Title: Proceedings of the 64<sup>th</sup> General Meeting of the Showa University Society
Abstract:Brain hypothermia therapy was developed as a brain protective treatment in the 1940s.Thereafter, many studies were performed in the development of various brain protective therapies.Recently, techniqu...Brain hypothermia therapy was developed as a brain protective treatment in the 1940s.Thereafter, many studies were performed in the development of various brain protective therapies.Recently, techniques controlling brain temperature have progressed considerably.We have developed a pharmacological brain cooling method with indomethacin, a nonselective cyclooxygenase inhibitor, without the use of cooling blankets in patients.We have also developed a nasopharyngeal cooling method to control brain temperature quickly and safely following neuronal injury.These new techniques provided quick induction of brain temperature control and do not require special facilities.One of the neuroprotective mechanisms of brain hypothermia is thought to be antioxidative stress.Oxidative stress causes brain and neuronal cell injury in various neuronal conditions, including neurological emergencies and neurodegenerative diseases.Oxidative stress also has an important role in neuroin ammation.We developed a technique for free radical monitoring using an ex vivo electron spin resonance spin trapping method in patients with neuroemergencies.We have reported the kinetics of free radicals in the blood in both the laboratory and clinical setting.Free radical monitoring is useful and may prove valuable for clarifying the pathophysiology of neuroemergency diseases and the effectiveness of antioxidative stress therapies involving free radical scavenging, brain hypothermia, and molecular hydrogen therapy.Here, we review the results of our studies into various neuroprotective therapies in acute neuronal conditions.Read More