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1158, 1161, 1179, 1183, 1193, 1208, 1229, 1237, 1249, 1261, 1267, 1287, 1303, 1332, 1363, 1366, 1376, 1392, 1397, 1402, 1407, 1419, 1422, 1434, 1497, 1514, 1590, 1598, 1623, 1628, 1638, 1664, 1692, 1704, 1718, 1731, 1746, 1763, 1769, 1778, 1786, 1793, 1800, 1813, 1832, 1849, 1862, 1888, 1921, 1949, 1972, 1986, 2010, 2038, 2074, 2078, 2094, 2104, 2110, 2121, 2139, 2145, 2164, 2185, 2195, 2228, 2232, 2247, 2254, 2258, 2261, 2266, 2282, 2305, 2336, 2343, 2396, 2433, 2448, 2468, 2480, 2487, 2507, 2517, 2520, 2566, 2587, 2615, 2619, 2631, 2656, 2677, 2698, 2705, 2712, 2766, 2774, 2783, 2789, 2798, 2836, 2845, 2900, 2914, 2955, 3004, 3018, 3049, 3065, 3074, 3131, 3137, 3147, 3181, 3194, 3201, 3226, 3232, 3279, 3318, 3321, 3328, 3387, 3398, 3432, 3447, 3450, 3476, 3486, 3512, 3519, 3539, 3544, 3552, 3565, 3586, 3605, 3646, 3654, 3687, 3701, 3731, 3749, 3766, 3794, 3814, 3842, 3868, 3886, 3890, 3917, 3925, 3933, 3958, 3963, 3975, 4001, 4017, 4027, 4044, 4060, 4068, 4074, 4093, 4101, 4122, 4144, 4166, 4198, 4223, 4240, 4318, 4325, 4339, 4364, 4378, 4381, 4393], 'Cardiology/American': [6, 42], 'Heart': [7, 43, 558], 'Association': [8, 44, 559], 'Expert': [9, 45, 258, 1383, 1454, 1507, 1546, 1558], 'Consensus': [10, 46, 259, 1384, 1455, 1508, 1547, 1559, 1571, 3441], 'Document': [11, 47, 1385, 1509], 'on': [12, 48, 256, 566, 632, 684, 914, 1839, 1938, 1975, 2241, 3779], 'Electron-Beam': [13, 49], 'Computed': [14, 50, 1997], 'Tomography': [15, 51], 'for': [16, 52, 304, 316, 328, 340, 360, 387, 401, 451, 606, 610, 613, 638, 729, 742, 774, 810, 874, 878, 951, 1149, 1233, 1278, 1290, 1371, 1394, 1451, 1706, 1714, 1725, 1990, 2126, 2155, 2182, 2219, 2393, 2437, 2522, 2533, 2604, 2709, 2726, 2737, 2754, 2776, 3029, 3104, 3149, 3178, 3249, 3374, 3378, 3405, 3651, 3799, 3839, 3848, 3883, 3902, 3919, 3940, 3955, 3960, 4135, 4158, 4195, 4208, 4389], 'the': [17, 53, 272, 286, 294, 317, 341, 357, 403, 485, 510, 521, 526, 550, 564, 594, 626, 635, 651, 654, 685, 701, 721, 725, 800, 803, 851, 893, 898, 909, 937, 941, 948, 963, 973, 977, 1012, 1026, 1090, 1101, 1116, 1127, 1156, 1171, 1201, 1205, 1209, 1214, 1227, 1235, 1264, 1285, 1288, 1298, 1304, 1310, 1317, 1329, 1364, 1390, 1395, 1420, 1423, 1429, 1446, 1461, 1481, 1492, 1495, 1502, 1506, 1511, 1515, 1536, 1566, 1588, 1636, 1649, 1654, 1687, 1693, 1711, 1716, 1727, 1747, 1770, 1776, 1779, 1784, 1790, 1803, 1820, 1828, 1833, 1875, 1889, 1918, 1933, 1947, 1960, 1970, 2008, 2011, 2015, 2028, 2091, 2095, 2101, 2108, 2122, 2135, 2143, 2158, 2183, 2193, 2229, 2233, 2244, 2255, 2277, 2280, 2394, 2431, 2478, 2508, 2515, 2523, 2545, 2551, 2564, 2601, 2628, 2675, 2699, 2702, 2710, 2767, 2772, 2779, 2796, 2799, 2807, 2833, 2837, 2875, 2898, 2953, 2956, 2965, 2985, 2989, 3005, 3016, 3019, 3021, 3054, 3057, 3063, 3099, 3121, 3128, 3135, 3179, 3227, 3230, 3261, 3276, 3288, 3297, 3302, 3319, 3326, 3329, 3335, 3344, 3353, 3359, 3393, 3396, 3411, 3430, 3433, 3448, 3461, 3473, 3481, 3507, 3510, 3517, 3524, 3528, 3550, 3563, 3603, 3652, 3682, 3688, 3699, 3727, 3739, 3743, 3761, 3780, 3792, 3824, 3831, 3840, 3866, 3884, 3915, 3921, 3934, 3956, 3973, 3986, 3999, 4015, 4025, 4049, 4058, 4066, 4070, 4072, 4098, 4105, 4127, 4164, 4193, 4205, 4220, 4251, 4268, 4323, 4391, 4406], 'Diagnosis': [18, 54, 1987], 'and': [19, 55, 88, 123, 176, 243, 249, 282, 309, 334, 370, 480, 571, 573, 584, 612, 641, 661, 689, 696, 748, 830, 903, 928, 979, 1204, 1294, 1309, 1325, 1360, 1368, 1415, 1464, 1517, 1521, 1702, 1724, 1789, 1815, 1856, 1886, 1905, 1928, 1988, 2034, 2041, 2051, 2137, 2295, 2310, 2320, 2427, 2502, 2532, 2569, 2658, 2672, 2818, 2827, 2889, 2917, 2974, 2995, 3024, 3093, 3110, 3164, 3189, 3224, 3238, 3270, 3315, 3348, 3457, 3483, 3496, 3509, 3516, 3532, 3569, 3581, 3612, 3678, 3758, 3769, 3791, 3827, 3852, 3923, 3971, 4084, 4163, 4185, 4216, 4283, 4310, 4321, 4346, 4355, 4368, 4370], 'Prognosis': [20, 56], 'Coronary': [22, 58, 843, 1991, 3465], 'Artery': [23, 59, 1992], 'Disease': [24, 60, 1993], 'Free': [25], 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'Bruce': [66, 133], 'H.': [67, 134, 136], 'Brundage,': [68], 'Victor': [69, 139, 1867], 'F.': [70, 140, 142], 'Froelicher,': [71], 'Philip': [72, 145, 1307, 1854], 'Greenland,': [73], 'Scott': [74, 149, 1857], 'M.': [75, 80, 110, 150, 152, 160, 162, 217, 219], 'Grundy,': [76], 'Rory': [77, 155], 'Hachamovitch,': [78], 'Gerald': [79, 159], 'Pohost,': [81], 'Leslee': [82, 165], 'J.': [83, 125, 166, 168, 245, 247], 'Shaw,': [84], 'William': [85, 89, 117, 120, 171, 177, 232, 238], 'S.': [86, 93, 96, 107, 118, 172, 174, 183, 185, 189, 191, 211, 213, 233, 235], 'Weintraub': [87, 175, 236], 'L.': [90, 121, 178, 180, 239, 241], 'WintersJr': [91, 122, 181, 242], 'James': [92, 182], 'Forrester,': [94], 'Pamela': [95, 188], 'Douglas,': [97], 'David': [98, 194], 'P.': [99, 195, 197], 'Faxon,': [100], 'John': [101, 200], 'D.': [102, 201, 203], 'Fisher,': [103], 'Gabriel': [104, 206], 'Gregoratos,': [105], 'Judith': [106, 210], 'Hochman,': [108], 'Adolph': [109, 216], 'HutterJr,': [111], 'Sanjiv': [112, 222], 'Kaul,': [113], 'Weintraub,': [119], 'Michael': [124, 244], 'Wolk': [126, 248], "O'RourkeRobert": [129, 228], "O'Rourke": [131, 230], ',': [132, 138, 144, 148, 154, 158, 164, 170, 187, 193, 199, 205, 209, 215, 221, 225, 231, 237], 'BrundageBruce': [135], 'Brundage': [137], 'FroelicherVictor': [141], 'Froelicher': [143], 'GreenlandPhilip': [146], 'Greenland': [147, 1855], 'GrundyScott': [151], 'Grundy': [153], 'HachamovitchRory': [156], 'Hachamovitch': [157], 'PohostGerald': [161], 'Pohost': [163], 'ShawLeslee': [167], 'Shaw': [169], 'WeintraubWilliam': [173, 234], 'WintersJrWilliam': [179, 240], 'ForresterJames': [184], 'Forrester': [186], 'DouglasPamela': [190], 'Douglas': [192], 'FaxonDavid': [196], 'Faxon': [198], 'FisherJohn': [202], 'Fisher': [204], 'GregoratosGabriel': [207], 'Gregoratos': [208], 'HochmanJudith': [212], 'Hochman': [214], 'HutterJrAdolph': [218], 'HutterJr': [220], 'KaulSanjiv': [223], 'Kaul': [224], 'WolkMichael': [246], 'American': [250, 553, 2096], 'Cardiology': [253, 556], 'Task': [254], 'Force': [255], 'Clinical': [257], 'Documents': [260, 1456, 1548, 1560], 'Originally': [261], 'published4': [262], 'Jul': [263], '2000https://doi.org/10.1161/01.CIR.102.1.126Circulation.': [264], '2000;102:126–140Executive': [265], 'SummaryCoronary': [266], 'artery': [267, 307, 346, 409, 456, 1239, 1923, 2053, 2944, 3466, 3514, 3547, 3579, 3601, 3892], 'calcification': [268, 3444, 3467, 3976], 'is': [269, 283, 299, 310, 646, 856, 945, 1018, 1031, 1054, 1113, 1195, 1257, 1381, 1409, 1494, 1540, 2007, 2021, 2398, 2485, 2492, 2514, 2563, 2636, 2670, 2795, 2851, 2893, 2962, 2976, 3062, 3081, 3187, 3235, 3389, 3445, 3458, 3489, 3502, 3530, 3555, 3559, 3746, 3802, 3880, 4011, 4079, 4109, 4291, 4376], 'part': [270, 3446], 'development': [273, 522, 1637, 2077, 3449], 'atherosclerosis;': [275], 'it': [276, 890, 2212, 2513, 2975, 3418, 3488], 'occurs': [277, 2475, 3452, 3468], 'exclusively': [278, 3453, 3595], 'in': [279, 285, 349, 366, 389, 411, 425, 440, 509, 520, 530, 582, 616, 650, 679, 692, 706, 717, 755, 827, 955, 986, 1041, 1071, 1084, 1088, 1181, 1213, 1221, 1328, 1335, 1426, 1489, 1525, 1604, 1635, 1684, 1710, 1721, 1735, 1797, 1819, 1835, 1870, 2022, 2070, 2134, 2176, 2189, 2192, 2243, 2297, 2313, 2358, 2367, 2382, 2477, 2494, 2529, 2539, 2679, 2719, 2859, 2919, 3089, 3266, 3341, 3454, 3460, 3469, 3472, 3480, 3493, 3497, 3562, 3576, 3638, 3738, 3788, 3823, 3835, 3870, 3896, 3910, 3927, 3943, 3977, 3990, 4014, 4024, 4048, 4137, 4153, 4178, 4201, 4219, 4238, 4343, 4396], 'atherosclerotic': [280, 551, 1733, 3455, 3928, 4002, 4063, 4102], 'arteries': [281, 3720], 'absent': [284, 1063, 3459], 'normal': [287, 2503, 2534, 2642, 2682, 3462, 4032], 'vessel': [288, 3463], 'wall.': [289], 'Electron-beam': [290], 'computed': [291, 794, 2063], 'tomography': [292, 2064], '(EBCT),': [293], 'focus': [295], 'this': [297, 622, 997, 1150, 1159, 1256, 1279, 1490, 1599, 1639, 1764, 1798, 1806, 1850, 1863, 1950, 1979, 2005, 2150, 2518, 2580, 2887, 3606], 'document,': [298, 3607], 'a': [300, 384, 398, 444, 499, 518, 648, 674, 712, 737, 744, 766, 836, 848, 879, 987, 1034, 1044, 1060, 1073, 1111, 1175, 1258, 1400, 1579, 1583, 1621, 1644, 1700, 1811, 1882, 1943, 2048, 2084, 2162, 2252, 2259, 2289, 2333, 2340, 2347, 2434, 2481, 2584, 2613, 2616, 2694, 2706, 2727, 2757, 2860, 2894, 2998, 3046, 3077, 3182, 3252, 3267, 3284, 3308, 3322, 3369, 3424, 3503, 3584, 3613, 3619, 3642, 3811, 3937, 4041, 4045, 4061, 4081, 4123], 'highly': [301, 4012], 'sensitive': [302, 3575], 'technique': [303, 400, 3324, 3355, 3394], 'detecting': [305, 454, 730, 1726, 3655, 3920], 'coronary': [306, 330, 345, 408, 455, 524, 854, 864, 866, 875, 1107, 1120, 1238, 1403, 1708, 1732, 1922, 2052, 2632, 2808, 2828, 2943, 3513, 3520, 3546, 3578, 3588, 3600, 3656, 3719, 3740, 3800, 3891, 3929, 4033, 4062, 4146, 4319, 4340, 4383], 'calcium': [308, 376, 478, 529, 542, 690, 867, 943, 1036, 1065, 1102, 1108, 1185, 1210, 1398, 2054, 3515, 3580, 3591, 3745, 3767, 3772, 3795, 3801, 3926, 4094, 4112, 4407], 'being': [311, 532, 1197, 1314, 1809, 2625, 2722, 2735, 3881], 'used': [312, 575, 3096, 3819, 3863], 'with': [313, 443, 495, 546, 861, 872, 1115, 1118, 1189, 1284, 1428, 1466, 1737, 1881, 1957, 2202, 2362, 2465, 2596, 2621, 2641, 2652, 2660, 2681, 2696, 2731, 2756, 2839, 2862, 2897, 3172, 3301, 3312, 3332, 3402, 3410, 3598, 3641, 3820, 3874, 3898, 3967, 3985, 4040, 4097, 4117, 4183, 4186, 4273], 'increasing': [314, 3821], 'frequency': [315, 3822], 'screening': [318, 607, 1164, 2987, 3183, 3254, 3286, 3303, 3310, 3323, 3336, 3345, 3354, 3360, 3836, 3961, 4157, 4226], 'asymptomatic': [320, 368, 608, 680, 886, 956, 1086, 1135, 1712, 1821, 2994, 3154, 3211, 3400, 3837, 4154, 4179, 4210, 4221, 4232, 4262, 4397], 'people': [321, 1136, 4211], 'assess': [323, 2027], 'those': [324, 1000, 2595, 2639, 2659, 2755, 3025, 3171, 3291, 3305, 3399, 3844, 4182], 'at': [325, 372, 1050, 1056, 1218, 1653, 1827, 1874, 1942, 3523, 3596, 3685, 3845, 3952, 4267], 'high': [326, 738, 1057, 3751, 3846, 4111, 4120], 'risk': [327, 416, 862, 873, 911, 954, 974, 984, 1014, 1053, 1094, 1122, 1334, 1709, 1817, 2032, 2071, 3404, 3413, 3847, 3900, 3969, 4043, 4121, 4165, 4196, 4217, 4259, 4294, 4324, 4347, 4360, 4365, 4394], 'developing': [329, 1077, 1794, 3849, 4167], 'heart': [331, 2665], 'disease': [332, 347, 1121, 2040, 2678, 3133, 3208, 3228], '(CHD)': [333], 'cardiac': [335, 697, 2577, 2592, 2748, 2784, 2903, 3380, 3702, 3714, 4150], 'events,': [336, 865], 'as': [337, 339, 383, 397, 419, 908, 1399, 1488, 1510, 1620, 1679, 1681, 2113, 2115, 2207, 2853, 2902, 2946, 2981, 3070, 3076, 3127, 4140, 4142, 4278, 4359], 'well': [338, 1475, 1680, 3082, 3423], 'diagnosis': [342, 837], 'obstructive': [344, 732, 812, 1719, 1787, 2186, 2438, 2542, 2606, 2713, 3091, 3157, 3856, 4020], '(CAD)': [348], 'symptomatic': [350, 617, 1722], 'patients.': [351, 618, 708, 957], 'The': [352, 375, 734, 760, 797, 840, 930, 1251, 1319, 1632, 1982, 2017, 2236, 2264, 2273, 2302, 2571, 3144, 3185, 3383, 3537, 3667, 3704, 4242, 4285], 'use': [353, 1105, 1260, 1391, 1589, 2144, 2294, 2395, 2899, 3064, 3136, 3957], 'EBCT': [355, 392, 473, 541, 567, 588, 605, 678, 695, 705, 741, 809, 942, 966, 1007, 1064, 1148, 1163, 1180, 1231, 1273, 1324, 1359, 1367, 1393, 1657, 1705, 1814, 1919, 1976, 2060, 2309, 2397, 3440, 3568, 3632, 3725, 3860, 3879, 3918, 3959, 3996, 4056, 4264, 4375], 'has': [356, 378, 393, 762, 778, 1575, 1999, 2082, 2152, 2692, 3087, 3209, 3371, 3533, 3775, 3817, 3861, 4400], 'greatest': [358], 'potential': [359, 385, 4194, 4206], 'further': [361, 1353, 2738], 'determination': [362, 1182, 3397], 'risk,': [364], 'particularly': [365, 1082, 2753], 'elderly': [367, 1085], 'patients': [369, 609, 693, 887, 1087, 1736, 2531, 2540, 2572, 2588, 2620, 2640, 2651, 2680, 2721, 2734, 3871, 3897, 4028], 'others': [371, 2355], 'intermediate': [373, 1051, 1119], 'risk.': [374, 1058], 'score': [377, 944, 950, 1037, 1066, 1211, 4113, 4408], 'been': [379, 395, 780, 992, 1224, 1677, 2001, 2083, 2153, 2168, 2199, 2693, 3176, 3247, 3264, 3372, 3573, 3776, 3818, 3862, 3906, 4401], 'advocated': [380], 'by': [381, 901, 976, 1316, 1453, 1480, 1557, 1565, 1757, 1846, 1946, 2014, 2058, 2331, 2388, 2984, 3052, 3134, 3681, 3724, 4403], 'some': [382, 2359, 2787, 4404], 'surrogate': [386, 3061], 'age': [388, 538, 4312, 4332], 'risk-assessment': [390], 'models.': [391], 'also': [394, 574, 592, 647, 710, 1068, 1676, 2099], 'proposed': [396, 3177], 'useful': [399, 1070], 'assessing': [402, 1372, 2560], 'progression': [404, 1192, 1373, 1728, 3887], 'or': [405, 504, 1062, 1138, 1191, 1374, 1443, 1468, 1535, 1552, 1582, 1613, 1671, 1729, 1751, 1759, 1913, 2061, 2402, 2609, 2663, 2683, 2724, 2883, 2941, 3000, 3038, 3118, 3155, 3674, 3784, 3888], 'regression': [406, 1190, 1248, 1375, 1730, 3889], 'stenosis': [410, 1240], 'response': [412, 1236, 3342], 'treatment': [414], 'factors': [417, 985, 1095, 2033, 3901, 3970, 4295], 'such': [418, 907, 3069, 3978, 4277, 4358], 'hypercholesterolemia.EBCT': [420], 'uses': [421, 3608], 'an': [422, 749, 1019, 1382, 2132, 2466, 2745, 2854, 2863, 3210, 3609], 'electron': [423, 3610], 'beam': [424], 'stationary': [426, 3614], 'tungsten': [427, 3615], 'targets,': [428], 'which': [429, 671, 824, 1134, 2020, 3214], 'permits': [430, 475], 'very': [431, 2951, 3574, 3628, 4007], 'rapid': [432, 3629, 3705], 'scanning': [433, 3630, 3815], 'times.': [434, 3631], 'Serial': [435], 'transaxial': [436, 3634], 'images': [437, 3635], 'are': [438, 464, 888, 1152, 1282, 1343, 1440, 1457, 1471, 2129, 2250, 2323, 2441, 2456, 2548, 2594, 2646, 2810, 2815, 2867, 2890, 2911, 2959, 3009, 3027, 3221, 3241, 3436, 3636, 3665, 3670, 3679, 3721, 4313, 4333, 4348, 4386], 'obtained': [439, 465, 577, 3637, 3671], '100': [441, 3639], 'ms': [442, 3640], 'thickness': [445, 3645], '3': [447, 3647], '6': [449, 3649], 'mm': [450, 3650], 'purposes': [452], 'calcium.': [457, 513, 3657], 'Thirty': [458, 3658], '40': [460, 3660], 'adjacent': [461, 3661], 'axial': [462, 3662], 'scans': [463, 1232, 3663, 3668], 'during': [466, 2874, 3213, 3672, 3830], '1': [467, 1758, 3673], '2': [469, 1760, 1847, 2160, 3675, 4051, 4129, 4171], 'breath-holding': [470, 3676], 'sequences.': [471], 'Current': [472], 'software': [474, 3763], 'quantification': [476, 3765], 'area': [479, 1020, 2194, 3768, 3793], 'density.': [481, 3770], 'Histological': [482], 'studies': [483, 735, 994, 1146, 1269, 1362, 2495, 2700, 2768, 2831, 2935], 'support': [484], 'association': [486], 'tissue': [488, 3757], 'densities': [489], '130': [491], 'Hounsfield': [492, 3789], 'units': [493], '(HU)': [494], 'calcified': [496], 'plaque.': [497], 'However,': [498, 877, 1126, 1200], 'plaque': [500, 3553, 3558, 3589, 4344], 'vulnerable': [501], 'fissure': [503], 'erosion': [505], 'can': [506, 825, 1274, 2268, 3124, 3140, 3196, 3217], 'be': [507, 783, 859, 882, 1039, 1049, 1081, 1097, 1124, 1167, 1275, 1478, 1533, 1562, 1618, 2047, 2056, 2351, 2386, 2413, 2460, 2751, 2871, 2993, 3095, 3107, 3125, 3141, 3160, 3197, 3218, 3357, 3427, 4038, 4088, 4115, 4235, 4336], 'present': [508, 1379, 2493, 3561, 3873], 'absence': [511, 3564], 'Also,': [514, 3760], 'sex': [515], 'differences': [516], 'play': [517], 'role': [519, 1365, 3951], 'calcium,': [525, 1924, 4069], 'prevalence': [527, 691, 3223], 'women': [531], 'half': [533, 2120, 3333, 4143], 'that': [534, 995, 1033, 1187, 1255, 1386, 1439, 1616, 2141, 2173, 2215, 2279, 2318, 2370, 2404, 2444, 2473, 2486, 2496, 2769, 3084, 3139, 3392, 3408, 3478, 3543, 3945, 3947, 3953, 3972, 3991, 4228, 4253, 4385, 4405], 'men': [536], 'until': [537], '60': [539], 'years.': [540], 'scores': [543, 868, 1008, 1109, 1186], 'have': [544, 765, 991, 1223, 1675, 2167, 2174, 2198, 2408, 2770, 2786, 2930, 2936, 3153, 3175, 3246, 3363, 3572, 3905, 4030, 4191], 'correlated': [545], 'pathological': [547], 'examination': [548], 'plaque.This': [552], '(ACC)/American': [557], '(AHA)': [560], 'Writing': [561, 623, 804, 1252, 1350, 1601, 1694, 1765, 1771, 1851, 1864, 1871, 1951, 1980, 2274, 3982], 'Group': [562, 624, 805, 1253, 1351, 1602, 1695, 1772, 1852, 1865, 1872, 1952, 2275, 3983], 'reviewed': [563, 593], 'literature': [565, 932, 1129, 1646], 'published': [568, 715, 931, 1128, 1268, 1673, 3909], 'between': [569, 687, 2030, 3506], '1988': [570], '1999': [572, 841], 'information': [576], 'when': [578, 885, 1110, 1805, 2415, 2803, 3113], 'possible': [579, 1032, 2036, 3409, 3419], 'from': [580, 587, 1141, 1648, 1658, 2500, 3295, 4214], 'articles': [581], 'press': [583], 'data': [585, 716, 967, 1342, 2804, 3058, 3908], 'sets': [586], 'research': [589, 1357, 1884], 'centers.': [590], 'We': [591, 709], 'Blue': [595], 'Cross/Blue': [596], 'Shield': [597], '(BC/BS)': [598], 'Technology': [599, 2075], 'Evaluation': [600], 'Center': [601], '(TEC)': [602], 'assessment': [603, 676, 1331, 1896, 1974, 3885, 4395], 'CAD': [611, 757, 776, 813, 1720, 2607, 2873, 3092, 3158], 'diagnosing': [614, 775, 811], 'CHD': [615, 688, 896, 953, 1052, 1194, 1333, 1816, 2267, 3869, 4136, 4162, 4169, 4199, 4327], 'Three': [619], 'members': [620, 645, 801, 1691, 1762, 1768, 1848], 'attended': [625, 1945], 'recent': [627, 960], 'AHA': [628, 1305, 1518, 1834, 1876, 3935, 4243], 'Prevention': [629, 1299, 1829, 1877, 4244, 4269, 4287], 'V': [630, 1300, 1830, 4245, 4270, 4288], 'Conference': [631, 1301, 1831, 4246, 4271, 4289], '"Identification': [633], 'High-Risk': [636], 'Patient': [637], 'Primary': [639], 'Prevention,"': [640], 'one': [642, 959, 1887, 2116, 2119, 4377], 'our': [644, 1345, 2446], 'participant': [649], 'design': [652, 2024], 'National': [655, 980], 'Institutes': [656], 'Health/National': [658], 'Heart,': [659], 'Lung,': [660], 'Blood': [662], 'Institute': [663], '(NIH/NHLBI)': [664], 'forthcoming': [665], 'Multiethnic': [666], 'Study': [667], 'Atherosclerosis': [669], '(MESA),': [670], 'will': [672, 1139, 1322, 1549, 1561, 2026, 2046, 2055, 2385, 3426], 'include': [673, 1550, 2142, 2650, 2824, 2979], 'prospective': [675], 'people.We': [681], 'performed': [682, 711], 'meta-analysis': [683, 713], 'relationship': [686, 1607, 2029], 'undergoing': [694], 'catheterization': [698, 2578, 2593, 2749], 'determine': [700, 2067, 3421], 'diagnostic': [702, 722, 2171, 2196, 2561, 2576, 2703], 'accuracy': [703, 752, 768, 1777, 2191, 2432, 2562], 'catheterized': [707], 'order': [718], 'compare': [720, 2497], 'characteristics': [723, 2704, 2773, 3431], 'available': [726, 905, 1169, 1442, 1534, 1977, 3412, 4292], 'alternative': [727, 772, 786, 1781], 'tests': [728, 2224, 2361, 2369, 2401, 2775, 4022], 'angiographic': [731, 3545], 'CAD.': [733, 839, 2187, 2714], 'demonstrate': [736, 3391], 'sensitivity': [739, 2568, 2635], 'CAD,': [743, 1788, 2439, 2777, 4076], 'much': [745, 2114], 'lower': [746, 3364, 3728], 'specificity,': [747], 'overall': [750], 'predictive': [751, 767, 2450], '≈70%': [754], 'typical': [756], 'patient': [758, 1045, 1117, 1369, 2344, 2377, 2546], 'populations.': [759], 'test': [761, 880, 1005, 2178, 2190, 2204, 2349, 2436, 2469, 2498, 2525, 2535, 2554, 2567, 2598, 2623, 2634, 2643, 2668, 2685, 2708, 2728, 2865, 2966, 3067, 3346, 3997, 4010, 4036], 'proven': [763], 'approximately': [769], 'equivalent': [770], 'methods': [773, 788, 3435], 'but': [777, 999, 1263, 2098, 3376, 4077], 'not': [779, 807, 934, 1003, 1131, 1166, 1472, 1531, 1541, 1576, 1909, 2088, 2379, 2410, 3010, 3377, 3593, 4080, 4087], 'found': [781, 3490], 'superior': [784], 'noninvasive': [787, 2435, 2707], '(eg,': [789, 2308, 2419, 3035], 'SPECT': [790], '[single': [791], 'photon': [792], 'emission': [793], 'tomography]': [795], 'imaging).': [796], 'majority': [798, 2954, 4026], 'would': [806, 2217, 2750], 'recommend': [808, 1911], 'because': [814, 1460, 2964, 3012, 3726, 3748], 'its': [816, 1593, 1926, 2023, 2068, 3215, 3750], 'low': [817, 1061, 1074, 2363, 2758, 4042, 4305], 'specificity': [818, 2364, 2669], '(high': [819], 'percentage': [820], 'false-positive': [822], 'results),': [823], 'result': [826, 2366, 2614, 2866, 2967], 'additional': [828, 1341, 1361, 1761, 2373], 'expensive': [829, 2353], 'unnecessary': [831], 'testing': [832, 2262, 2271, 3381, 3434], 'rule': [834], 'out': [835], 'ACC/AHA': [842, 1483, 1567, 1600], 'Angiography': [844], 'Guideline': [845], 'reached': [847], 'similar': [849], 'conclusion.1Because': [850], 'severity': [852], 'atherosclerosis': [855, 3477, 4320, 4384], 'known': [857, 1738, 3083], 'associated': [860, 2201], 'should': [869, 891, 1165, 1504, 2991, 2996, 3106, 3159], 'likewise': [870], 'correlate': [871, 1188], 'events.': [876, 4328], 'most': [883, 2556, 2697, 2920, 3022, 4349], 'valuable': [884, 1040, 4237], 'screened,': [889], 'increase': [892, 2133], 'likelihood': [894, 1075, 1717, 3867, 4073], 'above': [897], 'probability': [899, 3551], 'determined': [900, 975], 'standard': [902, 2782, 3101, 3122, 3620], 'readily': [904], 'assessments,': [906], 'Framingham': [910, 949, 978], 'model': [912], 'based': [913, 3778], 'levels': [915], 'blood': [917, 3737], 'pressure,': [918], 'cholesterol,': [919, 923, 4304, 4307], 'high-density': [920], 'lipoprotein': [921, 4302], '(HDL)': [922], 'cigarette': [924, 4297], 'smoking,': [925, 4298], 'plasma': [926], 'glucose,': [927], 'age.': [929, 3499], 'does': [933, 1130, 3256, 3592], 'completely': [935], 'answer': [936], 'question': [938], 'whether': [940, 1006, 1043, 3251], 'additive': [946], 'defining': [952, 3577], 'In': [958, 1155, 1955, 2452, 2511, 2582, 2949], 'large': [961, 1883, 3534], 'study,2': [962], 'addition': [964], 'provided': [968, 1578, 1773], 'no': [969, 1625, 3950, 3968], 'incremental': [970, 1010, 2230], 'value': [971, 3146], 'Cholesterol': [981], 'Education': [982], 'Program': [983], 'direct': [988, 3166, 4337], 'comparison.': [989], 'There': [990, 2045, 3904], 'other': [993, 1013, 1093, 1326, 1416, 2035, 2661, 2805, 3066, 3828, 4275, 4356], 'examine': [996], 'point,234': [998], 'reports': [1001], 'did': [1002], 'adequately': [1004], 'were': [1009, 1630, 1696], 'factor': [1015, 2086, 4361, 4366], 'data.': [1016], 'This': [1017, 1079, 1405, 2961], 'important': [1022, 2792], 'current': [1023, 2111, 2245, 3277], 'investigation,': [1024], 'including': [1025, 1925, 4004, 4181, 4296], "NIH/NHLBI's": [1027], 'MESA': [1028, 1311, 2012, 2018], 'study.': [1029], 'It': [1030, 1843, 3080, 4399], 'positive': [1035, 2454, 3309, 3504, 4055], 'might': [1038, 1347, 4254], 'determining': [1042, 1072, 1234, 1715], 'who': [1046, 2573, 2589, 2645, 2970, 3026, 3152, 3292, 3306, 3872, 4029], 'appears': [1047], 'actually': [1055], 'Conversely,': [1059, 2638], 'may': [1067, 1080, 1096, 1123, 1530, 2350, 2365, 3582, 4037, 4086, 4114], 'prove': [1069], 'CHD.': [1078, 1739, 3857, 4224, 4241], 'beneficial': [1083], 'whom': [1089], 'management': [1091], 'modified': [1098], 'according': [1099], 'score.': [1103], 'Selected': [1104], 'physician': [1112], 'faced': [1114], 'appropriate.': [1125], 'clearly': [1132, 4314], 'define': [1133, 2579], 'require': [1137, 1270, 1348], 'benefit': [1140, 3294, 4213], 'EBCT.': [1142, 1591], 'Additional': [1143, 1668, 1767], 'appropriately': [1144], 'designed': [1145, 1245, 1355, 1459, 4248], 'purpose': [1151, 3653, 3841], 'strongly': [1153], 'encouraged.': [1154], 'setting': [1157], 'degree': [1160, 2788], 'uncertainty,': [1162], 'made': [1168], 'general': [1172], 'public': [1173], 'without': [1174, 2225, 2375, 2541], "physician's": [1176], 'request.The': [1177], 'usefulness': [1178, 3916], 'changing': [1184], 'currently': [1196, 1313, 1683, 4255], 'studied': [1198, 1217, 2922, 3882], 'intensively.': [1199], 'test-to-test': [1202], 'variability': [1203], 'interrater': [1206], 'reliability': [1207], 'measurement': [1212], 'same': [1215, 3525], 'individual': [1216, 1741, 1822], 'close': [1219], 'intervals': [1220], 'time': [1222, 1804, 2421, 3707, 3954], 'deterrents': [1225], 'recommendation': [1228, 1286], 'serial': [1230, 3633], 'lesions': [1241, 1734, 3475, 3495, 3893], 'medical': [1243, 2080, 2256, 3912], 'interventions': [1244, 2901, 2945, 3895], 'cause': [1247], 'disease.': [1250, 2543, 2666], 'concluded': [1254, 3946], 'promising': [1259], 'EBCT,': [1262], 'small': [1265, 3470], 'number': [1266, 2163, 2260, 2586, 2618, 3786], 'corroboration': [1271], 'before': [1272, 2292, 3694], 'widely': [1276, 1441, 1542], 'recommended': [1277, 3248], 'purpose.Our': [1280], 'conclusions': [1281], 'consistent': [1283, 4039, 4116], 'Agency': [1289], 'Health': [1291], 'Care': [1292], 'Policy': [1293], 'Research–funded': [1295], 'BC/BS': [1296, 1879, 1899, 1934, 1961, 1983], 'TEC,': [1297, 1880], 'report': [1302, 2006, 4290], '(Dr': [1306, 1866, 1953], 'Greenland),': [1308], 'project': [1312, 2013], 'planned': [1315], 'NIH/NHLBI.': [1318], 'latter': [1320], 'study': [1321, 3370, 3798], 'evaluate': [1323], 'techniques': [1327, 2166, 3148], 'long-term': [1330], '6500': [1336], 'apparently': [1337], 'healthy': [1338, 3023, 3965], 'people.': [1339, 4155, 4263, 4398], 'As': [1340, 2612, 4373], 'obtained,': [1344], 'conclusion': [1346], 'revision.This': [1349], 'encourages': [1352], 'properly': [1354, 4229], 'outcomes': [1356, 3350], 'using': [1358, 2778, 2840], 'follow-up': [1370, 2876, 2934], 'CHD.I.': [1377], 'PreambleThe': [1378], 'document': [1380, 1408, 1585, 1640, 1748, 1807], 'includes': [1387], 'evidence': [1388, 1462, 1529, 1537, 2392, 2416], 'about': [1389, 2328], 'detection': [1396, 1785, 1920, 2184, 2711], 'marker': [1401], 'atherosclerosis.': [1404], 'type': [1406, 2519], 'intended': [1410], 'inform': [1412, 1520], 'practitioners,': [1413], 'payers,': [1414], 'interested': [1417], 'parties': [1418], 'opinion': [1421], 'ACC,': [1424], 'often': [1425, 2409, 2474, 2910, 2937, 2952, 2968], 'collaboration': [1427], 'AHA,': [1430], 'concerning': [1431, 1656, 1775], 'evolving': [1432], 'areas': [1433, 1526], 'clinical': [1435, 1469, 1523, 2043, 2299, 2383, 2654, 2716, 3850, 4168, 4326], 'practice': [1436, 1447, 1470, 1524, 1892, 2717], 'and/or': [1437, 2761, 3192, 3366], 'technologies': [1438, 2307], 'new': [1444, 1795, 2079, 2146, 2208, 2234, 2284, 2306, 2329, 2348, 2482], 'community.': [1448], 'Topics': [1449], 'chosen': [1450, 2752, 2802], 'coverage': [1452], 'so': [1458], 'base': [1463], 'experience': [1465], 'technology': [1467, 1796, 1895, 2081, 2151, 2209, 2285, 2330], 'considered': [1473, 3108, 4266], 'sufficiently': [1474], 'developed': [1476, 3936], 'evaluated': [1479, 2057, 2771], 'formal': [1482], 'Practice': [1484, 1568], 'Guidelines': [1485, 1569], 'process.': [1486], 'Often,': [1487], 'case,': [1491], 'topic': [1493], 'subject': [1496, 2861, 3604], 'considerable': [1498, 3907], 'ongoing': [1499], 'investigation.': [1500], 'Thus,': [1501, 2667, 3716, 4204], 'reader': [1503], 'view': [1505], 'best': [1512, 2834, 3100, 3385, 4096], 'attempt': [1513], 'ACC': [1516, 1574, 1655, 1958], 'guide': [1522], 'where': [1527], 'rigorous': [1528, 2290], 'yet': [1532], 'date': [1539], 'accepted.': [1543], 'Where': [1544], 'feasible,': [1545], 'indications': [1551], 'contraindications.': [1553], 'Some': [1554], 'topics': [1555], 'covered': [1556], 'addressed': [1563], 'subsequently': [1564, 1672], 'Committee.II.': [1570], 'Statement': [1572], 'MethodThe': [1573], 'previously': [1577, 2356], 'scientific': [1580, 3938, 3992], 'statement': [1581, 3939], 'consensus': [1584], 'relative': [1586, 3145, 3754], 'At': [1592, 1686], 'first': [1594, 1633, 1688, 4145], 'meeting,': [1595, 1689], 'each': [1596], 'member': [1597, 1861, 1900], 'indicated': [1603, 1965, 3989], 'writing': [1605, 3931], 'any': [1606, 2226, 2283, 3204, 3379], 'advisory': [1609], 'committees,': [1610], "speakers'": [1611], 'bureaus,': [1612], 'stock': [1614], 'holdings': [1615], 'could': [1617, 3293, 4234], 'perceived': [1619], 'conflict': [1622], 'interest;': [1624], 'relevant': [1626, 1669, 2003], 'conflicts': [1627], 'interest': [1629], 'reported.': [1631], 'step': [1634], 'was': [1641, 1808, 1825, 1844, 2210, 2213, 2417, 3949, 3980, 4247, 4265], 'obtain': [1643, 2924], 'complete': [1645], 'review': [1647], 'Griffith': [1650], 'Resource': [1651], 'Library': [1652, 1663], '1995': [1659], '1998': [1661], '(National': [1662], "Medicine's": [1665], 'Elhill': [1666], 'System).': [1667], 'prior': [1670], 'references': [1674], 'identified,': [1678], 'manuscripts': [1682], 'press.': [1685], 'various': [1690, 3911], 'asked': [1697], 'provide': [1699, 2832, 3583], 'description': [1701], 'analysis': [1703, 2521], 'identifying': [1707, 3150, 3843], 'patient,': [1713], 'patients,': [1723], 'Each': [1740], 'contributor': [1742], 'these': [1744, 2972], 'parts': [1745], 'had': [1749, 3307], 'his': [1750], 'her': [1752], 'initial': [1753], 'written': [1754], 'presentation': [1755], 'critiqued': [1756], 'Group.': [1766, 1981], 'text': [1774], 'test,': [1780, 2747], 'approaches': [1782], 'economic': [1791, 2238], 'impact': [1792], 'era': [1799, 2246], 'constrained': [1801], 'resources.During': [1802], 'developed,': [1810, 2211], 'discussion': [1812], 'prediction': [1818], '(atherosclerotic': [1823], 'burden)': [1824], 'held': [1826], 'San': [1836], 'Francisco,': [1837], 'Calif,': [1838], 'October': [1840], '28,': [1841], '1998.': [1842], 'cochaired': [1845], '(Drs': [1853], 'Grundy).': [1858], 'A': [1859, 3771, 3797, 3994, 4225], 'third': [1860, 2117, 2793, 3484], 'Froelicher)': [1868], 'participated': [1869], 'III': [1873], 'Conference.The': [1878], 'staff': [1885], 'AHCPR': [1890], 'evidence-based': [1891], 'centers,': [1893], 'provides': [1894], 'services': [1897, 2140], 'plans,': [1901, 1904], 'managed': [1902], 'care': [1903, 2128], 'others.': [1906], 'They': [1907, 1915], 'do': [1908], 'directly': [1910], 'reimbursement': [1912], 'nonreimbursement.': [1914], 'recently': [1916, 2000], 'assessed': [1917, 3161], 'cost-effectiveness,': [1927], 'presented': [1929], 'their': [1930, 1966, 1973, 3033], 'results': [1931, 1971, 2337, 2455, 2499, 2526, 2536, 2552, 2624, 2644, 2718, 3068, 3200], 'Medical': [1935], 'Advisory': [1936, 1962], 'Board': [1937], 'December': [1939], '10,': [1940], '1998,': [1941], 'meeting': [1944], 'Chair': [1948], "O'Rourke).": [1954], 'discussions': [1956], 'leadership,': [1959], 'Panel': [1963], 'TEC': [1964], 'willingness': [1967], 'make': [1969], '"TEC': [1984], 'Assessment': [1985, 4134], 'Screening': [1989, 2830], 'With': [1994, 2906], 'Electron': [1995], 'Beam': [1996], 'Tomography"': [1998], 'completed.*Also': [2002], 'initiation': [2009], 'NHLBI.': [2016], 'protocol,': [2019], 'phase,': [2025], 'baseline': [2031], 'indicators': [2037], 'subclinical': [2039, 4382], 'future': [2042, 2281], 'outcomes.': [2044], '10-year': [2049], 'follow-up,': [2050], 'either': [2059], 'helical': [2062, 3570], '(CT)': [2065], 'utility': [2069], 'stratification.III.': [2072], 'Principles': [2073], 'AssessmentThe': [2076], 'major': [2085, 4172], 'contributing': [2087], 'only': [2089, 2732, 3112, 3810], 'improved': [2092, 2177], 'health': [2093, 2105, 2127, 3034, 3941, 4173], 'public,': [2097], 'rising': [2102], 'cost': [2103, 2231], 'care.5': [2106], 'On': [2107], 'basis': [2109], 'estimates,': [2112], 'higher': [2123, 2203, 3403], 'real': [2124], 'expenditures': [2125], 'due': [2130, 3854, 4351], 'volume': [2136], 'intensity': [2138], 'technology.567': [2147], 'Of': [2148], 'course,': [2149], 'invaluable': [2154], 'many': [2156, 2270, 4141, 4209], 'patients.During': [2157], 'past': [2159, 3832], 'decades,': [2161], 'innovative': [2165], 'introduced': [2169], 'within': [2170, 3804, 4126], 'cardiology': [2172, 2197], 'resulted': [2175], 'performance': [2179], '(ie,': [2180], 'sensitivity)': [2181], 'Improvements': [2188], 'uniformly': [2200], 'costs.': [2205], 'Historically,': [2206], 'expected': [2214], 'users': [2216], 'pay': [2218], 'newer,': [2220], 'more': [2221, 2325, 2457, 2868, 2891, 3257, 3491], 'high-tech': [2222], 'imaging': [2223, 2483, 3072, 3086], 'justification': [2227], 'technology.': [2235], 'resulting': [2237], 'pressures': [2239], 'placed': [2240], 'physicians': [2242], 'healthcare': [2248, 2315, 2321, 3298], 'reform': [2249], 'forcing': [2251], 'rethinking': [2253], 'applications': [2257], 'modalities.': [2263, 2272, 3382], 'evaluation': [2265, 2291, 2479, 2739], 'utilize': [2269], 'accepted': [2276], 'principle': [2278], 'must': [2286, 3362], 'now': [2287], 'undergo': [2288], 'routine': [2293, 2602], 'application': [2296], 'daily': [2298], 'decision': [2300, 2381], 'making.': [2301], 'limited': [2303, 2488, 3050], 'diffusion': [2304], 'contrast-enhanced': [2311], 'echocardiography)': [2312], "today's": [2314], 'market': [2316], 'indicates': [2317], 'clinicians': [2319], 'administrators': [2322], 'making': [2324], 'cautious': [2326], 'choices': [2327], 'awaiting': [2332], 'greater': [2334, 2617, 4065, 4071], 'compendium': [2335], 'applied': [2338, 3142], 'throughout': [2339], 'wide': [2341], 'variety': [2342], 'subsets.': [2345], 'Although': [2346, 3500, 3567], 'less': [2352], 'than': [2354, 2806, 3120, 3259, 3618], 'available,': [2357], 'cases,': [2360], 'add-on': [2368], 'lead': 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