Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation

Name: Work Video:
Duration: 3 min 30 s
Tuo Deng; Wenwen Zhang; Yanling Zhang; Mengqi Zhang; Zhikun Huan; Chunxiao Yu; Xiujuan Zhang; Yan Wang; Jin Xu
{'id': 'https://openalex.org/W4246139191', 'doi': 'https://doi.org/10.21203/rs.3.rs-47941/v1', 'title': 'Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation', 'display_name': 'Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation', 'publication_year': 2020, 'publication_date': '2020-10-07', 'ids': {'openalex': 'https://openalex.org/W4246139191', 'doi': 'https://doi.org/10.21203/rs.3.rs-47941/v1'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-47941/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-47941/v1.pdf?c=1602093061000', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.researchsquare.com/article/rs-47941/v1.pdf?c=1602093061000', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051204480', 'display_name': 'Tuo Deng', 'orcid': 'https://orcid.org/0000-0001-7569-0788'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tuo Deng', 'raw_affiliation_strings': ['Shandong Provincial Hospital'], 'affiliations': [{'raw_affiliation_string': 'Shandong Provincial Hospital', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100401875', 'display_name': 'Wenwen Zhang', 'orcid': 'https://orcid.org/0009-0001-2245-2951'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenwen Zhang', 'raw_affiliation_strings': ['Shandong Provincial Hospital'], 'affiliations': [{'raw_affiliation_string': 'Shandong Provincial Hospital', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100621557', 'display_name': 'Yanling Zhang', 'orcid': 'https://orcid.org/0000-0001-6344-8804'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanling Zhang', 'raw_affiliation_strings': ['Shandong Provincial Hospital'], 'affiliations': [{'raw_affiliation_string': 'Shandong Provincial Hospital', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100751727', 'display_name': 'Mengqi Zhang', 'orcid': 'https://orcid.org/0000-0003-2090-6320'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mengqi Zhang', 'raw_affiliation_strings': ['Shandong Provincial Hospital'], 'affiliations': [{'raw_affiliation_string': 'Shandong Provincial Hospital', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085429268', 'display_name': 'Zhikun Huan', 'orcid': 'https://orcid.org/0000-0001-8577-3552'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhikun Huan', 'raw_affiliation_strings': ['Shandong Provincial Hospital'], 'affiliations': [{'raw_affiliation_string': 'Shandong Provincial Hospital', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016649767', 'display_name': 'Chunxiao Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunxiao Yu', 'raw_affiliation_strings': ['Shandong Provincial Hospital'], 'affiliations': [{'raw_affiliation_string': 'Shandong Provincial Hospital', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100623756', 'display_name': 'Xiujuan Zhang', 'orcid': 'https://orcid.org/0000-0003-4005-4444'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiujuan Zhang', 'raw_affiliation_strings': ['Shandong Provincial Hospital'], 'affiliations': [{'raw_affiliation_string': 'Shandong Provincial Hospital', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100322617', 'display_name': 'Yan Wang', 'orcid': 'https://orcid.org/0000-0002-1257-6635'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Wang', 'raw_affiliation_strings': ['Shandong Provincial Hospital'], 'affiliations': [{'raw_affiliation_string': 'Shandong Provincial Hospital', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100782197', 'display_name': 'Jin Xu', 'orcid': 'https://orcid.org/0000-0002-4745-9850'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'jin xu', 'raw_affiliation_strings': ['Shandong Provincial Hospital'], 'affiliations': [{'raw_affiliation_string': 'Shandong Provincial Hospital', 'institution_ids': ['https://openalex.org/I4210116517']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.866359, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 69, 'max': 73}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disorders and Treatments', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disorders and Treatments', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11221', 'display_name': 'Bone health and treatments', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11219', 'display_name': 'Bone Metabolism and Diseases', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/runx2', 'display_name': 'RUNX2', 'score': 0.46789396}, {'id': 'https://openalex.org/keywords/bone-remodeling', 'display_name': 'Bone remodeling', 'score': 0.46136728}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.90721685}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.89804196}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.66534305}, {'id': 'https://openalex.org/C2776886416', 'wikidata': 'https://www.wikidata.org/wiki/Q4941567', 'display_name': 'Bone mineral', 'level': 3, 'score': 0.64837545}, {'id': 'https://openalex.org/C2776541429', 'wikidata': 'https://www.wikidata.org/wiki/Q165328', 'display_name': 'Osteoporosis', 'level': 2, 'score': 0.60620546}, {'id': 'https://openalex.org/C2778288131', 'wikidata': 'https://www.wikidata.org/wiki/Q327362', 'display_name': 'Triiodothyronine', 'level': 3, 'score': 0.5720605}, {'id': 'https://openalex.org/C526584372', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid', 'level': 2, 'score': 0.5673833}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.55855906}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.51458305}, {'id': 'https://openalex.org/C2993291352', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid function', 'level': 3, 'score': 0.51353383}, {'id': 'https://openalex.org/C2776363554', 'wikidata': 'https://www.wikidata.org/wiki/Q14907085', 'display_name': 'RUNX2', 'level': 4, 'score': 0.46789396}, {'id': 'https://openalex.org/C170033053', 'wikidata': 'https://www.wikidata.org/wiki/Q952019', 'display_name': 'Bone remodeling', 'level': 2, 'score': 0.46136728}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.31621975}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-47941/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-47941/v1.pdf?c=1602093061000', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12902-021-00715-8', 'pdf_url': 'https://bmcendocrdisord.biomedcentral.com/counter/pdf/10.1186/s12902-021-00715-8', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-47941/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-47941/v1.pdf?c=1602093061000', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.6}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1499030250', 'https://openalex.org/W1557709535', 'https://openalex.org/W1580261433', 'https://openalex.org/W1838573250', 'https://openalex.org/W1972172317', 'https://openalex.org/W1984955249', 'https://openalex.org/W1987113787', 'https://openalex.org/W1989580745', 'https://openalex.org/W2002529898', 'https://openalex.org/W2026517605', 'https://openalex.org/W2035046404', 'https://openalex.org/W2050620478', 'https://openalex.org/W2068297397', 'https://openalex.org/W2072820535', 'https://openalex.org/W2072874190', 'https://openalex.org/W2077054205', 'https://openalex.org/W2081592691', 'https://openalex.org/W2086476305', 'https://openalex.org/W2089162996', 'https://openalex.org/W2101928531', 'https://openalex.org/W2108897036', 'https://openalex.org/W2126677756', 'https://openalex.org/W2126694870', 'https://openalex.org/W2129106643', 'https://openalex.org/W2147717944', 'https://openalex.org/W2155993910', 'https://openalex.org/W2157445945', 'https://openalex.org/W2170303355', 'https://openalex.org/W2263803297', 'https://openalex.org/W2301290492', 'https://openalex.org/W2426984495', 'https://openalex.org/W2522328809', 'https://openalex.org/W2525024148', 'https://openalex.org/W2761947361', 'https://openalex.org/W2766405024', 'https://openalex.org/W2767543492', 'https://openalex.org/W2808780019', 'https://openalex.org/W590558202'], 'related_works': ['https://openalex.org/W9880915', 'https://openalex.org/W6249462', 'https://openalex.org/W4113043', 'https://openalex.org/W18727715', 'https://openalex.org/W18446069', 'https://openalex.org/W16879547', 'https://openalex.org/W16791313', 'https://openalex.org/W15423165', 'https://openalex.org/W13886662', 'https://openalex.org/W11624785'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'As': [2], 'the': [3, 27, 35, 95, 98, 126, 138], 'incidence': [4], 'of': [5, 29, 56, 75, 118, 129, 137, 162, 176], 'secretory': [6], 'osteoporosis': [7, 12], 'increases,': [8], 'bone': [9, 32, 51], 'loss': [10], 'and': [11, 13, 34, 50, 87, 100, 121, 132, 155, 164, 178, 193], 'their': [14], 'relationships': [15], 'with': [16, 59, 72, 113, 135, 151, 156, 183], 'thyroid-stimulating': [17], 'hormone': [18], '(TSH)': [19], 'have': [20], 'received': [21], 'increased': [22, 125, 152, 157, 167], 'attention.': [23], 'In': [24, 63], 'this': [25], 'study,': [26], 'role': [28], 'TSH': [30, 49, 76, 103, 107, 115, 153, 177, 189], 'in': [31, 168, 187, 195], 'metabolism': [33], 'underlying': [36], 'possible': [37], 'mechanisms': [38], 'were': [39, 70, 91, 110, 166, 180], 'investigated.': [40, 92], 'Methods': [41], 'We': [42], 'analyzed': [43], 'serum': [44, 102, 108], 'triiodothyronine': [45], '(FT3),': [46], 'tetraiodothyronine': [47], '(FT4),': [48], 'mineral': [52], 'density': [53], '(BMD)': [54], 'levels': [55, 90, 128, 161], '114': [57], 'men': [58], 'normal': [60, 184], 'thyroid': [61, 185], 'function.': [62], 'addition,': [64], 'osteoblasts': [65], 'from': [66], 'rat': [67, 196], 'calvarial': [68], 'samples': [69], 'treated': [71], 'different': [73, 78], 'doses': [74], 'for': [77], 'times': [79], 'at': [80, 116], 'each': [81], 'time': [82], 'point.': [83], 'The': [84, 159, 173], 'related': [85], 'gene': [86], 'protein': [88, 160], 'expression': [89], 'Results': [93], 'Comparing': [94], 'BMD': [96, 179], 'between': [97], 'high-level': [99], 'low-level': [101], 'group': [104], 'showed': [105], 'that': [106], 'concentrations': [109, 117, 175], 'positively': [111, 181], 'correlated': [112, 182], 'BMD.': [114], '10': [119], 'mU/mL': [120, 123], '100': [122], 'significantly': [124], 'mRNA': [127], 'ALP,': [130], 'COI1': [131], 'Runx2': [133, 163], 'compared': [134], 'those': [136], 'control': [139], '(P': [140], '&lt;': [141, 144], '0.05,': [142], 'P': [143], '0.01).': [145], 'BMP2': [146], 'activity': [147], 'was': [148], 'enhanced': [149], 'both': [150], 'concentration': [154], 'time.': [158], 'osterix': [165], 'a': [169], 'dose-dependent': [170], 'manner.': [171], 'Conclusions': [172], 'circulating': [174], 'function': [186], 'males.': [188], 'promoted': [190], 'osteoblast': [191], 'proliferation': [192], 'differentiation': [194], 'primary': [197], 'osteoblasts.': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4246139191', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2025-01-20T05:54:34.875076', 'created_date': '2022-05-12'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
