Publication Information

{'id': 'https://openalex.org/W4252192851', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs18-ct073', 'title': 'Abstract CT073: Pembrolizumab after two or more lines of prior therapy in patients with advanced small-cell lung cancer (SCLC): Results from the KEYNOTE-028 and KEYNOTE-158 studies', 'display_name': 'Abstract CT073: Pembrolizumab after two or more lines of prior therapy in patients with advanced small-cell lung cancer (SCLC): Results from the KEYNOTE-028 and KEYNOTE-158 studies', 'publication_year': 2019, 'publication_date': '2019-07-01', 'ids': {'openalex': 'https://openalex.org/W4252192851', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs18-ct073'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs18-ct073', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S59378366', 'display_name': 'Clinical Trials', 'issn_l': '1740-7745', 'issn': ['1740-7745', '1740-7753'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'proceedings-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090832721', 'display_name': 'Hyun Cheol Chung', 'orcid': 'https://orcid.org/0000-0002-0920-9471'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyun Cheol Chung', 'raw_affiliation_strings': ['Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026538331', 'display_name': 'Sarina A. Piha‐Paul', 'orcid': 'https://orcid.org/0000-0001-9455-1660'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarina A. Piha-Paul', 'raw_affiliation_strings': ['The University of Texas MD Anderson Cancer Center, Houston, TX'], 'affiliations': [{'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, TX', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080626646', 'display_name': 'José A. López-Martín', 'orcid': 'https://orcid.org/0000-0001-7530-3207'}, 'institutions': [{'id': 'https://openalex.org/I4210101691', 'display_name': 'Hospital Universitario 12 De Octubre', 'ror': 'https://ror.org/00qyh5r35', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101691', 'https://openalex.org/I4210139293']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Jose Lopez-Martin', 'raw_affiliation_strings': ['Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210101691']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000418012', 'display_name': 'Jan H.M. Schellens', 'orcid': 'https://orcid.org/0000-0001-6832-1976'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I2799557411', 'display_name': 'Dutch Cancer Society', 'ror': 'https://ror.org/0368jnd28', 'country_code': 'NL', 'type': 'other', 'lineage': ['https://openalex.org/I2799557411']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jan H.M. Schellens', 'raw_affiliation_strings': ['Netherlands Cancer Institute, Amsterdam, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Netherlands Cancer Institute, Amsterdam, Netherlands', 'institution_ids': ['https://openalex.org/I2898336195', 'https://openalex.org/I2799557411']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080746799', 'display_name': 'Steven Kao', 'orcid': 'https://orcid.org/0000-0003-4531-7397'}, 'institutions': [{'id': 'https://openalex.org/I4210093547', 'display_name': 'Chris O’Brien Lifehouse', 'ror': 'https://ror.org/00qeks103', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210093547']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Steven Kao', 'raw_affiliation_strings': ["Chris O'Brien Lifehouse, Camperdown, NSW, Australia"], 'affiliations': [{'raw_affiliation_string': "Chris O'Brien Lifehouse, Camperdown, NSW, Australia", 'institution_ids': ['https://openalex.org/I4210093547']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048013287', 'display_name': 'Wilson H. Miller', 'orcid': 'https://orcid.org/0000-0002-7408-1574'}, 'institutions': [{'id': 'https://openalex.org/I2801824472', 'display_name': 'Jewish General Hospital', 'ror': 'https://ror.org/056jjra10', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801824472']}, {'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Wilson H. Miller', 'raw_affiliation_strings': ['Segal Cancer Centre, Jewish General Hospital, Rossy Cancer Network and McGill University, Montreal, Quebec, Canada'], 'affiliations': [{'raw_affiliation_string': 'Segal Cancer Centre, Jewish General Hospital, Rossy Cancer Network and McGill University, Montreal, Quebec, Canada', 'institution_ids': ['https://openalex.org/I2801824472', 'https://openalex.org/I5023651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028020706', 'display_name': 'Jean‐Pierre Delord', 'orcid': 'https://orcid.org/0000-0001-7305-5561'}, 'institutions': [{'id': 'https://openalex.org/I4210128666', 'display_name': 'Institut Claudius Regaud', 'ror': 'https://ror.org/03pa87f90', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128666']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Pierre Delord', 'raw_affiliation_strings': ['Department of Oncology, Institut Claudius Regaud Institut Universitaire du Cancer-Oncopole, Toulouse, France'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Institut Claudius Regaud Institut Universitaire du Cancer-Oncopole, Toulouse, France', 'institution_ids': ['https://openalex.org/I4210128666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071577235', 'display_name': 'Bo Gao', 'orcid': 'https://orcid.org/0000-0002-7881-6603'}, 'institutions': [{'id': 'https://openalex.org/I2802314053', 'display_name': 'Blacktown & Mount Druitt Hospital', 'ror': 'https://ror.org/017bddy38', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802314053']}, {'id': 'https://openalex.org/I4210140513', 'display_name': 'Sydney Local Health District', 'ror': 'https://ror.org/04w6y2z35', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I2801351115', 'https://openalex.org/I4210140513']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Bo Gao', 'raw_affiliation_strings': ['Blacktown Hospital Western Sydney Local Health District, Blacktown, NSW, Australia'], 'affiliations': [{'raw_affiliation_string': 'Blacktown Hospital Western Sydney Local Health District, Blacktown, NSW, Australia', 'institution_ids': ['https://openalex.org/I2802314053', 'https://openalex.org/I4210140513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028596081', 'display_name': 'David Planchard', 'orcid': 'https://orcid.org/0000-0002-1565-8310'}, 'institutions': [{'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'David Planchard', 'raw_affiliation_strings': ['Department of Medical Oncology, Thoracic Group, Gustave Roussy, Villejuif, France'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Thoracic Group, Gustave Roussy, Villejuif, France', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039952118', 'display_name': 'Maya Gottfried', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801839060', 'display_name': 'Meir Medical Center', 'ror': 'https://ror.org/04pc7j325', 'country_code': 'IL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801839060']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Maya Gottfried', 'raw_affiliation_strings': ['Oncology, Meir Medical Center, Kfar Saba, Israel'], 'affiliations': [{'raw_affiliation_string': 'Oncology, Meir Medical Center, Kfar Saba, Israel', 'institution_ids': ['https://openalex.org/I2801839060']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062297013', 'display_name': 'Alona Zer', 'orcid': 'https://orcid.org/0000-0001-6597-5261'}, 'institutions': [{'id': 'https://openalex.org/I2800389475', 'display_name': 'Rabin Medical Center', 'ror': 'https://ror.org/01vjtf564', 'country_code': 'IL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800389475', 'https://openalex.org/I64767286']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Alona Zer', 'raw_affiliation_strings': ['Rabin Medical Center, Petah Tikva, Israel'], 'affiliations': [{'raw_affiliation_string': 'Rabin Medical Center, Petah Tikva, Israel', 'institution_ids': ['https://openalex.org/I2800389475']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065124595', 'display_name': 'Shadia I. Jalal', 'orcid': 'https://orcid.org/0000-0001-8938-7077'}, 'institutions': [{'id': 'https://openalex.org/I1283055418', 'display_name': 'Indiana University Health', 'ror': 'https://ror.org/01aaptx40', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283055418', 'https://openalex.org/I4388446366', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shadia I. Jalal', 'raw_affiliation_strings': ['Indiana University, Simon Cancer Center, Indianapolis, IN'], 'affiliations': [{'raw_affiliation_string': 'Indiana University, Simon Cancer Center, Indianapolis, IN', 'institution_ids': ['https://openalex.org/I1283055418', 'https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052242950', 'display_name': 'Nicolas Penel', 'orcid': 'https://orcid.org/0000-0001-5243-1548'}, 'institutions': [{'id': 'https://openalex.org/I4210131356', 'display_name': 'Centre Oscar Lambret', 'ror': 'https://ror.org/03xfq7a50', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210131356', 'https://openalex.org/I4210141925']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Nicolas Penel', 'raw_affiliation_strings': ['Centre Oscar Lambret, Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Centre Oscar Lambret, Lille, France', 'institution_ids': ['https://openalex.org/I4210131356']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053602981', 'display_name': 'Janice M. Mehnert', 'orcid': 'https://orcid.org/0000-0002-1043-3008'}, 'institutions': [{'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}, {'id': 'https://openalex.org/I4390039325', 'display_name': 'Rutgers Cancer Institute of New Jersey', 'ror': 'https://ror.org/0060x3y55', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I102322142', 'https://openalex.org/I4390039302', 'https://openalex.org/I4390039325']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Janice M. Mehnert', 'raw_affiliation_strings': ['Rutgers Cancer Institute of New Jersey, New Brunswick, NJ'], 'affiliations': [{'raw_affiliation_string': 'Rutgers Cancer Institute of New Jersey, New Brunswick, NJ', 'institution_ids': ['https://openalex.org/I102322142', 'https://openalex.org/I4390039325']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076983415', 'display_name': 'Ignacio Matos', 'orcid': 'https://orcid.org/0000-0002-6396-630X'}, 'institutions': [{'id': 'https://openalex.org/I4387155398', 'display_name': "Vall d'Hebron Institute of Oncology", 'ror': 'https://ror.org/054xx3904', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4387153040', 'https://openalex.org/I4387155398']}], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ignacio Matos', 'raw_affiliation_strings': ["Vall d'Hebron Institute of Oncology, Barcelona, Spain"], 'affiliations': [{'raw_affiliation_string': "Vall d'Hebron Institute of Oncology, Barcelona, Spain", 'institution_ids': ['https://openalex.org/I4387155398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069141052', 'display_name': 'Jaafar Bennouna', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106090', 'display_name': "Institut de Cancérologie de l'Ouest", 'ror': 'https://ror.org/01m6as704', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106090']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jaafar Bennouna', 'raw_affiliation_strings': ["Institut de Cancérologie de l'Ouest, Nantes, France"], 'affiliations': [{'raw_affiliation_string': "Institut de Cancérologie de l'Ouest, Nantes, France", 'institution_ids': ['https://openalex.org/I4210106090']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100638261', 'display_name': 'Dong‐Wan Kim', 'orcid': 'https://orcid.org/0000-0001-5124-7132'}, 'institutions': [{'id': 'https://openalex.org/I2802835388', 'display_name': 'Seoul National University Hospital', 'ror': 'https://ror.org/01z4nnt86', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802835388']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Dong-Wan Kim', 'raw_affiliation_strings': ['Seoul National University Hospital, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Seoul National University Hospital, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I2802835388']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101665227', 'display_name': 'Lei Xu', 'orcid': 'https://orcid.org/0000-0002-3573-8334'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lei Xu', 'raw_affiliation_strings': ['Merck & Co., Inc., Kenilworth, NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co., Inc., Kenilworth, NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109348433', 'display_name': 'Suba Krishnan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Suba Krishnan', 'raw_affiliation_strings': ['Merck & Co., Inc., Kenilworth, NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co., Inc., Kenilworth, NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053725787', 'display_name': 'Kevin Norwood', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin Norwood', 'raw_affiliation_strings': ['Merck & Co., Inc., Kenilworth, NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co., Inc., Kenilworth, NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041066193', 'display_name': 'Patrick A. Ott', 'orcid': 'https://orcid.org/0000-0002-4253-943X'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrick A. Ott', 'raw_affiliation_strings': ['Dana-Farber Cancer Institute, Boston, MA.'], 'affiliations': [{'raw_affiliation_string': 'Dana-Farber Cancer Institute, Boston, MA.', 'institution_ids': ['https://openalex.org/I4210117453']}]}], 'institution_assertions': [], 'countries_distinct_count': 8, 'institutions_distinct_count': 24, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.351, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.605942, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 74, 'max': 77}, 'biblio': {'volume': None, 'issue': None, 'first_page': 'CT073', 'last_page': 'CT073'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.6094347}, {'id': 'https://openalex.org/keywords/progression-free-survival', 'display_name': 'Progression-free survival', 'score': 0.52374697}, {'id': 'https://openalex.org/keywords/surrogate-endpoint', 'display_name': 'Surrogate endpoint', 'score': 0.42955837}], 'concepts': [{'id': 'https://openalex.org/C2780057760', 'wikidata': 'https://www.wikidata.org/wiki/Q13896859', 'display_name': 'Pembrolizumab', 'level': 4, 'score': 0.9467037}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8269041}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.66757107}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.6094347}, {'id': 'https://openalex.org/C2779984678', 'wikidata': 'https://www.wikidata.org/wiki/Q2145898', 'display_name': 'Response Evaluation Criteria in Solid Tumors', 'level': 4, 'score': 0.5912232}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5794039}, {'id': 'https://openalex.org/C2780739268', 'wikidata': 'https://www.wikidata.org/wiki/Q2112244', 'display_name': 'Progression-free survival', 'level': 3, 'score': 0.52374697}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.5187307}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.43283793}, {'id': 'https://openalex.org/C141341695', 'wikidata': 'https://www.wikidata.org/wiki/Q2368661', 'display_name': 'Surrogate endpoint', 'level': 2, 'score': 0.42955837}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42608}, {'id': 'https://openalex.org/C2778822529', 'wikidata': 'https://www.wikidata.org/wiki/Q1951525', 'display_name': 'Progressive disease', 'level': 3, 'score': 0.41841748}, {'id': 'https://openalex.org/C31760486', 'wikidata': 'https://www.wikidata.org/wiki/Q7180990', 'display_name': 'Phases of clinical research', 'level': 3, 'score': 0.40886188}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.3866352}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.2556332}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.24257287}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs18-ct073', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S59378366', 'display_name': 'Clinical Trials', 'issn_l': '1740-7745', 'issn': ['1740-7745', '1740-7753'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.85, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3172671185', 'https://openalex.org/W3031735911', 'https://openalex.org/W3030034569', 'https://openalex.org/W2981548200', 'https://openalex.org/W2899585536', 'https://openalex.org/W2899528185', 'https://openalex.org/W2587744462', 'https://openalex.org/W2581205085', 'https://openalex.org/W2024340610', 'https://openalex.org/W1584669207'], 'abstract_inverted_index': {'Background:': [0], 'The': [1, 168, 264], 'antitumor': [2, 395], 'activity': [3, 396], 'of': [4, 54, 72, 92, 109, 184, 207, 248, 252, 288, 303, 357, 407, 416, 424, 493, 514], 'the': [5, 19, 29, 200, 253, 414, 506, 515], 'anti-PD-1': [6], 'monoclonal': [7], 'antibody': [8], 'pembrolizumab': [9, 50, 433], 'in': [10, 18, 28, 43, 85, 96, 107, 118, 126, 171, 219, 352, 397, 496], 'patients': [11, 41, 58, 83, 272, 351, 374, 398, 417, 497], 'with': [12, 399, 413, 498], 'advanced': [13, 63, 400, 499], 'SCLC': [14, 216, 350, 401], 'has': [15], 'been': [16], 'evaluated': [17], 'Phase': [20, 30], 'Ib': [21], 'basket': [22, 32], 'study': [23, 33], 'KEYNOTE-028': [24, 507], '(KN028;': [25], 'NCT02054806)': [26], 'and': [27, 45, 80, 111, 143, 190, 197, 242, 277, 323, 333, 338, 342, 344, 354, 508], 'II': [31], 'KEYNOTE-158': [34, 509], '(KN158;': [35], 'NCT02628067).': [36], 'We': [37], 'present': [38], 'outcomes': [39], 'for': [40, 133, 139, 158, 225, 340, 346, 518], 'enrolled': [42], 'KN028': [44, 97, 353], 'KN158': [46, 355], 'who': [47, 402], 'were': [48, 81, 98, 194, 223, 240, 291, 336, 411, 434], 'receiving': [49], 'after': [51, 488], '≥2': [52, 90, 405], 'lines': [53, 91, 247, 406, 492], 'prior': [55, 358, 408, 494], 'therapy.Methods:': [56], 'Eligible': [57], 'had': [59, 74, 88, 244, 273, 279, 310, 362, 375, 403], 'histologically/cytologically': [60], 'confirmed': [61], 'incurable': [62], 'SCLC,': [64], 'measurable': [65], 'disease': [66, 163], 'per': [67, 180, 283, 307], 'RECIST': [68, 181], '1.1,': [69], 'ECOG': [70], 'PS': [71], '0/1,': [73], 'experienced': [75, 385], 'progression/failure': [76], 'on': [77], 'standard': [78], 'therapy,': [79], 'immunotherapy-naive;': [82], 'included': [84, 218], 'this': [86, 204], 'analysis': [87], 'received': [89, 245, 404], 'systemic': [93, 249], 'therapy.': [94, 250, 409], 'Patients': [95], 'required': [99, 125], 'to': [100, 419], 'have': [101, 420], 'PD-L1-positive': [102], 'tumors': [103], '(membranous': [104], 'PD-L1': [105, 121], 'expression': [106, 122], '≥1%': [108], 'tumor': [110, 120], 'associated': [112], 'inflammatory': [113], 'cells': [114], 'or': [115, 137, 151, 161, 165, 389, 490], 'positive': [116], 'staining': [117], 'stroma);': [119], 'was': [123, 130, 156, 174, 209, 234, 259, 266, 295, 317, 326], 'not': [124, 296], 'KN158.': [127], 'Radiographic': [128], 'imaging': [129], 'performed': [131], 'Q8W': [132], '6': [134], 'mo': [135, 322], '(KN028)': [136], 'Q9W': [138], '1': [140], 'y': [141, 160], '(KN158),': [142], 'Q12W': [144], 'thereafter.': [145], 'Pembrolizumab': [146, 392, 487], '(10': [147], 'mg/kg': [148], 'Q2W': [149], '[KN028]': [150], '200': [152], 'mg': [153], 'Q3W': [154], '[KN158])': [155], 'administered': [157], '2': [159], 'until': [162], 'progression': [164], 'intolerable': [166], 'toxicity.': [167], 'primary': [169], 'endpoint': [170], 'both': [172, 220], 'studies': [173, 510], 'objective': [175], 'response': [176, 185, 208, 276, 282, 311, 422], 'rate': [177], '(ORR)': [178], 'assessed': [179], '1.1.': [182], 'Duration': [183], '(DOR),': [186], 'progression-free': [187], 'survival': [188, 192], '(PFS),': [189], 'overall': [191], '(OS)': [193], 'secondary': [195], 'endpoints': [196], 'estimated': [198, 418], 'using': [199], 'Kaplan-Meier': [201, 308], 'method.': [202], 'For': [203], 'analysis,': [205], 'assessment': [206], 'by': [210], 'independent': [211, 284], 'central': [212, 285], 'review.Results:': [213], 'Of': [214], '131': [215], 'pts': [217], 'trials,': [221], '83': [222], 'eligible': [224], 'efficacy': [226], 'analyses': [227], '(KN158,': [228], 'n=64;': [229], 'KN028,': [230], 'n=19).': [231], 'Median': [232, 293, 315], 'age': [233], '62': [235], '(range,': [236, 261, 298], '24–84)': [237], 'y,': [238], '64%': [239], 'men,': [241], '36%': [243], '≥3': [246], 'As': [251], 'data': [254], 'cutoff': [255], 'date,': [256], 'median': [257, 324], 'follow-up': [258], '7.7': [260, 327], '0.5–48.7)': [262], 'mo.': [263, 314, 331, 428], 'ORR': [265], '19.3%': [267], '(95%': [268, 319, 328], 'CI,': [269, 320, 329], '11.4-29.4).': [270], 'Two': [271], 'a': [274, 280, 363, 421], 'complete': [275], '14': [278, 287], 'partial': [281], 'review;': [286], '16': [289, 304], 'responders': [290, 305], 'PD-L1-positive.': [292], 'DOR': [294], 'reached': [297], '4.1-35.8': [299], '[ongoing]': [300], 'mo).': [301], '9': [302], '(61%': [306], 'estimate)': [309], 'lasting': [312], '≥18': [313], 'PFS': [316], '2.0': [318], '1.9-3.4)': [321], 'OS': [325], '5.2-10.1)': [330], '12-': [332], '24-month': [334], 'rates': [335], '16.9%': [337], '13.1%': [339], 'PFS,': [341], '34%': [343], '21%': [345, 384], 'OS.': [347], 'Among': [348], 'all': [349], 'irrespective': [356], 'therapies': [359], '(N=131),': [360], '8%': [361], 'grade': [364, 369, 376], '3': [365, 373], 'treatment-related': [366, 371, 378], 'AE': [367, 388], '(no': [368], '4': [370], 'AEs).': [372], '5': [377], 'AEs': [379], '(intestinal': [380], 'ischemia,': [381], 'pneumonia,': [382], 'encephalopathy).': [383], 'an': [386], 'immune-mediated': [387], 'infusion': [390], 'reaction.Conclusions:': [391], 'demonstrated': [393], 'promising': [394], 'Responses': [410], 'durable,': [412], 'majority': [415], 'duration': [423], 'at': [425], 'least': [426], '18': [427], 'No': [429], 'unexpected': [430], 'toxicities': [431], 'from': [432, 505], 'observed.Citation': [435], 'Format:': [436], 'Hyun': [437], 'Cheol': [438], 'Chung,': [439], 'Sarina': [440], 'A.': [441, 485], 'Piha-Paul,': [442], 'Jose': [443], 'Lopez-Martin,': [444], 'Jan': [445], 'H.M.': [446], 'Schellens,': [447], 'Steven': [448], 'Kao,': [449], 'Wilson': [450], 'H.': [451], 'Miller': [452], 'Jr.,': [453], 'Jean-Pierre': [454], 'Delord,': [455], 'Bo': [456], 'Gao,': [457], 'David': [458], 'Planchard,': [459], 'Maya': [460], 'Gottfried,': [461], 'Alona': [462], 'Zer,': [463], 'Shadia': [464], 'I.': [465], 'Jalal,': [466], 'Nicolas': [467], 'Penel,': [468], 'Janice': [469], 'M.': [470], 'Mehnert,': [471], 'Ignacio': [472], 'Matos,': [473], 'Jaafar': [474], 'Bennouna,': [475], 'Dong-Wan': [476], 'Kim,': [477], 'Lei': [478], 'Xu,': [479], 'Suba': [480], 'Krishnan,': [481], 'Kevin': [482], 'Norwood,': [483], 'Patrick': [484], 'Ott.': [486], 'two': [489], 'more': [491], 'therapy': [495], 'small-cell': [500], 'lung': [501], 'cancer': [502], '(SCLC):': [503], 'Results': [504], '[abstract].': [511], 'In:': [512], 'Proceedings': [513], 'American': [516], 'Association': [517], 'Cancer': [519, 533], 'Research': [520], 'Annual': [521], 'Meeting': [522], '2019;': [523], '2019': [524], 'Mar': [525], '29-Apr': [526], '3;': [527], 'Atlanta,': [528], 'GA.': [529], 'Philadelphia': [530], '(PA):': [531], 'AACR;': [532], 'Res': [534], '2019;79(13': [535], 'Suppl):Abstract': [536], 'nr': [537], 'CT073.': [538]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4252192851', 'counts_by_year': [{'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-15T08:49:23.910242', 'created_date': '2022-05-12'}