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427, 456, 609, 698, 738, 791, 837, 1097, 1107, 1121, 1257, 1381], 'control': [424], 'definite': [428], 'which': [432, 845], 'measured': [433], 'functional': [434, 611, 633, 704, 774, 888], 'outcome': [435, 612, 634, 705, 889], '(death': [436], 'or': [437, 484, 544, 950, 1062], 'dependency;': [438], 'modified': [439], 'Rankin': [440], '6)': [443], 'at': [444, 546, 548, 613, 637, 718, 798, 1070, 1677], 'than': [446], 'month': [448, 617], 'after': [449, 560, 690, 747, 954, 1101], 'stroke.': [450, 1102], 'extracted': [453, 1576], 'verified': [455], 'principal': [457], 'investigators': [458], 'all': [460, 1023], 'major': [461], 'trials.': [462], 'Published': [463], 'unpublished': [465], 'used.Main': [468], 'ResultsEighteen': [469], 'comprising': [471], '5727': [472], 'included': [475], 'testing': [478, 487], 'urokinase': [479], '(UK),': [480], 'streptokinase,': [481], 'recombinant': [482], 'pro-UK,': [483], 'rtPA.': [485], 'rtPA': [488, 684, 737, 784, 811, 843, 1026, 1103, 1123], 'contributed': [489], '≈50%': [490], '(patients': [494], 'trials);': [496], 'new': [498, 927], 'trial': [499], 'UK': [501], '565': [503], 'identified;': [506], '4984': [507], '(15': [509], 'trials)': [510], 'treated': [512, 555], 'stroke;': [517], '16': [519], 'used': [521], 'intravenous': [522, 683, 1122, 1849], 'administration': [523, 1171], '(96%': [524], 'patients;': [526], 'Figure).': [527], 'Download': [528], 'figureDownload': [529], 'PowerPointEffect': [530], 'agents': [533, 777, 804], '(vs': [534], 'control)': [535], 'on': [542, 796, 944, 1416, 1628, 1888], '"death': [543], 'dependency"': [545], 'follow-up': [547, 618, 641, 722, 802], 'months.Overall,': [552], 'among': [553], 'up': [556, 686, 743], 'despite': [563, 1079], 'increase': [565, 957, 1081], 'intracranial': [567, 570, 582, 645, 824, 1089], 'hemorrhage': [568, 571, 583, 825], '(fatal': [569], 'odds': [572], 'ratio': [573], '[OR],': [574], '4.34;': [575], '95%': [576, 586, 599, 621, 708, 725, 780, 787, 807, 814, 829, 861, 871, 894, 904, 974, 988], 'CI,': [577, 587, 600, 622, 709, 726, 781, 788, 808, 815, 862, 872, 895, 905, 975, 989], '3.14,': [578], '5.99': [579], 'symptomatic': [581, 823], 'OR,': [584, 778, 785, 805, 812, 827, 859, 869, 892, 902, 972, 986], '3.37;': [585], '2.68,': [588], '4.22)': [589], 'death': [591, 797, 856, 961, 1061], 'by': [592, 1577], 'months': [596], '(OR,': [597, 706, 723], '1.33;': [598], '1.15,': [601], '1.53),': [602], 'reduced': [604, 1060], 'proportion': [606], 'poor': [610, 632, 703, 773, 887], '(OR': [619], '0.84;': [620], '0.75,': [623], '0.95).': [624], 'There': [625], 'heterogeneity': [627, 656], 'deaths': [636, 717], 'end': [639, 720, 800], 'but': [642, 818], 'not': [643, 995, 1039, 1173], 'hemorrhage.': [646, 1090], 'undertook': [648], 'subgroup': [649], 'analyses': [650], 'explore': [652], 'potential': [653], 'sources': [654], 'including': [657], '(1)': [658], 'drug,': [660], '(2)': [661], 'time': [662, 849, 937, 1152], 'treatment,': [664], '(3)': [665], 'concomitant': [666], 'aspirin': [667, 1005, 1159], 'heparin': [669], 'use,': [670, 1160], '(4)': [671], "patients'": [673], 'age,': [674, 1163], '(5)': [676], 'severity': [678], 'stroke.Trials': [681], 'suggested': [692], 'that': [693, 910], 'it': [694], 'could': [695], 'be': [696, 920, 1078, 1095, 1105, 1148, 1201], 'associated': [697, 1106], 'favorable': [700], 'risk/benefit': [701], 'ratio:': [702], '0.80;': [707], '0.69,': [710, 816], '0.93)': [711], 'no': [713, 732, 792, 978], 'significant': [714, 793], 'excess': [715, 821], '1.17;': [724], '0.95,': [727], '1.45).': [728], 'However,': [729, 834, 1132], 'there': [730], 'direct': [733], 'comparisons': [735], 'other': [739, 912], 'drugs.For': [741], '(1311': [749], 'patients,': [750], '50%': [751], 'whom': [753], 'came': [754], 'Institute': [758], 'Neurological': [760, 1802, 1860], 'Disorders': [761], '[NINDS]': [764], 'Trial),': [765], 'therapy': [767, 1053, 1120], 'appeared': [768], 'effective': [770], 'reducing': [772], 'outcomes': [775], '(all': [776, 803, 962], '0.66;': [779], '0.53,': [782], '0.83;': [783], '0.64;': [786], '0.5,': [789], '0.83)': [790], 'adverse': [794], '1.13;': [806], '0.86,': [809], '1.48;': [810], '0.97;': [813], '1.36)': [817], 'still': [819], '(rtPA': [826], '3.40;': [828], 'CI': [830], '1.48': [831], '7.84).': [833], '<3-': [836], '3-': [838], '6-hour': [840], 'trials,': [844], 'both': [848], 'windows,': [850], 'showed': [851], 'same': [853], 'risk': [854, 959, 1962], '(<3': [857, 890], '1.75;': [860], '0.91,': [863], '3.36;': [864], '1.38;': [870], '1.05,': [873], '1.82)': [874], 'a': [876, 1129, 1376, 1691, 1967], 'nonsignificant': [877], 'trend': [878], '<3-hour': [880], 'being': [882], 'better': [883], 'terms': [885], '0.69;': [893], '0.44,': [896], '1.09;': [897], '0.88;': [903], '0.73,': [906], '1.06).': [907], 'suggests': [909], 'some': [911], 'time-related': [913], 'factor,': [914], 'like': [915], 'severity,': [917, 1165], 'may': [918, 956, 1104], 'important': [921], 'requires': [923], 'further': [924], 'exploration': [925], 'clarify': [930], 'relationship': [932], 'between': [933], '"tissue': [934], 'injury"': [935], '(ie,': [936, 1064], 'severity)': [940], 'rtPA.Based': [942], 'mostly': [943, 1087], 'nonrandom': [945], 'comparisons,': [946], 'antithrombotic': [947, 965, 981], 'drugs': [948, 966, 982], '(aspirin': [949], 'heparin)': [951], 'soon': [953], '24': [968], 'thrombolysis,': [971, 1891], '1.95;': [973], '1.45,': [976], '2.62;': [977], '14': [984], 'days,': [985], '0.89;': [987], '0.58,': [990], '1.37).': [991], 'Tabular': [992], 'available': [996, 1040, 1189], 'sufficient': [998, 1042], 'detail': [999, 1043], 'before': [1007], 'stroke.There': [1009], 'too': [1011], 'few': [1012], 'aged': [1016], '>80': [1017], 'years': [1018], '(42': [1019], 'total': [1021], 'combined)': [1027], 'older': [1035], 'patients.Tabular': [1036], "severity.Reviewers'": [1050], 'ConclusionsOverall,': [1051], 'dependency': [1063], 'alive': [1067], 'independent)': [1069], 'months.': [1074], 'appears': [1076], 'early': [1083], 'late': [1085], 'deaths,': [1086], 'benefits': [1092], 'seem': [1093], 'greater': [1096], 'sooner': [1100], 'less': [1108], 'hazard': [1109], 'benefit.': [1112], 'justify': [1115], 'license': [1130], 'exists.': [1131], 'optimum': [1134], 'criteria': [1135], 'identify': [1137], 'benefit': [1143], 'least': [1145], 'harmed,': [1149], 'latest': [1151], 'window,': [1153], 'prior': [1158], 'increasing': [1161], 'patient': [1162], 'agent,': [1166], 'dose,': [1167], 'route': [1169], 'clear.': [1174], 'Further': [1175], 'therefore': [1180], 'needed.Note:': [1181], 'full': [1183, 1198], 'text': [1184], 'review': [1187], 'Library': [1193], '(for': [1194], 'subscribers:': [1195], 'www.update-software.com/Cochrane).': [1196], 'article': [1199], 'should': [1200], 'cited': [1202], 'as:': [1203], 'JM,': [1205], 'G,': [1208, 1438, 1499, 2041], 'T,': [1210, 1834], 'E.': [1212], 'Thrombolysis': [1213, 1601, 1744, 1927], '(Cochrane': [1218], 'Review).': [1219], 'In:': [1220], 'Library.': [1223], 'Issue': [1224, 2081], '4,': [1225], '2003.': [1226], 'Oxford,': [1227], 'UK:': [1228], 'Update': [1229], 'Software,': [1230], '©': [1231], 'Library,': [1233], 'John': [1234], 'Wiley': [1235], '&': [1236, 1489, 1772], 'Sons': [1237], 'Ltd.We': [1238], 'grateful': [1240], 'Hazel': [1242], 'Fraser': [1243], 'Brenda': [1245], 'Thomas': [1246], 'Editorial': [1252], 'Office': [1253], 'ongoing': [1255], 'assistance': [1256], 'literature': [1258], 'searching': [1259], 'administration.FootnotesCorrespondence': [1261], 'Prof': [1263], 'Neurosciences,': [1269], 'Crewe': [1273], 'Rd,': [1274], 'Edinburgh': [1275], 'EH4': [1276], '2XU,': [1277], 'UK.': [1278], 'E-mail': [1279], '[email': [1280], 'protected]': [1281], 'Back': [1283], 'top': [1285], 'Next': [1286], 'FiguresReferencesRelatedDetailsCited': [1287], 'By': [1288], 'Arslan': [1289], 'E': [1290, 1595], 'Cetinkaya': [1292], 'O': [1293], '(2022)': [1294, 1333], 'Analysis': [1295], 'demographic': [1298], 'characteristics': [1299], 'profile': [1302], 'strokes': [1306], 'admitted': [1307], 'emergency': [1310], 'centre': [1311], 'Somalia': [1314], 'population,': [1315], 'African': [1316], 'Journal': [1317, 1540, 1580, 1800, 1805, 1857, 1933, 1971, 2065], 'Emergency': [1319], 'Medicine,': [1320, 1349, 1699, 1728, 1896], '10.1016/j.afjem.2022.04.010,': [1321], '12:3,': [1322], '(216-224),': [1323], 'Online': [1324, 1352, 1393, 1494, 1549, 1586, 1637, 1703, 1777, 1813, 1827, 1865, 1899, 1939, 1977, 2028, 2074], 'publication': [1325, 1353, 1394, 1495, 1550, 1587, 1638, 1704, 1778, 1814, 1828, 1866, 1900, 1940, 1978, 2029, 2075], 'date:': [1326, 1354, 1395, 1496, 1551, 1588, 1639, 1705, 1779, 1815, 1829, 1867, 1901, 1941, 1979, 2030, 2076], '1-Sep-2022.': [1327], 'Doig': [1328, 1641, 1707], 'D': [1329, 1366, 1471, 1642, 1708, 1923], 'Brown': [1331, 1644, 1710], 'M': [1332, 1413, 1440, 1560, 1645, 1670, 1711, 1788, 1841], 'care': [1336], 'management': [1338], 'carotid': [1340], 'artery': [1341], 'stenosis': [1342], "Pathy's": [1343, 1722], 'Principles': [1344, 1723], 'Practice': [1346, 1725], 'Geriatric': [1348, 1727], '10.1002/9781119484288.ch47,': [1350], '(598-618),': [1351], '15-Apr-2022.': [1355], 'Qin': [1356, 1461], 'Z,': [1357, 1462], 'Chon': [1358, 1465], 'C,': [1359, 1466, 1509, 1915], 'Kwok': [1360, 1467], 'J,': [1361, 1513, 1591, 1732, 1874, 1911, 1986, 1988, 1998], 'Woo': [1362], 'P': [1363, 1920], 'Lam': [1365, 1470], '(2021)': [1367], 'Dose–Response': [1368], 'Relationship': [1369], 'Threshold': [1371], 'Drug': [1372], 'Dosage': [1373], 'Identification': [1374], 'Novel': [1377], 'Hybrid': [1378], 'Mechanical-Thrombolytic': [1379], 'System': [1380], 'Ultra-Low': [1383], 'Dose': [1384], 'Patch,': [1385], 'Cellular': [1386], 'Bioengineering,': [1389], '10.1007/s12195-021-00683-y,': [1390], '14:6,': [1391], '(627-637),': [1392], '1-Dec-2021.': [1396], 'Sedighi': [1397], 'M,': [1398, 1406, 1515, 1517, 1904, 1913, 1948, 1984, 1990, 2002, 2004], 'Sewell': [1399], 'R,': [1400, 1558, 1617, 1872, 1908, 1918, 1996], 'Nazari': [1401], 'A,': [1402, 1408, 1436, 1782, 2000], 'Abbaszadeh': [1403], 'S,': [1404, 1507, 1615, 1786, 1870, 2035, 2039], 'Cheraghi': [1405], 'Amini': [1407], 'Heydari': [1409], 'Z': [1410], 'Rafieian-Kopaei': [1412], 'A': [1414, 1571], 'Review': [1415], 'Most': [1418], 'Important': [1419], 'Medicinal': [1420], 'Plants': [1421], 'Effective': [1422], 'Cardiac': [1424], 'Ischemia-Reperfusion': [1425], 'Injury,': [1426], 'Current': [1427], 'Pharmaceutical': [1428], 'Design,': [1429], '10.2174/1381612825666190329144016,': [1430], '25:3,': [1431], '(352-358)': [1432], 'Eren': [1433], 'F,': [1434, 1464], 'Yıldoğan': [1435], 'Öngün': [1437], 'Işık': [1439], 'Öztürk': [1442], 'Ş': [1443], '(2019)': [1444], 'Trombolitik': [1445], 'tedavi': [1446], 'uygulanan': [1447], 'iskemik': [1448], 'inme': [1449], 'hastalarında': [1450], 'hematolojik': [1451], 've': [1452], 'biyokimyasal': [1453], 'parametrelerin': [1454], 'prognostik': [1455], 'değeri,': [1456], 'Pamukkale': [1457], 'Medical': [1458, 1487], 'Journal,': [1459], '10.31362/patd.481507': [1460], 'Ciucci': [1463], 'J': [1468, 1519, 1742, 1758, 2006, 2009], '(2018)': [1472], 'Model': [1473], 'development': [1474], 'comparison': [1476], 'low': [1478], 'hemorrhage-risk': [1479], 'endoluminal': [1480], 'patch': [1481], 'Engineering': [1488], 'Physics,': [1490], '10.1016/j.medengphy.2018.08.003,': [1491], '61,': [1492], '(32-40),': [1493], '1-Nov-2018.': [1497], 'Gadodia': [1498], 'Rizk': [1500], 'N,': [1501, 1554], 'Camp': [1502], 'D,': [1503, 1756, 1982], 'Bryant': [1504], 'K,': [1505, 1511, 1944, 2037, 2043], 'Zimmerman': [1506], 'Brasher': [1508], 'Connelly': [1510], 'Dunn': [1512], 'Frankel': [1514], 'Ido': [1516], 'Lugtu': [1518], 'Nahab': [1521], 'F': [1522], '(2016)': [1523, 1924], 'Presenting': [1524], 'Symptoms': [1525], 'Dysphagia': [1527], 'Screen': [1528], 'Predict': [1529], 'Outcome': [1530], 'Mild': [1532], 'Rapidly': [1534], 'Improving': [1535], 'Patients,': [1539], 'Diseases,': [1545, 2070], '10.1016/j.jstrokecerebrovasdis.2016.07.049,': [1546], '25:12,': [1547], '(2876-2881),': [1548], '1-Dec-2016.': [1552], 'Simons': [1553], 'Mitchell': [1555], 'P,': [1556], 'Dowling': [1557], 'Gonzales': [1559], 'Yan': [1562], 'B': [1563], '(2015)': [1564], 'Thrombus': [1565], 'composition': [1566], 'stroke:': [1570], 'histopathological': [1572], 'thrombus': [1575], 'endovascular': [1578], 'retrieval,': [1579], 'Neuroradiology,': [1582], '10.1016/j.neurad.2014.01.124,': [1583], '42:2,': [1584], '(86-92),': [1585], '1-Apr-2015.': [1589], 'Murray': [1592, 1733], 'V,': [1593, 1734], 'G': [1599, 1739, 1878], '(2014)': [1600, 1792], 'ischaemic': [1604, 1747], 'Database': [1607, 1750], 'Systematic': [1609, 1752], 'Reviews,': [1610, 1753], '10.1002/14651858.CD000213.pub3,': [1611], '2016:1': [1612], 'Eugine': [1613], 'Leo': [1614], 'Manavalan': [1616], 'Reeta': [1618], 'Vija': [1619], 'K': [1620], 'Afsar': [1622], 'S': [1623, 2048], '(2013)': [1624], 'Effect': [1625, 1883, 2050], 'Andrographolide': [1627], 'vitro': [1630, 1890], 'Thrombolytic': [1631], 'Activity,': [1632], 'Pharmacologia,': [1633], '10.5567/pharmacologia.2013.586.589,': [1634], '4:11,': [1635], '(586-589),': [1636], '1-Nov-2013.': [1640], '(2012)': [1646, 1674, 1712, 1819], 'Care': [1649, 1715, 1769], 'Management': [1651, 1717], 'Carotid': [1653, 1719], 'Artery': [1654, 1720], 'Stenosis': [1655, 1721], 'Disease': [1657], 'Health': [1659], 'Older': [1662], 'Patient,': [1663], '10.1002/9781118451786.ch11,': [1664], '(261-298)': [1665], 'Le': [1666], 'Jeune': [1667], 'I,': [1668], 'Simmonds': [1669], 'Poole': [1672], 'L': [1673, 1761, 1950], 'Patient': [1675], 'need': [1676], 'heart': [1679], 'workforce': [1681], 'planning:': [1682], 'supply': [1686], 'demand': [1688], 'analysis': [1689], 'large': [1692], 'teaching': [1693], "hospital's": [1694], 'medical': [1696], 'unit,': [1697], '10.7861/clinmedicine.12-4-312,': [1700], '12:4,': [1701], '(312-316),': [1702], '1-Aug-2012.': [1706], '10.1002/9781119952930.ch57,': [1729], '(655-674)': [1730], 'E,': [1736], '(2009)': [1743, 1762], '10.1002/14651858.CD000213.pub2': [1754], 'Friedman': [1755], 'Claassen': [1757], 'Hirsch': [1760], 'Continuous': [1763], 'Electroencephalogram': [1764], 'Monitoring': [1765], 'Intensive': [1768], 'Unit,': [1770], 'Anesthesia': [1771], 'Analgesia,': [1773], '10.1213/ane.0b013e3181a9d8b5,': [1774], '109:2,': [1775], '(506-523),': [1776], '1-Aug-2009.': [1780], 'Kamal': [1781], 'Khealani': [1783], 'B,': [1784], 'Ansari': [1785], 'Afridi': [1787], 'Syed': [1790], 'N': [1791], 'Early': [1793], 'Presentation': [1796], 'Pakistan,': [1798], 'Canadian': [1799], 'Sciences': [1803, 1808], '/': [1804], 'Canadien': [1806], 'des': [1807], 'Neurologiques,': [1809], '10.1017/S0317167100006545,': [1810], '36:2,': [1811], '(181-186),': [1812], '1-Mar-2009.': [1816], 'Lindley': [1817], 'R': [1818], 'Rehabilitation,': [1821], 'Brain': [1822], 'Impairment,': [1823], '10.1375/brim.9.2.97,': [1824], '9:2,': [1825], '(97-102),': [1826], '1-Sep-2008.': [1830], 'Inatomi': [1831], 'Y,': [1832, 1836, 1992], 'Yonehara': [1833], 'Hashimoto': [1835], 'Hirano': [1837], 'T': [1838], 'Uchino': [1840], '(2008)': [1842], 'Pre-hospital': [1843], 'delay': [1844], 'rt-PA': [1850], 'Japan,': [1856], 'Sciences,': [1861], '10.1016/j.jns.2008.02.018,': [1862], '270:1-2,': [1863], '(127-132),': [1864], '1-Jul-2008.': [1868], 'Prasad': [1869], 'Kashyap': [1871], 'Deopujari': [1873], 'Purohit': [1875], 'H,': [1876, 2033], 'Taori': [1877], 'Daginawala': [1880], 'H': [1881, 1953, 2045], '(2007)': [1882, 1954], 'Fagonia': [1885], 'Arabica': [1886], '(Dhamasa)': [1887], 'BMC': [1892], 'Complementary': [1893], 'Alternative': [1895], '10.1186/1472-6882-7-36,': [1897], '7:1,': [1898], '1-Dec-2007.': [1902], 'Dirks': [1903], 'Niessen': [1905], 'L,': [1906, 1994], 'Huijsman': [1907], 'van': [1909, 1916], 'Wijngaarden': [1910], 'Minkman': [1912], 'Franke': [1914], 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