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'calcification': [20, 56, 161], '(VC)': [21], 'is': [22, 35, 51], 'an': [23], 'active': [24], 'process': [25, 140], 'involves': [27], 'the': [28, 60, 90, 131, 139, 148, 157, 164, 177], 'mineral': [29], 'deposition': [30], 'calcium-phosphate': [32], 'complexes.': [33], 'VC': [34, 109, 142], 'closely': [36], 'related': [37, 129], 'to': [38, 122, 130], 'cardiovascular': [39, 153, 167], 'diseases,': [40], 'such': [41], 'as': [42], 'hypertension,': [43], 'heart': [44], 'failure,': [45], 'calcific': [47], 'aortic': [48], 'stenosis,': [49], 'type': [53], 'ectopic': [55], 'occurs': [58], 'in': [59, 89], 'vessel': [61], 'walls.': [62], 'The': [63], 'sirtuins': [64, 183], '(silent': [65], 'mating-type': [66], 'information': [67], 'regulation': [68, 91], '2;': [69], 'SIRTs),': [70], 'family': [73], 'histone': [75], 'deacetylases': [76], 'whose': [77], 'function': [78], 'relies': [79], 'on': [80, 105, 176], 'nicotinamide': [81], 'adenine': [82], 'dinucleotide': [83], '(NAD+).': [84], 'They': [85], 'have': [86, 102, 119], 'non-negligible': [87], 'functions': [88], 'energy': [93], 'metabolism,': [94], 'senescence,': [95], 'apoptosis,': [96], 'other': [98], 'biological': [99], 'processes.': [100], 'Sirtuins': [101, 118], 'important': [103], 'effects': [104], 'bone': [106, 116], 'homeostasis': [107], 'processes': [110], 'share': [112], 'many': [113], 'similarities': [114], 'formation.': [117], 'been': [120], 'confirmed': [121], 'deacetylate': [123], 'variety': [125], 'target': [127], 'proteins': [128], 'occurrence': [132], 'development': [134, 165], 'VC,': [136], 'thereby': [137], 'affecting': [138], 'providing': [144], 'new': [145], 'possibilities': [146], 'for': [147], 'prevention': [149], 'treatment': [151], 'diseases.': [154], 'To': [155], 'facilitate': [156], 'understanding': [158], 'vascular': [160], 'accelerate': [163], 'drugs,': [168], 'we': [169], 'reviewed': [170], 'summarized': [172], 'recent': [173], 'research': [174], 'progress': [175], 'relationship': [178], 'between': 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