Incretin‐based therapies

Name: Work Video:
Duration: 3 min 30 s
Michael A. Nauck; Juris J. Meier
{'id': 'https://openalex.org/W4251091689', 'doi': 'https://doi.org/10.1002/9781118387658.ch48', 'title': 'Incretin‐based therapies', 'display_name': 'Incretin‐based therapies', 'publication_year': 2015, 'publication_date': '2015-03-06', 'ids': {'openalex': 'https://openalex.org/W4251091689', 'doi': 'https://doi.org/10.1002/9781118387658.ch48'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/9781118387658.ch48', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'other', 'type_crossref': 'other', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067359287', 'display_name': 'Michael A. Nauck', 'orcid': 'https://orcid.org/0000-0002-5749-6954'}, 'institutions': [{'id': 'https://openalex.org/I4210138993', 'display_name': 'St. Josef-Hospital', 'ror': 'https://ror.org/046vare28', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799784675', 'https://openalex.org/I4210138993', 'https://openalex.org/I4210153564']}, {'id': 'https://openalex.org/I904495901', 'display_name': 'Ruhr University Bochum', 'ror': 'https://ror.org/04tsk2644', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I904495901']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michael A. Nauck', 'raw_affiliation_strings': ['Professor of Internal Medicine Division of Diabetology and Gastrointestinal Endocrinology, Medical Department 1, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany'], 'affiliations': [{'raw_affiliation_string': 'Professor of Internal Medicine Division of Diabetology and Gastrointestinal Endocrinology, Medical Department 1, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany', 'institution_ids': ['https://openalex.org/I4210138993', 'https://openalex.org/I904495901']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002832666', 'display_name': 'Juris J. Meier', 'orcid': 'https://orcid.org/0000-0002-5835-8019'}, 'institutions': [{'id': 'https://openalex.org/I4210138993', 'display_name': 'St. Josef-Hospital', 'ror': 'https://ror.org/046vare28', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799784675', 'https://openalex.org/I4210138993', 'https://openalex.org/I4210153564']}, {'id': 'https://openalex.org/I904495901', 'display_name': 'Ruhr University Bochum', 'ror': 'https://ror.org/04tsk2644', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I904495901']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Juris J. Meier', 'raw_affiliation_strings': ['Division of Diabetes and Gastrointestinal Endocrinology, University Hospital St. Josef-Hospital, Ruhr-University Bochum, Gudrunstr, Bochum, Germany'], 'affiliations': [{'raw_affiliation_string': 'Division of Diabetes and Gastrointestinal Endocrinology, University Hospital St. Josef-Hospital, Ruhr-University Bochum, Gudrunstr, Bochum, Germany', 'institution_ids': ['https://openalex.org/I4210138993', 'https://openalex.org/I904495901']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.906667, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 76, 'max': 79}, 'biblio': {'volume': None, 'issue': None, 'first_page': '726', 'last_page': '744'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10401', 'display_name': 'Diabetes Treatment and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10401', 'display_name': 'Diabetes Treatment and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vildagliptin', 'display_name': 'Vildagliptin', 'score': 0.9534054}, {'id': 'https://openalex.org/keywords/incretin', 'display_name': 'Incretin', 'score': 0.8998647}, {'id': 'https://openalex.org/keywords/saxagliptin', 'display_name': 'Saxagliptin', 'score': 0.884794}, {'id': 'https://openalex.org/keywords/lixisenatide', 'display_name': 'Lixisenatide', 'score': 0.5994098}, {'id': 'https://openalex.org/keywords/alogliptin', 'display_name': 'Alogliptin', 'score': 0.5364327}, {'id': 'https://openalex.org/keywords/linagliptin', 'display_name': 'Linagliptin', 'score': 0.44545674}], 'concepts': [{'id': 'https://openalex.org/C2780533449', 'wikidata': 'https://www.wikidata.org/wiki/Q417762', 'display_name': 'Exenatide', 'level': 4, 'score': 0.9572327}, {'id': 'https://openalex.org/C2776453732', 'wikidata': 'https://www.wikidata.org/wiki/Q421042', 'display_name': 'Vildagliptin', 'level': 4, 'score': 0.9534054}, {'id': 'https://openalex.org/C2778881409', 'wikidata': 'https://www.wikidata.org/wiki/Q1420402', 'display_name': 'Incretin', 'level': 4, 'score': 0.8998647}, {'id': 'https://openalex.org/C2780282729', 'wikidata': 'https://www.wikidata.org/wiki/Q3121121', 'display_name': 'Saxagliptin', 'level': 5, 'score': 0.884794}, {'id': 'https://openalex.org/C2781308992', 'wikidata': 'https://www.wikidata.org/wiki/Q2526479', 'display_name': 'Liraglutide', 'level': 4, 'score': 0.78307176}, {'id': 'https://openalex.org/C2779284873', 'wikidata': 'https://www.wikidata.org/wiki/Q419832', 'display_name': 'Sitagliptin', 'level': 4, 'score': 0.7397538}, {'id': 'https://openalex.org/C2776442814', 'wikidata': 'https://www.wikidata.org/wiki/Q6659956', 'display_name': 'Lixisenatide', 'level': 5, 'score': 0.5994098}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5641313}, {'id': 'https://openalex.org/C2780012697', 'wikidata': 'https://www.wikidata.org/wiki/Q4734170', 'display_name': 'Alogliptin', 'level': 5, 'score': 0.5364327}, {'id': 'https://openalex.org/C2776398474', 'wikidata': 'https://www.wikidata.org/wiki/Q424611', 'display_name': 'Glucagon-like peptide-1', 'level': 4, 'score': 0.5344462}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5206765}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5106359}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.49521747}, {'id': 'https://openalex.org/C156490143', 'wikidata': 'https://www.wikidata.org/wiki/Q412214', 'display_name': 'Dipeptidyl peptidase-4', 'level': 4, 'score': 0.49151334}, {'id': 'https://openalex.org/C3020479747', 'wikidata': 'https://www.wikidata.org/wiki/Q1029907', 'display_name': 'Gastric emptying', 'level': 3, 'score': 0.4791783}, {'id': 'https://openalex.org/C2780668416', 'wikidata': 'https://www.wikidata.org/wiki/Q202758', 'display_name': 'Hypoglycemia', 'level': 3, 'score': 0.4643301}, {'id': 'https://openalex.org/C2780031085', 'wikidata': 'https://www.wikidata.org/wiki/Q909745', 'display_name': 'Linagliptin', 'level': 4, 'score': 0.44545674}, {'id': 'https://openalex.org/C2777180221', 'wikidata': 'https://www.wikidata.org/wiki/Q3025883', 'display_name': 'Type 2 diabetes', 'level': 3, 'score': 0.34711254}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.32430542}, {'id': 'https://openalex.org/C2779422922', 'wikidata': 'https://www.wikidata.org/wiki/Q1029907', 'display_name': 'Stomach', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/9781118387658.ch48', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'score': 0.51, 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 64, 'referenced_works': ['https://openalex.org/W1532170875', 'https://openalex.org/W1562038277', 'https://openalex.org/W1585447752', 'https://openalex.org/W1854533075', 'https://openalex.org/W1970406523', 'https://openalex.org/W1976287166', 'https://openalex.org/W1976503602', 'https://openalex.org/W1977102586', 'https://openalex.org/W1977619586', 'https://openalex.org/W1981183973', 'https://openalex.org/W1984740259', 'https://openalex.org/W1984845045', 'https://openalex.org/W1991951001', 'https://openalex.org/W1993287695', 'https://openalex.org/W2004409542', 'https://openalex.org/W2011238752', 'https://openalex.org/W2018192866', 'https://openalex.org/W2028272916', 'https://openalex.org/W2029071587', 'https://openalex.org/W2036167841', 'https://openalex.org/W2038953694', 'https://openalex.org/W2042207312', 'https://openalex.org/W2063715420', 'https://openalex.org/W2064780710', 'https://openalex.org/W2071835038', 'https://openalex.org/W2074142099', 'https://openalex.org/W2083473802', 'https://openalex.org/W2097374449', 'https://openalex.org/W2097621088', 'https://openalex.org/W2098459806', 'https://openalex.org/W2101246901', 'https://openalex.org/W2102511839', 'https://openalex.org/W2103058881', 'https://openalex.org/W2103075451', 'https://openalex.org/W2103364479', 'https://openalex.org/W2103828712', 'https://openalex.org/W2107949845', 'https://openalex.org/W2108646121', 'https://openalex.org/W2109688740', 'https://openalex.org/W2111865924', 'https://openalex.org/W2112981414', 'https://openalex.org/W2113367996', 'https://openalex.org/W2128243640', 'https://openalex.org/W2129377335', 'https://openalex.org/W2133244310', 'https://openalex.org/W2137352234', 'https://openalex.org/W2138077952', 'https://openalex.org/W2139485303', 'https://openalex.org/W2139562487', 'https://openalex.org/W2141946042', 'https://openalex.org/W2143752451', 'https://openalex.org/W2150849997', 'https://openalex.org/W2151848850', 'https://openalex.org/W2152984355', 'https://openalex.org/W2153449155', 'https://openalex.org/W2159205789', 'https://openalex.org/W2160274347', 'https://openalex.org/W2162001095', 'https://openalex.org/W2163229244', 'https://openalex.org/W2164416879', 'https://openalex.org/W2170606300', 'https://openalex.org/W2171512247', 'https://openalex.org/W2172193326', 'https://openalex.org/W2344620176'], 'related_works': ['https://openalex.org/W4251091689', 'https://openalex.org/W4235703269', 'https://openalex.org/W4221092299', 'https://openalex.org/W3180182860', 'https://openalex.org/W2989539681', 'https://openalex.org/W2385294593', 'https://openalex.org/W2146774087', 'https://openalex.org/W2116254891', 'https://openalex.org/W2094997999', 'https://openalex.org/W2082751271'], 'abstract_inverted_index': {'Incretin-based': [0, 99], 'medications': [1, 100], 'make': [2], 'use': [3], 'of': [4, 8, 71], 'the': [5, 9, 69, 72], 'glucose-lowering': [6], 'properties': [7], 'gut-derived': [10], 'incretin': [11], 'hormone': [12], 'glucagon-like': [13], 'peptide': [14], '1': [15], '(GLP-1),': [16], 'which': [17], 'glucose-dependently': [18], 'stimulates': [19], 'insulin': [20, 141], 'secretion,': [21, 24], 'suppresses': [22], 'glucagon': [23], 'decelerates': [25], 'gastric': [26], 'emptying,': [27], 'and': [28, 31, 53, 65, 91, 105, 120], 'reduces': [29], 'appetite': [30], 'food': [32], 'intake.': [33], 'GLP-1': [34, 44], 'itself': [35], 'has': [36], 'a': [37], 'very': [38], 'short': [39], 'half-life.': [40], 'Therefore,': [41], 'longer': [42], 'acting': [43], 'receptor': [45], 'agonists': [46], 'like': [47], 'exenatide,': [48], 'liraglutide,': [49], 'exenatide': [50], 'once': [51, 66], 'weekly,': [52, 67], 'lixisenatide': [54], 'need': [55], 'to': [56, 79, 95, 129], 'be': [57, 80, 136], 'injected': [58], 'subcutaneously': [59], 'at': [60], 'intervals': [61], 'between': [62], 'twice': [63], 'daily': [64], 'or': [68, 113], 'activity': [70], 'proteolytic': [73], 'enzyme': [74], 'dipeptidyl': [75], 'peptidase-4': [76], '(DPP-4)': [77], 'needs': [78], 'inhibited': [81], 'by': [82], 'DPP-4': [83, 121], 'inhibitors': [84, 122], 'such': [85], 'as': [86, 126], 'sitagliptin,': [87], 'vildagliptin,': [88], 'saxagliptin,': [89], 'linagliptin,': [90], 'alogliptin': [92], 'in': [93, 138], 'order': [94], 'exploit': [96], 'this': [97], 'potential.': [98], 'do': [101], 'not': [102], 'provoke': [103], 'hypoglycemia,': [104], 'either': [106], 'induce': [107], 'some': [108], 'weight': [109], 'loss': [110], '(incretin': [111], 'mimetics)': [112], 'are': [114, 123], 'weight-neutral': [115], '(DPP-4': [116], 'inhibitors).': [117], 'Incretin': [118], 'mimetics': [119], 'mainly': [124], 'used': [125, 137], 'an': [127], 'add-on': [128], 'oral': [130], 'antidiabetic': [131], 'agents,': [132], 'but': [133], 'can': [134], 'also': [135], 'conjunction': [139], 'with': [140], 'treatment.': [142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4251091689', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-10T18:20:51.838390', 'created_date': '2022-05-12'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
