Molecular mechanisms and therapeutic targets for diabetic kidney disease

Name: Work Video:
Duration: 3 min 30 s
Katherine R. Tuttle; Rajiv Agarwal; Charles E. Alpers; George L. Bakris; Frank C. Brosius; Peter Kolkhof; Jaime Uribarri
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'https://openalex.org/W3177122952', 'https://openalex.org/W3194427696', 'https://openalex.org/W3194763937', 'https://openalex.org/W3195404919', 'https://openalex.org/W3205089872', 'https://openalex.org/W3205935676', 'https://openalex.org/W3207290141', 'https://openalex.org/W3211312223', 'https://openalex.org/W4200576759', 'https://openalex.org/W4206077470', 'https://openalex.org/W4213426937', 'https://openalex.org/W4226060169'], 'related_works': ['https://openalex.org/W4391941342', 'https://openalex.org/W4382055447', 'https://openalex.org/W2953771978', 'https://openalex.org/W2899084033', 'https://openalex.org/W2809647437', 'https://openalex.org/W2111650087', 'https://openalex.org/W2012225890', 'https://openalex.org/W1995085194', 'https://openalex.org/W1503373895', 'https://openalex.org/W1143447605'], 'abstract_inverted_index': {'Diabetic': [0, 61, 157, 218, 408, 486, 529, 650, 690, 800, 1019, 1192, 1898], 'kidney': [1, 15, 47, 62, 98, 132, 155, 158, 172, 204, 219, 255, 289, 312, 315, 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805, 882, 915, 950, 980, 1024, 1052, 1087, 1117, 1162, 1175, 1181, 1197, 1245, 1293, 1312, 1336, 1342, 1367, 1398, 1428, 1433, 1477, 1482, 1538, 1554, 1635, 1671, 1691, 1706, 1759, 1765, 1852, 1858, 1889, 1903, 1976, 1982, 1988, 2049, 2059, 2083, 2089, 2100, 2133, 2143, 2220, 2231, 2238, 2301, 2311, 2338, 2373, 2383, 2405, 2446, 2477, 2487, 2525, 2557, 2634, 2641, 2646, 2658, 2685, 2725, 2767, 2805, 2826, 2861, 2937, 2955, 3015, 3096, 3112, 3164, 3219, 3237, 3265, 3308, 3328, 3341, 3354, 3383, 3427, 3435, 3442, 3502, 3550, 3559, 3579, 3728, 3744, 3757, 3787, 3849], 'substantially': [10, 167], 'increases': [11, 168], 'the': [12, 42, 93, 128, 169, 199, 250, 285, 346, 418, 461, 518, 563, 625, 1140, 1156, 1159, 1282, 1289, 1377, 1422, 1453, 1471, 1506, 1785, 1790, 1983, 2106, 2115, 2194, 2197, 2234, 2249, 2252, 2399, 2432, 2471, 2502, 2726, 2729, 2809, 2902, 2932, 2973, 3023, 3134, 3158, 3171, 3185, 3246, 3266, 3279, 3377, 3396, 3431, 3474, 3497, 3533, 3597, 3607, 3769, 3925], 'risk': [13, 26, 170, 183, 3926], 'of': [14, 27, 96, 130, 171, 184, 253, 287, 337, 349, 422, 428, 437, 452, 464, 507, 586, 616, 628, 670, 758, 849, 871, 905, 939, 977, 1002, 1042, 1076, 1114, 1139, 1173, 1242, 1275, 1285, 1298, 1385, 1424, 1473, 1502, 1517, 1573, 1641, 1646, 1668, 1711, 1733, 1747, 1784, 1793, 1809, 1840, 1880, 1949, 1978, 1990, 2003, 2026, 2033, 2196, 2233, 2251, 2275, 2287, 2333, 2419, 2434, 2473, 2624, 2679, 2716, 2728, 2783, 2847, 2863, 2919, 2934, 2989, 3098, 3114, 3128, 3136, 3154, 3166, 3182, 3187, 3235, 3262, 3268, 3278, 3323, 3395, 3433, 3439, 3467, 3535, 3556, 3606, 3629, 3690, 3731, 3773, 3809, 3844, 3851, 3914, 3927, 3988], 'failure': [16, 173, 600, 2436, 3906], 'cardiovascular': [18, 175, 605, 1427, 1476, 2476], 'events.': [19, 176], 'Despite': [20, 177], 'treatment,': [21, 178], 'there': [22, 34, 120, 179, 191, 277, 1380], 'is': [23, 35, 64, 121, 180, 192, 221, 278, 366, 417, 511, 549, 579, 765, 844, 1144, 1268, 1279, 1294, 1381, 2927, 3737], 'substantial': [24, 181], 'residual': [25, 182], 'progression': [29, 56, 186, 213, 597, 2415, 3850], 'with': [30, 187, 430, 439, 509, 517, 858, 862, 1713, 1720, 1729, 1755, 1761, 1848, 1854, 2439, 2482, 2497, 2523, 2553, 2786, 3048, 3670, 3717, 3726, 3740, 3748, 3796, 3904, 3918, 3965, 3975, 3994], 'existing': [31, 90, 188, 247], 'therapies.': [32, 189], 'Therefore,': [33, 190], 'an': [36, 193, 1371, 1609, 2677], 'urgent': [37, 194, 580], 'need': [38, 195, 578], 'to': [39, 49, 84, 196, 206, 241, 368, 415, 513, 551, 558, 581, 595, 598, 741, 787, 831, 880, 912, 947, 1049, 1084, 1165, 1223, 1340, 1373, 1505, 1527, 1698, 2019, 2057, 2105, 2111, 2141, 2309, 2330, 2381, 2492, 2879, 3019, 3256, 3333, 3338, 3548, 3592, 3616, 3661, 3776, 3784, 3834, 3878, 3901], 'better': [40, 197, 589], 'understand': [41, 198], 'molecular': [43, 94, 200, 251, 759], 'mechanisms': [44, 201, 594, 760, 781, 1948, 2002, 2056, 2140, 2308, 2380, 2766, 2825, 2954, 2988], 'driving': [45, 202], 'diabetic': [46, 97, 131, 154, 203, 254, 288, 311, 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'inflammatory': [105, 262, 2288, 3115, 3263], 'mediators—factors': [108, 265], 'are': [110, 267, 3526, 3793], 'largely': [111, 268], 'unaddressed': [112, 269], 'as': [113, 144, 146, 270, 301, 303, 679, 767, 1271, 1370, 1514, 2037, 2039, 2975, 2977, 3532], 'primary': [114, 271], 'treatment': [115, 272, 1423, 1472, 2060, 2144, 2312, 2384, 2785], 'targets': [116, 273], 'for': [118, 149, 275, 306, 345, 384, 460, 624, 770, 852, 866, 1149, 1296, 1643, 2030, 2108, 2431, 2931, 3470, 3543, 3861, 3942], 'increasing': [122, 279, 1008, 1499, 1689], 'supporting': [124, 281], 'key': [125, 282, 1146], 'roles': [126, 283], 'pathophysiology': [129, 286, 3786], 'disease.': [133, 156, 290, 313], 'Results': [134, 291, 2500], 'from': [135, 292, 556, 739, 829, 1221, 1376, 1535, 1605, 2501, 2876, 3249, 3376, 3663, 3715, 3876], 'recent': [136, 293], 'clinical': [137, 294, 1434, 1483, 2768, 2827, 2877, 2956, 3879], 'trials': [138, 295], 'highlight': [139, 296], 'promising': [140, 297], 'drug': [142, 299], 'therapies,': [143, 300], 'well': [145, 302, 2976], 'role': [148, 305, 2195, 2250, 3127, 3181, 3277, 3394, 3432], 'dietary': [150, 307, 3061, 3129], 'strategies,': [151, 308], 'treating': [153, 310], 'Chronic': [314, 329, 444, 608], '(CKD),': [317], 'characterized': [318], 'albuminuria,': [320], 'low': [321], 'estimated': [322, 367], 'glomerular': [323, 776, 1003, 1150, 1167, 1276, 1344, 1574, 1797, 1810, 2201, 2256, 3608, 3637, 3698, 3817], 'filtration': [324, 1670], 'rate': [325], '(eGFR),': [326], 'or': [327, 857, 1715, 3665, 3751], 'both,1GBD': [328], 'Kidney': [330, 445, 609], 'Disease': [331, 350, 446, 465, 610, 629], 'CollaborationGlobal,': [332, 447, 611], 'regional,': [333, 448, 612], 'national': [335, 450, 614], 'chronic': [338, 453, 617, 886, 2488, 2559, 3137, 3521], 'disease,': [340, 455, 619, 3307], '1990-2017:': [341, 456, 620], 'systematic': [343, 458, 622, 2444], 'analysis': [344, 459, 623], 'Global': [347, 462, 626], 'Burden': [348, 463, 627], 'Study': [351, 466, 630], 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1254, 1350, 1613, 1905, 2062, 2146, 2314, 2386, 3194, 3881], 'Am': [494, 537, 658, 698, 808, 1027, 1200, 1906, 3025, 3311, 3641, 3702, 3821, 3882], 'Soc': [495, 538, 659, 699, 809, 1028, 1201, 1907, 3312, 3642, 3703, 3822, 3883], 'Nephrol.': [496, 539, 660, 700, 810, 1029, 1202, 1676, 1908, 2595, 2734, 2771, 2830, 2959, 3313, 3563, 3643, 3704, 3823, 3884], '2017;': [497, 540, 661, 701, 811, 1030, 1203, 1909, 2066, 2150, 2318, 2390, 3079], '12:': [498, 541, 662, 702, 812, 1031, 1204, 1910], '2032-2045Crossref': [499, 542, 663, 703, 813, 1032, 1205, 1911], '(753)': [502, 545, 666, 706, 816, 1035, 1208, 1914], 'The': [505, 577, 1264, 1665, 1685, 3303], 'DKD': [510, 763, 3716, 3798, 3928], 'expected': [512], 'increase': [514, 552, 1369, 2021, 2273, 3257, 3924], 'parallel': [516], 'rise': [519], 'prevalence,3Alicic': [523], 'projected': [550], 'nearly': [554], '50%,': [555], '537': [557], '783': [559], 'people,': [561], 'next': [564], '24': [565], 'years.4International': [566], 'Diabetes': [567, 569, 573, 2448, 2568], 'FederationIDF': [568], 'Atlas.10th': [570], 'ed.': [571], 'International': [572], 'Federation,': [574], '2021Google': [575], 'improve': [582], 'diagnosis': [583], 'management': [585], 'DKD,': [587], 'including': [588, 2495], 'target': [592], 'related': [603, 3783], '(CV)': [606], 'risk.1GBD': [607], 'Mechanisms': [669], 'can': [675, 2412, 2970], 'be': [676, 3765, 3902], 'broadly': [677], 'classified': [678], 'fibrotic.3Alicic': [684], 'Scholar,5Pérez-Morales': [708], 'R.E.': [709, 3211], 'Del': [710], 'Pino': [711], 'M.D.': [712], 'Valdivielso': [713], 'J.M.': [714, 3932], 'al.Inflammation': [716], 'disease.Nephron.': [720], '143:': [722], '12-16Crossref': [723], '(57)': [726], 'Scholar,6Mora-Fernández': [728, 818, 1210], 'Domínguez-Pimentel': [730, 820, 1212], 'V.': [731, 821, 1213, 1324, 1662, 2466], 'de': [732, 822, 1214, 3120], 'Fuentes': [733, 823, 1215], 'M.M.': [734, 824, 1216], 'al.Diabetic': [736, 826, 1218], 'physiology': [740, 830, 1222], 'therapeutics.J': [742, 832, 1224], 'Physiol.': [743, 833, 992, 1129, 1225, 1257, 1353, 1616, 2065, 2149, 2317, 2389, 3198], '2014;': [744, 834, 1226, 1354, 1955, 2009, 2995, 3314, 3361, 3479], '592:': [745, 835, 1227], '3997-4012Crossref': [746, 836, 1228], '(99)': [749, 839, 1231], 'In': [752, 1136, 1362, 1491, 1708, 2098, 2621, 2780, 3832], 'this': [753, 1179, 3674, 3718], 'review,': [754], 'current': [756], 'understanding': [757], 'drive': [762, 3215], 'pathogenesis': [764, 3186], 'presented': [766], 'basis': [769], 'advancing': [771], 'therapeutic': [772], 'interventions.': [773], 'Hyperglycemia': [774, 1876], 'induces': [775], 'hyperfiltration': [777, 843, 1004, 1345], 'hypertension,': [779], 'hemodynamic': [780, 910, 945, 1047, 1082, 1575, 1745, 1811, 1838], 'long': [784, 3613], 'been': [785, 3614, 3659, 3898], 'recognized': [786, 1270], 'initiate': [788], 'propagate': [790], 'diabetes.3Alicic': [794], 'Glomerular': [842], 'exacerbated': [845], 'levels': [848, 3730], 'amino': [850, 913, 948, 978, 1050, 1085, 1115, 1243], 'acids,': [851], 'example,': [853, 867, 3862], 'after': [854, 3191], 'protein': [855, 1979, 2857], 'overfeeding,': [856], 'hormonal': [859], 'changes': [860], 'poor': [863], 'glycemic': [864, 941, 1078, 2421], 'control,': [865], 'level': [870], 'glucagon.7Rhee': [872], 'C.M.': [873, 3417], 'Kalantar-Zadeh': [874], 'K.': [875, 1566, 1802, 1940, 1946, 1994, 2000, 2158, 2711, 2980, 2986], 'Novel': [878], 'approaches': [879], 'hypoglycemia': [881], 'burnt-out': [883], 'disease.Curr': [888], 'Opin': [889], 'Nephrol': [890], 'Hypertens.': [891], '2022;': [892], '31:': [893], '72-81Crossref': [894], '(0)': [897, 1622, 2740, 3204, 3297, 3366, 3414], 'Scholar,': [899, 930, 967, 1067, 1104, 1593, 1624, 1660, 2462, 2512, 2539, 2582, 3457, 3486], '8Tuttle': [900], 'Bruton': [902, 933, 1039, 1070], 'J.L.': [903, 934, 1040, 1071], 'Effect': [904, 1041], 'insulin': [906, 1043, 2549], 'therapy': [907, 1044], 'renal': [909, 916, 944, 951, 983, 1046, 1053, 1081, 1088, 1120, 1248, 1334, 2478, 2720, 2898, 3440], 'response': [911, 946, 1048, 1083, 1697], 'acids': [914, 949, 979, 1051, 1086, 1116, 1244, 3375], 'hypertrophy': [917, 1054], 'non-insulin-dependent': [919, 1056], 'diabetes.Kidney': [920, 1057], '1992;': [922, 1059], '42:': [923, 1060], '167-173Abstract': [924, 1061], '9Tuttle': [931, 1068], 'Perusek': [935, 1072], 'M.C.': [936, 1073, 1595, 2543], 'al.Effect': [938, 1075], 'strict': [940, 1077], 'control': [942, 1079], 'enlargement': [952, 1089], 'insulin-dependent': [954, 1091], 'mellitus.N': [956, 1093], 'Engl': [957, 1094], 'Med.': [959, 1096], '1991;': [960, 1097], '324:': [961, 1098], '1626-1632Crossref': [962, 1099], '(142)': [965, 1102], '10Tuttle': [968, 1105], 'Puhlman': [970, 1107, 1235], 'M.E.': [971, 1108, 1236, 3117], 'Cooney': [972, 1109, 1237], 'S.K.': [973, 1110, 1238], 'Short': [974, 1111, 1239], 'R.A.': [975, 1112, 1240], 'Effects': [976, 1113, 1241], 'glucagon': [981, 1118, 1246], 'hemodynamics': [984, 1121, 1249], 'diabetes.Am': [988, 1125, 1253], 'Physiol': [990, 1127, 1255, 1351, 1614, 2063, 2147, 2315, 2387, 3195], 'Renal': [991, 1128, 1256, 1352, 1615, 2064, 2148, 2316, 2388], '2002;': [993, 1130, 1258], '282:': [994, 1131, 1259], 'F103-F112Crossref': [995, 1132, 1260], 'These': [999, 2326], 'circulating': [1000], 'mediators': [1001, 1177, 2035, 3169], 'primarily': [1005], 'act': [1006], 'perfusion': [1009], 'through': [1010, 2607, 2853, 2972], 'afferent': [1011, 1529, 1690, 1723], 'arteriole': [1012], 'dilation.3Alicic': [1013], 'Scholar,8Tuttle': [1037], 'addition,': [1137, 1492], 'activation': [1138, 1977, 2165, 2232, 2860, 3350], 'renin': [1141, 1533, 1603], 'angiotensin': [1142], 'system': [1143], 'local': [1147, 3110, 3258], 'hyperfiltration.': [1151], 'Angiotensin': [1152, 1169], 'II': [1153, 1170], 'production': [1154, 3472], 'within': [1155, 2637, 3473, 3529], 'constricts': [1158], 'efferent': [1160, 1541, 1693, 1734], 'arteriole,': [1161], 'thereby,': [1163, 1800], 'contributes': [1164], 'higher': [1166], 'pressure.': [1168], 'stimulates': [1171], 'expression': [1172, 1366, 2029, 2230, 2274, 2290], 'proinflammatory': [1174, 2034, 2334, 2747, 2806, 2935, 3168], 'profibrotic': [1176, 2336], 'via': [1178, 1608, 1887, 2114, 2978], 'barotrauma': [1180], 'also': [1182, 2745, 3379, 3738, 3794], 'direct': [1184], 'cellular': [1185], 'effects.3Alicic': [1186], 'Scholar,10Tuttle': [1233], 'sodium-glucose': [1265, 1748, 1841, 2680], 'cotransporter-2': [1266], '(SGLT2)': [1267], 'now': [1269], 'another': [1272, 2279, 2928, 3653], 'important': [1273], 'modulator': [1274], 'hemodynamics.': [1277], 'It': [1278], 'expressed': [1280], 'luminal': [1283], 'surface': [1284], 'epithelial': [1286, 2723, 3384], 'cells': [1287, 1607, 2168, 2640, 2724], 'proximal': [1290, 1454, 2612, 2638, 2721], 'convoluted': [1291], 'tubule': [1292, 1455], 'responsible': [1295], '90%': [1297], 'filtered': [1299], 'reabsorption.11Alicic': [1301], 'Neumiller': [1303, 1389, 1545, 2649, 2755, 2814, 2943], 'J.J.': [1304, 1390, 1546, 2650, 2756, 2815, 2944], 'Johnson': [1305, 1391, 1547, 2651], 'E.J.': [1306, 1392, 1548, 2652, 2754, 2813, 2942], 'al.Sodium-glucose': [1308, 1394, 1550, 2654], 'cotransporter': [1309, 1395, 1418, 1467, 1551, 1749, 1842, 2655, 2681], 'inhibition': [1311, 1397, 1444, 1553, 1700, 2627, 2657, 2846], 'disease.Diabetes.': [1315, 1401, 1557, 2661], '68:': [1317, 1403, 1559, 2663], '248-257Crossref': [1318, 1404, 1560, 2664], '(55)': [1321, 1407, 1563, 2667, 3649, 3710, 3829], 'Scholar,12Vallon': [1323], 'Gerasimova': [1325], 'M.': [1326, 2043, 2127, 2295, 2367, 3053, 3086, 3207, 3419, 3930], 'Rose': [1327], 'M.A.': [1328], 'al.SGLT2': [1330, 2429], 'inhibitor': [1331, 2678, 2731], 'empagliflozin': [1332, 1578, 1814], 'reduces': [1333, 1633, 1796, 3771], 'growth': [1335, 1923, 2348, 2794], 'albuminuria': [1337, 3664], 'proportion': [1339], 'hyperglycemia': [1341], 'prevents': [1343], 'Akita': [1348], 'mice.Am': [1349], '306:': [1355], 'F194-F204Crossref': [1356], '(318)': [1359], 'hyperglycemic': [1363], 'conditions,': [1364, 3522], 'SGLT2': [1365, 1443, 1493, 1647, 1699, 2403, 2587, 2615, 2626, 2730], 'activity': [1368], 'adaptation': [1372], 'reclaim': [1374], 'urine,': [1378], 'but': [1379], 'maladaptive': [1383], 'consequence': [1384], 'worsening': [1386], 'hyperglycemia.11Alicic': [1387], 'Scholar,13Heerspink': [1409], 'H.J.': [1410, 1459], 'Perkins': [1411, 1460, 1741, 1834], 'B.A.': [1412, 1461, 1742, 1835], 'Fitchett': [1413, 1462], 'D.H.': [1414, 1463], 'al.Sodium': [1416, 1465], 'inhibitors': [1420, 1469, 1494, 1648, 1751, 1844, 2404, 2430, 2588, 2616], 'mellitus:': [1426, 1475], 'effects,': [1430, 1479], 'potential': [1431, 1480, 1639, 3126], 'mechanisms,': [1432, 1481, 1788], 'applications.Circulation.': [1435, 1484], '2016;': [1436, 1485], '134:': [1437, 1486], '752-772Crossref': [1438, 1487], 'Therapeutically,': [1442], 'lowers': [1445], 'blood': [1446], 'decreasing': [1449, 1692, 2608], 'reabsorption': [1451, 1511], 'at': [1452], 'resulting': [1456], 'glucosuria.13Heerspink': [1458], 'restore': [1495], 'tubuloglomerular': [1496, 1794], 'feedback': [1497, 1795], 'distal': [1500], 'delivery': [1501], 'sodium': [1503], 'chloride': [1504], 'macula': [1507], 'densa,': [1508], 'where': [1509], 'solute': [1510], 'generates': [1512, 1967], 'adenosine': [1513, 1518, 2855], 'by-product': [1516], 'triphosphate': [1519], 'utilization.': [1520], 'Adenosine': [1521], 'acts': [1522], 'paracrine': [1525], 'manner': [1526], 'enhance': [1528], 'arteriolar': [1530, 1542, 1694, 1724, 1735], 'vasoconstriction,': [1531], 'suppress': [1532], 'release': [1534, 1604, 2332, 3113, 3267], 'juxtaglomerular': [1536, 1606], 'cells,': [1537, 2102, 2614, 3264, 3332], 'perhaps': [1539, 3329], 'constriction.11Alicic': [1543], 'Scholar,14Kidokoro': [1565], 'Cherney': [1567, 1803], 'D.Z.I.': [1568, 1804], 'Bozovic': [1569, 1805], 'A.': [1570, 1806, 2584, 2670, 3300], 'al.Evaluation': [1572, 1808], 'function': [1576, 1812], 'mice': [1581, 1817], 'using': [1582, 1818], 'vivo': [1584, 1820], 'imaging.Circulation.': [1585, 1821], '140:': [1587, 1823], '303-315Crossref': [1588, 1824], '(124)': [1591, 1827], '15Ortiz-Capisano': [1594], 'Atchison': [1596], 'D.K.': [1597], 'Harding': [1598], 'P.': [1599, 1628, 3463], 'al.Adenosine': [1601], 'inhibits': [1602], 'A1': [1610], 'receptor-TRPC-mediated': [1611], 'pathway.Am': [1612], '2013;': [1617, 2906], '305:': [1618], 'F1209-F1219Crossref': [1619], '16Heerspink': [1625], 'H.J.L.': [1626, 2427], 'Perco': [1627], 'Mulder': [1629], 'S.': [1630, 3005, 3007, 3270, 3387], 'al.Canagliflozin': [1632], 'inflammation': [1634, 1888, 2050, 2084, 2113, 2134, 2190, 2245, 2302, 2374, 2645, 3111, 3382, 3441], 'fibrosis': [1636, 1890, 3356, 3789], 'biomarkers:': [1637], 'mechanism': [1640, 2930], 'action': [1642], 'beneficial': [1644], 'effects': [1645, 1746, 1839, 2472, 2687, 3063], 'disease.Diabetologia.': [1652], '62:': [1654], '1154-1166Crossref': [1655], '(145)': [1658, 2704], '17Vallon': [1661], 'Thomson': [1663], 'S.C.': [1664], 'tubular': [1666, 2613, 2639, 2722], 'hypothesis': [1667], 'nephron': [1669], 'disease.Nat': [1674], 'Rev': [1675, 2594, 2770, 2829, 2958, 3562], '16:': [1678, 3565, 3886], '317-336Crossref': [1679], '(102)': [1682], 'relative': [1686], 'balance': [1687], 'between': [1688], 'constriction': [1695], 'may': [1701, 2589, 2841, 3336, 3676, 3764, 3923], 'vary': [1702], 'age.': [1707], 'physiological': [1709], 'studies': [1710, 3582], 'humans': [1712], 'normal': [1714, 1766, 1859], 'GFR,': [1717], 'younger': [1718], 'T1D': [1721, 3727, 3750], 'demonstrated': [1722], 'constriction,': [1725], 'whereas': [1726], 'older': [1727], 'T2D': [1730, 3752], 'had': [1731, 3754], 'dilation.18van': [1736], 'Bommel': [1737, 1830], 'E.J.M.': [1738, 1831], 'Lytvyn': [1739, 1832], 'Y.': [1740, 1833, 1919, 2344, 2674, 2868, 3272, 3389], 'al.Renal': [1744, 1837], 'hyperfiltering': [1753, 1846], 'function.Kidney': [1768, 1861], '97:': [1771, 1864], '631-635Abstract': [1772, 1865], '(17)': [1780, 1873], 'Irrespective': [1783], 'precise': [1786], 'vasoregulatory': [1787], 'whole,': [1791], 'restoration': [1792], 'hypertension': [1798], 'and,': [1799], 'hyperfiltration.14Kidokoro': [1801], 'Scholar,18van': [1829], 'prompts': [1877], 'series': [1879], 'intracellular': [1881, 1964, 2327], 'promote': [1884, 3847], '(Figure': [1891, 2291], '1).3Alicic': [1892], 'Scholar,19Zhao': [1916], 'L.': [1917, 2342, 3934], 'Zou': [1918, 2343], 'Liu': [1920, 2345], 'F.': [1921, 2160, 2346], 'Transforming': [1922, 2347], 'factor-beta1': [1924, 2349], 'disease.Front': [1928, 2353], 'Cell': [1929, 2354], 'Dev': [1930, 2355], 'Biol.': [1931, 2356], '8:': [1933, 2358, 3480], '187Crossref': [1934, 2359], '(34)': [1937, 2362], 'Scholar,20Reidy': [1939], 'Kang': [1941, 1995, 2981], 'H.M.': [1942, 1996, 2982], 'Hostetter': [1943, 1997, 2983], 'T.': [1944, 1998, 2188, 2243, 2425, 2518, 2672, 2707, 2984], 'Susztak': [1945, 1999, 2985], 'Molecular': [1947, 2001, 2987], 'disease.J': [1952, 2006, 2992], 'Clin': [1953, 2007, 2993, 3285, 3402, 3447], 'Invest.': [1954, 2008, 2091, 2994], '124:': [1956, 2010, 2996], '2333-2340Crossref': [1957, 2011, 2997], '(448)': [1960, 2014, 3000], 'Altered': [1963], 'metabolism': [1966, 3095], 'advanced': [1968, 3090, 3130], 'glycation': [1969, 3010, 3058, 3091, 3131], 'end': [1970, 3011, 3059, 3092], 'products': [1971, 3012, 3060], '(AGEs),': [1972], 'reactive': [1973, 2630], 'oxygen': [1974, 2631], 'species,': [1975], 'kinase': [1980, 1985, 2858], 'C': [1981], 'Janus': [1984], '(JAK)-signal': [1986], 'transducer': [1987], 'activator': [1989], 'transcription': [1991], '(STAT)': [1992], 'pathways.20Reidy': [1993], 'Podocytes': [2017], 'exposed': [2018], 'AGE': [2020, 2109, 2635], 'nuclear': [2022, 2217, 2920], 'factor': [2023, 2218, 2921], 'κB–associated': [2024], 'upregulation': [2025, 2862], 'messenger': [2027], 'RNA': [2028], 'variety': [2032], 'much': [2038], '25-fold.21Pichler': [2040], 'Afkarian': [2042, 2126, 2294, 2366], 'Dieter': [2044, 2128, 2296, 2368], 'B.P.': [2045, 2129, 2297, 2369], 'Immunity': [2048, 2132, 2300, 2372], 'translating': [2055, 2139, 2307, 2379], 'biomarkers': [2058, 2142, 2310, 2382], 'targets.Am': [2061, 2145, 2313, 2385], '312:': [2067, 2151, 2319, 2391], 'F716-F731Crossref': [2068, 2152, 2320, 2392], '(108)': [2071, 2155, 2323, 2395], 'Scholar,22Anderberg': [2073], 'R.J.': [2074], 'Meek': [2075], 'R.L.': [2076], 'Hudkins': [2077], 'K.L.': [2078], 'al.Serum': [2080], 'amyloid': [2081, 2277], 'A': [2082, 2859], 'podocytes.Lab': [2090], '2015;': [2092, 2173, 2205, 2260, 2699], '95:': [2093], '250-262Crossref': [2094], 'podocytes': [2099], 'endothelial': [2101], 'AGEs': [2103, 2272, 2968, 3042], 'bind': [2104, 3253], 'receptor': [2107, 2119, 2224, 2408, 2870], '(RAGE),': [2110], 'produce': [2112], 'nucleotide-binding': [2116, 2221], 'oligomerization': [2117, 2222], 'domain–like': [2118, 2223], 'pyrin': [2120, 2225], 'domain': [2121, 2226], 'containing': [2122, 2227], '3': [2123, 2228], 'inflammasome.21Pichler': [2124], 'Scholar,23Shahzad': [2157], 'Bock': [2159], 'Dong': [2161], 'W.': [2162, 3055], 'al.Nlrp3-inflammasome': [2164], 'non-myeloid-derived': [2167], 'aggravates': [2169], 'nephropathy.Kidney': [2171], '87:': [2174, 2206, 2261], '74-84Abstract': [2175], '(234)': [2183], 'Scholar,24Sakai': [2185], 'N.': [2186, 2241, 3459, 3624, 3685, 3804, 3982], 'Wada': [2187, 2242], 'Revisiting': [2189, 2244], 'nephropathy:': [2193, 2248, 3875], 'Nlrp3': [2198, 2253], 'inflammasome': [2199, 2254], 'resident': [2202, 2257], 'cells.Kidney': [2203, 2258], '12-14Abstract': [2207, 2262], 'Together,': [2216], 'κB': [2219, 2922], 'induce': [2229, 2617], 'interleukins': [2235], '(IL),': [2236], 'IL-1β': [2237], 'IL-18,': [2239], 'respectively.24Sakai': [2240], 'Moreover,': [2271], 'serum': [2276], 'A,': [2278], 'RAGE': [2280, 3183], 'activator,': [2281], 'perpetuates': [2283], 'feed-forward': [2285], 'cycle': [2286], 'gene': [2289, 3969], '1).21Pichler': [2292], 'signals': [2328], 'lead': [2329, 3337], 'ongoing': [2331], 'mediators,': [2335], 'factors,': [2337], 'immune': [2339], 'cell': [2340, 3251, 3385], 'recruitment.19Zhao': [2341], 'Scholar,21Pichler': [2364], 'Notably,': [2398, 3713], 'newer': [2400], 'glucose-lowering': [2401], 'agents,': [2402], 'glucagon-like': [2406], 'peptide-1': [2407], 'agonists': [2409, 2871], '(GLP-1': [2410], 'RAs),': [2411], 'prevent': [2413, 2842, 3677], 'CKD': [2414, 3231], 'T2D,': [2417, 3919, 3966], 'independent': [2418], 'their': [2420, 3020, 3250], 'effects.25Neuen': [2422], 'B.L.': [2423], 'Young': [2424, 3462], 'Heerspink': [2426], 'prevention': [2433], 'patients': [2438, 2481, 2552, 3669, 3747], 'diabetes:': [2442], 'meta-analysis.Lancet': [2447], 'Endocrinol.': [2449, 2569], '7:': [2451], '845-854Abstract': [2452], '(339)': [2460], '26Cannon': [2463], 'C.P.': [2464], 'Perkovic': [2465], 'Agarwal': [2467], 'al.Evaluating': [2470], 'canagliflozin': [2474], 'events': [2479], 'mellitus': [2486, 3558], 'according': [2491], 'baseline': [2493], 'HbA1c,': [2494], 'HbA1c': [2498], '<7%:': [2499], 'CREDENCE': [2503], 'trial.Circulation.': [2504], '141:': [2506], '407-410Crossref': [2507], '(65)': [2510], '27Mann': [2513], 'J.F.E.': [2514], 'Buse': [2515], 'J.B.': [2516, 3552], 'Idorn': [2517], 'al.Potential': [2520], 'protection': [2522, 3662, 3714], 'liraglutide': [2524], 'semaglutide:': [2526], 'Exploratory': [2527], 'mediation': [2528], 'analysis.Diabetes': [2529], 'Obes': [2530], 'Metab.': [2531, 3449], '2021;': [2532, 2596, 2772, 2831, 2960, 3223, 3287, 3404, 3450, 3512, 3885], '23:': [2533], '2058-2066Crossref': [2534], '(3)': [2537], '28Tuttle': [2540], 'Lakshmanan': [2542], 'Rayner': [2544], 'B.': [2545, 3423], 'al.Dulaglutide': [2547], 'versus': [2548], 'glargine': [2550], 'moderate-to-severe': [2558], '(AWARD-7):': [2562], 'multicentre,': [2564], 'open-label,': [2565], 'randomised': [2566], 'trial.Lancet': [2567], '2018;': [2570], '6:': [2571], '605-617Abstract': [2572], '(233)': [2580], '29Kang': [2583], 'Jardine': [2585], 'M.J.': [2586], 'offer': [2590], 'benefit': [2591], 'beyond': [2592], 'diabetes.Nat': [2593], '17:': [2597, 2773, 2832, 2961], '83-84Crossref': [2598], '(12)': [2601, 3958], 'By': [2604], 'ameliorating': [2605], 'glucotoxicity': [2606, 2717], 'influx': [2610], 'into': [2611, 3170], 'potent': [2618], 'anti-inflammatory': [2619, 2684], 'effects.': [2620], 'preclinical': [2622], 'models': [2623, 2782], 'suppresses': [2628], 'hyperglycemia-induced': [2629], 'species': [2632], 'generation': [2633], 'formation': [2636], 'attenuates': [2642], 'surrounding': [2643], 'tubulointerstitial': [2644], 'fibrosis.11Alicic': [2647], 'Scholar,30Ojima': [2669], 'Matsui': [2671], 'Nishino': [2673], 'al.Empagliflozin,': [2676], 'exerts': [2683], 'antifibrotic': [2686], 'experimental': [2689], 'nephropathy': [2691], 'partly': [2692], 'suppressing': [2694], 'AGEs-receptor': [2695], 'axis.Horm': [2696], 'Metab': [2697], 'Res.': [2698, 2905], '47:': [2700], '686-692Crossref': [2701], 'Scholar,31Eleftheriadis': [2706], 'Pissas': [2708], 'G.': [2709], 'Tsogka': [2710], 'unifying': [2714], 'model': [2715], 'human': [2719, 3475], 'effect': [2727], 'dapagliflozin.Int': [2732], 'Urol': [2733], '52:': [2736], '1179-1189Crossref': [2737], 'GLP-1': [2743, 2788, 2839, 2869, 2925], 'RAs': [2744, 2840, 2926], 'downregulate': [2746], 'pathways': [2748, 3469], 'nonpancreatic': [2750], 'organs.32Alicic': [2751], 'Cox': [2753, 2812, 2941], 'Incretin': [2759, 2818, 2947], 'drugs': [2760, 2819, 2948], 'biological': [2765, 2824, 2953], 'evidence.Nat': [2769, 2828, 2957], '227-244Crossref': [2774, 2833, 2962], '(27)': [2777, 2836, 2965], 'rodent': [2781], 'RA': [2789], 'decreased': [2790], 'oxidative': [2791, 2843], 'stress,': [2792], 'transforming': [2793], 'factor-beta': [2795], '(TGF-β1),': [2797], 'intercellular': [2798], 'adhesion': [2799], 'molecule-1,': [2800], 'tumor': [2801], 'necrosis': [2802], 'factor-α,': [2803], 'IL-1β,': [2804], 'macrophages': [2807], 'kidney.32Alicic': [2810], 'stress': [2844], 'nicotinamide': [2848], 'adenine': [2849], 'dinucleotide': [2850], 'phosphatase': [2851], 'oxidase': [2852], 'cyclic': [2854], 'monophosphate–dependent': [2856], 'heme': [2864], 'oxygenase-1.33Kawanami': [2865], 'D.': [2866], 'Takashi': [2867], 'outcomes': [2878], 'mechanisms.Front': [2880], 'Pharmacol.': [2881], '11:': [2883, 3513], '967Crossref': [2884], '(22)': [2887], 'Scholar,34Yang': [2889], 'H.': [2890, 2892], 'Li': [2891], 'Wang': [2893], 'Z.': [2894], 'al.Exendin-4': [2896], 'ameliorates': [2897], 'ischemia-reperfusion': [2899], 'injury': [2900, 3353], 'rat.J': [2903], 'Surg': [2904], '182:': [2907], '825-832Abstract': [2908], '(25)': [2915, 3227], 'Inhibition': [2918], 'signaling': [2923, 3156], 'proposed': [2929], 'suppression': [2933], 'cytokine': [2936, 3259], 'chemokine': [2938], 'expression.32Alicic': [2939], 'exposure': [2969], 'occur': [2971], 'diet': [2974], 'hyperglycemia.20Reidy': [2979], 'Scholar,35Uribarri': [3002], 'J.': [3003, 3343, 3478], 'Woodruff': [3004], 'Goodman': [3006], 'al.Advanced': [3009, 3057], 'foods': [3014, 3214], 'practical': [3017], 'guide': [3018], 'reduction': [3021, 3370], 'diet.J': [3024], 'Diet': [3026], 'Assoc.': [3027], '2010;': [3028], '110:': [3029], '911-916.e912Abstract': [3030], '(746)': [3038], 'Dietary': [3041, 3089], 'escape': [3044], 'gastrointestinal': [3045], 'absorption': [3046], 'interact': [3047], 'colonic': [3049], 'microbiota,36Yacoub': [3050], 'Nugent': [3052], 'Cai': [3054, 3271, 3388], 'restriction': [3062], 'bacterial': [3065], 'gut': [3066, 3099, 3159, 3304, 3381, 3476, 3498], 'microbiota': [3067, 3378, 3426, 3434], 'peritoneal': [3069], 'dialysis': [3070], 'patients;': [3071], 'randomized': [3073], 'open': [3074], 'label': [3075], 'controlled': [3076], 'trial.PLoS': [3077], 'One.': [3078, 3360], '12e0184789Crossref': [3080], '(63)': [3083], 'Scholar,37Snelson': [3085], 'Coughlan': [3087], 'products:': [3093], 'digestion,': [3094], 'modulation': [3097], 'microbial': [3100, 3167], 'ecology.Nutrients.': [3101], '22:': [3103], '215Crossref': [3104], '(82)': [3106], 'triggering': [3109], 'mediators.38Garay-Sevilla': [3116], 'Beeri': [3118], 'M.S.': [3119], 'la': [3121], 'Maza': [3122], 'M.P.': [3123], 'al.The': [3125, 3180, 3276, 3393], 'endproducts': [3132], 'development': [3135, 3504, 3534, 3848], 'non-infectious': [3138], 'diseases:': [3139, 3430], 'narrative': [3141], 'review.Nutr': [3142], 'Res': [3143, 3284, 3401, 3446], 'Rev.': [3144], '33:': [3146], '298-311Crossref': [3147], '(6)': [3150, 3455], 'Activation': [3153], 'RAGE-dependent': [3155], 'causes': [3160], 'mucosal': [3161], 'barrier': [3162, 3189, 3217], 'dysfunction': [3163, 3190], 'translocation': [3165], 'systemic': [3172], 'circulation.39Raman': [3173], 'K.G.': [3174], 'Sappington': [3175], 'P.L.': [3176], 'Yang': [3177], 'intestinal': [3188, 3216], 'hemorrhagic': [3192], 'shock.Am': [3193], 'Gastrointest': [3196], 'Liver': [3197], '2006;': [3199], '291:': [3200], 'G556-G565Crossref': [3201], 'Scholar,40Snelson': [3206], 'Tan': [3208], 'S.M.': [3209], 'Clarke': [3210], 'al.Processed': [3213], 'permeability': [3218], 'microvascular': [3220], 'diseases.Sci': [3221], 'Adv.': [3222], '7eabe4841Crossref': [3224], 'As': [3230], 'progresses,': [3232], 'greater': [3233], 'amounts': [3234], 'ammonia': [3236], 'urea': [3238], 'shift': [3241], 'toward': [3242], 'Gram-negative': [3243], 'bacteria': [3244], 'gut.': [3247], 'Lipopolysaccharides': [3248], 'walls': [3252], 'toll-like': [3254, 3324], 'receptor-4': [3255, 3325], 'production,': [3260], 'recruitment': [3261], 'lipopolysaccharides.41Zhang': [3269], 'Meng': [3273, 3390], 'microbiome': [3280, 3397, 3499], 'mellitus.Diabetes': [3283, 3400], 'Pract.': [3286, 3403], '172:': [3288, 3405], '108645Abstract': [3289, 3406], 'Scholar,42Ramezani': [3299], 'Raj': [3301], 'D.S.': [3302], 'microbiome,': [3305], 'targeted': [3309], 'interventions.J': [3310], '25:': [3315], '657-670Crossref': [3316], '(397)': [3319], 'Exposure': [3322], 'podocytes,': [3327], 'these': [3334], 'lipopolysaccharides': [3335], 'injury,': [3339], 'inflammation,': [3340], 'fibrosis.43Ma': [3342], 'Chadban': [3344], 'S.J.': [3345], 'Zhao': [3346], 'C.Y.': [3347], 'al.TLR4': [3349], 'promotes': [3351, 3380], 'podocyte': [3352], 'interstitial': [3355], 'nephropathy.PLoS': [3359], '9:': [3362], 'e97985Crossref': [3363], 'Diabetes-associated': [3369], 'protective': [3372, 3835], 'short-chain': [3373], 'fatty': [3374], 'disruption.41Zhang': [3386], 'Scholar,44Mosterd': [3416], 'Kanbay': [3418], 'van': [3420], 'den': [3421], 'Born': [3422], 'al.Intestinal': [3425], 'derived': [3436], 'metabolites': [3437], 'inmodulation': [3438], 'progression.Best': [3444], 'Pract': [3445], 'Endocrinol': [3448, 3510], '35:': [3451], '101484Crossref': [3452], '45Reichardt': [3458], 'Duncan': [3460], 'S.H.': [3461], 'al.Phylogenetic': [3465], 'distribution': [3466], 'three': [3468], 'propionate': [3471], 'microbiota.ISME': [3477], '1323-1335Crossref': [3481], '(530)': [3484], '46Diener': [3487], 'Reyes-Escogido': [3489], 'M.L.': [3490], 'Jimenez-Ceja': [3491], 'L.M.': [3492], 'al.Progressive': [3494], 'shifts': [3495], 'reflect': [3500], 'prediabetes': [3501], 'treatment-naive': [3507], 'Mexican': [3508], 'cohort.Front': [3509], '(Lausanne).': [3511], '602326Crossref': [3514], '(2)': [3517], 'Complex': [3520], 'especially': [3523], 'essentially': [3527], '"diseases': [3528], 'diseases,"': [3530], 'such': [3531, 3767], 'present': [3540], 'major': [3541, 3603], 'challenges': [3542], 'deciphering': [3544], 'reproducible': [3545], 'genetic': [3546, 3758, 3836], 'contributions': [3547], 'susceptibility': [3549], 'severity.47Cole': [3551], 'Florez': [3553], 'J.C.': [3554], 'Genetics': [3555], 'complications.Nat': [3561], '377-390Crossref': [3566], '(163)': [3569], 'Advances': [3572], 'acquiring': [3574], 'large': [3575, 3909], 'datasets': [3576], 'genome-wide': [3580, 3910, 3985], 'association': [3581, 3627, 3688, 3807, 3911, 3937, 3986], 'yielded': [3584], 'insights': [3586], 'shed': [3588], 'light': [3589], 'predisposition': [3591], 'DKD.': [3593], 'Missense': [3594], 'mutations': [3595], 'COL4A3': [3598, 3656, 3719, 3735], 'gene,': [3599], 'encodes': [3601], 'structural': [3604], 'component': [3605], 'basement': [3609, 3638, 3699, 3818], 'membrane': [3610, 3639, 3700, 3819], '(GBM),': [3611], 'known': [3615], 'Alport': [3618], 'syndrome.48Salem': [3619], 'R.M.': [3620, 3681, 3800], 'Todd': [3621, 3682, 3801], 'J.N.': [3622, 3683, 3802], 'Sandholm': [3623, 3684, 3803, 3981], 'al.Genome-wide': [3626, 3687, 3806, 3936], 'study': [3628, 3689, 3808, 3912, 3938, 3987], 'highlights': [3633, 3694, 3813], 'biology': [3634, 3695, 3814], 'involved': [3635, 3696, 3815], 'collagen.J': [3640, 3701, 3820], '30:': [3645, 3706, 3825], '2000-2016Crossref': [3646, 3707, 3826], 'Recently,': [3652], 'variant': [3654, 3675, 3720, 3736, 3770, 3895, 3970], '(rs55703767)': [3657], 'linked': [3660], '"diabetic': [3666], 'nephropathy"': [3667], 'T1D,': [3671], 'suggesting': [3672, 3920], 'disordered': [3678], 'collagen': [3679, 3785], 'expression.48Salem': [3680], 'was': [3721, 3972], 'most': [3722], 'evident': [3723], 'glycated': [3732], 'hemoglobin.': [3733], 'less': [3741], 'GBM': [3742], 'thickening': [3743], 'glomerulosclerosis': [3745], 'among': [3746], 'either': [3749], 'who': [3753], 'biopsy': [3756], 'data.': [3759], 'Thus,': [3760], '"second-hit"': [3762], 'phenomenon': [3763], 'operative': [3766], 'consequences': [3772], 'hyperglycemia,': [3774], 'damage.': [3778], 'Variants': [3779], 'genes': [3782], '(DDR1,': [3790], 'COLEC11,': [3791], 'BMP7)': [3792], 'various': [3797], 'phenotypes.48Salem': [3799], 'contrast': [3833], 'variants,': [3837], 'APOL-l': [3838], 'G1/G2': [3839], 'alleles': [3840], 'observed': [3841], 'African': [3845, 3915, 3950], 'ancestry': [3846], 'nondiabetic': [3852], 'often': [3854], 'when': [3855], 'accompanied': [3856, 3865], '"second': [3859], 'hit,"': [3860], 'viral': [3863], 'illness': [3864], 'interferon': [3869], 'state.49Friedman': [3870], 'D.J.': [3871], 'Pollak': [3872], 'M.R.': [3873], 'APOL1': [3874], 'genetics': [3877], 'applications.Clin': [3880], '294-303Crossref': [3887], '(11)': [3890], 'Another': [3893], 'APOL-1': [3894], '(rs9622363)': [3896], 'recently': [3899], 'reported': [3900], 'meta-analysis': [3913], 'American': [3916], 'it': [3922], 'progression.50Guan': [3929], 'Keaton': [3931], 'Dimitrov': [3933], 'identifies': [3939], 'novel': [3940], 'loci': [3941], 'diabetes-attributed': [3945], 'end-stage': [3946], 'Americans.Hum': [3951], 'Genomics.': [3952], '13:': [3954], '21Crossref': [3955], 'Among': [3961], 'European': [3963], 'cohort': [3964], 'GABRR1': [3968], '(rs9942471)': [3971], 'highly': [3973], 'microalbuminuria.51van': [3976], 'Zuydam': [3977], 'N.R.': [3978], 'Ahlqvist': [3979], 'E.': [3980], 'subjects': [3993], 'diab': [3997]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4281918786', 'counts_by_year': [{'year': 2024, 'cited_by_count': 166}, {'year': 2023, 'cited_by_count': 81}, {'year': 2022, 'cited_by_count': 13}], 'updated_date': '2025-01-03T21:54:33.225910', 'created_date': '2022-06-13'}
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