Title: Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites
Abstract: Chapter 12 Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites Tina Weber, Tina WeberSearch for more papers by this authorPaul M. Selzer, Paul M. SelzerSearch for more papers by this author Tina Weber, Tina WeberSearch for more papers by this authorPaul M. Selzer, Paul M. SelzerSearch for more papers by this author Book Editor(s):Charles Q. Meng, Charles Q. Meng Boehringer Ingelheim Animal Health, 3239 Satellite Boulevard, Duluth, GA, 30096 United StatesSearch for more papers by this authorAnn E. Sluder, Ann E. Sluder Vaccine and Immunotherapy Center, Massachusetts General Hospital, 149 13th St., Charlestown, MA, 02129 United StatesSearch for more papers by this author First published: 01 June 2018 https://doi.org/10.1002/9783527802883.ch12Citations: 1 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary Efficient control of arthropod ectoparasite infestations has a long-standing history in the agriculture and veterinary sectors, aiming to decrease the parasite burden of affected crops and animals. Ligand-gated chloride channels (LGCCs) modulated by γ-aminobutyric acid (GABA) and glutamate have been identified as suitable molecular targets, and several classes of potent parasiticides have been devised. Due to the increase in cross-resistance and decreased development of new chemical entities, an urgent need for new parasiticides or prevention schemes has emerged. In the past decade, an innovative isoxazoline chemotype appeared to offer promise for inhibiting LGCCs with a new mode of action and distinct binding site from that of historical agents. Considerable efforts have focused on optimizing the antiparasitic activity of isoxazolines and may provide the potential for future human use. Citing Literature Ectoparasites: Drug Discovery Against Moving Targets RelatedInformation
Publication Year: 2018
Publication Date: 2018-06-01
Language: en
Type: other
Indexed In: ['crossref']
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Cited By Count: 2
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