Publication Information

{'id': 'https://openalex.org/W4246132346', 'doi': 'https://doi.org/10.1016/j.vaccine.2018.07.076', 'title': 'Immunogenicity and safety of measles-mumps-rubella vaccine at two different potency levels administered to healthy children aged 12–15 months: A phase III, randomized, non-inferiority trial', 'display_name': 'Immunogenicity and safety of measles-mumps-rubella vaccine at two different potency levels administered to healthy children aged 12–15 months: A phase III, randomized, non-inferiority trial', 'publication_year': 2018, 'publication_date': '2018-08-10', 'ids': {'openalex': 'https://openalex.org/W4246132346', 'doi': 'https://doi.org/10.1016/j.vaccine.2018.07.076', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30104117'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.vaccine.2018.07.076', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27359860', 'display_name': 'Vaccine', 'issn_l': '0264-410X', 'issn': ['0264-410X', '1873-2518'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.vaccine.2018.07.076', 'any_repository_has_fulltext': True}, 'authorships': [], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3500, 'currency': 'USD', 'value_usd': 3500, 'provenance': 'doaj'}, 'apc_paid': {'value': 3500, 'currency': 'USD', 'value_usd': 3500, 'provenance': 'doaj'}, 'fwci': 1.083, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.784851, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '36', 'issue': '38', 'first_page': '5781', 'last_page': '5788'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11135', 'display_name': 'Virology and Viral Diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11135', 'display_name': 'Virology and Viral Diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10833', 'display_name': 'Vaccine Coverage and Hesitancy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/3306', 'display_name': 'Health'}, 'field': {'id': 'https://openalex.org/fields/33', 'display_name': 'Social Sciences'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, {'id': 'https://openalex.org/T11243', 'display_name': 'Respiratory viral infections research', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mmr-vaccine', 'display_name': 'MMR vaccine', 'score': 0.89353114}, {'id': 'https://openalex.org/keywords/measles-mumps-rubella-vaccine', 'display_name': 'Measles-Mumps-Rubella Vaccine', 'score': 0.7998502}], 'concepts': [{'id': 'https://openalex.org/C2776646718', 'wikidata': 'https://www.wikidata.org/wiki/Q908104', 'display_name': 'MMR vaccine', 'level': 5, 'score': 0.89353114}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8588967}, {'id': 'https://openalex.org/C2909545207', 'wikidata': 'https://www.wikidata.org/wiki/Q908104', 'display_name': 'Measles-Mumps-Rubella Vaccine', 'level': 5, 'score': 0.7998502}, {'id': 'https://openalex.org/C2780868878', 'wikidata': 'https://www.wikidata.org/wiki/Q1660197', 'display_name': 'Immunogenicity', 'level': 3, 'score': 0.7322842}, {'id': 'https://openalex.org/C2776438120', 'wikidata': 'https://www.wikidata.org/wiki/Q79793', 'display_name': 'Measles', 'level': 3, 'score': 0.7177918}, {'id': 'https://openalex.org/C2778814567', 'wikidata': 'https://www.wikidata.org/wiki/Q155857', 'display_name': 'Rubella', 'level': 4, 'score': 0.70074445}, {'id': 'https://openalex.org/C57992300', 'wikidata': 'https://www.wikidata.org/wiki/Q2066956', 'display_name': 'Potency', 'level': 3, 'score': 0.48777157}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4764374}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.40824106}, {'id': 'https://openalex.org/C22070199', 'wikidata': 'https://www.wikidata.org/wiki/Q192995', 'display_name': 'Vaccination', 'level': 2, 'score': 0.3576922}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.33268633}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000071497', 'descriptor_name': 'Immunogenicity, Vaccine', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008459', 'descriptor_name': 'Measles virus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D022542', 'descriptor_name': 'Measles-Mumps-Rubella Vaccine', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D009109', 'descriptor_name': 'Mumps virus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D012412', 'descriptor_name': 'Rubella virus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D064166', 'descriptor_name': 'Vaccine Potency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004797', 'descriptor_name': 'Enzyme-Linked Immunosorbent Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007117', 'descriptor_name': 'Immunization, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071497', 'descriptor_name': 'Immunogenicity, Vaccine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007223', 'descriptor_name': 'Infant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008457', 'descriptor_name': 'Measles', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D008457', 'descriptor_name': 'Measles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008459', 'descriptor_name': 'Measles virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022542', 'descriptor_name': 'Measles-Mumps-Rubella Vaccine', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D022542', 'descriptor_name': 'Measles-Mumps-Rubella Vaccine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009107', 'descriptor_name': 'Mumps', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D009107', 'descriptor_name': 'Mumps', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009109', 'descriptor_name': 'Mumps virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012409', 'descriptor_name': 'Rubella', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D012409', 'descriptor_name': 'Rubella', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012412', 'descriptor_name': 'Rubella virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014613', 'descriptor_name': 'Vaccines, Attenuated', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D014613', 'descriptor_name': 'Vaccines, Attenuated', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014613', 'descriptor_name': 'Vaccines, Attenuated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017778', 'descriptor_name': 'Vaccines, Combined', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D017778', 'descriptor_name': 'Vaccines, Combined', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017778', 'descriptor_name': 'Vaccines, Combined', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.vaccine.2018.07.076', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27359860', 'display_name': 'Vaccine', 'issn_l': '0264-410X', 'issn': ['0264-410X', '1873-2518'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://trepo.tuni.fi/handle/10024/104484', 'pdf_url': 'https://trepo.tuni.fi/bitstream/10024/104484/1/Immunogenicity_and_safety_of_2018.pdf', 'source': {'id': 'https://openalex.org/S4306401860', 'display_name': 'Tampere University Institutional Repository (Tampere University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I150589677', 'host_organization_name': 'Tampere University of Applied Sciences', 'host_organization_lineage': ['https://openalex.org/I150589677'], 'host_organization_lineage_names': ['Tampere University of Applied Sciences'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30104117', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.vaccine.2018.07.076', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27359860', 'display_name': 'Vaccine', 'issn_l': '0264-410X', 'issn': ['0264-410X', '1873-2518'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.79, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1963498445', 'https://openalex.org/W2012430242', 'https://openalex.org/W2047934143', 'https://openalex.org/W2069509950', 'https://openalex.org/W2078545989', 'https://openalex.org/W2084324948', 'https://openalex.org/W2096913021', 'https://openalex.org/W2097197935', 'https://openalex.org/W2099023464', 'https://openalex.org/W2101268179', 'https://openalex.org/W2107790667', 'https://openalex.org/W2111341289', 'https://openalex.org/W21672902', 'https://openalex.org/W2298630271', 'https://openalex.org/W2328460585', 'https://openalex.org/W2473870092', 'https://openalex.org/W2612559477', 'https://openalex.org/W2739313217', 'https://openalex.org/W2745745220', 'https://openalex.org/W2751209349', 'https://openalex.org/W2752102979', 'https://openalex.org/W2916550790'], 'related_works': ['https://openalex.org/W3140802292', 'https://openalex.org/W3126271444', 'https://openalex.org/W3031928778', 'https://openalex.org/W3031764876', 'https://openalex.org/W2391209698', 'https://openalex.org/W2370227630', 'https://openalex.org/W2365302381', 'https://openalex.org/W2355561777', 'https://openalex.org/W216826928', 'https://openalex.org/W1980128823'], 'abstract_inverted_index': {'The': [0, 96, 172], 'potency': [1, 59, 71, 234], 'of': [2, 15, 27, 54, 201, 229, 259, 273], 'live': [3], 'viral': [4], 'vaccines': [5, 221], 'decreases': [6], 'over': [7], 'time.': [8], 'We': [9], 'compared': [10, 241], 'the': [11, 28, 57, 68, 94, 146, 163, 183, 189, 198, 270, 278, 286], 'immunogenicity': [12, 108], 'and': [13, 114, 121, 126, 216, 218, 225, 288], 'safety': [14, 212, 226], 'GSK': [16], 'measles-mumps-rubella': [17], 'vaccine': [18, 139, 165], '(MMR-RIT)': [19], 'formulations': [20], 'at': [21, 56, 67], 'two': [22], 'different': [23], 'potencies': [24], 'with': [25, 232], 'that': [26, 167], 'commercially-available': [29], 'MMR': [30, 79, 87, 106, 143, 219, 244, 289], 'II': [31, 80, 107, 220, 245, 290], 'formulation.In': [32], 'this': [33, 62, 74], 'phase': [34], 'III': [35], 'observer-blind': [36], 'clinical': [37, 275], 'study': [38, 63, 75, 97], '(NCT01681992),': [39], '4516': [40], 'healthy': [41], 'children': [42], 'aged': [43], '12-15': [44], 'months': [45], 'were': [46, 117, 151, 205, 214, 283], 'randomized': [47], '(1:1:1': [48], 'ratio)': [49], 'to': [50, 102, 137, 242], 'receive': [51], 'one': [52], 'dose': [53, 84, 228], 'MMR-RIT': [55, 66, 104, 217, 230, 287], 'minimum': [58], 'used': [60, 72], 'for': [61, 73, 149, 186], '(MMR-RIT-Min)': [64], 'or': [65, 77, 86], 'second': [69, 83, 279], 'lowest': [70], '(MMR-RIT-Med),': [76], 'control': [78], 'vaccine.': [81], 'A': [82], '(MMR-RIT': [85], 'II)': [88], 'was': [89, 196, 254, 272], 'administered': [90], '42': [91], 'days': [92], 'after': [93, 141], 'first.': [95], 'had': [98, 222], '10': [99], 'co-primary': [100], 'objectives': [101, 148], 'evaluate': [103], 'versus': [105], 'via': [109], 'a': [110, 237], 'hierarchical': [111], 'procedure.': [112], 'Anti-measles': [113], 'anti-rubella': [115], 'antibodies': [116, 123], 'measured': [118, 159, 179, 247, 265], 'by': [119, 124, 160, 180, 248, 266], 'ELISA': [120, 125, 161, 249], 'anti-mumps': [122], 'unenhanced': [127, 267], 'plaque': [128], 'reduction': [129], 'neutralization': [130], 'test': [131], '(PRNT).Each': [132], 'formulation': [133, 231], 'induced': [134, 155, 236], 'immune': [135, 156, 173, 239, 260, 281], 'responses': [136, 157, 204, 282], 'all': [138], 'antigens': [140, 166], 'each': [142], 'dose.': [144], 'While': [145], 'primary': [147], 'MMR-RIT-Min': [150], 'not': [152, 255], 'met,': [153], 'MMR-RIT-Med': [154, 176], 'as': [158], 'against': [162, 177, 262], 'three': [164], 'met': [168], 'pre-specified': [169], 'non-inferiority': [170, 184], 'criteria.': [171], 'response': [174, 240, 261], 'following': [175], 'mumps': [178, 263], 'PRNT': [181], 'failed': [182], 'criterion': [185], 'seroresponse': [187], 'rate:': [188], '97.5%': [190], 'confidence': [191], 'interval': [192], 'lower': [193, 233], 'limit': [194, 200], '(-10.94%)': [195], 'beyond': [197], 'pre-defined': [199], '-10%.': [202], 'Immune': [203], 'comparable': [206, 284], 'among': [207, 285], 'groups': [208], 'post-dose': [209], '2.': [210], 'No': [211], 'concerns': [213], 'identified,': [215], 'similar': [223], 'reactogenicity': [224], 'profiles.One': [227], '(MMR-RIT-Med)': [235], 'non-inferior': [238], 'commercial': [243], 'vaccine,': [246], 'in': [250, 257], 'one-year-old': [251], 'children.': [252], 'Non-inferiority': [253], 'demonstrated': [256], 'terms': [258], 'virus': [264], 'PRNT,': [268], 'although': [269], 'difference': [271], 'uncertain': [274], 'relevance.': [276], 'After': [277], 'dose,': [280], 'groups.': [291]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4246132346', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}], 'updated_date': '2025-01-05T20:43:28.301950', 'created_date': '2022-05-12'}