Title: Near-infrared sensitive nanoparticle-mediated photothermal ablation of ventricular myocardium
Abstract: Radiofrequency (RF) catheter ablation is the current standard of care for patients with medically refractory ventricular tachycardia. 1 Cronin E.M. Bogun F.M. Maury P. et al. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: executive summary. Heart Rhythm. 2020; 17: e155-e205 Abstract Full Text Full Text PDF PubMed Scopus (44) Google Scholar Despite improvements in catheter technology, higher-density mapping, and ablation techniques, outcomes remain plateaued. One shortcoming of RF ablation is the inability to consistently create transmural lesions in regions of scar due to limitations of RF depth, and the inability of RF to penetrate regions of scar and/or fat. 2 Barkagan M. Leshem E. Shapira-Daniels A. et al. Histopathological characterization of radiofrequency ablation in ventricular scar tissue. JACC Clin Electrophysiol. 2019; 5: 920-931 Crossref PubMed Scopus (27) Google Scholar Furthermore, RF requires continuous tissue contact, irrigated RF can lead to excessive fluid accumulation in patients with compromised left ventricular function, and extreme tissue temperatures can lead to "steam pops" and cardiac perforation. Near-infrared sensitive (NIRS) nanoparticles may have the ability to overcome current RF ablation limitations by creating deeper, transmural lesions in a precise region of interest. Near-infrared (NIR) light can penetrate tissue depths >1 cm, which is applicable to ventricular wall thickness. Once exposed to NIR light, NIRS nanoparticles could create cardiac ablation lesions via photothermal heating.
Publication Year: 2022
Publication Date: 2022-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 1
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