Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4247545610', 'doi': 'https://doi.org/10.21203/rs.3.rs-15480/v3', 'title': 'Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques', 'display_name': 'Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques', 'publication_year': 2020, 'publication_date': '2020-09-16', 'ids': {'openalex': 'https://openalex.org/W4247545610', 'doi': 'https://doi.org/10.21203/rs.3.rs-15480/v3'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-15480/v3', 'pdf_url': 'https://www.researchsquare.com/article/rs-15480/v3.pdf?c=1631870284000', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.researchsquare.com/article/rs-15480/v3.pdf?c=1631870284000', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100348564', 'display_name': 'Hao Li', 'orcid': 'https://orcid.org/0000-0002-2125-9092'}, 'institutions': [{'id': 'https://openalex.org/I4210128921', 'display_name': 'The First Affiliated Hospital, Sun Yat-sen University', 'ror': 'https://ror.org/037p24858', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128921']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hao Li', 'raw_affiliation_strings': ['Sun Yat-sen University First Affiliated Hospital'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University First Affiliated Hospital', 'institution_ids': ['https://openalex.org/I4210128921', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110376042', 'display_name': 'Liqian Cui', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128921', 'display_name': 'The First Affiliated Hospital, Sun Yat-sen University', 'ror': 'https://ror.org/037p24858', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128921']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Liqian Cui', 'raw_affiliation_strings': ['Sun Yat-sen University First Affiliated Hospital'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University First Affiliated Hospital', 'institution_ids': ['https://openalex.org/I4210128921', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004743509', 'display_name': 'Liping Cao', 'orcid': 'https://orcid.org/0000-0002-1747-6107'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Liping Cao', 'raw_affiliation_strings': ['Guangzhou Huiai Hospital'], 'affiliations': [{'raw_affiliation_string': 'Guangzhou Huiai Hospital', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057228969', 'display_name': 'Yizhi Zhang', 'orcid': 'https://orcid.org/0000-0002-0422-0006'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yizhi Zhang', 'raw_affiliation_strings': ['Guangzhou Huiai Hospital'], 'affiliations': [{'raw_affiliation_string': 'Guangzhou Huiai Hospital', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083543862', 'display_name': 'Yueheng Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yueheng Liu', 'raw_affiliation_strings': ['Second Xiangya Hospital'], 'affiliations': [{'raw_affiliation_string': 'Second Xiangya Hospital', 'institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047084765', 'display_name': 'Wenhao Deng', 'orcid': 'https://orcid.org/0000-0003-3316-6691'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wenhao Deng', 'raw_affiliation_strings': ['Guangzhou Huiai Hospital'], 'affiliations': [{'raw_affiliation_string': 'Guangzhou Huiai Hospital', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101854442', 'display_name': 'Wenjin Zhou', 'orcid': 'https://orcid.org/0009-0009-8416-1621'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wenjin Zhou', 'raw_affiliation_strings': ['Guangzhou Huiai Hospital'], 'affiliations': [{'raw_affiliation_string': 'Guangzhou Huiai Hospital', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5110376042'], 'corresponding_institution_ids': ['https://openalex.org/I4210128921', 'https://openalex.org/I157773358'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.85331, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 69, 'max': 73}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10049', 'display_name': 'Magnetic properties of thin films', 'score': 0.9311, 'subfield': {'id': 'https://openalex.org/subfields/3107', 'display_name': 'Atomic and Molecular Physics, and Optics'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10049', 'display_name': 'Magnetic properties of thin films', 'score': 0.9311, 'subfield': {'id': 'https://openalex.org/subfields/3107', 'display_name': 'Atomic and Molecular Physics, and Optics'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10378', 'display_name': 'Advanced MRI Techniques and Applications', 'score': 0.9062, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lasso', 'display_name': 'Lasso', 'score': 0.42059866}], 'concepts': [{'id': 'https://openalex.org/C154945302', 'wikidata': 'https://www.wikidata.org/wiki/Q11660', 'display_name': 'Artificial intelligence', 'level': 1, 'score': 0.735021}, {'id': 'https://openalex.org/C12267149', 'wikidata': 'https://www.wikidata.org/wiki/Q282453', 'display_name': 'Support vector machine', 'level': 2, 'score': 0.6783236}, {'id': 'https://openalex.org/C58693492', 'wikidata': 'https://www.wikidata.org/wiki/Q551875', 'display_name': 'Neuroimaging', 'level': 2, 'score': 0.5677845}, {'id': 'https://openalex.org/C119857082', 'wikidata': 'https://www.wikidata.org/wiki/Q2539', 'display_name': 'Machine learning', 'level': 1, 'score': 0.52685463}, {'id': 'https://openalex.org/C143409427', 'wikidata': 'https://www.wikidata.org/wiki/Q161238', 'display_name': 'Magnetic resonance imaging', 'level': 2, 'score': 0.4802354}, {'id': 'https://openalex.org/C2776174506', 'wikidata': 'https://www.wikidata.org/wiki/Q131755', 'display_name': 'Bipolar disorder', 'level': 3, 'score': 0.4520223}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.43133083}, {'id': 'https://openalex.org/C37616216', 'wikidata': 'https://www.wikidata.org/wiki/Q3218363', 'display_name': 'Lasso (programming language)', 'level': 2, 'score': 0.42059866}, {'id': 'https://openalex.org/C69738355', 'wikidata': 'https://www.wikidata.org/wiki/Q1228929', 'display_name': 'Linear discriminant analysis', 'level': 2, 'score': 0.4119809}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39456245}, {'id': 'https://openalex.org/C2780733359', 'wikidata': 'https://www.wikidata.org/wiki/Q331769', 'display_name': 'Mood', 'level': 2, 'score': 0.3533476}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.3364209}, {'id': 'https://openalex.org/C153180895', 'wikidata': 'https://www.wikidata.org/wiki/Q7148389', 'display_name': 'Pattern recognition (psychology)', 'level': 2, 'score': 0.32552284}, {'id': 'https://openalex.org/C126838900', 'wikidata': 'https://www.wikidata.org/wiki/Q77604', 'display_name': 'Radiology', 'level': 1, 'score': 0.17412195}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.11846411}, {'id': 'https://openalex.org/C136764020', 'wikidata': 'https://www.wikidata.org/wiki/Q466', 'display_name': 'World Wide Web', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-15480/v3', 'pdf_url': 'https://www.researchsquare.com/article/rs-15480/v3.pdf?c=1631870284000', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12888-020-02886-5', 'pdf_url': 'https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-020-02886-5', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-15480/v4', 'pdf_url': 'https://www.researchsquare.com/article/rs-15480/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-15480/v3', 'pdf_url': 'https://www.researchsquare.com/article/rs-15480/v3.pdf?c=1631870284000', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Reduced inequalities', 'id': 'https://metadata.un.org/sdg/10', 'score': 0.67}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1810343284', 'https://openalex.org/W1884423413', 'https://openalex.org/W1930790356', 'https://openalex.org/W1964827701', 'https://openalex.org/W1968487444', 'https://openalex.org/W1970389605', 'https://openalex.org/W1974192710', 'https://openalex.org/W1976073163', 'https://openalex.org/W1982931669', 'https://openalex.org/W1986485707', 'https://openalex.org/W1990288178', 'https://openalex.org/W1991436494', 'https://openalex.org/W1995665686', 'https://openalex.org/W1997313699', 'https://openalex.org/W2001770029', 'https://openalex.org/W2002736671', 'https://openalex.org/W2004696161', 'https://openalex.org/W2005238835', 'https://openalex.org/W2007213925', 'https://openalex.org/W2018290008', 'https://openalex.org/W2021601390', 'https://openalex.org/W2024386029', 'https://openalex.org/W2031276009', 'https://openalex.org/W2035358875', 'https://openalex.org/W2041198871', 'https://openalex.org/W2045393809', 'https://openalex.org/W2059237009', 'https://openalex.org/W2071214311', 'https://openalex.org/W2071797780', 'https://openalex.org/W2079735985', 'https://openalex.org/W2086562272', 'https://openalex.org/W2101368129', 'https://openalex.org/W2108395010', 'https://openalex.org/W2115934049', 'https://openalex.org/W2117200371', 'https://openalex.org/W2119848633', 'https://openalex.org/W2123809443', 'https://openalex.org/W2124250881', 'https://openalex.org/W2127048684', 'https://openalex.org/W2132637444', 'https://openalex.org/W2134676768', 'https://openalex.org/W2136162329', 'https://openalex.org/W2146233605', 'https://openalex.org/W2162250733', 'https://openalex.org/W2163266267', 'https://openalex.org/W2166995157', 'https://openalex.org/W2168372372', 'https://openalex.org/W2343166011', 'https://openalex.org/W2413394923', 'https://openalex.org/W2418826365', 'https://openalex.org/W2553221005', 'https://openalex.org/W2620688866', 'https://openalex.org/W2762624863', 'https://openalex.org/W2789891488', 'https://openalex.org/W2790879392', 'https://openalex.org/W2791321831', 'https://openalex.org/W2791830608', 'https://openalex.org/W2801745895', 'https://openalex.org/W2888193947', 'https://openalex.org/W2902045707', 'https://openalex.org/W2917778834', 'https://openalex.org/W2925024134', 'https://openalex.org/W2945729004', 'https://openalex.org/W3043771006', 'https://openalex.org/W4230674625', 'https://openalex.org/W4239528975'], 'related_works': ['https://openalex.org/W4205958290', 'https://openalex.org/W2899084033', 'https://openalex.org/W2748952813', 'https://openalex.org/W2380927352', 'https://openalex.org/W2353567328', 'https://openalex.org/W2345184372', 'https://openalex.org/W2339674921', 'https://openalex.org/W2146076056', 'https://openalex.org/W2099369243', 'https://openalex.org/W1809065030'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], ':': [2, 82, 154, 243], 'Bipolar': [3], 'disorder': [4, 10], '(BPD)': [5], 'is': [6, 12], 'a': [7, 57, 64, 163], 'common': [8], 'mood': [9], 'that': [11], 'often': [13], 'goes': [14], 'misdiagnosed': [15], 'or': [16], 'undiagnosed.': [17], 'Recently,': [18], 'machine': [19, 60], 'learning': [20], 'techniques': [21], 'have': [22, 38], 'been': [23], 'combined': [24], 'with': [25, 79, 87, 160, 198], 'neuroimaging': [26], 'methods': [27], 'to': [28, 55, 75, 136, 187, 235, 262], 'aid': [29, 263], 'in': [30, 50, 95, 123, 218, 256, 264, 270], 'the': [31, 41, 96, 124, 143, 157, 171, 189, 219, 237, 257, 265, 271], 'diagnosis': [32], 'of': [33, 43, 66, 120, 165, 203, 208, 214, 240, 246, 253, 259, 268], 'BPD.': [34, 80], 'However,': [35], 'most': [36], 'studies': [37], 'focused': [39], 'on': [40, 46, 140], 'construction': [42, 258], 'classifiers': [44, 261], 'based': [45], 'single-modality': [47], 'MRI.': [48], 'Hence,': [49], 'this': [51], 'study,': [52], 'we': [53, 180, 232], 'aimed': [54], 'construct': [56, 188], 'support': [58], 'vector': [59], '(SVM)': [61], 'model': [62, 145], 'using': [63, 156], 'combination': [65, 245], 'structural': [67, 247], 'and': [68, 89, 100, 112, 148, 184, 212, 231, 248], 'functional': [69, 249], 'MRI,': [70], 'which': [71, 193], 'could': [72, 194], 'be': [73, 252], 'used': [74, 181], 'accurately': [76], 'identify': [77, 196], 'patients': [78, 86, 197], 'Methods': [81], 'In': [83], 'total,': [84], '44': [85], 'BPD': [88, 199, 269], '36': [90], 'healthy': [91], 'controls': [92], 'were': [93, 103, 115, 129, 168, 233], 'enrolled': [94], 'study.': [97], 'Clinical': [98], 'evaluation': [99], 'MRI': [101, 250], 'scans': [102], 'performed': [104], 'for': [105], 'each': [106, 121], 'subject.': [107], 'Next,': [108, 179], 'image': [109], 'pre-processing,': [110], 'VBM': [111, 183], 'ReHo': [113, 118, 176, 185], 'analyses': [114], 'performed.': [116, 152], 'The': [117, 226], 'values': [119], 'subject': [122], 'clusters': [125, 167], 'showing': [126], 'significant': [127], 'differences': [128], 'extracted.': [130], 'Further,': [131], 'LASSO': [132], 'approach': [133], 'was': [134, 146, 151, 229], 'recruited': [135], 'screen': [137], 'features.': [138], 'Based': [139], 'selected': [141], 'features,': [142], 'SVM': [144, 191, 260], 'established,': [147], 'discriminant': [149], 'analysis': [150], 'Results': [153], 'After': [155], 'two-sample': [158], 't-test': [159], 'multiple': [161], 'comparisons,': [162], 'total': [164], '8': [166], 'extracted': [169], 'from': [170], 'data': [172, 186, 221], '(VBM': [173], '=': [174, 177], '6;': [175], '2).': [178], 'both': [182], 'new': [190], 'classifier,': [192], 'effectively': [195], 'at': [200], 'an': [201], 'accuracy': [202], '87.5%': [204], '(95%CI:': [205, 210, 216], '72.5-95.3%),': [206], 'sensitivity': [207], '86.4%': [209], '64.0-96.4%),': [211], 'specificity': [213], '88.9%': [215], '63.9-98.0%)': [217], 'test': [220], '(': [222], 'p': [223], '=0.0022).': [224], 'Limitations:': [225], 'sample': [227], 'size': [228], 'small,': [230], 'unable': [234], 'eliminate': [236], 'potential': [238], 'effects': [239], 'medications.': [241], 'Conclusions': [242], 'A': [244], 'can': [251], 'added': [254], 'value': [255], 'accurate': [266], 'identification': [267], 'clinic.': [272]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4247545610', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2025-01-07T08:20:26.692867', 'created_date': '2022-05-12'}