Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4283658829', 'doi': 'https://doi.org/10.1161/circresaha.122.320783', 'title': 'KMT2D-NOTCH Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome', 'display_name': 'KMT2D-NOTCH Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome', 'publication_year': 2022, 'publication_date': '2022-07-22', 'ids': {'openalex': 'https://openalex.org/W4283658829', 'doi': 'https://doi.org/10.1161/circresaha.122.320783', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35762338'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.122.320783', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.122.320783', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.122.320783', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102944226', 'display_name': 'Zhiyun Yu', 'orcid': 'https://orcid.org/0000-0001-6568-9978'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}, {'id': 'https://openalex.org/I63135867', 'display_name': 'University of Cincinnati', 'ror': 'https://ror.org/01e3m7079', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63135867']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhiyun Yu', 'raw_affiliation_strings': ['Center for Stem Cell and Organoid Medicine, CuSTOM, Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., Y.M., M.G.).', 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).', 'University of Cincinnati School of Medicine, Cincinnati, OH (Z.Y., M.G., Y.M., M.G.).'], 'affiliations': [{'raw_affiliation_string': 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'Center for Stem Cell and Organoid Medicine, CuSTOM, Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'University of Cincinnati School of Medicine, Cincinnati, OH (Z.Y., M.G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I63135867']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007171666', 'display_name': 'Xin Zhou', 'orcid': 'https://orcid.org/0000-0001-8089-4507'}, 'institutions': [{'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}, {'id': 'https://openalex.org/I25790992', 'display_name': 'Cardiovascular Institute of the South', 'ror': 'https://ror.org/02c2gwm94', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I25790992']}, {'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xin Zhou', 'raw_affiliation_strings': ['Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Department of Genetics (X.Z., M.P.S.), Stanford School of Medicine, Stanford, CA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics (X.Z., M.P.S.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}, {'raw_affiliation_string': 'Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I25790992']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100383204', 'display_name': 'Ziyi Liu', 'orcid': 'https://orcid.org/0000-0002-2460-6782'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ziyi Liu', 'raw_affiliation_strings': ["Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).'], 'affiliations': [{'raw_affiliation_string': 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041061724', 'display_name': 'Victor Pastrana-Gomez', 'orcid': 'https://orcid.org/0000-0002-0937-5517'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Victor Pastrana-Gomez', 'raw_affiliation_strings': ["Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).'], 'affiliations': [{'raw_affiliation_string': 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100345633', 'display_name': 'Yu Liu', 'orcid': 'https://orcid.org/0000-0001-7110-127X'}, 'institutions': [{'id': 'https://openalex.org/I25790992', 'display_name': 'Cardiovascular Institute of the South', 'ror': 'https://ror.org/02c2gwm94', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I25790992']}, {'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}, {'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yu Liu', 'raw_affiliation_strings': ['Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Department of Medicine, Division of Cardiovascular Medicine (Y.L., J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I25790992']}, {'raw_affiliation_string': 'Department of Medicine, Division of Cardiovascular Medicine (Y.L., J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011565179', 'display_name': 'Minzhe Guo', 'orcid': 'https://orcid.org/0000-0002-5502-9172'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}, {'id': 'https://openalex.org/I63135867', 'display_name': 'University of Cincinnati', 'ror': 'https://ror.org/01e3m7079', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63135867']}, {'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Minzhe Guo', 'raw_affiliation_strings': ['Center for Stem Cell and Organoid Medicine, CuSTOM, Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., Y.M., M.G.).', 'Department of Pediatrics, Division of Pediatric Cardiology (M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).', 'University of Cincinnati School of Medicine, Cincinnati, OH (Z.Y., M.G., Y.M., M.G.).'], 'affiliations': [{'raw_affiliation_string': 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'Center for Stem Cell and Organoid Medicine, CuSTOM, Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'University of Cincinnati School of Medicine, Cincinnati, OH (Z.Y., M.G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I63135867']}, {'raw_affiliation_string': 'Department of Pediatrics, Division of Pediatric Cardiology (M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100730429', 'display_name': 'Lei Tian', 'orcid': 'https://orcid.org/0000-0002-7485-9366'}, 'institutions': [{'id': 'https://openalex.org/I25790992', 'display_name': 'Cardiovascular Institute of the South', 'ror': 'https://ror.org/02c2gwm94', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I25790992']}, {'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lei Tian', 'raw_affiliation_strings': ['Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,"], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I25790992']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064878571', 'display_name': 'Timothy M. Olson', 'orcid': 'https://orcid.org/0000-0003-2716-9423'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}, {'id': 'https://openalex.org/I2802423016', 'display_name': 'WinnMed', 'ror': 'https://ror.org/02s47w807', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802423016']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Timothy J. Nelson', 'raw_affiliation_strings': ["Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Department of Molecular Pharmacology & Experimental Therapeutics (T.J.N.), Mayo Clinic, Rochester, MN.', 'Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine (T.J.N.), Mayo Clinic, Rochester, MN.', 'General Internal Medicine and Transplant Center, Department of Internal Medicine (T.J.N.), Mayo Clinic, Rochester, MN.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pharmacology & Experimental Therapeutics (T.J.N.), Mayo Clinic, Rochester, MN.', 'institution_ids': ['https://openalex.org/I1330342723']}, {'raw_affiliation_string': 'General Internal Medicine and Transplant Center, Department of Internal Medicine (T.J.N.), Mayo Clinic, Rochester, MN.', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine (T.J.N.), Mayo Clinic, Rochester, MN.', 'institution_ids': ['https://openalex.org/I2802423016', 'https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010947561', 'display_name': 'Nian Wang', 'orcid': 'https://orcid.org/0000-0001-6547-8580'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}, {'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I186667990', 'display_name': 'Neurosciences Institute', 'ror': 'https://ror.org/0460vf117', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I186667990']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nian Wang', 'raw_affiliation_strings': ["Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Department of Radiology and Imaging Sciences (N.W.), Indiana University, Indianapolis, IN.', 'Stark Neurosciences Research Institute (N.W.), Indiana University, Indianapolis, IN.'], 'affiliations': [{'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'Department of Radiology and Imaging Sciences (N.W.), Indiana University, Indianapolis, IN.', 'institution_ids': ['https://openalex.org/I55769427']}, {'raw_affiliation_string': 'Stark Neurosciences Research Institute (N.W.), Indiana University, Indianapolis, IN.', 'institution_ids': ['https://openalex.org/I55769427', 'https://openalex.org/I186667990']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071239027', 'display_name': 'Seema Mital', 'orcid': 'https://orcid.org/0000-0002-7643-4484'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Seema Mital', 'raw_affiliation_strings': ["Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,"], 'affiliations': [{'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011636981', 'display_name': 'David Chitayat', 'orcid': 'https://orcid.org/0000-0003-1944-7294'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}, {'id': 'https://openalex.org/I4210141030', 'display_name': 'SickKids Foundation', 'ror': 'https://ror.org/04374qe70', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210141030']}, {'id': 'https://openalex.org/I1291836623', 'display_name': 'Mount Sinai Hospital', 'ror': 'https://ror.org/05deks119', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1291836623', 'https://openalex.org/I4210130843']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'David Chitayat', 'raw_affiliation_strings': ['Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children (D.C.), University of Toronto, ON, Canada.', 'The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital (D.C.), University of Toronto, ON, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children (D.C.), University of Toronto, ON, Canada.', 'institution_ids': ['https://openalex.org/I185261750', 'https://openalex.org/I2801317318', 'https://openalex.org/I4210141030']}, {'raw_affiliation_string': 'The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital (D.C.), University of Toronto, ON, Canada.', 'institution_ids': ['https://openalex.org/I185261750', 'https://openalex.org/I1291836623']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047561254', 'display_name': 'Joseph C. Wu', 'orcid': 'https://orcid.org/0000-0001-7765-3112'}, 'institutions': [{'id': 'https://openalex.org/I194456095', 'display_name': 'California Institute for Regenerative Medicine', 'ror': 'https://ror.org/033m8b439', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I194456095']}, {'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}, {'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}, {'id': 'https://openalex.org/I25790992', 'display_name': 'Cardiovascular Institute of the South', 'ror': 'https://ror.org/02c2gwm94', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I25790992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph C. Wu', 'raw_affiliation_strings': ['Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Department of Medicine, Division of Cardiovascular Medicine (Y.L., J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.', 'Department of Radiology (J.C.W.), Stanford School of Medicine, Stanford, CA.', 'Institute for Stem Cell Biology and Regenerative Medicine (J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.'], 'affiliations': [{'raw_affiliation_string': 'Institute for Stem Cell Biology and Regenerative Medicine (J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I194456095']}, {'raw_affiliation_string': 'Department of Radiology (J.C.W.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I25790992']}, {'raw_affiliation_string': 'Department of Medicine, Division of Cardiovascular Medicine (Y.L., J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044292612', 'display_name': 'Marlene Rabinovitch', 'orcid': 'https://orcid.org/0000-0001-7886-7104'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}, {'id': 'https://openalex.org/I25790992', 'display_name': 'Cardiovascular Institute of the South', 'ror': 'https://ror.org/02c2gwm94', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I25790992']}, {'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marlene Rabinovitch', 'raw_affiliation_strings': ['Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Department of Pediatrics, Division of Pediatric Cardiology (M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.'], 'affiliations': [{'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I25790992']}, {'raw_affiliation_string': 'Department of Pediatrics, Division of Pediatric Cardiology (M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071721806', 'display_name': 'Sean M. Wu', 'orcid': 'https://orcid.org/0000-0002-0000-3821'}, 'institutions': [{'id': 'https://openalex.org/I25790992', 'display_name': 'Cardiovascular Institute of the South', 'ror': 'https://ror.org/02c2gwm94', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I25790992']}, {'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}, {'id': 'https://openalex.org/I194456095', 'display_name': 'California Institute for Regenerative Medicine', 'ror': 'https://ror.org/033m8b439', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I194456095']}, {'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sean M. Wu', 'raw_affiliation_strings': ['Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Department of Medicine, Division of Cardiovascular Medicine (Y.L., J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.', 'Department of Pediatrics, Division of Pediatric Cardiology (M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'Institute for Stem Cell Biology and Regenerative Medicine (J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I25790992']}, {'raw_affiliation_string': 'Department of Medicine, Division of Cardiovascular Medicine (Y.L., J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}, {'raw_affiliation_string': 'Institute for Stem Cell Biology and Regenerative Medicine (J.C.W., S.M.W.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I194456095']}, {'raw_affiliation_string': 'Department of Pediatrics, Division of Pediatric Cardiology (M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024120181', 'display_name': 'M Snyder', 'orcid': 'https://orcid.org/0000-0003-0784-7987'}, 'institutions': [{'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}, {'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael P. Snyder', 'raw_affiliation_strings': ["Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Department of Genetics (X.Z., M.P.S.), Stanford School of Medicine, Stanford, CA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics (X.Z., M.P.S.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.467; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051605432', 'display_name': 'Yifei Miao', 'orcid': 'https://orcid.org/0000-0002-8764-1067'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}, {'id': 'https://openalex.org/I63135867', 'display_name': 'University of Cincinnati', 'ror': 'https://ror.org/01e3m7079', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63135867']}, {'id': 'https://openalex.org/I25790992', 'display_name': 'Cardiovascular Institute of the South', 'ror': 'https://ror.org/02c2gwm94', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I25790992']}, {'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yifei Miao', 'raw_affiliation_strings': ['Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'Center for Stem Cell and Organoid Medicine, CuSTOM, Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., Y.M., M.G.).', 'Department of Pediatrics, Division of Pediatric Cardiology (M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).', 'University of Cincinnati School of Medicine, Cincinnati, OH (Z.Y., M.G., Y.M., M.G.).'], 'affiliations': [{'raw_affiliation_string': 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'Center for Stem Cell and Organoid Medicine, CuSTOM, Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'University of Cincinnati School of Medicine, Cincinnati, OH (Z.Y., M.G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I63135867']}, {'raw_affiliation_string': 'Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I25790992']}, {'raw_affiliation_string': 'Department of Pediatrics, Division of Pediatric Cardiology (M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I4210137306']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048865077', 'display_name': 'Mingxia Gu', 'orcid': 'https://orcid.org/0000-0001-7405-8473'}, 'institutions': [{'id': 'https://openalex.org/I25790992', 'display_name': 'Cardiovascular Institute of the South', 'ror': 'https://ror.org/02c2gwm94', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I25790992']}, {'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mingxia Gu', 'raw_affiliation_strings': ['Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular Institute (X.Z., Y.L., L.T., J.C.W., M.R., S.M.W., Y.M., M.G.), Stanford School of Medicine, Stanford, CA.', 'institution_ids': ['https://openalex.org/I25790992']}, {'raw_affiliation_string': 'Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': "Cincinnati Children's Hospital Medical Center, Room R4.464; MLC 7029, 3333 Burnet Ave, Cincinnati, OH 45229,", 'institution_ids': ['https://openalex.org/I1285204247']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 14, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.436913, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 81}, 'biblio': {'volume': '131', 'issue': '3', 'first_page': '280', 'last_page': '282'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11677', 'display_name': 'Molecular Mechanisms of Cardiac Development and Regeneration', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11677', 'display_name': 'Molecular Mechanisms of Cardiac Development and Regeneration', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10300', 'display_name': 'Epidemiology and Management of Congenital Heart Disease', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Molecular Basis of Rett Syndrome and Related Disorders', 'score': 0.9814, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/congenital-heart-defects', 'display_name': 'Congenital Heart Defects', 'score': 0.531974}, {'id': 'https://openalex.org/keywords/heart-regeneration', 'display_name': 'Heart Regeneration', 'score': 0.527688}], 'concepts': [{'id': 'https://openalex.org/C2779545397', 'wikidata': 'https://www.wikidata.org/wiki/Q1641399', 'display_name': 'Hypoplastic left heart syndrome', 'level': 3, 'score': 0.5026567}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.48415738}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3279165}, {'id': 'https://openalex.org/C2780074459', 'wikidata': 'https://www.wikidata.org/wiki/Q389735', 'display_name': 'Heart disease', 'level': 2, 'score': 0.14777109}], 'mesh': [{'descriptor_ui': 'D006330', 'descriptor_name': 'Heart Defects, Congenital', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018636', 'descriptor_name': 'Hypoplastic Left Heart Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003331', 'descriptor_name': 'Coronary Vessels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018636', 'descriptor_name': 'Hypoplastic Left Heart Syndrome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.122.320783', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.122.320783', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308708', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2021.08.30.457716', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2021/09/09/2021.08.30.457716.full.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35762338', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.122.320783', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.122.320783', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.43}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 5, 'referenced_works': ['https://openalex.org/W2145601239', 'https://openalex.org/W2292709386', 'https://openalex.org/W2811281266', 'https://openalex.org/W3038630761', 'https://openalex.org/W3049056316'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'HomeCirculation': [0], 'ResearchVol.': [1], '131,': [2, 2570], 'No.': [3], '3KMT2D-NOTCH': [4], 'Mediates': [5, 28], 'Coronary': [6, 29, 1074], 'Abnormalities': [7, 30], 'in': [8, 31, 1114, 1192, 1244, 1263, 1318, 1339, 1353, 1372, 1384, 1441, 1458, 1487, 1496, 1504, 1513, 1522, 1532, 1541, 1553, 1578, 1733, 1756, 1784, 1805, 1810, 1820, 1850, 1884, 1909, 1918, 1970, 1978, 2000, 2015, 2089, 2262, 2273], 'Hypoplastic': [9, 32, 1044, 2140], 'Left': [10, 33, 2141], 'Heart': [11, 34, 2142, 2176, 2205, 2227, 2579], 'Syndrome': [12, 35, 2143], 'Free': [13], 'AccessLetterPDF/EPUBAboutView': [14], 'PDFView': [15], 'EPUBSections': [16], 'ToolsAdd': [17], 'to': [18, 1103, 1172, 1222, 1361, 1588, 1900, 1965, 1992, 2047, 2311, 2427, 2557], 'favoritesDownload': [19], 'citationsTrack': [20], 'citationsPermissions': [21], 'ShareShare': [22], 'onFacebookTwitterLinked': [23], 'InMendeleyReddit': [24], 'Jump': [25], 'toFree': [26], 'AccessLetterPDF/EPUBKMT2D-NOTCH': [27], 'Zhiyun': [36, 75], 'Yu,': [37], 'Xin': [38, 149], 'Zhou,': [39], 'Ziyi': [40, 195], 'Liu,': [41, 45], 'Victor': [42, 225], 'Pastrana-Gomez,': [43], 'Yu': [44, 77, 135, 181, 255, 2171, 2302], 'Minzhe': [46, 299], 'Guo,': [47], 'Lei': [48, 382], 'Tian,': [49], 'Timothy': [50, 409], 'J.': [51, 410, 412], 'Nelson,': [52], 'Nian': [53, 473], 'Wang,': [54], 'Seema': [55, 505], 'Mital,': [56], 'David': [57, 530], 'Chitayat,': [58], 'Joseph': [59, 582], 'C.': [60, 583, 585], 'Wu,': [61, 66], 'Marlene': [62, 654], 'Rabinovitch,': [63], 'Sean': [64, 699], 'M.': [65, 700, 702], 'Michael': [67, 778], 'P.': [68, 779, 781, 2382], 'Snyder,': [69], 'Yifei': [70, 803, 808, 2335], 'Miao': [71, 805, 2401], 'and': [72, 102, 136, 182, 325, 421, 444, 480, 536, 556, 563, 625, 742, 855, 927, 1071, 1083, 1099, 1117, 1139, 1166, 1212, 1220, 1260, 1284, 1305, 1327, 1346, 1437, 1454, 1475, 1482, 1508, 1536, 1548, 1573, 1640, 1652, 1699, 1713, 1718, 1807, 1876, 1897, 1925, 1936, 1944, 1995, 2011, 2028, 2074, 2087, 2134, 2159, 2190, 2206, 2218, 2221, 2241, 2293, 2303, 2323, 2329, 2385, 2388, 2537], 'Mingxia': [73, 928, 933, 2357], 'Gu': [74, 930], 'YuZhiyun': [76], 'https://orcid.org/0000-0001-6568-9978': [78], 'Perinatal': [79, 198, 228, 302, 832, 958], 'Institute,': [80, 199, 229, 303, 833, 959], 'Division': [81, 106, 200, 230, 278, 304, 329, 360, 414, 533, 607, 677, 724, 756, 834, 859, 906, 960], 'of': [82, 107, 123, 126, 154, 160, 176, 201, 231, 271, 276, 279, 287, 305, 330, 346, 349, 358, 361, 370, 397, 415, 419, 430, 448, 478, 510, 518, 534, 540, 549, 561, 570, 600, 605, 608, 616, 632, 637, 642, 670, 675, 678, 687, 717, 722, 725, 733, 749, 754, 757, 766, 785, 791, 835, 860, 876, 879, 899, 904, 907, 916, 961, 978, 981, 1001, 1024, 1033, 1042, 1053, 1063, 1129, 1157, 1163, 1240, 1393, 1399, 1464, 1484, 1501, 1510, 1527, 1538, 1566, 1711, 1721, 1766, 1796, 1832, 1904, 1932, 1941, 1950, 1988, 1997, 2097, 2120, 2156, 2164, 2209, 2214, 2289, 2327, 2390, 2463, 2491], 'Pulmonary': [83, 202, 232, 306, 836, 962], 'Biology,': [84, 109, 203, 233, 307, 332, 837, 862, 963], 'Cincinnati': [85, 110, 124, 204, 234, 308, 333, 347, 811, 838, 863, 877, 937, 964, 979, 2338, 2361], 'Children’s': [86, 111, 205, 235, 309, 334, 812, 839, 864, 938, 965, 2339, 2362], 'Hospital': [87, 112, 206, 236, 310, 335, 512, 543, 567, 813, 840, 865, 939, 966, 2109, 2117, 2340, 2363], 'Medical': [88, 113, 207, 237, 311, 336, 557, 814, 841, 866, 940, 967, 2341, 2364], 'Center,': [89, 114, 208, 238, 312, 337, 446, 815, 842, 867, 941, 968, 2342, 2365], 'Cincinnati,': [90, 115, 128, 209, 239, 313, 338, 351, 823, 843, 868, 881, 949, 969, 983, 2350, 2373], 'OH': [91, 116, 129, 210, 240, 314, 339, 352, 824, 844, 869, 882, 950, 970, 984, 2351, 2374], '(Z.Y.,': [92, 117, 130, 211, 241, 315, 340, 353, 845, 870, 883, 971, 985], 'Z.L.,': [93, 118, 212, 242, 316, 341, 846, 871, 972], 'V.P.-G.,': [94, 119, 213, 243, 317, 342, 847, 872, 973], 'M.G.,': [95, 131, 214, 244, 318, 354, 848, 884, 974, 986], 'Y.M.,': [96, 120, 132, 172, 215, 245, 267, 319, 343, 355, 366, 393, 596, 666, 683, 713, 762, 849, 873, 885, 895, 912, 975, 987, 997], 'M.G.).': [97, 121, 133, 216, 246, 320, 344, 356, 850, 874, 886, 976, 988], 'Center': [98, 321, 456, 851, 2194], 'for': [99, 142, 188, 218, 248, 292, 322, 375, 402, 457, 466, 498, 513, 523, 544, 575, 621, 647, 692, 738, 771, 796, 852, 921, 1006, 1236, 2043, 2061, 2066, 2110, 2139, 2226, 2316], 'Stem': [100, 323, 622, 739, 853, 2432, 2503], 'Cell': [101, 324, 623, 740, 854], 'Organoid': [103, 326, 856], 'Medicine,': [104, 127, 161, 177, 272, 277, 288, 327, 350, 371, 398, 601, 606, 617, 633, 643, 671, 688, 718, 723, 734, 750, 767, 792, 857, 880, 900, 917, 982, 1002], 'CuSTOM,': [105, 328, 858], 'Developmental': [108, 331, 861], 'University': [122, 345, 517, 548, 569, 875, 977, 2096, 2163], 'School': [125, 159, 175, 270, 286, 348, 369, 396, 599, 615, 631, 641, 669, 686, 716, 732, 748, 765, 790, 878, 898, 915, 980, 1000], '*Z.': [134, 180], 'X.': [137, 183, 2182, 2304], 'Zhou': [138, 151, 184, 2183, 2305], 'contributed': [139, 185, 1964, 2306], 'equally.': [140, 186], 'Search': [141, 187, 217, 247, 291, 374, 401, 465, 497, 522, 574, 646, 691, 770, 795, 920, 1005], 'more': [143, 189, 219, 249, 293, 376, 403, 467, 499, 524, 576, 648, 693, 772, 797, 922, 1007, 1976], 'papers': [144, 190, 220, 250, 294, 377, 404, 468, 500, 525, 577, 649, 694, 773, 798, 923, 1008], 'by': [145, 191, 221, 251, 295, 378, 405, 469, 501, 526, 578, 650, 695, 774, 799, 924, 1009, 1060, 1091, 1231, 1270, 1669, 1687, 1708, 1744, 1866, 2094, 2125, 2203, 2233, 2318], 'this': [146, 192, 222, 252, 296, 379, 406, 470, 502, 527, 579, 651, 696, 775, 800, 925, 1010, 1025, 1034], 'author': [147, 193, 223, 253, 297, 380, 407, 471, 503, 528, 580, 652, 697, 776, 801, 926, 1011], ',': [148, 194, 224, 254, 298, 381, 408, 472, 504, 529, 581, 653, 698, 777, 802], 'ZhouXin': [150], 'https://orcid.org/0000-0001-8089-4507': [152], 'Department': [153, 275, 357, 418, 429, 447, 477, 509, 539, 560, 604, 636, 674, 721, 753, 784, 903], 'Genetics': [155, 558, 786], '(X.Z.,': [156, 166, 261, 387, 590, 660, 707, 787, 889, 991], 'M.P.S.),': [157, 788], 'Stanford': [158, 174, 269, 285, 368, 395, 598, 614, 630, 640, 668, 685, 715, 731, 747, 764, 789, 897, 914, 999, 2131, 2188], 'Stanford,': [162, 178, 273, 289, 372, 399, 602, 618, 634, 644, 672, 689, 719, 735, 751, 768, 793, 901, 918, 1003], 'CA.': [163, 179, 274, 290, 373, 400, 603, 619, 635, 645, 673, 690, 720, 736, 752, 769, 794, 902, 919, 1004], 'Cardiovascular': [164, 259, 280, 385, 588, 609, 658, 705, 726, 887, 989], 'Institute': [165, 260, 386, 491, 589, 620, 659, 706, 737, 888, 990, 2155], 'Y.L.,': [167, 262, 388, 591, 661, 708, 890, 992], 'L.T.,': [168, 263, 389, 592, 662, 709, 891, 993], 'J.C.W.,': [169, 264, 283, 390, 593, 612, 663, 710, 729, 892, 994], 'M.R.,': [170, 265, 391, 594, 664, 711, 893, 995], 'S.M.W.,': [171, 266, 365, 392, 595, 665, 682, 712, 761, 894, 911, 996], 'M.G.),': [173, 268, 367, 394, 597, 667, 684, 714, 763, 896, 913, 998], 'LiuZiyi': [196], 'Liu': [197, 257, 2478], 'Pastrana-GomezVictor': [226], 'Pastrana-Gomez': [227], 'LiuYu': [256], 'https://orcid.org/0000-0001-7110-127X': [258], 'Medicine': [281, 423, 443, 450, 459, 610, 627, 727, 744], '(Y.L.,': [282, 611, 728], 'S.M.W.),': [284, 613, 629, 730, 746], 'GuoMinzhe': [300], 'Guo': [301], 'Pediatrics,': [359, 511, 541, 676, 755, 905], 'Pediatric': [362, 416, 420, 679, 758, 908], 'Cardiology': [363, 680, 759, 909], '(M.R.,': [364, 681, 760, 910], 'TianLei': [383], 'Tian': [384, 2403], 'NelsonTimothy': [411], 'Nelson': [413], 'Cardiology,': [417], 'Adolescent': [422], '(T.J.N.),': [424, 436, 451, 460], 'Mayo': [425, 437, 452, 461, 2079, 2145], 'Clinic,': [426, 438, 453, 462, 2146], 'Rochester,': [427, 439, 454, 463, 2056], 'MN.': [428, 440, 455, 464], 'Molecular': [431], 'Pharmacology': [432], '&': [433, 2236], 'Experimental': [434], 'Therapeutics': [435], 'General': [441], 'Internal': [442, 449], 'Transplant': [445], 'Regenerative': [458, 626, 743], 'WangNian': [474], 'Wang': [475], 'https://orcid.org/0000-0001-6547-8580': [476], 'Radiology': [479, 638], 'Imaging': [481], 'Sciences': [482], '(N.W.),': [483, 492], 'Indiana': [484, 493], 'University,': [485, 494, 2132], 'Indianapolis,': [486, 495], 'IN.': [487, 496], 'Stark': [488], 'Neurosciences': [489], 'Research': [490, 2168, 2193, 2216], 'MitalSeema': [506], 'Mital': [507, 2200, 2283], 'https://orcid.org/0000-0002-7643-4484': [508], 'Sick': [514, 545, 2111], 'Children': [515, 546, 2112], '(S.M.),': [516], 'Toronto,': [519, 550, 571], 'ON,': [520, 551, 572], 'Canada.': [521, 552, 573], 'ChitayatDavid': [531], 'Chitayat': [532], 'Clinical': [535], 'Metabolic': [537], 'Genetics,': [538], 'The': [542, 553, 1972, 2296, 2383], '(D.C.),': [547, 568], 'Prenatal': [554], 'Diagnosis': [555], 'Program,': [559], 'Obstetrics': [562], 'Gynecology,': [564], 'Mount': [565, 2115], 'Sinai': [566, 2116], 'WuJoseph': [584], 'Wu': [586, 703, 2230], 'https://orcid.org/0000-0002-6068-8041': [587], 'Biology': [624, 741, 2602], '(J.C.W.,': [628, 745], '(J.C.W.),': [639], 'RabinovitchMarlene': [655], 'Rabinovitch': [656], 'https://orcid.org/0000-0001-7886-7104': [657], 'WuSean': [701], 'https://orcid.org/0000-0002-0000-3821': [704], 'SnyderMichael': [780], 'Snyder': [782], 'https://orcid.org/0000-0003-0784-7987': [783], 'MiaoYifei': [804], 'Correspondence': [806, 931], 'to:': [807, 932, 2334, 2356], 'Miao,': [809, 2336], 'PhD,': [810, 936, 2337, 2360], 'Room': [816, 942, 2343, 2366], 'R4.467;': [817, 2344], 'MLC': [818, 944, 2345, 2368], '7029,': [819, 945, 2346, 2369], '3333': [820, 946, 2347, 2370], 'Burnet': [821, 947, 2348, 2371], 'Ave,': [822, 948, 2349, 2372], '45229,': [825, 951, 2352, 2375], 'Email': [826, 952, 2353, 2376], 'E-mail': [827, 953], 'Address:': [828, 954], '[email': [829, 955], 'protected]': [830, 956], 'https://orcid.org/0000-0002-8764-1067': [831], 'GuMingxia': [929], 'Gu,': [934, 2358], 'MD,': [935, 2359], 'R4.464;': [943, 2367], 'https://orcid.org/0000-0001-7405-8473': [957], 'Originally': [1012, 2583], 'published28': [1013], 'Jun': [1014], '2022https://doi.org/10.1161/CIRCRESAHA.122.320783Circulation': [1015], 'Research.': [1016, 2228, 2565], '2022;131:280–282is': [1017], 'related': [1018], 'toMeet': [1019], 'the': [1020, 1029, 1061, 1064, 1111, 1182, 1189, 1227, 1241, 1366, 1415, 1564, 1670, 1677, 1709, 1719, 1794, 1797, 1817, 1821, 1829, 1901, 1930, 1951, 1966, 2007, 2048, 2059, 2062, 2090, 2095, 2150, 2187, 2204, 2222, 2251, 2263, 2274, 2286, 2562], 'First': [1021, 1183, 2563], 'AuthorsOther': [1022], 'version(s)': [1023], 'articleYou': [1026], 'are': [1027, 1916], 'viewing': [1028], 'most': [1030], 'recent': [1031], 'version': [1032], 'article.': [1035], 'Previous': [1036, 2555], 'versions:': [1037], 'June': [1038], '28,': [1039, 2585], '2022:': [1040], 'Ahead': [1041], 'Print': [1043], 'left': [1045, 1065, 1136, 1386, 1403, 1408, 2392, 2429, 2593], 'heart': [1046, 1057, 1132, 1196, 1205, 1246, 1387, 1409, 1489, 1515, 1543, 1737, 1787, 2393, 2430, 2594], 'syndrome': [1047, 1388], '(HLHS)': [1048], 'is': [1049, 2201, 2231], 'a': [1050, 1104, 1658, 1858, 1868, 2032, 2540], 'severe': [1051], 'form': [1052], 'single': [1054, 2126], 'ventricle': [1055, 1137, 1404, 2127], 'congenital': [1056], 'disease': [1058], 'characterized': [1059], 'underdevelopment': [1062], 'ventricle,': [1066], 'mitral': [1067], 'valve,': [1068, 1070], 'aortic': [1069], 'ascending': [1072], 'aorta.': [1073], 'arterial': [1075, 1085, 1159, 1164, 1333, 1368, 1920, 1998], 'abnormalities': [1076, 1371, 1383, 1969, 2027], 'such': [1077, 1274, 1322], 'as': [1078, 1275, 1323, 1622, 1633, 1667, 2058], 'thickened': [1079], 'wall,': [1080], 'kinking': [1081], 'arteries,': [1082], 'coronary': [1084, 1115, 1158, 1194, 1367, 1381, 1886, 1967, 1979, 2012, 2386, 2469], 'fistulous': [1086], 'communications': [1087], 'have': [1088, 2259], 'been': [1089, 2260], 'revealed': [1090, 1792, 1892, 1959], 'postmortem': [1092], 'examinations,1': [1093], 'which': [1094, 1169, 1349, 1915, 2003], 'may': [1095, 2004], 'impact': [1096], 'ventricular': [1097], 'development': [1098], 'intracardiac': [1100], 'hemodynamics,': [1101], 'leading': [1102], 'poor': [1105], 'prognosis': [1106], 'after': [1107], 'surgical': [1108], 'palliation.1': [1109], 'However,': [1110], 'intrinsic': [1112], 'defect': [1113, 1755, 1963], 'vessels': [1116], 'its': [1118], 'genetic': [1119, 1818], 'basis': [1120], 'remain': [1121], 'unclear.': [1122], 'Through': [1123], 'single-cell': [1124], 'RNA': [1125, 1377, 2255], 'sequencing': [1126, 1378, 2256], '(scRNA-seq)': [1127, 1379], 'analysis': [1128, 1295, 1392, 1431, 1463, 1752, 2462], 'human': [1130, 1203, 1406, 1488, 1514, 1542, 1735, 1811, 2498], 'fetal': [1131, 1204, 1245, 1407, 1736, 1786, 1812, 2017], 'with': [1133, 1150, 1161, 1313, 1618, 1676, 1696, 1749, 1982], 'an': [1134, 1154], 'underdeveloped': [1135, 1402], '(ULV)': [1138, 1405], 'endothelial': [1140, 1808, 2495], 'cells': [1141, 1148, 2466, 2496], '(ECs)': [1142], 'differentiated': [1143], 'from': [1144, 1201, 1599, 1649, 2071, 2130, 2144, 2149, 2174, 2186, 2250, 2497], 'induced': [1145, 1465], 'pluripotent': [1146, 1466, 2499, 2590], 'stem': [1147, 1467, 2591], '(iPSCs)': [1149], 'HLHS,': [1151], 'we': [1152, 1249, 1645, 1791, 1824, 1826], 'uncovered': [1153, 1380], 'abnormal': [1155], 'population': [1156, 1229], 'ECs': [1160, 1197, 1214, 1259, 1308, 1369, 1395, 1411, 1444], 'loss': [1162], 'features': [1165, 1999], 'decreased': [1167, 1521, 1700, 1764, 2008], 'proliferation,': [1168, 1343], 'were': [1170, 1199, 1268, 1350, 1412, 1456, 1551, 1684, 1802, 1975, 2092, 2104], 'attributed': [1171], 'HLHS': [1173, 1193, 1497, 1523, 1528, 1554, 1567, 1579, 1651, 1661, 1691, 1734, 1761, 1785, 1798, 1822, 1838, 1851, 1885, 1911, 1942, 2001, 2016, 2023], 'de': [1174], 'novo': [1175], 'mutation': [1176], '(DNM)': [1177], 'KMT2D-mediated': [1178, 1961], 'NOTCH': [1179, 1347, 1492, 1502, 1560, 1754, 1767, 1777, 1906, 1933, 1952, 1962, 1989, 2020], 'signaling': [1180, 1990], 'defect.Meet': [1181], 'Author,': [1184], 'see': [1185, 2331], 'p': [1186], '188To': [1187], 'reveal': [1188], 'transcriptomic': [1190], 'changes': [1191], 'vessels,': [1195], '(CDH5+)': [1198], 'sorted': [1200], 'dissociated': [1202], '(healthy': [1206], 'control': [1207, 1217, 1304, 1400, 1654, 1678, 2073], 'versus': [1208, 1218], 'ULV)': [1209], '(Figure': [1210, 1290, 1309, 1679, 1704, 1746, 1759, 1789, 1853, 1888, 1913, 1954], '[A])': [1211], 'iPSC-derived': [1213], '(iPSC-ECs,': [1215], 'healthy': [1216], 'HLHS)2': [1219], 'subjected': [1221], 'scRNA-seq.': [1223], 'We': [1224, 1840, 2050], 'first': [1225, 1827], 'excluded': [1226, 1261], 'endocardial': [1228, 1806, 2424], '(NPR3+)': [1230], 'selecting': [1232], 'CDH5+/NPR3−': [1233], 'vascular': [1234, 1247, 1258, 1307, 1394, 1410, 1443, 2009], 'ECs2': [1235], 'downstream': [1237, 1949], 'analysis.': [1238], 'Out': [1239], '6': [1242], 'sub-clusters': [1243], 'ECs,': [1248], 'focused': [1250], 'on': [1251, 1299, 1364, 1414, 1434, 1595, 2285], '4': [1252], 'clusters': [1253], '(Cluster': [1254], '0–3)': [1255], 'containing': [1256], 'predominate': [1257], 'those': [1262], 'transitional': [1264, 1423], 'states.': [1265], 'EC': [1266, 1320, 1328, 1342, 1355, 1470], 'subtypes': [1267], 'annotated': [1269], 'multiple': [1271], 'cell-type-specific': [1272], 'markers,': [1273], 'vein': [1276], '(NR2F2+,': [1277], 'Cluster': [1278, 1282, 1288], '0&2),': [1279], 'artery': [1280, 1286, 1344, 1382, 2013], '(MECOM+,': [1281], '1&3),': [1283], 'late': [1285, 1332, 1419], '(GJA5+,': [1287], '1)3': [1289], '[A],': [1291, 1310], 'left).': [1292, 1681], 'Gene': [1293], 'ontology': [1294, 1430, 1751], 'was': [1296, 1432, 1494, 1520, 1730, 1781, 1881, 2069, 2123, 2309], 'performed': [1297, 1433], 'based': [1298, 1594], 'differentially': [1300], 'expressed': [1301], 'genes': [1302, 1503, 1716, 1769, 1801, 1843, 1908, 1948], 'between': [1303], 'ULV': [1306, 1315, 1442, 1757], 'right).': [1311], 'Compared': [1312], 'control,': [1314], 'showed': [1316, 1438, 1575], 'defects': [1317, 1338, 1974, 2425], 'general': [1319], 'functions': [1321], 'cell': [1324, 1468, 1689, 1702, 1926, 1939, 1985], 'junction': [1325], 'organization': [1326], 'migration.': [1329], 'Notably,': [1330, 2019], 'C1': [1331], 'cluster': [1334, 1436], 'exhibited': [1335, 1663, 1763], 'cell-type': [1336], 'specific': [1337], 'endothelium': [1340], 'development,': [1341], 'morphogenesis,': [1345], 'signaling,': [1348], 'not': [1351, 1727, 2271], 'observed': [1352, 1783], 'other': [1354, 1983, 2297], 'subclusters.': [1356], 'These': [1357], 'results': [1358], 'intrigued': [1359], 'us': [1360], 'further': [1362, 1685, 1731, 1815], 'focus': [1363], 'understanding': [1365], '(AECs)': [1370], 'HLHS.Download': [1373], 'figureDownload': [1374], 'PowerPointFigure.': [1375], 'Single-cell': [1376, 2254, 2461], 'hypoplastic': [1385, 2391, 2428], '(HLHS).': [1389], 'A,': [1390, 2414, 2454], 'scRNA-seq': [1391], '(CDH5+/NPR3−).': [1396], 'UMAP': [1397], 'projection': [1398], 'vs': [1401, 1445], 'shown': [1413, 2272], 'left.': [1416], 'Cluster1:': [1417], 'GJA5+': [1418], 'artery.': [1420], 'Cluster4:': [1421], 'venous-to-endocardial': [1422], 'population.': [1424], 'N=1': [1425], 'per': [1426], 'group.': [1427], 'Then,': [1428], 'gene': [1429, 1530, 1750, 1864, 2025], 'each': [1435], 'downregulated': [1439], 'pathways': [1440], 'control.': [1446, 1589], 'GO': [1447], 'terms:': [1448], 'adjusted': [1449], 'P<0.05.': [1450], 'B,': [1451, 2456], 'Artery': [1452, 2599], 'differentiation': [1453, 1666], 'proliferation': [1455, 1565, 1571, 1577, 1695, 1927, 1940, 1994], 'impaired': [1457, 1664, 1694, 1993], 'HLHS.': [1459, 1971], 'Ba,': [1460], 'Flow': [1461], 'cytometry': [1462], '(iPSC)-arterial': [1469], '(AEC)': [1471], 'progenitors': [1472, 1674], 'percentage': [1473, 1703], '(left)': [1474], 'their': [1476], 'cell-cycle': [1477], 'statuses': [1478], '(right).': [1479], 'Bb,': [1480], 'Immunostaining': [1481, 1507, 1535], 'quantification': [1483, 1509, 1537], 'Ki67+': [1485], 'arteries': [1486, 1512, 1540, 1887], 'tissue.': [1490, 1516, 1544], 'C,': [1491], 'pathway': [1493, 1953], 'suppressed': [1495], 'AECs.': [1498, 1524], 'Ca,': [1499], 'qPCR': [1500, 1526, 1574], 'iPSC-AECs.': [1505, 1568, 1580], 'Cb,': [1506], 'NICD+': [1511], 'D,': [1517], 'KMT2D': [1518, 1878, 1894, 2538], 'expression': [1519, 1531, 1765, 1830, 2026], 'Da,': [1525], 'DNM': [1529], 'iPSC-ECs.': [1533], 'Db,': [1534], 'KMT2D+': [1539], 'E,': [1545], 'KMT2D-binding': [1546], 'capacity': [1547, 1896], 'H3K4me2': [1549, 1898], 'signal': [1550], 'reduced': [1552, 1671, 1740, 1849, 1883, 1893], 'iPSC-AECs': [1555, 1762], '(evaluated': [1556], 'via': [1557, 1872], 'ChIP-qPCR).': [1558], 'F,': [1559, 2511], 'ligands': [1561, 2021], 'treatment': [1562, 1931], 'improved': [1563, 1576, 1938], 'Both': [1569], 'BrdU': [1570], 'assay': [1572], 'N=4': [1581], 'technical': [1582], 'repeats.': [1583], 'FC:': [1584], 'fold': [1585], 'change': [1586], 'normalized': [1587], 'Statistics': [1590], '(GraphPad': [1591], 'Prism': [1592], '9.3.1):': [1593], 'additional': [1596], 'literature': [1597], 'support': [1598, 2173, 2185], 'similar': [1600], 'studies,': [1601], 'our': [1602, 1957], 'samples': [1603], 'fit': [1604], 'normal': [1605], 'distribution.': [1606], 'Parametric': [1607], 'test:': [1608, 1625], 'unpaired': [1609], '2-tailed': [1610], 't': [1611], 'test': [1612], '(2': [1613, 1627], 'groups),': [1614], 'ANOVA': [1615], '(>2': [1616], 'groups)': [1617], 'post': [1619], 'hoc': [1620], 'tests': [1621], 'indicated;': [1623], 'nonparametric': [1624], 'Mann-Whitney': [1626], 'groups).': [1628], 'Mean±SEM;': [1629], 'n=': [1630], 'biological': [1631], 'replicates': [1632], 'indicated.': [1634], 'aSMA': [1635], 'indicates': [1636], 'smooth': [1637], 'muscle': [1638], 'actin;': [1639], 'UMI,': [1641], 'unique': [1642], 'molecular': [1643], 'identifier.Next,': [1644], 'generated': [1646], 'pure': [1647], 'AECs': [1648, 1683, 1692, 1742, 1758, 1912, 1943, 1968, 1980], '3': [1650, 2572], 'age-matched': [1653], 'iPSC': [1655, 2063, 2067], 'lines2': [1656], 'using': [1657], 'published': [1659], 'protocol.4': [1660], 'iPSCs': [1662], 'AEC': [1665, 1673], 'evidenced': [1668], 'CXCR4+NT5E−/low': [1672], 'compared': [1675, 1981], '[B]a,': [1680, 1705], 'Mature': [1682], 'enriched': [1686, 1804], 'CXCR4+': [1688], 'sorting.': [1690], 'demonstrated': [1693], 'increased': [1697], 'G0/G1': [1698], 'S/G2/M': [1701], 'right),': [1706], 'accompanied': [1707], 'downregulation': [1710], 'Ki67': [1712, 1745], 'G1/S': [1714, 1722, 1946], 'transition': [1715, 1723, 1947], '(CCND1/2),': [1717], 'upregulation': [1720], 'inhibitor': [1724], 'CDKN2A/P16': [1725], '(data': [1726], 'shown).': [1728], 'This': [1729], 'validated': [1732], 'tissue': [1738, 1788, 2102], 'showing': [1739, 1753], 'proliferative': [1741], 'labeled': [1743], '[B]b).': [1747], 'Consistent': [1748], '[A]),': [1760], 'targeted': [1768, 1907], '(eg,': [1770, 1844], 'DLL4,': [1771], 'HEY1,': [1772], 'NOTCH1;': [1773], 'Figure': [1774], '[C]a).': [1775], 'Reduced': [1776], 'intracellular': [1778], 'domain': [1779], '(NICD)': [1780], 'also': [1782, 1882, 2051], '[C]b).Previously,': [1790], 'that': [1793, 1847, 1960, 2467], 'majority': [1795], 'DNMs': [1799], 'encoded': [1800], 'highly': [1803], 'populations': [1809], 'heart.2': [1813], 'To': [1814], 'understand': [1816], 'underpinnings': [1819], 'cases': [1823], 'studied,': [1825], 'examined': [1828], 'levels': [1831], 'several': [1833, 1905], 'key': [1834], 'chromatin': [1835, 1870, 2542], 'remodelers': [1836], 'harboring': [1837], 'DNMs.': [1839], 'identified': [1841], '5': [1842], 'FOXM1,': [1845], 'KMT2D)': [1846], 'significantly': [1848], 'iPSC-ECs': [1852], '[D]a).': [1854], 'Among': [1855], 'them,': [1856], 'KMT2D,': [1857], 'lysine': [1859], 'methyltransferase,': [1860], 'favors': [1861], 'NICD-RBPJ': [1862], 'complex-mediated': [1863], 'activation': [1865], 'maintaining': [1867, 1919], 'permissive': [1869, 2541], 'status': [1871], 'catalyzing': [1873], 'H3K4me1,': [1874], 'me2': [1875], 'me3.5': [1877], 'protein': [1879], 'level': [1880], '[D]b).': [1889], 'Additionally,': [1890], 'ChIP-qPCR': [1891], 'binding': [1895], 'signals': [1899], 'promoter': [1902], 'loci': [1903], 'mature': [1910], '[E]),': [1914], 'critical': [1917], 'characteristics': [1921], '(DLL4,': [1922], 'HEY1/2,': [1923], 'HES1)': [1924], '(CCND1).': [1928], 'Intriguingly,': [1929], 'ligand': [1934], 'Jag1': [1935], 'Dll1': [1937], 'upregulated': [1945], '[F]).In': [1955], 'summary,': [1956], 'study': [1958], 'NOTCH-related': [1973], 'pronounced': [1977], 'cardiac': [1984], 'types.': [1986], 'Disruption': [1987], 'led': [1991], 'maintenance': [1996], 'AECs,': [2002], 'partially': [2005], 'explain': [2006], 'density': [2010], 'malformation': [2014], 'heart.1': [2018], 'rescued': [2022], 'associated': [2024], 'cellular': [2029], 'phenotypes,': [2030], 'providing': [2031, 2044], 'potential': [2033], 'therapeutic': [2034], 'target.Article': [2035], 'InformationAcknowledgmentsWe': [2036], 'thank': [2037, 2052], 'Drs': [2038], 'Kyle': [2039], 'Loh,': [2040], 'Nanhua': [2041], 'Zhang': [2042, 2415], 'intellectual': [2045], 'consultant': [2046], 'project.': [2049], 'ReGen': [2053], 'Theranostics,': [2054], 'Inc': [2055], 'MN': [2057], 'manufacturer': [2060], 'lines.': [2064], 'Consent': [2065], 'generation': [2068], 'obtained': [2070, 2105], 'both': [2072], 'patients': [2075], 'under': [2076, 2106, 2195, 2266], 'approved': [2077, 2093, 2107], 'IRBs:': [2078, 2108], 'Clinic:': [2080], '10-006845;': [2081], 'Stanford:': [2082], 'IRB': [2083, 2099, 2113], '5443.': [2084], 'Tissue': [2085], 'collection': [2086], 'use': [2088], 'research': [2091], 'Washington:': [2098], 'STUDY00000380.': [2100], 'Human': [2101, 2160], 'sections': [2103], '1000011284;': [2114], 'REB#': [2118], '08-0009-E.Sources': [2119], 'FundingThis': [2121], 'work': [2122], 'supported': [2124], 'gift': [2128], 'fund': [2129], 'Todd': [2133], 'Karen': [2135], 'Wanek': [2136], 'Family': [2137], 'Program': [2138], 'NIH': [2147], '2R24HD000836-52': [2148], 'Eunice': [2151], 'Kennedy': [2152], 'Shriver': [2153], 'National': [2154], 'Child': [2157], 'Health': [2158, 2215], 'Development': [2161], '(The': [2162], 'Washington': [2165], 'Birth': [2166], 'Defects': [2167], 'Laboratory).': [2169], 'Z.': [2170], 'received': [2172, 2184], 'American': [2175, 2578], 'Association': [2177], '(AHA)': [2178], 'predoctoral': [2179], 'fellowship': [2180], '(Jan/2022-Dec/2023).': [2181], 'Aging': [2189], 'Ethnogeriatrics': [2191], '(SAGE)': [2192], 'NIH/NIA': [2196], 'grant': [2197], 'P30AG059307.': [2198], 'S.': [2199, 2282], 'funded': [2202, 2232], 'Stroke': [2207], 'Foundation': [2208], 'Canada': [2210], 'Chair,': [2211], 'Canadian': [2212], 'Institutes': [2213], '(CIHR)': [2217], 'ERA': [2219], 'PerMed,': [2220], 'Ted': [2223], 'Rogers': [2224], 'Centre': [2225], 'J.C.': [2229], 'R01': [2234, 2237], 'HL141371': [2235], 'HL126527.Data': [2238], 'AvailabilityRaw': [2239], 'data': [2240], 'complete': [2242], 'methods': [2243], 'can': [2244, 2277], 'be': [2245, 2278], 'made': [2246], 'available': [2247], 'upon': [2248], 'request': [2249], 'corresponding': [2252], 'author.': [2253], 'Seurat': [2257], 'object': [2258], 'deposited': [2261], 'GEO': [2264], 'database': [2265], 'accession': [2267], 'number': [2268], 'GSE138979.': [2269], 'Data': [2270], 'main': [2275], 'figure': [2276], 'accessed': [2279], 'via:': [2280], 'https://www.biorxiv.org/content/10.1101/2021.08.30.457716v3.Disclosures': [2281], 'serves': [2284], 'Advisory': [2287], 'Boards': [2288], 'Bristol': [2290], 'Myers': [2291], 'Squibb,': [2292], 'Tenaya': [2294], 'Therapeutics.': [2295], 'authors': [2298], 'report': [2299], 'no': [2300], 'conflicts.Footnotes*Z.': [2301], 'equally.This': [2307], 'manuscript': [2308], 'sent': [2310], 'Joyce': [2312], 'Bischoff,': [2313], 'Guest': [2314], 'Editor,': [2315], 'review': [2317], 'expert': [2319], 'referees,': [2320], 'editorial': [2321], 'decision,': [2322], 'final': [2324], 'disposition.For': [2325], 'Sources': [2326], 'Funding': [2328], 'Disclosures,': [2330], 'page': [2332], '282.Correspondence': [2333], 'yifei.[email': [2354], 'protected]orgCorrespondence': [2355], 'mingxia.[email': [2377], 'protected]orgReferences1.': [2378], 'Cole': [2379], 'CR,': [2380], 'Eghtesady': [2381], 'myocardial': [2384], 'histopathology': [2387], 'pathogenesis': [2389], 'syndrome.Cardiol': [2394], 'Young.': [2395], '2016;': [2396, 2550], '26:19–29.': [2397], 'doi:': [2398, 2436, 2473, 2507, 2552], '10.1017/S1047951115001171CrossrefMedlineGoogle': [2399], 'Scholar2.': [2400], 'Y,': [2402, 2420], 'L,': [2404, 2519], 'Martin': [2405], 'M,': [2406], 'Paige': [2407], 'SL,': [2408], 'Galdos': [2409], 'FX,': [2410], 'Li': [2411], 'J,': [2412], 'Klein': [2413], 'H,': [2416], 'Ma': [2417], 'N,': [2418, 2527], 'Wei': [2419], 'et': [2421, 2459, 2530], 'al.': [2422, 2460, 2531], 'Intrinsic': [2423], 'contribute': [2426], 'syndrome.Cell': [2431], 'Cell.': [2433, 2504], '2020;': [2434, 2505], '27:574–589.e8.': [2435], '10.1016/j.stem.2020.07.015CrossrefMedlineGoogle': [2437], 'Scholar3.': [2438], 'Su': [2439], 'T,': [2440], 'Stanley': [2441], 'G,': [2442, 2446, 2521], 'Sinha': [2443], 'R,': [2444], 'D’Amato': [2445], 'Das': [2447], 'S,': [2448, 2450], 'Rhee': [2449], 'Chang': [2451], 'AH,': [2452], 'Poduri': [2453], 'Raftrey': [2455], 'Dinh': [2457], 'TT,': [2458], 'early': [2464], 'progenitor': [2465], 'build': [2468], 'arteries.Nature.': [2470], '2018;': [2471], '559:356–362.': [2472], '10.1038/s41586-018-0288-7CrossrefMedlineGoogle': [2474], 'Scholar4.': [2475], 'Gage': [2476], 'BK,': [2477], 'JC,': [2479], 'Innes': [2480], 'BT,': [2481], 'MacParland': [2482], 'SA,': [2483], 'McGilvray': [2484], 'ID,': [2485], 'Bader': [2486], 'GD,': [2487], 'Keller': [2488], 'GM.': [2489], 'Generation': [2490], 'functional': [2492], 'liver': [2493], 'sinusoidal': [2494], 'stem-cell-derived': [2500], 'venous': [2501], 'angioblasts.Cell': [2502], '27:254–269.e9.': [2506], '10.1016/j.stem.2020.06.007CrossrefMedlineGoogle': [2508], 'Scholar5.': [2509], 'Oswald': [2510], 'Rodriguez': [2512], 'P,': [2513], 'Giaimo': [2514], 'BD,': [2515], 'Antonello': [2516], 'ZA,': [2517], 'Mira': [2518], 'Mittler': [2520], 'Thiel': [2522], 'VN,': [2523], 'Collins': [2524], 'KJ,': [2525], 'Tabaja': [2526], 'Cizelsky': [2528], 'W,': [2529], 'A': [2532], 'phospho-dependent': [2533], 'mechanism': [2534], 'involving': [2535], 'NCoR': [2536], 'controls': [2539], 'state': [2543], 'at': [2544], 'Notch': [2545], 'target': [2546], 'genes.Nucleic': [2547], 'Acids': [2548], 'Res.': [2549], '44:4703–4720.': [2551], '10.1093/nar/gkw105CrossrefMedlineGoogle': [2553], 'Scholar': [2554], 'Back': [2556], 'top': [2558], 'Next': [2559], 'FiguresReferencesRelatedDetailsRelated': [2560], 'articlesMeet': [2561], 'AuthorsCirculation': [2564], '2022;131:186-188': [2566], 'July': [2567], '22,': [2568], '2022Vol': [2569], 'Issue': [2571], 'Advertisement': [2573, 2597], 'Article': [2574], 'InformationMetrics': [2575], '©': [2576], '2022': [2577, 2586], 'Association,': [2580], 'Inc.https://doi.org/10.1161/CIRCRESAHA.122.320783PMID:': [2581], '35762338': [2582], 'publishedJune': [2584], 'KeywordsNOTCHcoronary': [2587], 'vesselsendothelial': [2588], 'cellsinduced': [2589], 'cellshypoplastic': [2592], 'syndromePDF': [2595], 'download': [2596], 'SubjectsCoronary': [2598], 'DiseaseEtiologyStem': [2600], 'CellsVascular': [2601]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4283658829', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}], 'updated_date': '2024-09-12T09:35:51.847382', 'created_date': '2022-06-29'}