Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4252843630', 'doi': 'https://doi.org/10.7326/0003-4819-95-6-784', 'title': 'Acute Intermittent Porphyria', 'display_name': 'Acute Intermittent Porphyria', 'publication_year': 1981, 'publication_date': '1981-12-01', 'ids': {'openalex': 'https://openalex.org/W4252843630', 'doi': 'https://doi.org/10.7326/0003-4819-95-6-784', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7305168'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-95-6-784', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071669604', 'display_name': 'Karl E. Anderson', 'orcid': 'https://orcid.org/0000-0002-6499-8573'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'KARL E. ANDERSON', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5071669604'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.368644, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 63, 'max': 67}, 'biblio': {'volume': '95', 'issue': '6', 'first_page': '784', 'last_page': '784'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12068', 'display_name': 'Neonatal Health and Biochemistry', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12845', 'display_name': 'Methemoglobinemia and Tumor Lysis Syndrome', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/porphobilinogen-deaminase', 'display_name': 'Porphobilinogen deaminase', 'score': 0.9475994}, {'id': 'https://openalex.org/keywords/porphobilinogen', 'display_name': 'Porphobilinogen', 'score': 0.8319936}, {'id': 'https://openalex.org/keywords/porphobilinogen-synthase', 'display_name': 'Porphobilinogen synthase', 'score': 0.5393432}, {'id': 'https://openalex.org/keywords/uroporphyrinogen-iii-decarboxylase', 'display_name': 'Uroporphyrinogen III decarboxylase', 'score': 0.4274854}], 'concepts': [{'id': 'https://openalex.org/C2778503633', 'wikidata': 'https://www.wikidata.org/wiki/Q415227', 'display_name': 'Porphobilinogen deaminase', 'level': 4, 'score': 0.9475994}, {'id': 'https://openalex.org/C2779028619', 'wikidata': 'https://www.wikidata.org/wiki/Q424247', 'display_name': 'Acute intermittent porphyria', 'level': 3, 'score': 0.84466195}, {'id': 'https://openalex.org/C2776682811', 'wikidata': 'https://www.wikidata.org/wiki/Q421178', 'display_name': 'Porphobilinogen', 'level': 3, 'score': 0.8319936}, {'id': 'https://openalex.org/C2777940757', 'wikidata': 'https://www.wikidata.org/wiki/Q271759', 'display_name': 'Porphyria', 'level': 2, 'score': 0.78103703}, {'id': 'https://openalex.org/C2781374117', 'wikidata': 'https://www.wikidata.org/wiki/Q5252382', 'display_name': 'Dehydratase', 'level': 3, 'score': 0.723079}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.71285707}, {'id': 'https://openalex.org/C44538786', 'wikidata': 'https://www.wikidata.org/wiki/Q17816567', 'display_name': 'Porphobilinogen synthase', 'level': 4, 'score': 0.5393432}, {'id': 'https://openalex.org/C2778417259', 'wikidata': 'https://www.wikidata.org/wiki/Q619815', 'display_name': 'Protoporphyrin', 'level': 3, 'score': 0.51985246}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.47371095}, {'id': 'https://openalex.org/C172110603', 'wikidata': 'https://www.wikidata.org/wiki/Q409065', 'display_name': 'Uroporphyrinogen III decarboxylase', 'level': 4, 'score': 0.4274854}, {'id': 'https://openalex.org/C2776217839', 'wikidata': 'https://www.wikidata.org/wiki/Q189621', 'display_name': 'Heme', 'level': 3, 'score': 0.42194536}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3748399}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3228528}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.24747732}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.16677001}, {'id': 'https://openalex.org/C2779480358', 'wikidata': 'https://www.wikidata.org/wiki/Q422926', 'display_name': 'Porphyrin', 'level': 2, 'score': 0.13396978}], 'mesh': [{'descriptor_ui': 'D000642', 'descriptor_name': 'Ammonia-Lyases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011163', 'descriptor_name': 'Hydroxymethylbilane Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011164', 'descriptor_name': 'Porphyrias', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000642', 'descriptor_name': 'Ammonia-Lyases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011163', 'descriptor_name': 'Hydroxymethylbilane Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011164', 'descriptor_name': 'Porphyrias', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-95-6-784', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7305168', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2889146990', 'https://openalex.org/W2782533099', 'https://openalex.org/W2403788404', 'https://openalex.org/W2133019703', 'https://openalex.org/W2061437759', 'https://openalex.org/W2054031054', 'https://openalex.org/W2033610485', 'https://openalex.org/W1974504902', 'https://openalex.org/W1974208449', 'https://openalex.org/W1645792073'], 'abstract_inverted_index': {'Letters': [0], 'and': [1, 44, 139, 182, 201, 229, 278], 'Corrections1': [2], 'December': [3, 307, 316], '1981Acute': [4], 'Intermittent': [5], 'PorphyriaKARL': [6], 'E.': [7, 16], 'ANDERSON,': [8, 17], 'M.D.,': [9, 12], 'SHIGERU': [10, 25], 'SASSA,': [11, 26], 'ATTALLAH': [13, 34], 'KAPPAS,': [14, 35], 'M.D.KARL': [15], 'M.D.Search': [18, 27, 36], 'for': [19, 28, 37, 250, 297, 302], 'more': [20, 29, 38], 'papers': [21, 30, 39], 'by': [22, 31, 40], 'this': [23, 32, 41], 'author,': [24, 33], 'authorAuthor,': [42], 'Article,': [43, 277], 'Disclosure': [45, 279], 'Informationhttps://doi.org/10.7326/0003-4819-95-6-784': [46], 'SectionsAboutPDF': [47], 'ToolsAdd': [48], 'to': [49, 60, 114, 146], 'favoritesDownload': [50], 'CitationsTrack': [51], 'CitationsPermissions': [52], 'ShareFacebookTwitterLinkedInRedditEmail': [53], 'ExcerptTo': [54], 'the': [55, 86, 123, 129, 222, 240, 253, 273], 'editor:': [56], 'Mustajoki': [57, 90], '(1)': [58], 'claims': [59], 'have': [61, 103], 'described': [62], 'a': [63, 81, 134, 162], 'new': [64], 'variant': [65], 'of': [66, 118, 137, 144, 196, 224, 239, 252], 'acute': [67, 165, 245, 304], 'intermittent': [68, 166, 246], 'porphyria.': [69, 167, 247], 'This': [70, 262], 'finding': [71], 'would': [72], 'be': [73], 'quite': [74], 'important': [75], 'if': [76], 'proved': [77], 'unequivocally,': [78], 'but': [79], 'such': [80], 'claim': [82], 'is': [83, 152, 264], 'premature': [84], 'from': [85, 206], 'data': [87], 'presented.': [88], 'First,': [89], 'states': [91], 'that': [92, 100], '"no': [93], 'hematologic': [94], 'or': [95], 'other': [96], 'cause': [97], 'was': [98], 'found': [99], 'could': [101], 'secondarily': [102], 'raised': [104], 'low': [105], '[porphobilinogen': [106], 'deaminase': [107, 126, 242], '(also': [108], 'known': [109], 'as': [110], 'uroporphyrinogen-I': [111, 199], 'synthase)]': [112], 'activity': [113, 127], 'normal."': [115], 'The': [116, 281], 'patient': [117], 'Case': [119], 'III-1,': [120], 'however,': [121], 'with': [122, 131, 164], 'highest': [124], 'porphobilinogen': [125, 241], 'among': [128], 'subjects': [130], 'porphyria,': [132], 'had': [133, 142], 'reticulocyte': [135, 150], 'count': [136, 151], '5%,': [138], 'three': [140], 'others': [141], 'counts': [143], '2.1%': [145], '2.5%.': [147], 'An': [148], 'increased': [149], 'certainly...References1.': [153], 'MUSTAJOKI': [154], 'P.': [155], 'Normal': [156], 'erythrocyte': [157, 177, 226], 'uroporphyrinogen': [158, 230], 'I': [159], 'synthase': [160, 200], 'in': [161, 184, 204, 244], 'kindred': [163], 'Ann': [168], 'Intern': [169], 'Med.': [170, 189], '1981;95:162-6.': [171], 'LinkGoogle': [172], 'Scholar2.': [173], 'ANDERSONSASSAPETERSONKAPPAS': [174], 'KSCA.': [175], 'Increased': [176], 'uroporphyrinogen-I-synthetase,': [178], 'δ-aminolevulinic': [179], 'acid': [180], 'dehydratase': [181, 228], 'protoporphyrin': [183, 202], 'hemolytic': [185], 'anemias.': [186], 'Am': [187], 'J': [188, 256], '1977;63:359-64.': [190], 'CrossrefMedlineGoogle': [191, 216, 234, 260], 'Scholar3.': [192], 'SASSABERNSTEIN': [193], 'SS.': [194], 'Levels': [195], 'δ-aminolevulinate': [197, 227], 'dehydratase,': [198], 'IX': [203], 'erythrocytes': [205], 'anemic': [207], 'mutant': [208], 'mice.': [209], 'Proc': [210], 'Natl': [211], 'Acad': [212], 'Sci': [213], 'USA.': [214], '1977;74:1181-4.': [215], 'Scholar4.': [217], 'SASSAGRANICKBICKERSLEVEREKAPPAS': [218], 'SSDRA.': [219], 'Studies': [220], 'on': [221, 272], 'inheritance': [223], 'human': [225], 'synthetase.': [231], 'Enzyme.': [232], '1973;16:326-33.': [233], 'Scholar5.': [235], 'ANDERSONREDDYANDERSONDESNICK': [236], 'PRKR.': [237], 'Characterization': [238], 'deficinency': [243], 'Immunologic': [248], 'evidence': [249], 'heterogeneity': [251], 'genetic': [254], 'defect.': [255], 'Clin': [257], 'Invest.': [258], '1981;68:1-12.': [259], 'Scholar': [261], 'content': [263], 'PDF': [265, 274, 318], 'only.': [266], 'To': [267], 'continue': [268], 'reading': [269], 'please': [270], 'click': [271], 'icon.': [275], 'Author,': [276], 'InformationAffiliations:': [280], 'Rockefeller': [282], 'University': [283], 'Hospital': [284], 'New': [285], 'York,': [286], 'NY': [287], '10021': [288], 'PreviousarticleNextarticle': [289], 'Advertisement': [290], 'FiguresReferencesRelatedDetails': [291], 'Metrics': [292], 'Cited': [293], 'ByA': [294], 'challenging': [295], 'diagnosis': [296], 'potential': [298], 'fatal': [299], 'diseases:': [300], 'Recommendations': [301], 'diagnosing': [303], 'porphyrias': [305], '1': [306, 315], '1981Volume': [308], '95,': [309], 'Issue': [310, 313], '6Page:': [311], '784-785KeywordsPorphyriaReticulocytes': [312], 'Published:': [314], '1981': [317], 'DownloadLoading': [319], '...': [320]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4252843630', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-13T12:43:24.544632', 'created_date': '2022-05-12'}