Abstract:This chapter provides the basic characteristics, side effects/toxicity, drug interactions, and dosing of the daklinza (daclatasvir). Daclatasvir binds to the N-terminus of nonstructural protein 5A (NS...This chapter provides the basic characteristics, side effects/toxicity, drug interactions, and dosing of the daklinza (daclatasvir). Daclatasvir binds to the N-terminus of nonstructural protein 5A (NS5A) and inhibits both viral RNA replication and virion assembly. Alterations in the structure of the NS5A protein allow replication to continue in the presence of daclatasvir. The mutations leading to resistance include the M28T, Q30E, Q30H, Q30R, L31V, Y93C, Y93H, and Y93N substitutions. Daclatasvir is indicated for use with sofosbuvir, with or without ribavirin, for the treatment of patients with chronic hepatitis C virus (HCV) genotype 1 or genotype 3 infection. Patients taking daclatasvir in combination with sofosbuvir and amiodarone are at high risk for symptomatic bradycardia. Daclatasvir may be taken without regard to food. When daclatasvir is used in combination with other agents, the contraindications applicable to those agents are applicable to combination therapies. Daclatasvir comes in 30 mg, 60 mg, and 90 mg tablets.Read More
Publication Year: 2017
Publication Date: 2017-08-30
Language: en
Type: other
Indexed In: ['crossref']
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