Institute of Brain Science', 'ror': 'https://ror.org/017stnw60', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101891']}, {'id': 'https://openalex.org/I58716616', 'display_name': 'Korea Institute of Science and Technology', 'ror': 'https://ror.org/05kzfa883', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I58716616']}, {'id': 'https://openalex.org/I4210140519', 'display_name': 'Korean Association Of Science and Technology Studies', 'ror': 'https://ror.org/04qh86j58', 'country_code': 'KR', 'type': 'other', 'lineage': ['https://openalex.org/I4210140519']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hae Nim Lee', 'raw_affiliation_strings': ['Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea', 'Department of Converging Science and Technology, Kyung Hee University, Seoul 02453, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Converging Science and Technology, Kyung Hee University, Seoul 02453, Republic of Korea', 'institution_ids': ['https://openalex.org/I35928602']}, {'raw_affiliation_string': 'Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210101891', 'https://openalex.org/I58716616', 'https://openalex.org/I4210140519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100635305', 'display_name': 'Lin Ning', 'orcid': 'https://orcid.org/0000-0001-6374-8823'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lin Ning', 'raw_affiliation_strings': ['Department of Bioengineering, Stanford University, Stanford, CA 94305, USA', 'Department of Neurobiology, Stanford University, Stanford, CA 94305, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioengineering, Stanford University, Stanford, CA 94305, USA', 'institution_ids': ['https://openalex.org/I97018004']}, {'raw_affiliation_string': 'Department of Neurobiology, Stanford University, Stanford, CA 94305, USA', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042652478', 'display_name': 'Hyunjoo Ryu', 'orcid': 'https://orcid.org/0000-0001-7998-6754'}, 'institutions': [{'id': 'https://openalex.org/I4210101891', 'display_name': 'Korea Institute of Brain Science', 'ror': 'https://ror.org/017stnw60', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101891']}, {'id': 'https://openalex.org/I58716616', 'display_name': 'Korea Institute of Science and Technology', 'ror': 'https://ror.org/05kzfa883', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I58716616']}, {'id': 'https://openalex.org/I4210140519', 'display_name': 'Korean Association Of Science and Technology Studies', 'ror': 'https://ror.org/04qh86j58', 'country_code': 'KR', 'type': 'other', 'lineage': ['https://openalex.org/I4210140519']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyunjoo Ryu', 'raw_affiliation_strings': ['Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210101891', 'https://openalex.org/I58716616', 'https://openalex.org/I4210140519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028654503', 'display_name': 'Xin Zhou', 'orcid': 'https://orcid.org/0000-0002-8198-2856'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xin X. Zhou', 'raw_affiliation_strings': ['Department of Bioengineering, Stanford University, Stanford, CA 94305, USA', 'Department of Neurobiology, Stanford University, Stanford, CA 94305, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioengineering, Stanford University, Stanford, CA 94305, USA', 'institution_ids': ['https://openalex.org/I97018004']}, {'raw_affiliation_string': 'Department of Neurobiology, Stanford University, Stanford, CA 94305, USA', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003270577', 'display_name': 'Hyeyeon Chun', 'orcid': 'https://orcid.org/0000-0002-5407-713X'}, 'institutions': [{'id': 'https://openalex.org/I4210101891', 'display_name': 'Korea Institute of Brain Science', 'ror': 'https://ror.org/017stnw60', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101891']}, {'id': 'https://openalex.org/I58716616', 'display_name': 'Korea Institute of Science and Technology', 'ror': 'https://ror.org/05kzfa883', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I58716616']}, {'id': 'https://openalex.org/I4210140519', 'display_name': 'Korean Association Of Science and Technology Studies', 'ror': 'https://ror.org/04qh86j58', 'country_code': 'KR', 'type': 'other', 'lineage': ['https://openalex.org/I4210140519']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyeyeon Chun', 'raw_affiliation_strings': ['Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210101891', 'https://openalex.org/I58716616', 'https://openalex.org/I4210140519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100754046', 'display_name': 'Yong Woo Lee', 'orcid': 'https://orcid.org/0000-0002-1478-6193'}, 'institutions': [{'id': 'https://openalex.org/I4210101891', 'display_name': 'Korea Institute of Brain Science', 'ror': 'https://ror.org/017stnw60', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101891']}, {'id': 'https://openalex.org/I58716616', 'display_name': 'Korea Institute of Science and Technology', 'ror': 'https://ror.org/05kzfa883', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I58716616']}, {'id': 'https://openalex.org/I4210140519', 'display_name': 'Korean Association Of Science and Technology Studies', 'ror': 'https://ror.org/04qh86j58', 'country_code': 'KR', 'type': 'other', 'lineage': ['https://openalex.org/I4210140519']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yong Woo Lee', 'raw_affiliation_strings': ['Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210101891', 'https://openalex.org/I58716616', 'https://openalex.org/I4210140519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069226369', 'display_name': 'Austin I. Lee-Richerson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Austin I. Lee-Richerson', 'raw_affiliation_strings': ['Department of Bioengineering, Stanford University, Stanford, CA 94305, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioengineering, Stanford University, Stanford, CA 94305, USA', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051046735', 'display_name': 'Cherlhyun Jeong', 'orcid': 'https://orcid.org/0000-0002-7584-3059'}, 'institutions': [{'id': 'https://openalex.org/I58716616', 'display_name': 'Korea Institute of Science and Technology', 'ror': 'https://ror.org/05kzfa883', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I58716616']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Cherlhyun Jeong', 'raw_affiliation_strings': ['Center for Theragnosis, Korea Institute of Science and Technology, Seoul 02792, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Center for Theragnosis, Korea Institute of Science and Technology, Seoul 02792, South Korea', 'institution_ids': ['https://openalex.org/I58716616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061736694', 'display_name': 'Michael Z. Lin', 'orcid': 'https://orcid.org/0000-0002-0492-1961'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Michael Z. Lin', 'raw_affiliation_strings': ['Department of Bioengineering, Stanford University, Stanford, CA 94305, USA', 'Department of Neurobiology, Stanford University, Stanford, CA 94305, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioengineering, Stanford University, Stanford, CA 94305, USA', 'institution_ids': ['https://openalex.org/I97018004']}, {'raw_affiliation_string': 'Department of Neurobiology, Stanford University, Stanford, CA 94305, USA', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026656606', 'display_name': 'Jihye Seong', 'orcid': 'https://orcid.org/0000-0001-8450-3315'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}, {'id': 'https://openalex.org/I4210101891', 'display_name': 'Korea Institute of Brain Science', 'ror': 'https://ror.org/017stnw60', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101891']}, {'id': 'https://openalex.org/I58716616', 'display_name': 'Korea Institute of Science and Technology', 'ror': 'https://ror.org/05kzfa883', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I58716616']}, {'id': 'https://openalex.org/I4210140519', 'display_name': 'Korean Association Of Science and Technology Studies', 'ror': 'https://ror.org/04qh86j58', 'country_code': 'KR', 'type': 'other', 'lineage': ['https://openalex.org/I4210140519']}, {'id': 'https://openalex.org/I88761825', 'display_name': 'Korea University of Science and Technology', 'ror': 'https://ror.org/000qzf213', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I88761825']}, {'id': 'https://openalex.org/I4210145660', 'display_name': 'Bio-Medical Science (South Korea)', 'ror': 'https://ror.org/046p12h21', 'country_code': 'KR', 'type': 'company', 'lineage': ['https://openalex.org/I4210145660']}, {'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR', 'US'], 'is_corresponding': True, 'raw_author_name': 'Jihye Seong', 'raw_affiliation_strings': ['Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea', 'Department of Bioengineering, Stanford University, Stanford, CA 94305, USA', 'Department of Converging Science and Technology, Kyung Hee University, Seoul 02453, Republic of Korea', 'Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioengineering, Stanford University, Stanford, CA 94305, USA', 'institution_ids': ['https://openalex.org/I97018004']}, {'raw_affiliation_string': 'Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210101891', 'https://openalex.org/I58716616', 'https://openalex.org/I4210140519']}, {'raw_affiliation_string': 'Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea', 'institution_ids': ['https://openalex.org/I88761825', 'https://openalex.org/I4210145660']}, {'raw_affiliation_string': 'Department of Converging Science and Technology, Kyung Hee University, Seoul 02453, Republic of Korea', 'institution_ids': ['https://openalex.org/I35928602']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5061736694', 'https://openalex.org/A5026656606'], 'corresponding_institution_ids': ['https://openalex.org/I97018004', 'https://openalex.org/I97018004', 'https://openalex.org/I4210101891', 'https://openalex.org/I58716616', 'https://openalex.org/I4210140519', 'https://openalex.org/I88761825', 'https://openalex.org/I4210145660', 'https://openalex.org/I35928602'], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'fwci': 1.71, 'has_fulltext': False, 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '40', 'issue': '2', 'first_page': '111080', 'last_page': '111080'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10691', 'display_name': 'Molecular Mechanisms of Retinal Degeneration and Regeneration', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10691', 'display_name': 'Molecular Mechanisms of Retinal Degeneration and Regeneration', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11708', 'display_name': 'Photochromic Materials and Molecular Switches', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cell-signaling', 'display_name': 'Cell Signaling', 'score': 0.50547}, {'id': 'https://openalex.org/keywords/small-gtpase', 'display_name': 'Small GTPase', 'score': 0.49003613}], 'concepts': [{'id': 'https://openalex.org/C2777093181', 'wikidata': 'https://www.wikidata.org/wiki/Q15331450', 'display_name': 'RHOA', 'level': 3, 'score': 0.9972075}, {'id': 'https://openalex.org/C126619667', 'wikidata': 'https://www.wikidata.org/wiki/Q901088', 'display_name': 'Guanine nucleotide exchange factor', 'level': 3, 'score': 0.66930866}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.64106953}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.5602223}, {'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.5583759}, {'id': 'https://openalex.org/C2780298669', 'wikidata': 'https://www.wikidata.org/wiki/Q415071', 'display_name': 'Small GTPase', 'level': 3, 'score': 0.49003613}, {'id': 'https://openalex.org/C108636557', 'wikidata': 'https://www.wikidata.org/wiki/Q21109354', 'display_name': 'Proto-oncogene tyrosine-protein kinase Src', 'level': 3, 'score': 0.48711705}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40479326}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36831984}], 'mesh': [{'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020742', 'descriptor_name': 'rhoA GTP-Binding Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022001', 'descriptor_name': 'Focal Adhesions', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D022001', 'descriptor_name': 'Focal Adhesions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D064067', 'descriptor_name': 'Rho Guanine Nucleotide Exchange Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D064067', 'descriptor_name': 'Rho Guanine Nucleotide Exchange Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020742', 'descriptor_name': 'rhoA GTP-Binding Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.celrep.2022.111080', 'pdf_url': 'http://www.cell.com/article/S2211124722008786/pdf', 'source': {'id': 'https://openalex.org/S169236886', 'display_name': 'Cell Reports', 'issn_l': '2211-1247', 'issn': ['2211-1247', '2639-1856'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2021.02.05.430013', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2021/05/14/2021.02.05.430013.full.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35830815', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.celrep.2022.111080', 'pdf_url': 'http://www.cell.com/article/S2211124722008786/pdf', 'source': {'id': 'https://openalex.org/S169236886', 'display_name': 'Cell Reports', 'issn_l': '2211-1247', 'issn': ['2211-1247', '2639-1856'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1567217875', 'https://openalex.org/W1934051049', 'https://openalex.org/W1965791697', 'https://openalex.org/W1972507748', 'https://openalex.org/W1975132186', 'https://openalex.org/W1979701688', 'https://openalex.org/W1982957540', 'https://openalex.org/W1984086927', 'https://openalex.org/W1990408088', 'https://openalex.org/W2005102765', 'https://openalex.org/W2020993672', 'https://openalex.org/W2024244222', 'https://openalex.org/W2026339935', 'https://openalex.org/W2026522246', 'https://openalex.org/W2027108471', 'https://openalex.org/W2027810531', 'https://openalex.org/W2027840594', 'https://openalex.org/W2029872541', 'https://openalex.org/W2048209624', 'https://openalex.org/W2049129806', 'https://openalex.org/W2049345986', 'https://openalex.org/W2050140768', 'https://openalex.org/W2052994710', 'https://openalex.org/W2060637453', 'https://openalex.org/W2061577820', 'https://openalex.org/W2063825596', 'https://openalex.org/W2066435037', 'https://openalex.org/W2079595896', 'https://openalex.org/W2087620960', 'https://openalex.org/W2093226717', 'https://openalex.org/W2100896736', 'https://openalex.org/W2111432848', 'https://openalex.org/W2112924183', 'https://openalex.org/W2117403796', 'https://openalex.org/W2123103161', 'https://openalex.org/W2123305987', 'https://openalex.org/W2128698960', 'https://openalex.org/W2135486974', 'https://openalex.org/W2146473598', 'https://openalex.org/W2153637044', 'https://openalex.org/W2165803049', 'https://openalex.org/W2169242829', 'https://openalex.org/W2191883975', 'https://openalex.org/W2321045150', 'https://openalex.org/W2321094842', 'https://openalex.org/W2332510269', 'https://openalex.org/W2443474297', 'https://openalex.org/W2487796353', 'https://openalex.org/W2586923082', 'https://openalex.org/W2589638834', 'https://openalex.org/W2886440289', 'https://openalex.org/W2947155741', 'https://openalex.org/W3144541799', 'https://openalex.org/W3185731648'], 'related_works': ['https://openalex.org/W4231400324', 'https://openalex.org/W2770830320', 'https://openalex.org/W2170225912', 'https://openalex.org/W2133424481', 'https://openalex.org/W2132021216', 'https://openalex.org/W2107411730', 'https://openalex.org/W2089809507', 'https://openalex.org/W2059598052', 'https://openalex.org/W2052668551', 'https://openalex.org/W2003608685'], 'abstract_inverted_index': {'How': [0], 'protein': [1], 'signaling': [2], 'networks': [3], 'respond': [4], 'to': [5, 53, 75, 111, 116, 122, 144, 148], 'different': [6], 'input': [7], 'strengths': [8], 'is': [9, 38], 'an': [10, 95], 'important': [11], 'but': [12, 30], 'poorly': [13], 'understood': [14], 'problem': [15], 'in': [16], 'cell': [17], 'biology.': [18], 'For': [19], 'example,': [20], 'RhoA': [21, 32, 46, 57, 74, 90, 97, 112, 127, 133], 'can': [22, 140], 'promote': [23], 'focal': [24], 'adhesion': [25], '(FA)': [26], 'growth': [27, 125], 'or': [28], 'disassembly,': [29], 'how': [31], 'activity': [33], 'mediates': [34], 'these': [35], 'opposite': [36], 'outcomes': [37], 'not': [39], 'clear.': [40], 'Here,': [41], 'we': [42, 63], 'develop': [43], 'a': [44, 100, 149], 'photoswitchable': [45], 'guanine': [47], 'nucleotide': [48], 'exchange': [49], 'factor': [50], '(GEF),': [51], 'psRhoGEF,': [52], 'precisely': [54], 'control': [55, 131], 'endogenous': [56], 'activity.': [58], 'Using': [59], 'this': [60], 'optical': [61], 'tool,': [62], 'discover': [64], 'that': [65, 81, 119, 138], 'peak': [66], 'FA': [67, 109, 124], 'disassembly': [68, 115], 'selectively': [69, 86], 'occurs': [70, 87], 'upon': [71, 88, 126], 'activation': [72, 83, 113, 134], 'of': [73, 107, 132], 'submaximal': [76, 89], 'levels.': [77], 'We': [78], 'also': [79], 'find': [80], 'Src': [82, 93, 102, 120], 'at': [84], 'FAs': [85], 'activation,': [91], 'identifying': [92], 'as': [94], 'amplitude-dependent': [96], 'effector.': [98], 'Finally,': [99], 'pharmacological': [101], 'inhibitor': [103], 'reverses': [104], 'the': [105, 108], 'direction': [106], 'response': [110], 'from': [114], 'growth,': [117], 'demonstrating': [118], 'functions': [121], 'suppress': [123], 'activation.': [128], 'Thus,': [129], 'rheostatic': [130], 'by': [135], 'psRhoGEF': [136], 'reveals': [137], 'cells': [139], 'use': [141], 'signal': [142], 'amplitude': [143], 'produce': [145], 'multiple': [146], 'responses': [147], 'single': [150], 'biochemical': [151], 'signal.': [152]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4285097145', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 2}], 'updated_date': '2024-09-18T16:59:25.760079', 'created_date': '2022-07-14'}