Title: Scientific Opinion on the developmental neurotoxicity potential of acetamiprid and imidacloprid
Abstract: EFSA JournalVolume 11, Issue 12 3471 OpinionOpen Access Scientific Opinion on the developmental neurotoxicity potential of acetamiprid and imidacloprid EFSA Panel on Plant Protection Products and their Residues (PPR), EFSA Panel on Plant Protection Products and their Residues (PPR)Search for more papers by this author EFSA Panel on Plant Protection Products and their Residues (PPR), EFSA Panel on Plant Protection Products and their Residues (PPR)Search for more papers by this author First published: 17 December 2013 https://doi.org/10.2903/j.efsa.2013.3471Citations: 24 Panel members: Alf Aagaard, Theo Brock, Ettore Capri, Sabine Duquesne, Metka Filipic, Antonio Hernandez-Jerez, Karen Ildico Hirsch-Ernst, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Matthias Liess, Alberto Mantovani, Colin Ockleford, Bernadette Ossendorp, Daniel Pickford, Robert Smith, Paulo Sousa, Ingvar Sundh, Aaldrik Tiktak, Ton Van Der Linden Correspondence: [email protected] Acknowledgement: The Panel wishes to thank the members of the Working Group on Acetamiprid and Imidacloprid Developmental Neurotoxicity: Antonio F. Hernández-Jerez, Karen Ildico Hirsch-Ernst, Alberto Mantovani, Colin D. Ockleford, Anna Bal-Price and Laura Ricceri for the preparatory work on this Scientific Opinion and EFSA's staff member Manuela Tiramani for the support provided to this Scientific Opinion. Adoption date: 21 November 2013 Published date: 17 December 2013 Question number: EFSA-Q-2012-00958 On request from: European Commission AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The European Food Safety Authority asked the Panel on Plant Protection Products (PPR) and their residues to deliver a Scientific Opinion on the developmental neurotoxicity (DNT) potential of the neonicotinoid insecticides acetamiprid and imidacloprid. An in vitro study (Kimura-Kuroda et al., 2012) suggested that excitation and/or desensitisation of nicotinic acetylcholine receptors (nAChRs) by these compounds might affect developing mammalian nervous systems as occurs with nicotine. To evaluate the DNT potential of acetamiprid and imidacloprid, the PPR Panel scrutinised the open literature, the draft assessments reports and dossiers submitted for approval. The Panel concludes that both compounds may affect neuronal development and function, although several methodological limitations have been identified. Considering the available DNT studies for imidacloprid and acetamiprid, important uncertainties still remain and further in vivo studies following OECD test guideline (TG) 426 are required to robustly characterise a DNT potential and dose-response relationships, particularly for acetamiprid. The Panel considers that current ARfDs may not be protective enough for the possible DNT of acetamiprid and imidacloprid and no reliable conclusion can be drawn as regards the ADI for acetamiprid. More conservative reference values are proposed based on the analysis of the existing toxicological data. However, the current ADI for imidacloprid is considered adequate to protect against its potential developmental neurotoxic effects. Limitations of the in vitro system used by Kimura-Kuroda et al. (2012) prevent its current use as a screening tool in the regulatory arena. 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