Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease

Name: Work Video:
Duration: 3 min 30 s
Khurrum Shahzad; Sameen Fatima; Hamzah Khawaja; Ahmed Elwakiel; Ihsan Gadi; Saira Ambreen; Silke Zimmermann; Peter R. Mertens; Ronald Biemann; Berend Isermann
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['https://openalex.org/W3029132570', 'https://openalex.org/W3021580357', 'https://openalex.org/W2806867311', 'https://openalex.org/W2531697796', 'https://openalex.org/W2380999069', 'https://openalex.org/W2166080653', 'https://openalex.org/W2100990796', 'https://openalex.org/W2081187932', 'https://openalex.org/W2026701965', 'https://openalex.org/W1997512772'], 'abstract_inverted_index': {'Efficient': [0, 217], 'therapies': [1, 218, 764], 'for': [2, 185, 219, 402, 468, 699, 740, 796, 820, 1053, 1872, 2077, 2155, 2321, 2753, 2974, 3079, 3255, 3820], 'diabetic': [3, 220, 606, 630, 647, 835, 876, 880, 914, 950, 1126, 1149, 1175, 1202, 1249, 1321, 1390, 1416, 1487, 1577, 2122, 2176, 2201, 2227, 2262, 2298, 2328, 2357, 2382, 2408, 2443, 2479, 2576, 2589, 2614, 2640, 2675, 2711, 2796, 2821, 2847, 2882, 2918, 2998, 3235, 3416, 3436, 3461, 3486, 3521, 3526, 3574, 3580, 3604, 3611, 3638, 3645, 3682, 3689, 3929, 3934, 3953, 3958, 3987, 3994], 'kidney': [4, 12, 95, 221, 229, 312, 436, 603, 631, 656, 664, 734, 790, 836, 856, 863, 1299, 1307, 1578, 1717, 1766, 2123, 2999], 'disease': [5, 222, 437, 604, 632, 2124], '(DKD),': [6, 223, 633], 'now': [7, 224], 'the': [8, 29, 189, 225, 246, 406, 445, 510, 557, 587, 611, 627, 652, 689, 713, 724, 754, 759, 855, 911, 961, 1071, 1092, 1119, 1123, 1231, 1272, 1352, 1506, 1591, 1611, 1621, 1636, 1664, 1690, 1751, 1788, 1825, 1867, 1883, 1899, 1904, 1946, 1949, 1963, 1970, 1974, 2026, 2067, 2074, 2085, 2108, 2128, 2232, 2330, 2342, 2413, 2509, 2513, 2518, 2645, 2758, 2762, 2778, 2852, 2954, 2989, 3118, 3121, 3124, 3128, 3179, 3191, 3361, 3364, 3367, 3371, 3389, 3415, 3499, 3536, 3545, 3562, 3587, 3621, 3629, 3701, 3816, 3861, 3945], 'leading': [9, 226], 'cause': [10, 227, 654, 3069], 'of': [11, 18, 26, 47, 52, 118, 228, 235, 243, 264, 269, 335, 477, 533, 559, 586, 599, 601, 610, 629, 637, 646, 655, 692, 723, 762, 827, 850, 913, 998, 1073, 1091, 1118, 1125, 1211, 1217, 1233, 1351, 1425, 1431, 1508, 1576, 1593, 1610, 1620, 1638, 1689, 1695, 1698, 1714, 1790, 1908, 1940, 1948, 2121, 2138, 2153, 2520, 2572, 2777, 2935, 2983, 2992, 3036, 3117, 3123, 3181, 3308, 3360, 3366, 3388, 3401, 3586, 3623, 3631, 3704, 3719, 3842, 3863, 3944], 'failure,': [13, 230], 'are': [14, 231, 3218], 'lacking.': [15, 232], 'One': [16, 233], 'hallmark': [17, 234, 826], 'DKD': [19, 88, 186, 236, 305, 403, 451, 458, 516, 642, 682, 693, 708, 968, 981, 1107, 1347], 'is': [20, 49, 180, 237, 266, 397, 439, 492, 554, 640, 650, 811, 824, 857, 982, 995, 1452, 1501, 3077, 3197, 3420, 3729], 'sterile': [21, 53, 82, 238, 270, 299, 442, 448, 500, 513, 965, 978, 999, 1289, 1303, 1344, 1605, 2147, 2317, 3738], 'inflammation': [22, 54, 83, 239, 271, 300, 449, 501, 514, 823, 966, 979, 1000, 1304, 1345, 1606], '(inflammation': [23, 240], 'in': [24, 71, 78, 87, 112, 162, 215, 241, 288, 295, 304, 329, 379, 432, 450, 472, 478, 490, 515, 548, 569, 605, 608, 757, 834, 854, 862, 872, 917, 947, 967, 980, 1096, 1108, 1111, 1122, 1171, 1204, 1248, 1279, 1298, 1317, 1346, 1355, 1386, 1418, 1462, 1484, 1505, 1517, 1550, 1598, 1607, 1635, 1663, 1671, 1716, 1765, 1782, 1792, 1805, 1811, 1865, 1993, 2066, 2127, 2144, 2159, 2197, 2297, 2378, 2478, 2575, 2610, 2710, 2736, 2817, 2917, 2997, 3016, 3040, 3127, 3157, 3186, 3299, 3318, 3323, 3370, 3392, 3411, 3457, 3485, 3520, 3573, 3603, 3610, 3637, 3644, 3681, 3710, 3727, 3747, 3758, 3776, 3799, 3846, 3850, 3854, 3875, 3884, 3928, 3952, 3986, 3993], 'absence': [25, 242], 'microorganisms),': [27, 244], 'but': [28, 155, 245, 372, 1145, 2172, 2353, 2585, 2792, 3231, 3432, 3990], 'underlying': [30, 247], 'molecular': [31, 248], 'mechanisms': [32, 249, 446, 511, 1575, 1637], 'remain': [33, 250, 452, 1348], 'poorly': [34, 251, 453], 'understood.': [35, 252], 'The': [36, 253, 848, 986, 1027, 1048, 1337, 2727, 2942, 3881], 'NLRP3': [37, 75, 177, 201, 208, 254, 292, 394, 418, 425, 460, 469, 487, 535, 541, 552, 566, 1049, 1068, 1093, 1120, 1273, 1295, 1353, 1595, 1612, 1639, 1666, 1691, 1696, 1740, 1761, 1778, 1791, 2994, 3125, 3368, 3707, 3724], 'inflammasome': [38, 69, 76, 178, 255, 286, 293, 395, 461, 470, 488, 560, 567, 994, 1069, 1121, 1274, 1296, 1354, 1450, 1482, 1596, 1613, 1640, 1667, 2995, 3080, 3126, 3149, 3183, 3297, 3369, 3708, 3725, 3856, 3885], '(innate': [39, 256], 'immune': [40, 195, 257, 412, 526, 1280], 'system': [41, 258], 'receptors': [42, 259], 'and': [43, 62, 84, 105, 172, 183, 187, 204, 260, 279, 301, 322, 389, 400, 404, 421, 463, 481, 495, 502, 517, 536, 545, 649, 668, 721, 775, 882, 1008, 1020, 1099, 1110, 1215, 1305, 1429, 1523, 1557, 1604, 1618, 1625, 1642, 1673, 1702, 1722, 1819, 1824, 1831, 1912, 1973, 2035, 2055, 2104, 2112, 2267, 2448, 2559, 2564, 2680, 2739, 2761, 2887, 2937, 2967, 3044, 3072, 3120, 3188, 3248, 3252, 3281, 3285, 3291, 3311, 3363, 3406, 3511, 3543, 3557, 3617, 3651, 3661, 3668, 3673, 3693, 3697, 3715, 3736, 3752, 3815, 3833, 3839, 3866, 3900, 3914, 3920, 3922, 3941, 3973, 3978], 'sensors': [44, 261], 'regulating': [45, 262], 'activation': [46, 70, 77, 179, 263, 287, 294, 396, 462, 471, 489, 1170, 1297, 1316, 1385, 1451, 1483, 1597, 1641, 2196, 2377, 2609, 2816, 2996, 3184, 3298, 3456, 3709, 3726], 'caspase-1)': [48, 265], 'a': [50, 211, 267, 428, 465, 475, 530, 579, 584, 634, 684, 737, 741, 793, 797, 812, 825, 860, 996, 1051, 1873, 1917, 1961, 2058, 2151, 2769, 2774, 2959, 3074, 3479, 3761, 3851], 'mechanism': [51, 268, 962, 997], 'known': [55, 272, 1001], 'to': [56, 81, 273, 298, 497, 556, 615, 712, 780, 815, 1002, 1293, 1342, 1459, 1601, 1685, 1891, 2013, 2020, 2040, 2102, 2550, 2556, 2757, 2951, 3028, 3177, 3189, 3199, 3220, 3277, 3478, 3706, 3731, 3787], 'be': [57, 210, 274, 427, 578, 781, 1003], 'activated': [58, 275, 1004, 3089, 3333], 'by': [59, 99, 276, 316, 1005, 1360, 1454, 2107, 2135, 2229, 2264, 2410, 2445, 2495, 2642, 2677, 2849, 2884, 3151, 3305, 3498, 3535, 3561, 3590, 3628, 3764, 3860, 3906], 'metabolic': [60, 277, 1006, 1054, 2737], 'stimuli': [61, 278, 1007], 'reactive': [63, 280, 1009, 1021, 1372], 'metabolites': [64, 281, 1010], 'associated': [65, 282, 440, 858, 1011], 'with': [66, 115, 128, 283, 332, 345, 441, 459, 571, 695, 859, 879, 1012, 1106, 1251, 1255, 1553, 1798, 1879, 1931, 1988, 2010, 2084, 2504, 2540, 2933, 2958, 3012, 3320, 3422, 3525, 3579, 3608, 3642, 3686, 3767, 3772, 3933, 3957], 'DKD,': [67, 284, 572, 1013, 1294, 3753], 'including': [68, 285, 1363], 'podocytes.': [72, 289, 473, 1812], 'However,': [73, 290, 444, 753, 975], 'whether': [74, 291, 1594, 2953, 3193, 3742], 'podocytes': [79, 192, 296, 409, 491, 524, 1356, 1485, 1599, 1783, 1994, 3017, 3187, 3711, 3728, 3748, 3759, 3777, 3801], 'contributes': [80, 297, 1458, 1600], 'glomerular': [85, 102, 106, 160, 302, 319, 323, 377, 945, 1525, 3390, 3412, 3546, 3558, 3571, 3596, 3655, 3713, 3733, 3750, 3855, 3902, 3916, 3923, 3967], 'damage': [86, 303, 3572, 3714, 3751], 'remains': [89, 306, 779, 984, 1784], 'unknown.': [90, 307, 1349, 1785], 'Here,': [91, 308], 'we': [92, 309, 484, 1794, 1860, 3001, 3206, 3383, 3754], 'found': [93, 310], 'that': [94, 166, 191, 311, 383, 408, 486, 523, 540, 551, 3595, 3609, 3643, 3723], 'damage,': [96, 313, 3734], 'as': [97, 199, 314, 416, 766, 1015, 1892, 2021, 2033, 2162, 2725, 3029, 3221, 3278, 3303, 3788, 3812, 3858, 3904], 'reflected': [98, 315, 3304, 3859, 3905], 'increased': [100, 317, 3410, 3484, 3519, 3602, 3664], 'albuminuria,': [101, 318, 3735], 'mesangial': [103, 320, 3531, 3538, 3908], 'expansion': [104, 321], 'basement': [107, 324, 3597], 'membrane': [108, 325, 3598], 'thickness': [109, 326, 3600], 'was': [110, 142, 149, 327, 359, 366, 1870, 1979, 2125, 2133, 2334, 2747, 2766, 2949, 2979, 3317, 3601, 3635, 3663, 3679, 3810], 'aggravated': [111, 328, 3570], 'hyperglycemic': [113, 126, 163, 330, 343, 380], 'mice': [114, 127, 331, 344, 1205, 1419, 1835, 1848, 1895, 1924, 1928, 1934, 1955, 1985, 1989, 1996, 2007, 2047, 2090, 2311, 2732, 3003, 3013, 3025, 3217, 3254, 3287, 3395, 3488, 3523, 3577, 3606, 3614, 3640, 3648, 3684, 3690, 3705, 3766, 3773, 3784, 3805, 3817, 3835, 3848, 3878, 3931, 3955, 3961, 3989], 'podocyte-specific': [116, 129, 139, 146, 333, 346, 356, 363, 1922, 2993, 3194], 'expression': [117, 334, 3313, 3671, 3745, 3845, 3976], 'an': [119, 336, 519, 971, 1502, 1937, 3005, 3203], 'Nlrp3': [120, 130, 140, 168, 337, 347, 357, 385, 1806, 3007, 3093, 3182, 3195, 3269, 3337, 3744, 3756, 3769, 3797, 3844], 'gain-of-function': [121, 338, 3008, 3196], 'mutant': [122, 339, 3037], '(Nlrp3A350V).': [123, 340], 'In': [124, 341, 701, 1227, 1683, 1736, 2082, 2512, 3653, 3699, 3965], 'contrast,': [125, 342], 'or': [131, 348, 563, 1371, 1802, 1807, 2945, 3263, 3826], 'Caspase-1': [132, 349], 'deficiency': [133, 141, 148, 350, 358, 365, 538], 'showed': [134, 351, 3594], 'protection': [135, 352], 'against': [136, 353, 2261, 2442, 2674, 2881], 'DKD.': [137, 216, 354, 433, 503, 700, 821, 1608, 3201], 'Intriguingly,': [138, 355], 'fully': [143, 360], 'protective,': [144, 361], 'while': [145, 362], 'caspase-1': [147, 157, 364, 374, 537, 1808, 1868, 3310, 3405, 3865], 'only': [150, 367, 2088], 'partially': [151, 368], 'protective.': [152, 369], 'Podocyte-specific': [153, 370], 'Nlrp3,': [154, 371], 'not': [156, 373, 1146, 2173, 2354, 2586, 2793, 3068, 3232, 3385, 3433, 3871, 3950], 'deficiency,': [158, 375], 'maintained': [159, 376, 2056], 'autophagy': [161, 378], 'mice,': [164, 381, 1859, 2018, 2161, 3274, 3302, 3418], 'suggesting': [165, 382, 522], 'podocyte': [167, 176, 200, 384, 393, 417, 534, 1460, 1518, 1602, 2268, 2287, 2449, 2468, 2681, 2700, 2888, 2907, 3624, 3669, 3843, 3946, 3974], 'exerts': [169, 202, 386, 419, 542, 1741], 'both': [170, 181, 387, 398, 493, 543, 1720], 'canonical': [171, 205, 388, 422, 544, 1721], 'non-canonical': [173, 203, 390, 420, 1723], 'effects.': [174, 391], 'Thus,': [175, 392], 'sufficient': [182, 399, 494, 3198, 3730], 'required': [184, 401, 496, 3078], 'supports': [188, 405], 'concept': [190, 407, 521], 'exert': [193, 410], 'some': [194, 411, 1282], 'cell–like': [196, 413, 527], 'functions.': [197, 414, 528], 'Hence,': [198, 415, 809], 'effects,': [206, 423], 'targeting': [207, 424, 707], 'may': [209, 426, 577, 969, 1285], 'promising': [212, 429, 1238], 'therapeutic': [213, 430, 581, 697, 705, 818, 973], 'approach': [214, 431, 3174, 3763], 'Translational': [434], 'StatementDiabetic': [435], '(DKD)': [438], 'inflammation.': [443, 1290, 3739], 'inducing': [447, 1616], 'defined.': [454], 'Recent': [455], 'work': [456], 'linked': [457, 768, 1105], 'suggested': [464], 'potential': [466, 580], 'role': [467, 1670, 1789, 3180], 'Using': [474], 'combination': [476], 'vivo': [479], 'gain-': [480, 1801], 'loss-of-function': [482, 1803, 1809], 'approaches,': [483], 'show': [485, 525], 'induce': [498], 'renal': [499, 884, 915, 964, 977, 1246, 1338, 1737, 3737], 'These': [504, 1984, 2006], 'data': [505, 2955], 'provide': [506], 'new': [507, 704, 738, 742, 763, 794, 798, 817], 'insights': [508], 'into': [509], 'triggering': [512, 963, 3122, 3365], 'support': [518], 'emerging': [520], 'Additionally,': [529], 'direct': [531], 'comparison': [532], 'suggests': [539], 'noncanonical': [546, 1780], 'effects': [547, 1694, 1743], 'podocytes,': [549, 1793], 'indicating': [550], 'inhibition': [553, 558, 568, 722, 1216, 1232, 1430, 3150], 'superior': [555], 'cytokine': [561, 1700], 'maturation': [562, 1701], 'signaling.': [564], 'Targeting': [565, 960], 'patients': [570, 607, 648, 1250], 'potentially': [573, 2560], 'using': [574, 2496, 2749, 2768, 3760], 'small-molecule': [575], 'compounds,': [576], 'approach.': [582], 'As': [583, 1916, 1960], 'consequence': [585], 'global': [588], 'diabetes': [589, 638, 1556], 'mellitus': [590], 'pandemic,1Kainz': [591], 'A.': [592, 2241, 2422, 2654, 2861], 'Hronsky': [593], 'M.': [594, 939, 1242, 1631], 'Stel': [595], 'V.S.': [596], 'et': [597, 732, 788, 870, 906, 1143, 1168, 1197, 1314, 1383, 1411, 1446, 1477, 1515, 1573, 1632, 1660, 1712, 1759, 2170, 2194, 2222, 2256, 2285, 2351, 2375, 2403, 2437, 2466, 2583, 2607, 2635, 2669, 2698, 2790, 2814, 2842, 2876, 2905, 3087, 3114, 3147, 3229, 3331, 3357, 3430, 3454], 'al.Prediction': [598], 'prevalence': [600, 628, 691], 'chronic': [602], 'countries': [609], 'European': [612, 1884], 'Union': [613], 'up': [614], '2025.Nephrol': [616], 'Dial': [617], 'Transplant.': [618], '2015;': [619, 1178, 1258, 1324, 1393, 1466, 2204, 2301, 2385, 2482, 2617, 2714, 2824, 2921, 3131, 3374, 3464], '30:': [620, 746, 802], 'iv113-iv118Crossref': [621], 'PubMed': [622, 677, 748, 804, 843, 895, 929, 955, 1037, 1059, 1085, 1132, 1157, 1186, 1222, 1266, 1332, 1401, 1436, 1494, 1532, 1562, 1585, 1650, 1731, 1772, 2184, 2212, 2245, 2274, 2304, 2365, 2393, 2426, 2455, 2485, 2597, 2625, 2658, 2687, 2717, 2804, 2832, 2865, 2894, 2924, 3061, 3103, 3134, 3168, 3243, 3347, 3377, 3444, 3472], 'Scopus': [623, 678, 749, 805, 844, 896, 930, 956, 1038, 1060, 1086, 1133, 1158, 1187, 1223, 1267, 1333, 1402, 1437, 1468, 1495, 1533, 1563, 1586, 1651, 1679, 1732, 1773, 2185, 2213, 2246, 2275, 2305, 2366, 2394, 2427, 2456, 2486, 2598, 2626, 2659, 2688, 2718, 2805, 2833, 2866, 2895, 2925, 3062, 3104, 3135, 3169, 3244, 3348, 3378, 3445, 3473], '(47)': [624], 'Google': [625, 680, 751, 807, 846, 898, 932, 958, 1040, 1062, 1088, 1135, 1160, 1189, 1225, 1269, 1335, 1404, 1439, 1470, 1497, 1535, 1565, 1588, 1653, 1681, 1734, 1775, 2187, 2215, 2248, 2277, 2307, 2368, 2396, 2429, 2458, 2488, 2600, 2628, 2661, 2690, 2720, 2807, 2835, 2868, 2897, 2927, 3064, 3106, 3137, 3171, 3246, 3350, 3380, 3447, 3475], 'Scholar': [626, 681, 752, 808, 847, 959, 1089, 1226, 1270, 1336, 1498, 1589, 1682, 1735, 1776, 2308, 2489, 2721, 2928, 3065, 3172, 3247, 3381, 3476], 'major': [635], 'complication': [636], 'mellitus,': [639], 'increasing.': [641], 'affects': [643, 944], 'approximately': [644], '40%': [645], 'currently': [651], 'main': [653], 'failure.2Alicic': [657], 'R.Z.': [658], 'Rooney': [659], 'M.T.': [660], 'Tuttle': [661], 'K.R.': [662], 'Diabetic': [663], 'disease:': [665], 'challenges,': [666], 'progress,': [667], 'possibilities.Clin': [669], 'J': [670], 'Am': [671, 1151, 2178, 2359, 2591, 2798, 3237, 3438], 'Soc': [672, 1152, 2179, 2360, 2592, 2799, 3238, 3439], 'Nephrol.': [673, 839, 1153, 2180, 2361, 2593, 2800, 3239, 3440], '2017;': [674, 3058, 3100, 3165, 3344], '12:': [675], '2032-2045Crossref': [676], '(939)': [679], 'constitutes': [683], 'persistent': [685, 2573, 3208, 3402, 3720], 'medical': [686], 'problem,': [687], 'reflecting': [688], 'increasing': [690], 'paired': [694], 'insufficient': [696], 'options': [698], 'recent': [702], 'years,': [703], 'approaches': [706, 819], 'have': [709, 1704], 'emerged,': [710], 'adding': [711], 'current': [714, 2068, 2129], 'standard': [715], '(i.e.,': [716], 'tight': [717], 'blood': [718, 2331, 2505, 2522, 2541, 3493, 3505, 3891], 'glucose': [719, 1365, 2332, 2491, 2498, 2523, 2542, 3261, 3494, 3824], 'control': [720, 1947, 2310, 3251, 3417, 3877], 'renin-angiotensin-aldosterone': [725], 'system).3Fu': [726], 'H.': [727, 783, 1445, 1476, 1629, 1707, 2221, 2282, 2402, 2463, 2634, 2695, 2841, 2902], 'Liu': [728, 784], 'S.': [729, 785, 1510, 3082, 3109, 3326, 3352], 'Bastacky': [730, 786], 'S.I.': [731, 787], 'al.Diabetic': [733, 789], 'diseases': [735, 791, 1672, 1718], 'revisited:': [736, 792], 'perspective': [739, 795], 'era.Mol': [743, 799], 'Metab.': [744, 800], '2019;': [745, 801, 1647], '250-263Crossref': [747, 803], '(65)': [750, 806], 'clinical': [755, 1228], 'value,': [756], 'particular': [758], 'long-term': [760, 1546], 'outcomes,': [761], 'such': [765, 1014], 'sodium-glucose': [767], 'transporter': [769], '2': [770, 875, 2551], 'inhibition,': [771], 'glucagon-like': [772], 'peptide-2': [773], 'antagonists,': [774], 'nonsteroidal': [776], 'mineralocorticoid': [777], 'antagonists': [778], 'established.3Fu': [782], 'there': [810], 'continuous': [813], 'need': [814], 'develop': [816], 'Sterile': [822], 'DKD.4Tang': [828], 'S.C.W.': [829], 'Yiu': [830], 'W.H.': [831], 'Innate': [832], 'immunity': [833], 'disease.Nat': [837], 'Rev': [838, 1080], '2020;': [840, 1677, 1728], '16:': [841], '206-222Crossref': [842], '(138)': [845], 'degree': [849], 'inflammatory': [851], 'cell': [852, 1339, 3656, 3968], 'accumulation': [853, 3533, 3910], 'decline': [861], 'function.5Chow': [864], 'F.': [865, 1140, 1165, 1311, 1380, 1709, 2167, 2191, 2217, 2348, 2372, 2398, 2580, 2604, 2630, 2787, 2811, 2837, 3226, 3427, 3451], 'Ozols': [866, 904], 'E.': [867, 905, 3111, 3144, 3354], 'Nikolic-Paterson': [868, 902], 'D.J.': [869, 903], 'al.Macrophages': [871], 'mouse': [873, 1522, 1796, 2063, 2754], 'type': [874, 948, 1554], 'nephropathy:': [877], 'correlation': [878], 'state': [881], 'progressive': [883], 'injury.Kidney': [885], 'Int.': [886, 920, 1177, 1257, 1323, 1392, 2203, 2384, 2616, 2823, 3463], '2004;': [887, 952], '65:': [888], '116-128Abstract': [889], 'Full': [890, 892, 924, 926, 1032, 1034, 1181, 1183, 1261, 1263, 1327, 1329, 1396, 1398, 2207, 2209, 2388, 2390, 2620, 2622, 2827, 2829, 3467, 3469], 'Text': [891, 893, 925, 927, 1033, 1035, 1182, 1184, 1262, 1264, 1328, 1330, 1397, 1399, 2208, 2210, 2389, 2391, 2621, 2623, 2828, 2830, 3468, 3470], 'PDF': [894, 928, 1036, 1185, 1265, 1331, 1400, 2211, 2392, 2624, 2831, 3471], '(430)': [897], 'Scholar,': [899, 933, 1041, 1063, 1136, 1161, 1190, 1536, 1566, 2249, 2278, 2430, 2459, 2662, 2691, 2869, 2898, 3107, 3138], '6Chow': [900], 'F.Y.': [901], 'al.Monocyte': [907], 'chemoattractant': [908], 'protein-1': [909], 'promotes': [910, 1148, 2175, 2292, 2356, 2473, 2588, 2705, 2795, 2912, 3234, 3435], 'development': [912, 3156], 'injury': [916, 1461, 3096, 3340], 'streptozotocin-treated': [918], 'mice.Kidney': [919], '2006;': [921], '69:': [922], '73-80Abstract': [923], '(358)': [931], '7Moriya': [934], 'R.': [935, 1045], 'Manivel': [936], 'J.C.': [937], 'Mauer': [938], 'Juxtaglomerular': [940], 'apparatus': [941], 'T-cell': [942], 'infiltration': [943], 'structure': [946], '1': [949, 1200, 1414, 2549, 3676, 3981], 'patients.Diabetologia.': [951], '47:': [953], '82-88Crossref': [954], '(46)': [957], 'present': [970], 'attractive': [972], 'target.': [974], 'how': [976], 'initiated': [983], 'unresolved.': [985], 'NLR': [987], 'family': [988], 'pyrin': [989], 'domain': [990, 1199, 1413], 'containing': [991, 3004], '3': [992, 2515, 2527], '(NLRP3)': [993], 'advanced': [1016, 1367], 'glycation': [1017, 1368], 'end': [1018, 1369], 'products': [1019], 'oxygen': [1022, 1373], 'species.8Schroder': [1023], 'K.': [1024, 1043, 1067, 1138, 1163, 1309, 1378, 1512, 1568, 2165, 2189, 2219, 2346, 2370, 2400, 2578, 2602, 2632, 2785, 2809, 2839, 3224, 3425, 3449], 'Tschopp': [1025, 1046], 'J.': [1026, 1047, 1065, 1758], 'inflammasomes.Cell.': [1028], '2010;': [1029, 1056, 1082], '140:': [1030], '821-832Abstract': [1031], '(4058)': [1039], '9Schroder': [1042], 'Zhou': [1044], 'inflammasome:': [1050], 'sensor': [1052], 'danger?.Science.': [1055], '327:': [1057], '296-300Crossref': [1058], '(841)': [1061], '10Tschopp': [1064], 'Schroder': [1066], 'activation:': [1070, 1668], 'convergence': [1072], 'multiple': [1074], 'signalling': [1075, 2289, 2470, 2702, 2909], 'pathways': [1076], 'on': [1077, 2057, 3551], 'ROS': [1078], 'production?.Nat': [1079], 'Immunol.': [1081, 1768], '10:': [1083, 1648], '210-215Crossref': [1084], '(1232)': [1087], 'Activation': [1090, 1350], 'inflammasome,': [1094, 1692], 'resulting': [1095], 'interleukin': [1097], '(IL)-1β': [1098], 'IL-18': [1100], 'maturation,': [1101], 'has': [1102, 1236, 1275, 1375, 1779], 'been': [1103, 1276, 1376, 1705, 2071], 'closely': [1104], 'humans': [1109], 'experimental': [1112, 2042], 'contexts.11Qiu': [1113], 'Y.Y.': [1114], 'Tang': [1115, 1444], 'L.Q.': [1116], 'Roles': [1117], 'pathogenesis': [1124, 1507], 'nephropathy.Pharmacol': [1127], 'Res.': [1128, 1465, 3130, 3373], '2016;': [1129, 1154, 2181, 2362, 2594, 2801, 3240, 3441], '114:': [1130], '251-264Crossref': [1131], '(118)': [1134], '12Shahzad': [1137], 'Bock': [1139, 1164, 1310, 1379, 2166, 2190, 2347, 2371, 2579, 2603, 2786, 2810, 3225, 3426, 3450], 'Al-Dabet': [1141, 2168, 2349, 2581, 2788, 3085, 3227, 3329, 3428], 'M.M.': [1142, 2169, 2350, 2582, 2789, 3086, 3228, 3330, 3429], 'al.Caspase-1,': [1144, 2171, 2352, 2584, 2791, 3230, 3431], 'caspase-3,': [1147, 2174, 2355, 2587, 2794, 3233, 3434, 3659], 'nephropathy.J': [1150, 2177, 2358, 2590, 2797, 3236, 3437], '27:': [1155, 2182, 2363, 2595, 2802, 3241, 3442], '2270-2275Crossref': [1156, 2183, 2364, 2596, 2803, 3242, 3443], '(68)': [1159, 2186, 2367, 2599, 2806, 3245, 3446], '13Shahzad': [1162], 'Dong': [1166, 1312, 1381, 2192, 2283, 2373, 2464, 2605, 2696, 2812, 2903, 3452], 'W.': [1167, 1313, 1382, 1754, 2193, 2284, 2374, 2465, 2606, 2697, 2813, 2904, 3146, 3453], 'al.Nlrp3-inflammasome': [1169, 1315, 1384, 2195, 2376, 2608, 2815, 3455], 'non-myeloid-derived': [1172, 1318, 1387, 2198, 2379, 2611, 2818, 3458], 'cells': [1173, 1284, 1301, 1319, 1388, 1864, 2054, 2199, 2380, 2612, 2819, 3459], 'aggravates': [1174, 1306, 1320, 1389, 2200, 2381, 2613, 2820, 3460, 3749], 'nephropathy.Kidney': [1176, 1322, 1391, 2202, 2383, 2615, 2822, 3462], '87:': [1179, 1325, 1394, 2205, 2386, 2618, 2825, 3465], '74-84Abstract': [1180, 1326, 1395, 2206, 2387, 2619, 2826, 3466], '(262)': [1188, 1334, 1403, 2214, 2395, 2627, 2834, 3474], '14Yang': [1191], 'S.M.': [1192, 1194, 1406, 1408], 'Ka': [1193, 1407], 'Wu': [1195, 1409], 'H.L.': [1196, 1410], 'al.Thrombomodulin': [1198, 1412], 'ameliorates': [1201, 1415, 2226, 2407, 2639, 2846], 'nephropathy': [1203, 1417, 2228, 2263, 2409, 2444, 2641, 2676, 2848, 2883], 'via': [1206, 1420, 1719, 3097, 3341], 'anti-NF-kappaB/NLRP3': [1207, 1421], 'inflammasome-mediated': [1208, 1422], 'inflammation,': [1209, 1423], 'enhancement': [1210, 1424], 'NRF2': [1212, 1426], 'antioxidant': [1213, 1427], 'activity': [1214, 1428, 3886], 'apoptosis.Diabetologia.': [1218, 1432], '2014;': [1219, 1433, 1491, 1582], '57:': [1220, 1434], '424-434Crossref': [1221, 1435], '(85)': [1224, 1438], 'case': [1229], 'reports,': [1230], 'IL-1β': [1234, 1624, 3407], 'signaling': [1235, 1764], 'shown': [1237], 'effects.15Balasubramaniam': [1239], 'G.': [1240], 'Almond': [1241], 'Dasgupta': [1243], 'B.': [1244, 1659, 2251, 2432, 2664, 2871], 'Improved': [1245], 'function': [1247, 1688], 'acute': [1252], 'gout': [1253], 'treated': [1254], 'anakinra.Kidney': [1256], '88:': [1259], '195-196Abstract': [1260], '(17)': [1268], 'Although': [1271], 'initially': [1277], 'described': [1278, 2163, 3813], 'cells,': [1281, 1739], 'epithelial': [1283, 1358], 'similarly': [1286], 'trigger': [1287], 'inflammasome-dependent': [1288], 'With': [1291], 'respect': [1292], 'resident': [1300], 'drives': [1302], 'damage.13Shahzad': [1308], 'types': [1340], 'contributing': [1341], 'NLRP3-dependent': [1343], '(glomerular': [1357], 'cells)': [1359], 'various': [1361], 'stimuli,': [1362], 'high': [1364], 'concentrations,': [1366], 'products,': [1370], 'species,': [1374], 'demonstrated.13Shahzad': [1377], 'Scholar,14Yang': [1405], 'Scholar,16Gao': [1440], 'P.': [1441, 1472], 'He': [1442], 'F.F.': [1443], 'al.NADPH': [1447], 'oxidase-induced': [1448], 'NALP3': [1449, 1481], 'driven': [1453], 'thioredoxin-interacting': [1455], 'protein': [1456, 1479, 2224, 2258, 2405, 2439, 2637, 2671, 2844, 2878, 3090, 3334], 'which': [1457, 1866, 3039, 3316, 3419, 3869], 'hyperglycemia.J': [1463], 'Diabetes': [1464, 2501], '2015504761Crossref': [1467], '(52)': [1469], 'Scholar,17Gao': [1471], 'Meng': [1473], 'X.F.': [1474], 'Su': [1475], 'al.Thioredoxin-interacting': [1478], 'mediates': [1480], 'during': [1486], 'nephropathy.Biochim': [1488], 'Biophys': [1489], 'Acta.': [1490], '1843:': [1492], '2448-2460Crossref': [1493], '(55)': [1496], 'Podocyte': [1499, 1543], 'dysfunction': [1500, 1603], 'early': [1503], 'event': [1504], 'DKD,18Majumder': [1509], 'Thieme': [1511], 'Batchu': [1513], 'S.N.': [1514], 'al.Shifts': [1516], 'histone': [1519], 'H3K27me3': [1520], 'regulate': [1521], 'human': [1524, 1950], 'disease.J': [1526, 1579], 'Clin': [1527, 1580, 3056], 'Invest.': [1528, 1581], '2018;': [1529], '128:': [1530], '483-499Crossref': [1531], '(70)': [1534], '19Meyer': [1537], 'T.W.': [1538], 'Bennett': [1539], 'P.H.': [1540], 'Nelson': [1541], 'R.G.': [1542], 'number': [1544, 3630], 'predicts': [1545], 'urinary': [1547], 'albumin': [1548, 2746, 2755], 'excretion': [1549], 'Pima': [1551], 'Indians': [1552], 'II': [1555], 'microalbuminuria.Diabetologia.': [1558], '1999;': [1559], '42:': [1560], '1341-1344Crossref': [1561], '(378)': [1564], '20Reidy': [1567], 'Kang': [1569], 'H.M.': [1570], 'Hostetter': [1571], 'T.': [1572, 2255, 2280, 2436, 2461, 2668, 2693, 2875, 2900, 3142], 'al.Molecular': [1574], '124:': [1583], '2333-2340Crossref': [1584], '(491)': [1587], 'raising': [1590], 'question': [1592, 3192], 'Assembly': [1609], 'activates': [1614], 'caspase-1,': [1615], 'cleavage': [1617], 'release': [1619, 1703], 'proinflammatory': [1622], 'cytokines': [1623], 'IL-18.21Yang': [1626], 'Y.': [1627], 'Wang': [1628, 1755, 2220, 2281, 2401, 2462, 2633, 2694, 2840, 2901], 'Kouadir': [1630], 'al.Recent': [1633, 1661], 'advances': [1634, 1662], 'its': [1643], 'inhibitors.Cell': [1644], 'Death': [1645], 'Dis.': [1646], '128Crossref': [1649], '(569)': [1652], 'Scholar,22Zhao': [1654], 'N.': [1655], 'Li': [1656], 'C.C.': [1657], 'Di': [1658], 'NEK7-licensed': [1665], 'mechanisms,': [1669], 'related': [1674], 'inhibitors.J': [1675], 'Autoimmun.': [1676], '113102515Crossref': [1678], '(28)': [1680], 'addition': [1684], 'this': [1686, 2094], '"canonical"': [1687], '"noncanonical"': [1693], 'independent': [1697], 'caspase-1–mediated': [1699], 'reported.23Xiang': [1706], 'Zhu': [1708], 'Xu': [1710], 'Z.': [1711], 'al.Role': [1713], 'inflammasomes': [1715], 'pathways.Front': [1724], 'Cell': [1725, 1910], 'Dev': [1726], 'Biol.': [1727, 3164], '8:': [1729], '106Crossref': [1730], '(38)': [1733], 'tubular': [1738], 'these': [1742, 3216], 'through': [1744, 2290, 2471, 2703, 2910], 'transforming': [1745], 'growth': [1746], 'factor': [1747], 'beta–Smad': [1748], 'signaling,': [1749], 'promoting': [1750], 'epithelial-mesenchymal': [1752], 'transformation.24Wang': [1753], 'X.': [1756], 'Chun': [1757], 'al.Inflammasome-independent': [1760], 'augments': [1762], 'TGF-beta': [1763], 'epithelium.J': [1767], '2013;': [1769, 2242, 2423, 2655, 2862], '190:': [1770], '1239-1249Crossref': [1771], '(165)': [1774], 'Whether': [1777], 'functions': [1781], 'To': [1786, 1856, 2987, 3740], 'address': [1787, 3190], 'used': [1795, 2032, 2065, 2092, 2126, 2950, 2973], 'models': [1797], 'genetically': [1799], 'superimposed': [1800], 'mutations': [1804], 'specifically': [1810, 3185, 3746, 3757], 'For': [1813], 'details,': [1814], 'please': [1815], 'see': [1816], 'Supplementary': [1817, 1821, 1826, 3566, 3694], 'Material': [1818], 'Methods,': [1820], 'Table': [1822], 'S1,': [1823], 'References.': [1827], 'Wild-type': [1828], '(C57BL/6,': [1829], '8-week-old)': [1830, 1834], 'Nlrp3A350VLoxP/LoxP': [1832], '(B6.129-Nlrp3tm1Hhf/J,': [1833], 'were': [1836, 1849, 1896, 1929, 1986, 2008, 2030, 2037, 2048, 2091, 2099, 2326, 2493, 2525, 2534, 2567, 2733, 2743, 2931, 2956, 2972, 3266, 3409, 3483, 3518, 3818, 3829, 3949, 3991], 'obtained': [1837, 1850, 1861, 1956, 1997, 2568], 'from': [1838, 1851, 1882, 1957, 1998, 2025, 2050, 2508, 3414, 3803, 3873], 'Jackson': [1839, 1958, 1999], 'Laboratories,': [1840], 'Bar': [1841], 'Harbor,': [1842], 'ME.': [1843], 'Nlrp3LoxP/LoxP': [1844, 3781], '(C57BL/6-Nlrp3': [1845], 'tm1.1': [1846], 'Mrl)': [1847], 'Taconic': [1852], 'Biosciences,': [1853], 'Rensselaer,': [1854], 'NY.': [1855], 'generate': [1857, 2014], 'Casp1LoxP/LoxP': [1858, 2015], 'embryonic': [1862, 2052], 'stem': [1863, 2053], 'gene': [1869, 1977], 'targeted': [1871], 'knockout': [1874], '(KO)-first': [1875], 'construct': [1876], '(reporter-tagged': [1877], 'insertion': [1878], 'conditional': [1880, 3768], 'potential)': [1881], 'Conditional': [1885], 'Mouse': [1886], 'Mutagenesis': [1887], 'Program': [1888], '(C57BL/6-Casp1tm1a(EUCOMM)Wtsi,': [1889], 'referred': [1890, 2019, 3027, 3219, 3276, 3786], 'Ctm1a).': [1893], 'Ctm1a': [1894, 1927], 'generated': [1897, 2045], 'at': [1898, 1903, 2078, 2150, 2981], 'animal': [1900, 2097], 'core': [1901], 'facility': [1902], 'Max': [1905], 'Planck': [1906], 'Institute': [1907], 'Molecular': [1909], 'Biology': [1911], 'Genetics,': [1913], 'Dresden,': [1914], 'Germany.': [1915], 'first': [1918, 2514], 'step': [1919], 'toward': [1920], 'generating': [1921, 1981], 'Casp1-KO': [1923], '(Casp1KO-Pod),': [1925], 'heterozygous': [1926], 'crossed': [1930, 1987, 2009, 3002], 'transgenic': [1932], 'C57BL/6J': [1933], 'ubiquitously': [1935], 'expressing': [1936, 1990, 3014, 3774], 'enhanced': [1938, 3712], 'variant': [1939], 'Saccharomyces': [1941], 'cerevisiae': [1942], 'FLP1': [1943], 'recombinase': [1944, 1965, 1992], 'under': [1945], 'β-actin': [1951], 'promoter': [1952], '(transgenic': [1953], 'B6.Cg-Tg[ACTFlpE]9205Dym/J': [1954], 'Laboratories).': [1959], 'result,': [1962], 'flippase': [1964], 'target': [1966], '(FRT)–flanked': [1967], 'region': [1968], 'comprising': [1969], 'lacZ': [1971], 'sequence': [1972], 'neomycin': [1975], 'selection': [1976], 'cassette': [1978], 'excised,': [1980], 'Casp1LoxP/wt': [1982, 2002], 'mice.': [1983, 2005, 2023, 3529, 3583, 3937], 'Cre': [1991, 3015, 3775], '(B6.Cg-Tg[NPHS2-cre]295Lbh/J': [1995], 'Laboratories),': [2000], 'yielding': [2001, 3020, 3780], '×': [2003, 2016, 3023, 3272, 3782], 'PodCre': [2004, 2017, 3024, 3273, 3279, 3783], 'each': [2011], 'other': [2012, 2062, 3324], 'Casp1KO-Pod': [2022], 'Mice': [2024, 2325, 2539], 'same': [2027], 'breeding': [2028], 'colony': [2029], 'always': [2031], 'controls,': [2034], 'litters': [2036], 'randomly': [2038], 'assigned': [2039], 'different': [2041], 'groups.': [2043], 'Newly': [2044], 'Casp1LoxP': [2046], 'derived': [2049], 'C57BL/6': [2051, 2059, 2075], 'background.': [2060], 'All': [2061, 2096], 'lines': [2064], 'study': [2069], 'had': [2070], 'backcrossed': [2072], 'onto': [2073], 'background': [2076], 'least': [2079], '9': [2080], 'generations.': [2081], 'accordance': [2083], 'approved': [2086, 2106], 'procedures,': [2087], 'male': [2089], 'throughout': [2093], 'study.': [2095, 2130], 'experiments': [2098], 'conducted': [2100], 'according': [2101, 2756], 'standards': [2103], 'procedures': [2105], 'local': [2109], 'Animal': [2110], 'Care': [2111], 'Use': [2113], 'Committee': [2114], '(Landesverwaltungsamt': [2115], 'Halle,': [2116], 'Germany).': [2117], 'A': [2118], 'streptozotocin-dependent': [2119], 'model': [2120], 'Persistent': [2131, 3808], 'hyperglycemia': [2132, 2574, 3209, 3809], 'induced': [2134, 3207, 3811], 'intraperitoneal': [2136], 'administration': [2137], '60': [2139], 'mg/kg': [2140, 3212], 'streptozotocin': [2141, 2344], 'freshly': [2142], 'dissolved': [2143], '0.05': [2145, 2315], 'mol/l': [2146, 2316], 'sodium': [2148, 2318], 'citrate': [2149, 2319], 'pH': [2152], '4.5': [2154], '5': [2156, 2322], 'consecutive': [2157, 2323], 'days': [2158, 2340], '8-week-old': [2160], 'previously.12Shahzad': [2164], 'Scholar,13Shahzad': [2188, 2369, 2601, 2808, 3448], 'Scholar,25Bock': [2216, 2397, 2629, 2836], 'Shahzad': [2218, 2399, 2631, 2838], 'al.Activated': [2223, 2257, 2404, 2438, 2636, 2670, 2843, 2877], 'C': [2225, 2259, 2406, 2440, 2638, 2672, 2845, 2879, 3091, 3335], 'epigenetically': [2230, 2411, 2643, 2850], 'inhibiting': [2231, 2265, 2412, 2446, 2644, 2678, 2851, 2885], 'redox': [2233, 2414, 2646, 2853], 'enzyme': [2234, 2415, 2647, 2854], 'p66Shc.Proc': [2235, 2416, 2648, 2855], 'Natl': [2236, 2417, 2649, 2856], 'Acad': [2237, 2418, 2650, 2857], 'Sci': [2238, 2419, 2651, 2858], 'U': [2239, 2420, 2552, 2652, 2859], 'S': [2240, 2421, 2653, 2860], '110:': [2243, 2424, 2656, 2863], '648-653Crossref': [2244, 2425, 2657, 2864], '(109)': [2247, 2428, 2660, 2867], '26Isermann': [2250, 2431, 2663, 2870], 'Vinnikov': [2252, 2433, 2665, 2872], 'I.A.': [2253, 2434, 2666, 2873], 'Madhusudhan': [2254, 2435, 2667, 2874], 'protects': [2260, 2441, 2673, 2880], 'endothelial': [2266, 2447, 2679, 2886], 'apoptosis.Nat': [2269, 2450, 2682, 2889], 'Med.': [2270, 2451, 2683, 2890], '2007;': [2271, 2452, 2684, 2891], '13:': [2272, 2453, 2685, 2892], '1349-1358Crossref': [2273, 2454, 2686, 2893], '(322)': [2276, 2457, 2689, 2896], '27Madhusudhan': [2279, 2460, 2692, 2899], 'al.Defective': [2286, 2467, 2699, 2906], 'insulin': [2288, 2469, 2553, 2701, 2908], 'p85-XBP1': [2291, 2472, 2704, 2911], 'ATF6-dependent': [2293, 2474, 2706, 2913], 'maladaptive': [2294, 2475, 2707, 2914], 'ER-stress': [2295, 2476, 2708, 2915], 'response': [2296, 2477, 2709, 2916], 'nephropathy.Nat': [2299, 2480, 2712, 2919], 'Commun.': [2300, 2481, 2713, 2920], '6:': [2302, 2483, 2715, 2922], '6496Crossref': [2303, 2484, 2716, 2923], '(110)': [2306, 2487, 2719, 2926], 'Age-matched': [2309, 2722], 'received': [2312, 2548], '100': [2313], 'ml': [2314], 'i.p.': [2320], 'days.': [2324], 'considered': [2327], 'when': [2329], 'level': [2333, 2765], 'higher': [2335, 2544], 'than': [2336, 2545], '300': [2337], 'mg/dl': [2338, 2547], '16': [2339], 'after': [2341, 2517, 2569], 'last': [2343], 'injection.12Shahzad': [2345], 'Blood': [2490, 2563, 3260, 3823], 'levels': [2492, 2543, 3307, 3408, 3514, 3862, 3896], 'determined': [2494, 2748, 2767], 'ACCU-CHEK': [2497], 'strips': [2499], '(Roche': [2500], 'Care,': [2502], 'Inc.)': [2503], 'samples': [2506, 2566, 2742], 'taken': [2507], 'tail': [2510], 'vein.': [2511], 'weeks': [2516, 2571, 3257], 'onset': [2519], 'diabetes,': [2521], 'values': [2524, 2982, 3262, 3825], 'measured': [2526, 2535], 'times': [2528], 'per': [2529, 2537], 'week,': [2530], 'and,': [2531, 3477], 'thereafter,': [2532], 'they': [2533, 3482], 'once': [2536], 'week.': [2538], '500': [2546], '(Lantus;': [2554], 'SANOFI)': [2555], 'avoid': [2557], 'excessive': [2558], 'lethal': [2561], 'hyperglycemia.': [2562], 'tissue': [2565, 2730, 3070], '24': [2570, 3256, 3821], 'mice.12Shahzad': [2577], 'littermates': [2723], 'served': [2724], 'controls.': [2726], 'day': [2728], 'before': [2729], 'preparation,': [2731], 'placed': [2734], 'individually': [2735], 'cages,': [2738], '12-hour': [2740], 'urine': [2741, 2763, 3500], 'collected.': [2744], 'Urine': [2745], 'enzyme-linked': [2750], 'immunosorbent': [2751], 'assay': [2752], "manufacturer's": [2759], 'instructions,': [2760], 'creatinine': [2764, 3513, 3895], 'commercially': [2770], 'available': [2771], 'kit': [2772], 'following': [2773], 'modified': [2775], 'version': [2776], 'Jaffe': [2779], 'method': [2780], '(X-Pand': [2781], 'automated': [2782], 'platform,': [2783], 'Siemens).12Shahzad': [2784], 'Statistical': [2929, 2977], 'analyses': [2930, 3585], 'performed': [2932, 3589], 'analysis': [2934], 'variance': [2936], 'Tukey': [2938], 'post': [2939], 'hoc': [2940], 'comparison.': [2941], 'Kolmogorov-Smirnov': [2943], 'test': [2944, 2948], "D'Agostino-Pearson": [2946], 'normality': [2947], 'determine': [2952, 3178, 3741], 'consistent': [2957], 'Gaussian': [2960], 'distribution.': [2961], 'StatistiXL': [2962], '(www.statistixl.com;': [2963], 'Microsoft': [2964], 'Office': [2965], 'suite)': [2966], 'Prism': [2968], '7': [2969], '(GraphPad': [2970], 'Software)': [2971], 'statistical': [2975], 'analyses.': [2976], 'significance': [2978], 'accepted': [2980], 'P': [2984], '≤': [2985], '0.05.': [2986], 'explore': [2988], 'functional': [2990], 'relevance': [2991], 'disease,': [3000], 'inducible': [3006], 'mutation': [3009], '(Nlrp3A350VLoxP/LoxP': [3010], 'mice)': [3011, 3280], '(NPHS2Cre': [3018, 3778], 'mice),': [3019, 3779], 'Nlrp3A350V': [3021], 'LoxP/LoxP': [3022], '(hereafter': [3026, 3785], 'Nlrp3V-Pod': [3030, 3282, 3301, 3394, 3487, 3522, 3575, 3605, 3639, 3683], 'mice;': [3031, 3790], 'Figure': [3032, 3289, 3397, 3503, 3509, 3516, 3541, 3555, 3567, 3666, 3695, 3791, 3837, 3898, 3912, 3926, 3971], '1a': [3033], ').': [3034, 3619, 3793, 3964], 'Expression': [3035], 'Nlrp3A350V,': [3038], 'humans,': [3041], 'if': [3042], 'systemically': [3043], 'constitutively': [3045], 'expressed,': [3046], 'causes': [3047], 'Muckle-Wells': [3048], 'syndrome,28Lachmann': [3049], 'H.J.': [3050], 'Periodic': [3051], 'fever': [3052], 'syndromes.Best': [3053], 'Pract': [3054], 'Res': [3055], 'Rheumatol.': [3057], '31:': [3059], '596-609Crossref': [3060], '(61)': [3063], 'does': [3066], 'generally': [3067], 'injury,': [3071, 3903], 'typically': [3073], 'second': [3075], 'stimulus': [3076], 'activation.29Nazir': [3081], 'Gadi': [3083, 3327], 'I.': [3084, 3328], 'al.Cytoprotective': [3088, 3332], 'averts': [3092, 3336], 'inflammasome-induced': [3094, 3338], 'ischemia-reperfusion': [3095, 3339], 'mTORC1': [3098, 3342], 'inhibition.Blood.': [3099, 3343], '130:': [3101, 3345], '2664-2677Crossref': [3102, 3346], '(94)': [3105, 3349], '30Toldo': [3108], 'Mezzaroma': [3110, 3353], 'McGeough': [3112, 3355], 'M.D.': [3113, 3356], 'al.Independent': [3115, 3358], 'roles': [3116, 3359], 'priming': [3119, 3362], 'heart.Cardiovasc': [3129, 3372], '105:': [3132, 3375], '203-212Crossref': [3133, 3376], '(56)': [3136, 3379], '31van': [3139], 'der': [3140], 'Heijden': [3141], 'Kritikou': [3143], 'Venema': [3145], 'al.NLRP3': [3148], 'MCC950': [3152], 'reduces': [3153], 'atherosclerotic': [3154], 'lesion': [3155], 'apolipoprotein': [3158], 'E-deficient': [3159], 'mice-brief': [3160], 'report.Arterioscler': [3161], 'Thromb': [3162], 'Vasc': [3163], '37:': [3166], '1457-1461Crossref': [3167], '(189)': [3170], 'This': [3173], 'enabled': [3175], 'us': [3176], 'aggravate': [3200, 3732], 'Following': [3202], 'established': [3204], 'protocol,': [3205], '(streptozotocin,': [3210], '40': [3211], 'body': [3213, 3264, 3827], 'weight': [3214], 'i.p.;': [3215], 'DM': [3222, 3253, 3286, 3576], 'mice)12Shahzad': [3223], 'monitored': [3249], 'nondiabetic': [3250, 3283, 3300, 3393, 3876], '(Figure': [3258, 3314, 3489, 3615, 3649, 3691, 3806, 3879, 3889, 3918, 3962], '1a).': [3259], 'weights': [3265, 3828], 'comparable': [3267, 3306, 3492, 3830], 'between': [3268, 3831], 'wild-type': [3270, 3527, 3581, 3612, 3646, 3687, 3832, 3935, 3959], '(Nlrp3wt/wt': [3271], 'hereafter': [3275], '(control)': [3284], '(Supplementary': [3288, 3396, 3508, 3515, 3665, 3836, 3897, 3925, 3970], 'S1A': [3290], 'B).': [3292, 3840], 'We': [3293], 'observed': [3294, 3951], 'no': [3295], 'spontaneous': [3296], 'cleaved': [3309, 3404, 3864, 3867], 'pro–IL-1β': [3312], '1b–d),': [3315], 'agreement': [3319], 'previous': [3321, 3423], 'observations': [3322], 'organs.29Nazir': [3325], 'Scholar,30Toldo': [3351], 'Accordingly,': [3382], 'did': [3384, 3870], 'observe': [3386], 'changes': [3387], 'phenotype': [3391], 'S1C–E).': [3398], 'Upon': [3399], 'induction': [3400, 3718], 'hyperglycemia,': [3403, 3721], 'extracts': [3413], 'congruent': [3421], 'reports,12Shahzad': [3424], 'larger': [3480], 'extent,': [3481], '1b–d).': [3490], 'Despite': [3491], 'levels,': [3495], 'albuminuria': [3496, 3716, 3888], '(determined': [3497], 'albumin–creatinine': [3501], 'ratio;': [3502], '1e),': [3504], 'urea': [3506, 3892], 'nitrogen': [3507], 'S1F),': [3510], 'plasma': [3512, 3894], 'S1G)': [3517], 'compared': [3524, 3578, 3607, 3641, 3685, 3932, 3956], '(PodCre)': [3528, 3582, 3613, 3647, 3688, 3936, 3960], 'Similarly,': [3530, 3938], 'matrix': [3532, 3909], '(reflected': [3534, 3560, 3627], 'fractional': [3537], 'area': [3539, 3548, 3564], '[FMA];': [3540], '1f': [3542], 'g),': [3544], 'surface': [3547], '(calculated': [3549], 'based': [3550], 'periodic': [3552], 'acid–Schiff': [3553], 'staining;': [3554], '1h),': [3556], 'fibrosis': [3559, 3924], 'Masson-stained': [3563], '(%);': [3565], 'S2)': [3568], 'revealed': [3569], 'Ultrastructural': [3584], 'glomeruli': [3588], 'transmission': [3591], 'electron': [3592], 'microscopy': [3593], '(GBM)': [3599], '2a': [3616, 3650], 'b': [3618], 'Furthermore,': [3620], 'density': [3622, 3943], 'foot': [3625, 3632, 3947], 'processes': [3626, 3948], 'processes/μm': [3633], 'GBM)': [3634], 'reduced': [3636, 3680, 3887, 3907, 3942, 3992], 'c).': [3652], 'parallel,': [3654, 3966], 'death': [3657, 3969], '(cleaved': [3658], 'immunoblotting,': [3660], 'immunostaining)': [3662], 'S3A–D),': [3667], 'marker': [3670, 3975], '(nephrin': [3672, 3977], "Wilms'": [3674, 3979], 'tumor': [3675, 3980], 'gene,': [3677, 3982], 'WT-1)': [3678, 3983], '2d–g': [3692], 'S3E': [3696], 'F).': [3698], 'summary,': [3700], 'genetic': [3702], 'predisposition': [3703], 'upon': [3717], 'establishing': [3722], 'endogenous': [3743], 'depleted': [3755], 'complementary': [3762], 'crossing': [3765], 'KO': [3770], '(Nlrp3LoxP/LoxP)': [3771], 'Nlrp3KO-Pod': [3789, 3804, 3834, 3847, 3930, 3954, 3988], '3a': [3792], 'Immunoblotting': [3794], 'demonstrated': [3795], 'efficient': [3796], 'deletion': [3798], 'primary': [3800], 'isolated': [3802], '3a).': [3807], 'previously,': [3814], 'assessed': [3819], 'weeks.': [3822], 'S4A': [3838], 'Loss': [3841], 'resulted': [3849], 'marked': [3852, 3882], 'reduction': [3853, 3883], 'activation,': [3857], 'IL-1β,': [3868], 'differ': [3872], 'those': [3874], '3b–d).': [3880], '3E);': [3890], 'nitrogen;': [3893], 'S4C': [3899], 'D);': [3901], '(FMA;': [3911], '3f': [3913, 3919], 'g);': [3915], 'hypertrophy': [3917], 'h);': [3921], 'S5)': [3927], 'GBM': [3939], 'thickening': [3940], '4a–c': [3963], 'S6A–D)': [3972], 'remained': [3984], 'stable': [3985]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4283731092', 'counts_by_year': [{'year': 2024, 'cited_by_count': 32}, {'year': 2023, 'cited_by_count': 41}, {'year': 2022, 'cited_by_count': 3}], 'updated_date': '2024-12-13T10:19:52.985896', 'created_date': '2022-07-01'}
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