Title: Nephrotoxicity assessment of the hydroethanolic leaf extract of Ziziphus mauritiana LAM (Rhamnaceae) in mammalians.
Abstract:Ziziphus mauritiana LAM is traditionally used in the treatment of various ailments.The purpose of this study was to check out the effect of the hydroethanolic leaf extract of Ziziphus mauritiana LAM o...Ziziphus mauritiana LAM is traditionally used in the treatment of various ailments.The purpose of this study was to check out the effect of the hydroethanolic leaf extract of Ziziphus mauritiana LAM on Wistar rats kidney functions.Determination of LD50 and the evaluation of the haematological, biochemical parameters followed by the histopathological assessment of kidney tissues in treated rats was carried out.The acute toxicity study showed a low toxicity with LD50 > 20000 mg /Kg.However, chronic treatment of rats resulted in a significant rise of platelet counts in both sexes of animals at experimental doses.Moreover, a significant increase of neutrophils in male was recorded but decreased in female rats at high doses.Biochemical analysis revealed significant increase of Urea and Creatinine in both sexes of rats followed by a decrease of uric acid in male rats at a dose of 1200mg / Kg. there was no significant difference in blood electrolytes except for Ca2+ at experimental doses in female rats compared to the control.Histopathological examination confirmed biochemical tests with presence of tissue damages.This study demonstrates the ability of the extract to cause thrombocytosis and induce kidney tissue damages in rats.Read More