Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4282936336', 'doi': 'https://doi.org/10.1158/1538-7445.am2022-lb542', 'title': 'Abstract LB542: Overexpression of the short isoform of Brd4 in ovarian carcinoma leads to highly aggressive tumor phenotype', 'display_name': 'Abstract LB542: Overexpression of the short isoform of Brd4 in ovarian carcinoma leads to highly aggressive tumor phenotype', 'publication_year': 2022, 'publication_date': '2022-06-15', 'ids': {'openalex': 'https://openalex.org/W4282936336', 'doi': 'https://doi.org/10.1158/1538-7445.am2022-lb542'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2022-lb542', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091795762', 'display_name': 'Ana Luiza Drumond-Bock', 'orcid': 'https://orcid.org/0000-0003-3555-7741'}, 'institutions': [{'id': 'https://openalex.org/I30558944', 'display_name': 'Oklahoma Medical Research Foundation', 'ror': 'https://ror.org/035z6xf33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I30558944']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ana Luiza Drumond-Bock', 'raw_affiliation_strings': ['1Oklahoma Medical Research Foundation, Oklahoma City, OK.'], 'affiliations': [{'raw_affiliation_string': '1Oklahoma Medical Research Foundation, Oklahoma City, OK.', 'institution_ids': ['https://openalex.org/I30558944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100385114', 'display_name': 'Luyao Wang', 'orcid': 'https://orcid.org/0000-0003-1595-6593'}, 'institutions': [{'id': 'https://openalex.org/I30558944', 'display_name': 'Oklahoma Medical Research Foundation', 'ror': 'https://ror.org/035z6xf33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I30558944']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Luyao Wang', 'raw_affiliation_strings': ['1Oklahoma Medical Research Foundation, Oklahoma City, OK.'], 'affiliations': [{'raw_affiliation_string': '1Oklahoma Medical Research Foundation, Oklahoma City, OK.', 'institution_ids': ['https://openalex.org/I30558944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100403144', 'display_name': 'Lin Wang', 'orcid': 'https://orcid.org/0000-0002-1446-3781'}, 'institutions': [{'id': 'https://openalex.org/I30558944', 'display_name': 'Oklahoma Medical Research Foundation', 'ror': 'https://ror.org/035z6xf33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I30558944']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lin Wang', 'raw_affiliation_strings': ['1Oklahoma Medical Research Foundation, Oklahoma City, OK.'], 'affiliations': [{'raw_affiliation_string': '1Oklahoma Medical Research Foundation, Oklahoma City, OK.', 'institution_ids': ['https://openalex.org/I30558944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056722498', 'display_name': 'Magdalena Cybula', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I30558944', 'display_name': 'Oklahoma Medical Research Foundation', 'ror': 'https://ror.org/035z6xf33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I30558944']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Magdalena Cybula', 'raw_affiliation_strings': ['1Oklahoma Medical Research Foundation, Oklahoma City, OK.'], 'affiliations': [{'raw_affiliation_string': '1Oklahoma Medical Research Foundation, Oklahoma City, OK.', 'institution_ids': ['https://openalex.org/I30558944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010751263', 'display_name': 'Maria Rostworowska', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I30558944', 'display_name': 'Oklahoma Medical Research Foundation', 'ror': 'https://ror.org/035z6xf33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I30558944']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maria Rostworowska', 'raw_affiliation_strings': ['1Oklahoma Medical Research Foundation, Oklahoma City, OK.'], 'affiliations': [{'raw_affiliation_string': '1Oklahoma Medical Research Foundation, Oklahoma City, OK.', 'institution_ids': ['https://openalex.org/I30558944']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080484300', 'display_name': 'Magdalena Bieniasz', 'orcid': 'https://orcid.org/0000-0001-7230-9881'}, 'institutions': [{'id': 'https://openalex.org/I30558944', 'display_name': 'Oklahoma Medical Research Foundation', 'ror': 'https://ror.org/035z6xf33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I30558944']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Magdalena Bieniasz', 'raw_affiliation_strings': ['1Oklahoma Medical Research Foundation, Oklahoma City, OK.'], 'affiliations': [{'raw_affiliation_string': '1Oklahoma Medical Research Foundation, Oklahoma City, OK.', 'institution_ids': ['https://openalex.org/I30558944']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.128, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.351006, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 60, 'max': 70}, 'biblio': {'volume': '82', 'issue': '12_Supplement', 'first_page': 'LB542', 'last_page': 'LB542'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9875, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9875, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9802, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12820', 'display_name': 'Chromatin Remodeling and Cancer', 'score': 0.9474, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/brd4', 'display_name': 'BRD4', 'score': 0.779762}], 'concepts': [{'id': 'https://openalex.org/C2779634854', 'wikidata': 'https://www.wikidata.org/wiki/Q18037206', 'display_name': 'BRD4', 'level': 5, 'score': 0.779762}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6523489}, {'id': 'https://openalex.org/C3019054536', 'wikidata': 'https://www.wikidata.org/wiki/Q172341', 'display_name': 'Ovarian carcinoma', 'level': 4, 'score': 0.540953}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5002284}, {'id': 'https://openalex.org/C2780427987', 'wikidata': 'https://www.wikidata.org/wiki/Q172341', 'display_name': 'Ovarian cancer', 'level': 3, 'score': 0.49982}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.41790956}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.39472672}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.22335407}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.13810915}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13707766}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.13581851}, {'id': 'https://openalex.org/C74401373', 'wikidata': 'https://www.wikidata.org/wiki/Q1829843', 'display_name': 'Bromodomain', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2022-lb542', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.7, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4287459879', 'https://openalex.org/W4233389644', 'https://openalex.org/W3164066485', 'https://openalex.org/W3128458146', 'https://openalex.org/W3015833062', 'https://openalex.org/W2991383501', 'https://openalex.org/W2408675456', 'https://openalex.org/W2227431445', 'https://openalex.org/W2173602200', 'https://openalex.org/W2062646866'], 'abstract_inverted_index': {'Abstract': [0], 'High-grade': [1], 'serous': [2], 'ovarian': [3, 46, 100, 117, 136, 322, 363], 'carcinoma': [4, 47, 137, 364], '(HGSOC)': [5], 'is': [6, 21, 37, 68, 94, 330], 'one': [7, 38], 'of': [8, 12, 18, 32, 39, 54, 88, 109, 133, 176, 189, 200, 209, 238, 261, 277, 291, 336, 356, 360, 374], 'the': [9, 15, 40, 80, 107, 259, 267, 278, 357, 375], 'deadliest': [10], 'types': [11], 'cancer': [13, 118, 323], 'in': [14, 45, 99, 103, 113, 135, 146, 149, 192, 203, 281, 289, 295, 313, 362], 'US.': [16], 'Occurrence': [17], 'sporadic': [19], 'HGSOC': [20, 282], 'associated': [22, 69, 195], 'with': [23, 70, 165, 196, 263, 315], 'high': [24, 174], 'genomic': [25], 'instability,': [26], 'which': [27, 294, 329], 'causes': [28], 'amplification': [29, 50, 276], 'and': [30, 59, 64, 67, 126, 148, 159, 206, 300, 325], 'deletion': [31], 'several': [33, 89], 'different': [34, 110], 'genes.': [35], 'BRD4': [36, 49, 55, 61, 111, 123, 279, 306], 'most': [41], 'frequently': [42], 'amplified': [43, 307], 'genes': [44], 'patients.': [48], 'leads': [51, 365], 'to': [52, 85, 105, 233, 254, 286, 320, 366], 'overexpression': [53, 132], 'proteins': [56], 'including': [57, 236], 'long': [58], 'short': [60, 81, 358], 'isoforms': [62, 112, 124], '(BRD4-L': [63, 125], 'BRD4-S,': [65], 'respectively),': [66], 'poor': [71], 'patient': [72], 'prognosis.': [73], 'Recently,': [74], 'it': [75], 'has': [76], 'been': [77], 'shown': [78], 'that': [79, 131, 216, 248, 275], 'isoform': [82, 359], 'BRD4-S': [83, 134, 217, 226, 292], 'contributes': [84], 'oncogenic': [86], 'properties': [87], 'tumor': [90, 144, 369], 'types;': [91], 'however,': [92], 'little': [93], 'known': [95], 'about': [96], 'its': [97], 'role': [98], 'cancer.': [101], 'Therefore,': [102], 'order': [104], 'interrogate': [106], 'function': [108], 'HGSOC,': [114], 'we': [115], 'generated': [116], 'cell': [119, 138, 156, 167, 190], 'lines': [120, 139], 'stably': [121], 'overexpressing': [122, 227], 'BRD-S).': [127], 'Our': [128], 'data': [129], 'revealed': [130], 'induces': [140], 'a': [141, 173, 187, 197, 331], 'highly': [142, 252, 298, 367], 'aggressive': [143, 299, 338, 368], 'phenotype': [145, 370], 'vitro': [147], 'vivo.': [150], 'Ovcar4-BRD4-S': [151, 171, 193, 249], 'cells': [152, 194, 201, 250], 'showed': [153], 'significantly': [154, 221], 'higher': [155, 198], 'proliferation': [157], 'rate': [158], 'increased': [160, 181, 207, 266], 'anchorage-independent': [161], 'growth': [162], 'when': [163], 'compared': [164], 'parental': [166, 224], 'lines.': [168], 'In': [169, 212, 270], 'addition,': [170], 'presents': [172], 'level': [175], 'DNA': [177], 'damage': [178], 'reflected': [179], 'by': [180], 'pH2AX': [182], 'foci.': [183], 'We': [184], 'also': [185, 230], 'observed': [186], 'disruption': [188], 'cycle': [191], 'number': [199], 'arrested': [202], 'G2/M': [204], 'phase': [205], 'population': [208], 'polyploid': [210], 'cells.': [211], 'vivo': [213], 'experiments': [214], 'demonstrated': [215, 247], 'expressing': [218], 'tumors': [219, 228], 'grow': [220], 'faster': [222], 'than': [223], 'tumors.': [225, 302], 'are': [229, 251], 'very': [231], 'resistant': [232], 'DNA-damage': [234], 'agents': [235], 'standard': [237], 'care': [239], 'platinum': [240], 'drugs.': [241], 'Finally,': [242], 'our': [243, 272], 'preliminary': [244], 'drug': [245], 'screening': [246], 'sensitive': [253], 'Wee1': [255, 311], 'inhibitor': [256], 'MK-1775.': [257], 'Furthermore,': [258], 'combination': [260, 314], 'MK-1775': [262], 'paclitaxel': [264, 316], 'synergistically': [265], 'antitumor': [268], 'effect.': [269], 'summary,': [271], 'studies': [273], 'indicate': [274], 'gene': [280], 'patients': [283], 'might': [284], 'lead': [285], 'an': [287], 'increase': [288], 'splicing': [290], 'transcript,': [293], 'consequence': [296], 'promotes': [297], 'platinum-resistant': [301], 'Precision': [303], 'therapies': [304], 'targeting': [305], 'tumors,': [308], 'such': [309], 'as': [310], 'inhibitors': [312], 'hold': [317], 'great': [318], 'promise': [319], 'improve': [321], 'treatment': [324], 'reduce': [326], 'chemotherapy': [327], 'resistance,': [328], 'critical': [332], 'problem': [333], 'for': [334, 378], 'eradication': [335], 'this': [337], 'tumor.': [339], 'Citation': [340], 'Format:': [341], 'Ana': [342], 'Luiza': [343], 'Drumond-Bock,': [344], 'Luyao': [345], 'Wang,': [346, 348], 'Lin': [347], 'Magdalena': [349, 353], 'Cybula,': [350], 'Maria': [351], 'Rostworowska,': [352], 'Bieniasz.': [354], 'Overexpression': [355], 'Brd4': [361], '[abstract].': [371], 'In:': [372], 'Proceedings': [373], 'American': [376], 'Association': [377], 'Cancer': [379, 390], 'Research': [380], 'Annual': [381], 'Meeting': [382], '2022;': [383], '2022': [384], 'Apr': [385], '8-13.': [386], 'Philadelphia': [387], '(PA):': [388], 'AACR;': [389], 'Res': [391], '2022;82(12_Suppl):Abstract': [392], 'nr': [393], 'LB542.': [394]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4282936336', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-12-14T07:59:09.416147', 'created_date': '2022-06-16'}