Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4282914015', 'doi': 'https://doi.org/10.1158/1538-7445.am2022-1298', 'title': 'Abstract 1298: An allosteric SHP2 inhibitor RMC-4550 induces immunogenicity in pancreatic adenocarcinoma (PDA) and enhances the cytotoxicity of CD8+ effector T cells', 'display_name': 'Abstract 1298: An allosteric SHP2 inhibitor RMC-4550 induces immunogenicity in pancreatic adenocarcinoma (PDA) and enhances the cytotoxicity of CD8+ effector T cells', 'publication_year': 2022, 'publication_date': '2022-06-15', 'ids': {'openalex': 'https://openalex.org/W4282914015', 'doi': 'https://doi.org/10.1158/1538-7445.am2022-1298'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2022-1298', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018620907', 'display_name': 'Agnieszka Looney', 'orcid': 'https://orcid.org/0000-0003-1216-8540'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Agnieszka Looney', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059903431', 'display_name': 'Uma Giri', 'orcid': 'https://orcid.org/0000-0001-9529-3173'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Uma Giri', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109567068', 'display_name': 'Yezi Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yezi Zhu', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112188382', 'display_name': 'Alex Somma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alex Somma', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065761881', 'display_name': 'Nisha Holay', 'orcid': 'https://orcid.org/0000-0003-4363-3521'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nisha Holay', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044819097', 'display_name': 'Milad Soleimani', 'orcid': 'https://orcid.org/0000-0003-3512-1083'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Milad Soleimani', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018960759', 'display_name': 'Heta Gandhi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Heta Gandhi', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102762627', 'display_name': 'Anna Capasso', 'orcid': 'https://orcid.org/0009-0001-1683-2958'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anna Capasso', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019366387', 'display_name': 'Jeanne Kowalski', 'orcid': 'https://orcid.org/0000-0003-3458-3024'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeanne Kowalski', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027419360', 'display_name': 'William Matsui', 'orcid': 'https://orcid.org/0000-0002-3088-0964'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William Matsui', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040018768', 'display_name': 'Carla Van Den Berg', 'orcid': 'https://orcid.org/0000-0003-1156-7216'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carla Van Berg', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046581734', 'display_name': 'Sabine Eckhardt', 'orcid': 'https://orcid.org/0000-0001-6958-5375'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S Gail Eckhardt', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001282420', 'display_name': 'Todd Triplett', 'orcid': 'https://orcid.org/0000-0001-5494-6510'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Todd Triplett', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066902945', 'display_name': 'Kyaw Lwin Aung', 'orcid': 'https://orcid.org/0000-0001-9889-0379'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kyaw Lwin Aung', 'raw_affiliation_strings': ['1University of Texas at Austin, Austin, TX.'], 'affiliations': [{'raw_affiliation_string': '1University of Texas at Austin, Austin, TX.', 'institution_ids': ['https://openalex.org/I86519309']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 60}, 'biblio': {'volume': '82', 'issue': '12_Supplement', 'first_page': '1298', 'last_page': '1298'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10782', 'display_name': 'Nanoplatforms for cancer theranostics', 'score': 0.9805, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12387', 'display_name': 'Galectins and Cancer Biology', 'score': 0.9795, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.56672305}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5029246}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.47978932}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.46787947}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.45941007}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45072013}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.43373668}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.42651707}, {'id': 'https://openalex.org/C79484868', 'wikidata': 'https://www.wikidata.org/wiki/Q5971673', 'display_name': 'IL-2 receptor', 'level': 4, 'score': 0.414569}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.36782384}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31941843}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.29485047}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.268457}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18764663}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2022-1298', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.71, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W891673278', 'https://openalex.org/W3152230514', 'https://openalex.org/W3147138563', 'https://openalex.org/W3092521730', 'https://openalex.org/W2796949944', 'https://openalex.org/W2409963492', 'https://openalex.org/W2395219877', 'https://openalex.org/W2366562690', 'https://openalex.org/W2095277644', 'https://openalex.org/W2045299745'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Immunotherapy': [2], 'is': [3, 369], 'ineffective': [4], 'in': [5, 19, 31, 115, 154, 188, 246, 291, 296, 308, 321, 326, 333, 337, 359, 361, 379, 389, 460], 'MSS': [6], 'PDA.': [7], 'Src': [8], 'homology-2': [9], 'domain-containing': [10], 'protein': [11], 'tyrosine': [12], 'phosphatase': [13], '(SHP2)': [14], 'mediates': [15], 'multiple': [16, 53], 'immunosuppressive': [17], 'mechanisms': [18], 'tumor': [20, 23, 41, 139, 276, 364], 'cells': [21, 102, 112, 153, 229, 295, 315, 320, 332, 472], 'and': [22, 44, 65, 75, 107, 124, 137, 141, 184, 197, 206, 230, 243, 250, 316, 323, 352, 385, 464], 'microenvironment': [24], '(TME).': [25], 'SHP2': [26, 127, 455], 'plays': [27], 'an': [28, 86, 306, 360, 366], 'important': [29], 'role': [30], 'oncogenic': [32], 'RAS': [33, 109, 390], 'signaling,': [34], 'the': [35, 159, 259, 302, 346, 466, 477], 'hallmark': [36], 'of': [37, 63, 120, 161, 176, 221, 241, 262, 293, 310, 328, 397, 415, 468, 476], 'PDA,': [38], 'that': [39, 69, 368], 'reduces': [40], 'MHC-I': [42, 140, 383], 'expression': [43, 143, 384, 388], 'promotes': [45], 'immunotherapy': [46], 'resistance': [47, 78], 'by': [48, 167, 371, 381, 403, 412], 'stabilizing': [49], 'PD-L1.': [50], 'It': [51], 'modulates': [52], 'T': [54, 152, 263, 314, 319, 331, 398, 418, 471], 'cell': [55, 134, 204, 264, 399], 'inhibitory': [56], 'pathways': [57], 'including': [58], 'PD-1': [59, 80, 168], 'signaling': [60], 'via': [61], 'dephosphorylation': [62], 'ITIM': [64], 'ITSM.': [66], 'We': [67], 'hypothesize': [68], 'SHP2i': [70, 236, 268, 350, 374], 'will': [71], 'increase': [72, 307], 'anti-PDA': [73], 'immunity': [74, 378], 'help': [76], 'overcome': [77, 402], 'to': [79, 129, 157, 202, 234, 281, 301, 345], 'blockade': [81], 'when': [82, 299], 'combined': [83, 178], 'with': [84, 92, 117, 179, 182, 269], 'gemcitabine,': [85], 'active': [87], 'cytotoxic': [88], 'agent': [89], 'against': [90], 'PDA': [91, 111, 253, 363, 392], 'pleiotropic': [93], 'immunomodulatory': [94], 'effects': [95], 'on': [96, 163, 223, 275], 'its': [97, 131], 'TME.': [98], 'Methods:': [99], 'Mouse': [100], 'KPC-luc': [101, 191], '(derived': [103], 'from': [104], 'LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre': [105], 'GEMM)': [106], 'human': [108, 227, 252], 'mutant': [110, 391], 'were': [113, 149, 199], 'treated': [114], 'vitro': [116, 155], 'various': [118], 'concentrations': [119], 'RMC-4550,': [121], 'a': [122, 189, 272, 324], 'potent': [123], 'selective': [125], 'allosteric': [126, 454], 'inhibitor,': [128], 'test': [130], 'cytotoxicity': [132, 220, 414, 467], 'using': [133, 210], 'viability': [135], 'assay': [136], 'measure': [138], 'PD-L1': [142, 245, 387, 394], 'upon': [144], 'IFNy': [145, 238], 'stimulation.': [146, 171], 'Human': [147], 'PBMC': [148], 'used': [150], 'for': [151, 480], 'experiments': [156], 'examine': [158], 'effect': [160, 233, 274, 367], 'RMC-4550': [162, 177, 222, 257, 338, 351, 407, 457], 'T-cell': [164], 'proliferation': [165, 400], 'inhibition': [166, 261], 'ligand': [169], '(PD-L1)': [170], 'In': [172, 214, 255, 266, 405], 'vivo': [173, 362], 'antitumor': [174, 377], 'activity': [175], 'αPD-1': [180, 183, 270, 340, 353], 'or': [181, 226], 'gemcitabine': [185, 342], 'was': [186, 217, 335, 401], 'investigated': [187], 'syngeneic': [190], 'subcutaneous': [192], 'model.': [193], 'After': [194], 'treatment,': [195], 'tumors': [196], 'spleens': [198], 'harvested,': [200], 'digested': [201], 'single': [203], 'suspensions,': [205], 'immune': [207, 294], 'infiltrates': [208], 'quantified': [209], 'flow': [211], 'cytometry.': [212], 'Results:': [213], 'vitro,': [215, 256], 'there': [216], 'no': [218, 231, 288], 'direct': [219], 'mouse': [224, 249], 'KPC': [225, 248], 'PDAC': [228], 'additive': [232], 'gemcitabine.': [235, 373], 'increases': [237], 'mediated': [239, 395], 'upregulation': [240], 'MHC-I,': [242], 'downregulates': [244], 'both': [247], 'MiaPaca-2': [251], 'cells.': [254, 393, 419], 'reverses': [258], 'PD-L1-mediated': [260], 'proliferation.': [265], 'vivo,': [267, 406], 'has': [271], 'combinatorial': [273], 'growth': [277], 'inhibition.': [278], 'Gemcitabine': [279], 'seems': [280], 'augment': [282], 'this': [283], 'effect.': [284], 'Preliminary': [285], 'data': [286], 'revealed': [287], 'significant': [289, 356], 'changes': [290], 'number': [292], 'treatment': [297], 'groups': [298], 'compared': [300, 344], 'control': [303, 347], 'group': [304, 343], 'while': [305], 'proportion': [309, 327], 'Granzyme': [311], 'B+': [312], 'CD8+': [313, 318, 330, 416, 469], 'Ki-67+': [317], 'spleen': [322], 'decrease': [325], 'PD1+': [329], 'TME': [334], 'observed': [336], 'plus': [339, 341], 'group.': [348], 'Conclusion:': [349], 'combination': [354], 'induces': [355, 458], 'anti-tumor': [357], 'benefit': [358], 'model,': [365], 'enhanced': [370], 'adding': [372], 'may': [375, 408], 'promote': [376], 'part': [380], 'increasing': [382], 'reducing': [386], 'suppression': [396], 'RMC-4550.': [404], 'potentiate': [409], 'anti-PD-1': [410], 'therapy': [411], 'enhancing': [413], 'effector': [417, 470], 'Citation': [420], 'Format:': [421], 'Agnieszka': [422], 'Looney,': [423], 'Uma': [424], 'Giri,': [425], 'Yezi': [426], 'Zhu,': [427], 'Alex': [428], 'Somma,': [429], 'Nisha': [430], 'Holay,': [431], 'Milad': [432], 'Soleimani,': [433], 'Heta': [434], 'Gandhi,': [435], 'Anna': [436], 'Capasso,': [437], 'Jeanne': [438], 'Kowalski,': [439], 'William': [440], 'Matsui,': [441], 'Carla': [442], 'Van': [443], 'Berg,': [444], 'S': [445], 'Gail': [446], 'Eckhardt,': [447], 'Todd': [448], 'Triplett,': [449], 'Kyaw': [450], 'Lwin': [451], 'Aung.': [452], 'An': [453], 'inhibitor': [456], 'immunogenicity': [459], 'pancreatic': [461], 'adenocarcinoma': [462], '(PDA)': [463], 'enhances': [465], '[abstract].': [473], 'In:': [474], 'Proceedings': [475], 'American': [478], 'Association': [479], 'Cancer': [481, 492], 'Research': [482], 'Annual': [483], 'Meeting': [484], '2022;': [485], '2022': [486], 'Apr': [487], '8-13.': [488], 'Philadelphia': [489], '(PA):': [490], 'AACR;': [491], 'Res': [493], '2022;82(12_Suppl):Abstract': [494], 'nr': [495], '1298.': [496]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4282914015', 'counts_by_year': [], 'updated_date': '2024-12-15T23:49:20.419415', 'created_date': '2022-06-16'}