Publication Information

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405, 526, 598, 630, 1005, 1032, 1107, 1340, 1354, 1372, 1458, 1490, 1538, 1990, 3340], 'as': [129, 185, 295, 739, 750, 818, 1058, 1327, 1773, 1821, 2437], 'syndrome': [134, 434, 1833, 2637, 3381, 3681, 3828, 3902, 4042, 4137], '(MetS).': [135], 'In': [136, 1578, 1741], 'observational': [137], 'studies,': [138, 1248], 'each': [139, 186], 'these': [141, 1068, 1582], 'factors': [142, 201, 1203, 1296, 1806, 2463, 2705, 3762, 3770], 'related': [144, 204, 516, 660, 1008, 1174, 1239, 1386, 3198, 3763], 'greater': [146], 'risk': [147, 636, 663, 761, 807, 842, 868, 942, 1045, 1390, 1552, 1689, 1920, 2483, 2640, 2682, 2704, 3769, 3831], 'coronary': [149, 638, 665, 708, 719, 725, 839, 1953, 1983, 2049, 2120, 2220, 2392, 2465, 2642, 2714, 3342, 3393], 'heart': [150, 639, 840, 1984, 2121, 2466, 2599, 2643, 2715, 3343], 'disease,1,2': [151], 'clinical': [153, 590, 736, 771, 975, 1266, 1369, 1567, 2723, 3102], 'trials': [154, 591, 737, 1568], 'have': [155, 166, 202, 253, 257, 328, 380, 389, 826, 836, 850, 870, 1123, 1233, 1384, 1470, 1521, 1526, 1535], 'been': [156, 203, 254, 381, 732, 1173, 1219, 1235, 1261, 1385, 1471], 'undertaken': [157, 533], 'prevent': [159, 1275], 'outcomes.3': [160], 'Persons': [161, 1112], 'with': [162, 466, 549, 599, 611, 631, 651, 673, 706, 812, 861, 897, 1002, 1023, 1038, 1115, 1221, 1518, 1588, 1711, 1743, 1988, 2219, 2604, 2750, 2778, 2936, 2965, 3337, 3385, 3391, 3431, 3834, 3905, 4135, 4141], 'triglycerides': [164, 907, 1658, 3339], 'often': [165], 'HDL-C': [168, 206, 216, 260, 337, 357, 407, 499, 519, 629, 689, 1645], 'small,': [171], 'dense': [172], 'LDL': [173, 646, 789, 798, 852, 872], 'particles.': [174], 'Estrogen': [175], 'therapy': [176, 461, 606, 633, 644, 672, 879, 900, 968, 986, 2212, 2480], 'excessive': [178], 'alcohol': [179], 'intake': [180], 'may': [181, 187, 306, 318, 369, 441, 1524, 1532, 1549], 'disrupt': [182], 'pattern,': [184], 'cause': [188], 'simultaneous': [189], 'increases': [190], 'in': [191, 210, 220, 264, 282, 341, 346, 386, 419, 485, 491, 502, 544, 654, 675, 696, 699, 718, 734, 894, 906, 916, 963, 969, 996, 1016, 1036, 1108, 1142, 1149, 1177, 1190, 1223, 1245, 1264, 1375, 1381, 1397, 1411, 1459, 1514, 1543, 1570, 1613, 1626, 1644, 1657, 1664, 1678, 1696, 1704, 1789, 1802, 1834, 1853, 1986, 2022, 2074, 2079, 2088, 2177, 2190, 2217, 2263, 2303, 2335, 2511, 2602, 2647, 2677, 2706, 2746, 2771, 2881, 2934, 2961, 3047, 3052, 3089, 3169, 3178, 3202, 3207, 3300, 3303, 3310, 3389, 3487, 3501, 3541, 3676, 3727, 3771, 3832, 3903, 4138], 'levels.A': [195], 'variety': [196, 397], 'environmental': [198], 'genetic': [200, 1289, 2175, 3298, 3967], 'certain': [211, 1547], 'populations.': [212], 'For': [213, 411, 648, 1213], 'instance,': [214, 412, 1214], 'lower': [215, 662, 1756, 1768, 2073], 'are': [218, 279, 359, 435, 448, 527, 999, 1152, 1408, 1491, 1498, 1575, 1800, 1807, 1826, 3969], 'found': [219], 'cigarette': [221], 'smokers,': [222], 'obese': [223], 'persons,': [224], 'inactive': [225], 'individuals,': [226], 'those': [228], 'who': [229, 388, 1748], 'use': [230, 415, 965, 1215], 'androgens': [231], 'or': [232, 298, 395, 426, 645, 724, 831, 833, 932, 1154, 1596, 2385, 2781], '17': [233], 'nor-derivatives': [234], 'progesterone.4,5': [236], 'Genetic': [237], 'variants': [238, 3968], 'lipoprotein': [240, 308, 323, 1928, 1993, 2029, 2047, 2114], 'lipase,': [241, 243], 'hepatic': [242, 2090], 'ester': [245], 'transfer': [246, 2184], 'protein,': [247], 'peroxisome': [249], 'proliferator-activated': [250], 'receptors': [251], '(PPAR)-α': [252], 'shown': [255, 1236], 'on': [259, 383, 579, 1087, 1113, 1423, 1959, 2028, 2213, 2326, 2355, 2414, 3440], 'populations,6–10': [265], 'contributing': [266], 'development': [269, 1228, 1769, 1836, 3099], 'MetS.How': [272], 'Do': [273, 1093, 1400, 1509], 'You': [274, 1094, 1401, 1510], 'Make': [275, 1095, 1402], 'Diagnosis?Lipid': [277], 'best': [280], 'obtained': [281, 733], 'a': [283, 291, 299, 467, 541, 565, 580, 715, 837, 925, 1416, 1619, 1628, 1640, 1647, 1660, 1754, 1766, 1847, 1880, 1919, 1931, 1956, 2678, 2879, 3101, 3347, 4087], "person's": [284], 'usual,': [285], 'healthy': [286, 2648], 'state.11,12': [287], 'concentrations': [289], 'after': [290, 372, 1341, 1539, 3427], 'recent': [292], 'illness': [293], 'such': [294, 738, 749, 1326], 'influenza,': [296], 'diarrhea,': [297], 'systemic': [300], 'disease': [301, 438, 640, 710, 830, 841, 1048, 1393, 1924, 1985, 2600, 2644, 2716, 3344], 'accompanied': [302, 443], 'by': [303, 363, 444, 844, 1100, 1776, 1866, 2744, 3345, 3553, 3605, 3679], 'weight': [304, 994, 1164, 1170, 1241, 1621, 3432, 3673], 'loss': [305, 1165, 1171, 1622], 'reduce': [307, 635, 759, 1601], 'levels,': [310, 1486], 'physicians': [312], 'should': [313, 531, 553, 800, 960, 1119, 1159, 1199, 1210], 'be': [314, 319, 442, 532, 554, 573, 588, 801, 816, 864, 921, 961, 1120, 1160, 1200, 1211, 1238, 1319, 1429], 'aware': [315], 'that': [316, 440, 447, 475, 625, 745, 1026, 1280], 'it': [317, 949], 'advisable': [320], 'defer': [322], 'testing': [324], 'until': [325], 'acute': [326], 'illnesses': [327], 'passed': [329], 'patient': [332, 537], 'has': [333, 509, 731, 1051, 1172, 1218, 1260, 1348], 'recovered.': [334], 'A': [335, 974, 2109, 3081, 3375, 3538, 3660, 3718, 3777], 'level': [338, 470, 1418, 1917], '(<40': [339], 'mg/dL': [340, 345, 1422, 1642, 1649, 1655, 1662], 'men': [342, 1987, 2077], '<50': [344], 'women)': [347], 'one': [349, 1444], 'diagnostic': [352, 375, 1447, 1501, 1815, 3103], 'criteria': [353, 376, 1436, 1448, 1502], 'for': [354, 377, 392, 422, 462, 498, 513, 637, 943, 1188, 1449, 1473, 1503, 1786, 1922, 1978, 2360, 2364, 2388, 2683, 2713, 3491, 3578, 3971], 'MetS.': [356, 1062, 1451], 'altered': [360], 'very': [361], 'little': [362], 'fasting': [364, 1335, 1377, 1406, 1417, 1431, 1456, 1467, 1480, 1529, 1557, 1590, 1713], 'status,': [365], 'but': [366, 1249, 1350, 1465, 1497, 3205], 'increase': [370, 1603, 1643, 1650, 3766], 'greatly': [371], 'eating,': [373], 'MetS': [379, 613, 814, 862, 914, 1505, 1520, 1772], 'based': [382], 'measurements': [384, 2568], 'done': [385], 'persons': [387, 420, 1042, 1148, 1747], 'typically': [390], 'fasted': [391], '12': [393], 'hours': [394], 'more.A': [396], 'conditions': [400, 1185], 'can': [401, 920, 1318], 'contribute': [402], 'elevated': [409, 521, 1455, 1536, 1712], 'triglycerides.': [410], 'primary': [413, 793], 'hypothyroidism,': [414], 'protease': [417], 'inhibitors': [418], 'treated': [421], 'HIV,': [423], 'excess': [424, 1287], 'endogenous': [425], 'exogenous': [427], 'glucocorticoids,': [428], 'acanthosis': [429], 'nigricans,': [430], 'polycystic': [432, 2284], 'ovary': [433, 2285], 'examples': [436], 'processes': [439], 'lipid': [445, 514, 525, 2149, 2240, 2264, 2526], 'abnormalities': [446, 905], 'characteristic': [449, 1359], 'MetS.13,14': [452], 'Diagnosis': [453], 'other': [455, 1041, 1204, 1295], 'diseases': [456], 'important': [458, 1187], 'before': [459, 2719], 'instituting': [460], 'dyslipidemia,': [463], 'screening': [465], 'thyroid-stimulating': [468], 'hormone': [469], 'ensure': [474], 'subclinical': [476], 'hypothyroidism': [477], 'not': [479, 572, 587, 903, 1365, 1499, 1525, 3206], 'missed.': [480], 'Glucose': [481, 1512], 'screening,': [482], 'discussed': [483], 'elsewhere': [484], 'article,': [487], 'also': [489, 607, 1234], 'setting.What': [493], 'Are': [494], 'Treatment': [496, 778, 1076, 2330, 2338, 3173], 'Options': [497], 'Triglycerides': [501, 3548], 'MetS?The': [504], 'Education': [507, 787, 2321], 'Program': [508, 779, 2322], 'set': [510, 802], 'forth': [511], 'guidelines': [512, 557, 774], 'management': [515], 'triglycerides.15': [522], 'Where': [523], 'only': [524, 1466], 'abnormal,': [528], 'lifestyle': [529, 1544, 1595, 1615, 1726, 1751, 2747, 2779], 'intervention': [530, 1616, 1733, 2780], 'first': [534, 1162, 1580], 'encouraged': [538], 'follow': [540, 1592], 'diet': [542], 'saturated': [545], 'fat': [546, 3607], 'cholesterol,': [548], 'caloric': [550], 'restriction.': [551], 'Exercise': [552, 3489, 3802], 'encouraged;': [555], 'recommend': [558], '30': [559], 'minutes': [560], 'exercise': [562, 570, 585, 1606], '5': [563, 1782], 'days': [564], 'week.16': [566], 'All': [567], 'need': [571, 586], 'taken': [574], 'at': [575, 711, 820, 865, 971, 1043, 1110, 1506, 2680], 'same': [577], 'time': [578], 'given': [581, 922], 'day,': [582], 'aerobic.Many': [589], 'demonstrate': [592], 'efficacy': [594, 1254], 'reducing': [596], 'LDL-cholesterol': [597], 'statin': [600, 605, 643, 899, 985], 'therapy.': [601, 797], 'The': [602, 1476, 1680, 1699, 1719, 1731, 1784, 1805, 2259, 2279, 2524, 2578, 2871, 3129, 3163, 3639, 3898, 3931], 'benefit': [603], 'extends': [608], 'patients': [610, 811, 848, 860, 896, 970, 980, 1037, 1587, 2935, 3390, 3677, 3833, 3904], 'type': [615, 2485, 2740, 2775], '2': [616, 1424, 1566, 1573, 1641, 2486, 2741, 2776, 3626, 3686], 'diabetes': [617, 1039, 2026, 2487, 2685, 2742, 2777], 'mellitus': [618, 2027, 2743], '(T2DM).': [619], 'However,': [620], 'there': [621], 'growing': [623], 'evidence': [624, 730], 'modifying': [626], 'drug': [632, 878], 'independently': [641, 3383], 'lowering.': [647], 'example,': [649], 'treatment': [650, 1114, 1273], 'nicotinic': [652, 930], 'acid': [653, 931], 'Coronary': [656, 2598, 3143], 'Drug': [657], 'Project': [658], 'was': [659, 1693, 1702, 1734], 'death': [666], 'over': [667, 1673], 'long-term': [668, 1251], 'follow-up.': [669], 'More': [670], 'recently,': [671], 'gemfibrozil': [674], 'Veterans': [677, 1995], 'Administration': [678], 'Intervention': [680, 2000], 'Trial': [681, 743, 1278, 2001], '(VA-HIT)': [682], 'led': [683, 1052], 'lowering': [686, 2527], '31%,': [688], 'raising': [690], '6%,': [692], 'no': [694], 'change': [695], 'LDL-C.': [697], 'Participants': [698], 'trial': [701, 1701], 'US': [703], 'military': [704], 'veterans': [705], 'known': [707], 'artery': [709, 1954, 2050, 2215, 2221, 3394], 'outset': [713], 'experienced': [714, 1618, 1753], '24%': [716], 'reduction': [717, 1027], 'events': [720], '(nonfatal': [721], 'myocardial': [722], 'infarction': [723], 'death)': [726], 'during': [727], 'follow-up.3': [728], 'Corroborating': [729], 'smaller': [735], 'Atherosclerosis': [742, 2581, 2970], '(HATS)': [744], 'used': [746, 1472], 'combination': [747, 937, 2387], 'therapies': [748], 'niacin': [751, 755], 'colestipol': [753], 'simvastatin': [757], 'progression': [763, 1554, 1757], 'atherosclerosis': [765], 'diminish': [767], 'number': [769], 'events.17According': [772], 'from': [775, 1072, 1555, 1882, 2570, 3254, 3775], 'Adult': [777, 2962], 'III': [780, 1779], '(ATP': [781], 'III)': [782], 'Program,': [788], 'target': [794], 'lipid-lowering': [796, 927], 'goals': [799, 885], 'according': [803, 1433], 'absolute': [806, 1686], 'patients.': [809], 'Many': [810], 'classified': [817], 'being': [819], 'risk,': [822], 'ie,': [823], 'they': [824, 834], 'established': [827], 'atherosclerotic': [828], 'cardiovascular': [829, 1047, 1392, 1838, 1923, 2440, 2932, 3768], 'T2DM,': [832, 1561], '10-year': [838], '>20%': [843], 'scoring.': [846], 'Such': [847], 'an': [851, 871, 1312, 1342, 1388, 1653, 1667, 3683], 'goal': [853, 873], '<100': [854], 'mg/dL.': [855, 876], 'Most': [856], 'remaining': [859], 'enough': [867], '<130': [875], 'If': [877], 'required': [881], 'achieve': [883], 'therapy,': [887], 'statins': [889], 'represent': [891], 'first-line': [892], 'therapy.However,': [893], 'many': [895, 1265], 'MetS,': [898, 1464], 'alone': [901], 'correct': [904], 'HDL.': [910], 'Especially': [911], 'when': [912, 984], 'occurs': [915], 'high-risk': [917], 'patients,': [918], 'consideration': [919], 'adding': [924], 'drug,': [928], 'eg,': [929], 'fibric': [933], 'acid.': [934], 'Unfortunately,': [935], 'statin+fibrate': [939], 'carries': [940], 'increased': [941, 1389, 3386], 'severe': [944, 3301], 'myopathy.': [945], 'With': [946, 3141, 3555, 4014], 'combination,': [948], 'prudent': [951], 'avoid': [953], 'doses': [955], 'statins.': [957], 'Furthermore,': [958], 'clinicians': [959], 'selective': [962], 'combined': [967, 4143], 'risk.': [973], 'advisory': [976], 'reviewed': [977], 'selection': [978], 'reasonable': [982], 'precautions': [983], 'used.18Blood': [988], 'Pressure': [989, 1141], '≥130/85': [990, 1128], 'mm': [991, 1034, 1137, 1637], 'HgBackgroundObesity': [992], 'gain': [995, 1242], 'middle': [997], 'age': [998], 'positively': [1000], 'correlated': [1001], 'highly': [1007, 1808], 'prevalence': [1011, 3899], 'incidence': [1013, 2773], 'hypertension': [1015], 'population': [1018, 1247, 2679, 3306], 'setting.19,20': [1019], 'This': [1020], 'fact,': [1021], 'coupled': [1022], 'demonstration': [1025], '<130/85': [1033, 1136], 'Hg': [1035, 1630, 1638], 'efficacious,': [1050], 'including': [1054, 1268, 1324], 'Trials': [1063], 'summary': [1065], 'reports': [1066], 'emphasized': [1067], 'opinions,': [1069], 'data': [1071, 1469, 1825], 'Hypertension': [1074, 1088], 'Optimal': [1075], '(HOT)': [1077], 'study': [1078, 1720], 'recommendations': [1081, 2359], 'Joint': [1084], 'Committee': [1086], 'reflect': [1089], 'intensive': [1091], 'approach.How': [1092], 'Diagnosis?Diagnosis': [1097], 'made': [1099, 1320], 'standard': [1101], 'assessment': [1102], 'sitting': [1104], 'subjects': [1109, 1612, 1710, 2749], 'rest.': [1111], 'medications': [1118, 1548], 'considered': [1121, 1427, 1500], 'satisfied': [1124], 'criterion': [1129], 'even': [1130], 'if': [1131], 'measured': [1132], 'Hg.Treatment': [1138], 'MetSMost': [1144], 'affected': [1147, 3678], 'setting': [1151], 'overweight': [1153], 'obese,': [1155], 'specific': [1157], 'attention': [1158, 1182], 'directed': [1161], 'toward': [1163], 'sodium': [1167], 'reduction.': [1168], 'Modest': [1169], 'improvement': [1176, 1542], 'pressure,': [1179], 'general': [1181, 3305], 'comorbid': [1184], 'pharmacotherapy': [1189], 'setting.': [1192], 'Patient': [1193], 'responses': [1194], 'individual': [1196], 'pharmacological': [1197], 'agents': [1198], 'monitored,': [1201], 'than': [1205, 2078], 'response': [1209], 'considered.': [1212], 'diuretics': [1217, 1259], 'associated': [1220, 3336, 3384, 4134], 'deterioration': [1222], 'glycemic': [1224], 'control': [1225], 'T2DM.21': [1230], 'Beta': [1231], 'blockers': [1232, 1257], 'T2DM': [1244, 1396, 1672, 1692, 1760], 'some': [1246], 'safety': [1252], 'beta': [1256], 'effectively': [1262], 'demonstrated': [1263], 'trials,': [1267, 1583], 'Antihypertensive': [1270, 2479], 'Lipid-Lowering': [1272], 'Attack': [1277], '(ALLHAT)': [1279], 'included': [1281, 1454, 1721], '>40': [1282], '000': [1283], 'patients.22,23Impaired': [1284], 'Fasting': [1285], 'GlucoseBackgroundAge,': [1286], 'adiposity,': [1288], 'predisposition,': [1290], 'inadequate': [1291], 'physical': [1292, 2361], 'activity,': [1293], 'promote': [1297], 'insulin': [1298, 1313, 1339, 1353, 1356, 1374, 1457, 1485, 2301, 2566, 2610], 'resistance,': [1299], 'reference': [1302], 'method': [1303], 'assess': [1305], 'severity': [1307], 'abnormality': [1310], 'clamp': [1314], 'study.24,25': [1315], 'Other': [1316], 'tests': [1317], 'without': [1321], 'indwelling': [1322], 'catheters,': [1323], 'options': [1325], 'frequently': [1329, 2571], 'sampled': [1330, 2572], 'intravenous': [1331, 2573], 'glucose': [1332, 1344, 1407, 1432, 1468, 1483, 1530, 1537, 1558, 1591, 1717, 2546, 2574, 2607, 2752], 'tolerance': [1333, 2575], 'test,': [1334], 'insulin,': [1336, 1481], 'postprandial': [1338], 'oral': [1343], 'load.': [1345], 'Each': [1346], 'approach': [1347], 'advantages,': [1349], 'determination': [1351], 'resistance': [1357, 2302, 2636], 'research': [1361, 1496], 'protocols': [1362], 'integral': [1366], 'regular': [1368], 'care.': [1370], 'Higher': [1371], 'postchallenge': [1379, 1482], 'state': [1380], 'nondiabetic': [1382], 'individuals': [1383, 1517], 'later': [1395], 'several': [1398], 'studies.26–30How': [1399], 'Diagnosis?Measures': [1404], 'important,': [1409], 'usual': [1413, 1594], 'outpatient': [1414], 'setting,': [1415], '110': [1419], '126': [1421], 'occasions': [1425], 'impaired': [1430, 1528, 1556, 1589, 2751], 'American': [1439, 1474, 2076, 2081, 3563], 'Diabetes': [1440, 3736], 'Association,': [1441], 'thus': [1442], 'fulfilling': [1443], 'European': [1452, 1584], 'experts': [1453], 'considering': [1460], 'diagnosis': [1461], 'criteria.': [1475], 'added': [1477], 'utility': [1478, 1812], 'glycosylated': [1488], 'hemoglobin': [1489], 'all': [1492, 2365, 4046], 'active': [1493], 'areas': [1494], 'present.How': [1508], 'Treat': [1511], 'Levels': [1513], 'MetS?Most': [1516], 'hyperglycemia.': [1522], 'They': [1523], 'definite': [1527], 'happen': [1533], 'eating.': [1540], 'An': [1541, 3332], 'habits': [1545, 1599], 'lessen': [1550], 'frank': [1560], 'results': [1564, 2654], 'completed': [1569], 'past': [1572], 'years': [1574, 1675, 2617], 'especially': [1576], 'important.': [1577], 'investigators': [1585], 'had': [1586, 1765], 'their': [1593, 1598, 1787, 1960], 'alter': [1597], 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'diabetes?': [2724], '263:': [2727], '2893–2898.CrossrefMedlineGoogle': [2728], 'Scholar30': [2729], 'Tuomilehto': [2730], 'Lindstrom': [2732], 'Eriksson': [2734], 'JG,': [2735], 'Prevention': [2738, 3171], 'changes': [2745], 'tolerance.': [2753], '344:': [2759], '1343–1350.CrossrefMedlineGoogle': [2760], 'Scholar31': [2761], 'Knowler': [2762], 'WC,': [2763], 'Barrett-Connor': [2764], 'Fowler': [2766], 'Reduction': [2770], 'metformin.': [2782], '346:': [2788], '393–403.CrossrefMedlineGoogle': [2789], 'Scholar': [2790], 'Previous': [2791], 'Back': [2792], 'top': [2794], 'Next': [2795], 'FiguresReferencesRelatedDetailsCited': [2796], 'By': [2797], 'Ong': [2798], 'K,': [2799, 2997, 3033, 3702, 4033], 'Cochran': [2800], 'B,': [2801, 2803, 2989, 3228, 3236, 3365, 3953, 3996, 4112], 'Manandhar': [2802], 'Thomas': [2804], 'S': [2805, 3192, 3796], 'Rye': [2807], 'K': [2808, 2955, 3595], '(2022)': [2809, 2870], 'maturation': [2811], 'remodelling,': [2813], 'Biochimica': [2814], 'Biophysica': 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