Publication Information

{'id': 'https://openalex.org/W4282980536', 'doi': 'https://doi.org/10.1158/1538-7445.am2022-3001', 'title': 'Abstract 3001: Targeting autophagy in acute lymphoblastic leukemia: Synergism between ponatinib, hydroxychloroquine and rapamycin', 'display_name': 'Abstract 3001: Targeting autophagy in acute lymphoblastic leukemia: Synergism between ponatinib, hydroxychloroquine and rapamycin', 'publication_year': 2022, 'publication_date': '2022-06-15', 'ids': {'openalex': 'https://openalex.org/W4282980536', 'doi': 'https://doi.org/10.1158/1538-7445.am2022-3001'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2022-3001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019004022', 'display_name': 'Andrea Ghelli Luserna di Rorà', 'orcid': 'https://orcid.org/0000-0002-9744-0533'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Ghelli Luserna Di Rora', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003869748', 'display_name': 'Eugenio Fonzi', 'orcid': 'https://orcid.org/0000-0001-8389-8220'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Eugenio Fonzi', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013862049', 'display_name': 'Lorenzo Ledda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Lorenzo Ledda', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071795681', 'display_name': 'Roberta Napolitano', 'orcid': 'https://orcid.org/0000-0003-3682-9606'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Roberta Napolitano', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016048586', 'display_name': 'Anna Ferrari', 'orcid': 'https://orcid.org/0000-0002-7022-9906'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Anna Ferrari', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070404868', 'display_name': 'Antonella Padella', 'orcid': 'https://orcid.org/0000-0001-9991-992X'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Antonella Padella', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023829300', 'display_name': 'Martina Ghetti', 'orcid': 'https://orcid.org/0000-0002-8156-3694'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Martina Ghetti', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007779887', 'display_name': 'Maria Teresa Bochicchio', 'orcid': 'https://orcid.org/0000-0001-9299-9189'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Maria Teresa Bochicchio', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020414573', 'display_name': 'Mouna Jandoubi', 'orcid': 'https://orcid.org/0000-0002-5774-7362'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mouna Jandoubi', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080885326', 'display_name': 'Cristina Mazzotti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cristina Mazzotti', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087362803', 'display_name': 'Matteo Paganelli', 'orcid': 'https://orcid.org/0009-0009-1321-8790'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Matteo Paganelli', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065909618', 'display_name': 'Claudio Cerchione', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Claudio Cerchione', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025719686', 'display_name': 'Giovanni Marconi', 'orcid': 'https://orcid.org/0000-0001-6309-0515'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanni Marconi', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018020819', 'display_name': 'Gerardo Musuraca', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gerardo Musuraca', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073761054', 'display_name': 'Giovanni Martinelli', 'orcid': 'https://orcid.org/0000-0002-1025-4210'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanni Martinelli', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054016975', 'display_name': 'Giorgia Simonetti', 'orcid': 'https://orcid.org/0000-0001-6954-969X'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giorgia Simonetti', 'raw_affiliation_strings': ['1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.'], 'affiliations': [{'raw_affiliation_string': '1IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.', 'institution_ids': ['https://openalex.org/I4210097834']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 60}, 'biblio': {'volume': '82', 'issue': '12_Supplement', 'first_page': '3001', 'last_page': '3001'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9873, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ponatinib', 'display_name': 'Ponatinib', 'score': 0.96526545}, {'id': 'https://openalex.org/keywords/hydroxychloroquine', 'display_name': 'Hydroxychloroquine', 'score': 0.56142896}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.47198707}], 'concepts': [{'id': 'https://openalex.org/C2780381907', 'wikidata': 'https://www.wikidata.org/wiki/Q198728', 'display_name': 'Ponatinib', 'level': 5, 'score': 0.96526545}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.71512526}, {'id': 'https://openalex.org/C2779123688', 'wikidata': 'https://www.wikidata.org/wiki/Q421094', 'display_name': 'Hydroxychloroquine', 'level': 5, 'score': 0.56142896}, {'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.49562943}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.477464}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4763715}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.47198707}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.4643863}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45903826}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22959676}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21414977}, {'id': 'https://openalex.org/C2779536868', 'wikidata': 'https://www.wikidata.org/wiki/Q419940', 'display_name': 'Dasatinib', 'level': 4, 'score': 0.14241138}, {'id': 'https://openalex.org/C2777583451', 'wikidata': 'https://www.wikidata.org/wiki/Q177094', 'display_name': 'Imatinib', 'level': 3, 'score': 0.13754031}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.07224855}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.06338033}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2022-3001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3153679424', 'https://openalex.org/W3150996080', 'https://openalex.org/W3149354770', 'https://openalex.org/W3124402827', 'https://openalex.org/W3110506613', 'https://openalex.org/W3041254650', 'https://openalex.org/W3027791452', 'https://openalex.org/W2979771750', 'https://openalex.org/W2520571625', 'https://openalex.org/W2013496366'], 'abstract_inverted_index': {'Abstract': [0], 'Currently,': [1], 'the': [2, 39, 58, 75, 98, 126, 129, 135, 138, 161, 166, 188, 199, 210, 225, 228, 254, 265, 270, 280, 288, 298, 317, 355, 371, 386, 449], 'role': [3, 388], 'of': [4, 77, 101, 104, 128, 137, 147, 160, 191, 213, 227, 246, 267, 269, 282, 302, 307, 321, 389, 448], 'autophagy': [5, 24, 50, 80, 322, 347, 390, 434], 'in': [6, 30, 36, 51, 69, 117, 134, 164, 178, 198, 217, 250, 257, 300, 316, 324, 337, 354, 360, 381, 392, 435], 'acute': [7, 436], 'lymphoblastic': [8, 437], 'leukemia': [9, 54], '(ALL)': [10], 'is': [11], 'not': [12, 295], 'fully': [13], 'understood': [14], 'however': [15], 'it': [16], 'has': [17, 45, 65], 'been': [18, 46], 'linked': [19], 'to': [20, 48], 'drug': [21], 'resistance.': [22], 'Several': [23], 'modulators': [25, 81], 'have': [26], 'proven': [27, 66], 'their': [28], 'efficacy': [29, 68, 76, 127, 226], 'single': [31, 118, 222, 260, 340, 363], 'agents': [32], 'or': [33, 305, 350], 'as': [34], 'chemo-sensitizer': [35], 'ALL.': [37], 'Recently,': [38], '3rd': [40], 'generation': [41], 'BCR-ABL1': [42], 'inhibitor,': [43], 'ponatinib,': [44, 113, 441], 'showed': [47, 153, 312], 'promote': [49], 'chronic': [52], 'myeloid': [53], '(CML)': [55], 'cells': [56, 333], 'and': [57, 62, 84, 90, 115, 132, 144, 157, 221, 293, 319, 329, 378, 443], 'combination': [59, 173], 'between': [60, 440], 'ponatinib': [61], 'hydroxychloroquine': [63, 442], '(HCQ)': [64], 'its': [67], 'neuroblastoma': [70], 'cells.': [71, 94], 'Here,': [72], 'we': [73, 96, 124, 272], 'tested': [74], 'combining': [78], 'different': [79, 289], '(ponatinib,': [82], 'HCQ': [83, 114], 'rapamycin)': [85], 'against': [86], 'ALL': [87, 93, 180, 214, 240, 290, 326, 332, 393], 'cell': [88, 108, 139, 162, 167, 181, 215, 291, 303, 327, 376], 'lines': [89, 109, 168, 216, 292, 328], 'primary': [91, 234, 330], 'leukemic': [92, 235, 331], 'Firstly,': [95], 'established': [97], 'IC50': [99], 'values': [100], 'a': [102, 154, 243, 313], 'panel': [103], 'Philadelphia': [105, 461], '(Ph)-positive/negative': [106], 'B-/T-ALL': [107, 383], '(n=6)': [110], 'treated': [111, 169, 201, 252, 334, 357], 'with': [112, 170, 202, 219, 253, 259, 297, 335, 339, 358, 362], 'rapamycin': [116, 444], 'agent.': [119], 'Then,': [120], 'using': [121], 'sub-toxic': [122], 'concentrations,': [123], 'evaluated': [125, 273], 'combinations': [130, 206, 230, 256, 271, 373], 'HCQ+Ponatinib': [131, 336], 'HCQ+Rapamycin': [133, 174, 359], 'reduction': [136, 159], 'viability': [140, 163, 304, 377], 'after': [141], '24,': [142], '48': [143], '72': [145], 'hours': [146], 'simultaneous': [148], 'treatment.': [149], 'Combination': [150], 'index': [151], 'analyses': [152, 311], 'synergic': [155, 176], 'time': [156], 'dosage-dependent': [158], 'all': [165], 'HCQ+Ponatinib.': [171, 203], 'The': [172, 204], 'resulted': [175], 'only': [177], 'Ph-negative': [179], 'lines.': [182], 'These': [183], 'results': [184], 'were': [185], 'confirmed': [186, 232], 'by': [187, 276], 'significant': [189, 244, 314, 344], 'induction': [190, 245, 306], 'apoptosis': [192, 247, 380], '(Annexin': [193], 'V': [194], 'and/or': [195], 'Caspase-3': [196], 'staining)': [197], 'samples': [200, 251, 356], 'two': [205, 229, 255], 'also': [207], 'significantly': [208], 'reduced': [209], 'proliferation': [211], 'capacity': [212], 'comparison': [218, 258, 338, 361], 'controls': [220], 'treatments.': [223, 261, 341, 364], 'Moreover,': [224], 'was': [231, 248, 284, 352], 'on': [233, 346], 'blasts': [236], 'isolated': [237], 'form': [238], 'adult': [239], 'patients(n=6).': [241], 'Indeed,': [242], 'seen': [249, 353], 'To': [262], 'deeper': [263], 'understand': [264], 'mechanism': [266], 'action': [268], 'LC3A/B': [274, 283], 'expression': [275, 281], 'flow': [277], 'cytometry.': [278], 'Interestingly,': [279], 'modified': [285], 'heterogeneously': [286], 'among': [287], 'did': [294], 'correlate': [296], 'response': [299], 'term': [301], 'apoptosis.': [308], 'Light': [309], 'microscopy': [310], 'increment': [315], 'number': [318, 349], 'diameter': [320, 351], 'vesicles': [323, 348], 'both': [325], 'Interstingly,': [342], 'no': [343], 'effect': [345], 'In': [365], 'conclusion,': [366], 'our': [367], 'findings': [368], 'show': [369], 'that': [370], 'identified': [372], 'effectively': [374], 'inhibit': [375], 'induce': [379], 'Ph-positive/negative': [382], 'cells,': [384], 'suggesting': [385], 'fundamental': [387], 'regulation': [391], 'survival.': [394], 'Citation': [395], 'Format:': [396], 'Andrea': [397], 'Ghelli': [398], 'Luserna': [399], 'Di': [400], 'Rora,': [401], 'Eugenio': [402], 'Fonzi,': [403], 'Lorenzo': [404], 'Ledda,': [405], 'Roberta': [406], 'Napolitano,': [407], 'Anna': [408], 'Ferrari,': [409], 'Antonella': [410], 'Padella,': [411], 'Martina': [412], 'Ghetti,': [413], 'Maria': [414], 'Teresa': [415], 'Bochicchio,': [416], 'Mouna': [417], 'Jandoubi,': [418], 'Cristina': [419], 'Mazzotti,': [420], 'Matteo': [421], 'Paganelli,': [422], 'Claudio': [423], 'Cerchione,': [424], 'Giovanni': [425, 429], 'Marconi,': [426], 'Gerardo': [427], 'Musuraca,': [428], 'Martinelli,': [430], 'Giorgia': [431], 'Simonetti.': [432], 'Targeting': [433], 'leukemia:': [438], 'Synergism': [439], '[abstract].': [445], 'In:': [446], 'Proceedings': [447], 'American': [450], 'Association': [451], 'for': [452], 'Cancer': [453, 464], 'Research': [454], 'Annual': [455], 'Meeting': [456], '2022;': [457], '2022': [458], 'Apr': [459], '8-13.': [460], '(PA):': [462], 'AACR;': [463], 'Res': [465], '2022;82(12_Suppl):Abstract': [466], 'nr': [467], '3001.': [468]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4282980536', 'counts_by_year': [], 'updated_date': '2024-12-15T14:50:32.161571', 'created_date': '2022-06-17'}