Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4284889422', 'doi': 'https://doi.org/10.1016/j.biotechadv.2022.108017', 'title': 'The cell density effect in animal cell-based bioprocessing: Questions, insights and perspectives', 'display_name': 'The cell density effect in animal cell-based bioprocessing: Questions, insights and perspectives', 'publication_year': 2022, 'publication_date': '2022-07-07', 'ids': {'openalex': 'https://openalex.org/W4284889422', 'doi': 'https://doi.org/10.1016/j.biotechadv.2022.108017', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35809763'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.biotechadv.2022.108017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160877137', 'display_name': 'Biotechnology Advances', 'issn_l': '0734-9750', 'issn': ['0734-9750', '1873-1899'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.biotechadv.2022.108017', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030670837', 'display_name': 'Jesús Lavado‐García', 'orcid': 'https://orcid.org/0000-0001-9993-6332'}, 'institutions': [{'id': 'https://openalex.org/I123044942', 'display_name': 'Universitat Autònoma de Barcelona', 'ror': 'https://ror.org/052g8jq94', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I123044942']}, {'id': 'https://openalex.org/I2801134892', 'display_name': 'Novo Nordisk Foundation', 'ror': 'https://ror.org/04txyc737', 'country_code': 'DK', 'type': 'facility', 'lineage': ['https://openalex.org/I2801134892']}, {'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK', 'ES'], 'is_corresponding': True, 'raw_author_name': 'Jesús Lavado-García', 'raw_affiliation_strings': ["Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193 Barcelona, Spain", 'Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': "Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193 Barcelona, Spain", 'institution_ids': ['https://openalex.org/I123044942']}, {'raw_affiliation_string': 'Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I2801134892', 'https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079439691', 'display_name': 'Pol Pérez‐Rubio', 'orcid': 'https://orcid.org/0000-0002-9892-6762'}, 'institutions': [{'id': 'https://openalex.org/I123044942', 'display_name': 'Universitat Autònoma de Barcelona', 'ror': 'https://ror.org/052g8jq94', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I123044942']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Pol Pérez-Rubio', 'raw_affiliation_strings': ["Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193 Barcelona, Spain"], 'affiliations': [{'raw_affiliation_string': "Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193 Barcelona, Spain", 'institution_ids': ['https://openalex.org/I123044942']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012939249', 'display_name': 'Laura Cervera', 'orcid': 'https://orcid.org/0000-0002-3639-2793'}, 'institutions': [{'id': 'https://openalex.org/I123044942', 'display_name': 'Universitat Autònoma de Barcelona', 'ror': 'https://ror.org/052g8jq94', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I123044942']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Laura Cervera', 'raw_affiliation_strings': ["Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193 Barcelona, Spain"], 'affiliations': [{'raw_affiliation_string': "Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193 Barcelona, Spain", 'institution_ids': ['https://openalex.org/I123044942']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077050654', 'display_name': 'Francesc Gòdia', 'orcid': 'https://orcid.org/0000-0002-4060-9887'}, 'institutions': [{'id': 'https://openalex.org/I123044942', 'display_name': 'Universitat Autònoma de Barcelona', 'ror': 'https://ror.org/052g8jq94', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I123044942']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Francesc Gòdia', 'raw_affiliation_strings': ["Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193 Barcelona, Spain"], 'affiliations': [{'raw_affiliation_string': "Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193 Barcelona, Spain", 'institution_ids': ['https://openalex.org/I123044942']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5030670837'], 'corresponding_institution_ids': ['https://openalex.org/I123044942', 'https://openalex.org/I2801134892', 'https://openalex.org/I96673099'], 'apc_list': {'value': 5300, 'currency': 'USD', 'value_usd': 5300, 'provenance': 'doaj'}, 'apc_paid': {'value': 5300, 'currency': 'USD', 'value_usd': 5300, 'provenance': 'doaj'}, 'fwci': 0.727, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.254083, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '60', 'issue': None, 'first_page': '108017', 'last_page': '108017'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11190', 'display_name': '3D Printing in Biomedical Research', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11124', 'display_name': 'Protein purification and stability', 'score': 0.9887, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transient', 'display_name': 'Transient (computer programming)', 'score': 0.4656969}], 'concepts': [{'id': 'https://openalex.org/C4916135', 'wikidata': 'https://www.wikidata.org/wiki/Q4119055', 'display_name': 'Bioprocess', 'level': 2, 'score': 0.82660276}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.5978984}, {'id': 'https://openalex.org/C204983608', 'wikidata': 'https://www.wikidata.org/wiki/Q2111958', 'display_name': 'Productivity', 'level': 2, 'score': 0.4662978}, {'id': 'https://openalex.org/C2780799671', 'wikidata': 'https://www.wikidata.org/wiki/Q17087362', 'display_name': 'Transient (computer programming)', 'level': 2, 'score': 0.4656969}, {'id': 'https://openalex.org/C18762648', 'wikidata': 'https://www.wikidata.org/wiki/Q42213', 'display_name': 'Work (physics)', 'level': 2, 'score': 0.4559127}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.45326918}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.32618237}, {'id': 'https://openalex.org/C112930515', 'wikidata': 'https://www.wikidata.org/wiki/Q4389547', 'display_name': 'Risk analysis (engineering)', 'level': 1, 'score': 0.32312727}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27353626}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.15452483}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.12029317}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C139719470', 'wikidata': 'https://www.wikidata.org/wiki/Q39680', 'display_name': 'Macroeconomics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C111919701', 'wikidata': 'https://www.wikidata.org/wiki/Q9135', 'display_name': 'Operating system', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002452', 'descriptor_name': 'Cell Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.biotechadv.2022.108017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160877137', 'display_name': 'Biotechnology Advances', 'issn_l': '0734-9750', 'issn': ['0734-9750', '1873-1899'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://backend.orbit.dtu.dk/ws/files/300391153/1_s2.0_S0734975022001136_main.pdf', 'pdf_url': 'https://backend.orbit.dtu.dk/ws/files/300391153/1_s2.0_S0734975022001136_main.pdf', 'source': {'id': 'https://openalex.org/S4306400705', 'display_name': 'Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I96673099', 'host_organization_name': 'Technical University of Denmark', 'host_organization_lineage': ['https://openalex.org/I96673099'], 'host_organization_lineage_names': ['Technical University of Denmark'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://ddd.uab.cat/record/268174', 'pdf_url': 'https://ddd.uab.cat/pub/artpub/2022/268174/Bioadv_a2022v60p108017.pdf', 'source': {'id': 'https://openalex.org/S4306400381', 'display_name': 'Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I123044942', 'host_organization_name': 'Universitat Autònoma de Barcelona', 'host_organization_lineage': ['https://openalex.org/I123044942'], 'host_organization_lineage_names': ['Universitat Autònoma de Barcelona'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://orbit.dtu.dk/en/publications/59d319c9-b38b-40f6-a360-60ecc53c3457', 'pdf_url': 'https://orbit.dtu.dk/files/300391153/1_s2.0_S0734975022001136_main.pdf', 'source': {'id': 'https://openalex.org/S4306400705', 'display_name': 'Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I96673099', 'host_organization_name': 'Technical University of Denmark', 'host_organization_lineage': ['https://openalex.org/I96673099'], 'host_organization_lineage_names': ['Technical University of Denmark'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35809763', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.biotechadv.2022.108017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160877137', 'display_name': 'Biotechnology Advances', 'issn_l': '0734-9750', 'issn': ['0734-9750', '1873-1899'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 145, 'referenced_works': ['https://openalex.org/W1009251650', 'https://openalex.org/W111840350', 'https://openalex.org/W1237020786', 'https://openalex.org/W1529294009', 'https://openalex.org/W190035913', 'https://openalex.org/W1940198378', 'https://openalex.org/W1963883344', 'https://openalex.org/W1963910405', 'https://openalex.org/W1965017622', 'https://openalex.org/W1972317518', 'https://openalex.org/W1972391056', 'https://openalex.org/W1974132622', 'https://openalex.org/W1974314236', 'https://openalex.org/W1975352290', 'https://openalex.org/W1976357498', 'https://openalex.org/W1977504181', 'https://openalex.org/W1978986817', 'https://openalex.org/W1979578972', 'https://openalex.org/W1995924547', 'https://openalex.org/W1997759747', 'https://openalex.org/W2002865954', 'https://openalex.org/W2005702260', 'https://openalex.org/W2006401683', 'https://openalex.org/W2007271687', 'https://openalex.org/W2007353945', 'https://openalex.org/W2007831086', 'https://openalex.org/W2010785903', 'https://openalex.org/W2011054562', 'https://openalex.org/W2011355291', 'https://openalex.org/W2020405271', 'https://openalex.org/W2020916353', 'https://openalex.org/W2027179160', 'https://openalex.org/W2028223954', 'https://openalex.org/W2029878671', 'https://openalex.org/W2030209236', 'https://openalex.org/W2031485466', 'https://openalex.org/W2031693543', 'https://openalex.org/W2035930100', 'https://openalex.org/W2041592431', 'https://openalex.org/W2045408545', 'https://openalex.org/W2045425110', 'https://openalex.org/W2051363813', 'https://openalex.org/W2052407981', 'https://openalex.org/W2052434790', 'https://openalex.org/W2057937232', 'https://openalex.org/W2060385448', 'https://openalex.org/W2060853839', 'https://openalex.org/W2062055088', 'https://openalex.org/W2062931279', 'https://openalex.org/W2067651229', 'https://openalex.org/W2068123969', 'https://openalex.org/W2071732315', 'https://openalex.org/W2072086239', 'https://openalex.org/W2072384527', 'https://openalex.org/W2074702555', 'https://openalex.org/W2076486604', 'https://openalex.org/W2077615126', 'https://openalex.org/W2077734110', 'https://openalex.org/W2079445254', 'https://openalex.org/W2080225003', 'https://openalex.org/W2080234366', 'https://openalex.org/W2080306478', 'https://openalex.org/W2080381436', 'https://openalex.org/W2086329572', 'https://openalex.org/W2087372975', 'https://openalex.org/W2090740100', 'https://openalex.org/W2093823043', 'https://openalex.org/W2094983180', 'https://openalex.org/W2099891847', 'https://openalex.org/W2106053795', 'https://openalex.org/W2110164688', 'https://openalex.org/W2112637529', 'https://openalex.org/W2113068862', 'https://openalex.org/W2115937971', 'https://openalex.org/W2118338200', 'https://openalex.org/W2122573768', 'https://openalex.org/W2123607534', 'https://openalex.org/W2130314959', 'https://openalex.org/W2148288556', 'https://openalex.org/W2149806740', 'https://openalex.org/W2152983088', 'https://openalex.org/W2153658061', 'https://openalex.org/W2166319456', 'https://openalex.org/W2174590326', 'https://openalex.org/W2186467938', 'https://openalex.org/W2223143741', 'https://openalex.org/W2283936063', 'https://openalex.org/W2289965054', 'https://openalex.org/W2463543633', 'https://openalex.org/W2474886186', 'https://openalex.org/W2560571121', 'https://openalex.org/W2587176473', 'https://openalex.org/W2598907213', 'https://openalex.org/W2617763129', 'https://openalex.org/W2619767562', 'https://openalex.org/W2620885442', 'https://openalex.org/W2663054479', 'https://openalex.org/W2725943195', 'https://openalex.org/W2769436211', 'https://openalex.org/W2782195408', 'https://openalex.org/W2783298268', 'https://openalex.org/W2793819443', 'https://openalex.org/W2800956912', 'https://openalex.org/W2805514309', 'https://openalex.org/W2806774268', 'https://openalex.org/W2813883312', 'https://openalex.org/W2884612756', 'https://openalex.org/W2891551181', 'https://openalex.org/W2894888704', 'https://openalex.org/W2894960312', 'https://openalex.org/W2912997303', 'https://openalex.org/W2917928050', 'https://openalex.org/W2938658550', 'https://openalex.org/W2941128990', 'https://openalex.org/W2948282929', 'https://openalex.org/W2965949950', 'https://openalex.org/W2969548990', 'https://openalex.org/W2969800101', 'https://openalex.org/W2971840444', 'https://openalex.org/W2974312460', 'https://openalex.org/W2981053352', 'https://openalex.org/W2994949405', 'https://openalex.org/W2997290520', 'https://openalex.org/W3004165769', 'https://openalex.org/W3011157242', 'https://openalex.org/W3015085465', 'https://openalex.org/W3030150866', 'https://openalex.org/W3036340597', 'https://openalex.org/W3041655526', 'https://openalex.org/W3047307337', 'https://openalex.org/W3048319370', 'https://openalex.org/W3091508072', 'https://openalex.org/W3092527046', 'https://openalex.org/W3106584957', 'https://openalex.org/W3107760758', 'https://openalex.org/W3120822589', 'https://openalex.org/W3125188899', 'https://openalex.org/W3162448264', 'https://openalex.org/W3183721651', 'https://openalex.org/W36700065', 'https://openalex.org/W4200069910', 'https://openalex.org/W4200473483', 'https://openalex.org/W4214493476', 'https://openalex.org/W4251300039', 'https://openalex.org/W654691995'], 'related_works': ['https://openalex.org/W4300826710', 'https://openalex.org/W3180666438', 'https://openalex.org/W3033918039', 'https://openalex.org/W2981179043', 'https://openalex.org/W2573602707', 'https://openalex.org/W2330704722', 'https://openalex.org/W2083924127', 'https://openalex.org/W2057263938', 'https://openalex.org/W2005275448', 'https://openalex.org/W1568297223'], 'abstract_inverted_index': {'One': [0], 'of': [1, 8, 20, 65, 89, 110, 113, 120, 129, 136, 150], 'the': [2, 6, 16, 33, 45, 66, 70, 80, 111, 114, 118, 121, 126, 130], 'main': [3, 67], 'challenges': [4], 'in': [5, 52, 74, 117], 'development': [7], 'bioprocesses': [9], 'based': [10], 'on': [11, 139], 'cell': [12, 21, 26, 34, 46, 101], 'transient': [13, 97], 'expression': [14, 98], 'is': [15, 29, 72, 123], 'commonly': [17], 'reported': [18, 115], 'reduction': [19], 'specific': [22], 'productivity': [23], 'at': [24, 99], 'increasing': [25], 'densities.': [27], 'This': [28], 'generally': [30], 'known': [31], 'as': [32], 'density': [35], 'effect': [36], '(CDE).': [37], 'Many': [38], 'efforts': [39], 'have': [40], 'been': [41], 'devoted': [42], 'to': [43, 49, 55, 59, 77, 94], 'understanding': [44, 119], 'metabolic': [47], 'implications': [48], 'this': [50, 75], 'phenomenon': [51], 'an': [53], 'attempt': [54], 'design': [56], 'operational': [57], 'strategies': [58], 'overcome': [60], 'it.': [61], 'A': [62, 107], 'comprehensive': [63], 'analysis': [64, 135], 'studies': [68, 116], 'regarding': [69], 'CDE': [71, 122, 140], 'provided': [73], 'work': [76, 138], 'better': [78], 'define': [79], 'elements': [81], 'comprising': [82], 'its': [83], 'cause': [84], 'and': [85, 91], 'impact.': [86], 'Then,': [87], 'examples': [88], 'methodologies': [90], 'approaches': [92], 'employed': [93], 'achieve': [95], 'successful': [96], 'high': [100], 'densities': [102], '(HCD)': [103], 'are': [104], 'thoroughly': [105], 'reviewed.': [106], 'critical': [108], 'assessment': [109], 'limitations': [112], 'presented,': [124], 'covering': [125], 'leading': [127], 'hypothesis': [128], 'molecular': [131], 'implications.': [132], 'The': [133], 'overall': [134], 'previous': [137], 'may': [141], 'offer': [142], 'useful': [143], 'insights': [144], 'for': [145], 'further': [146], 'research': [147], 'into': [148], 'manufacturing': [149], 'biologics.': [151]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4284889422', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 3}], 'updated_date': '2024-12-27T04:05:22.708781', 'created_date': '2022-07-09'}