Abstract: The aim of this research was to describe and to correlate knowledge, attitude and practice (KAP) of thepoultry breeders in preventing Avian Influenza (AI). This research used face-to-face interview, cross sectionaldesign study with a questionnaire for 100 respondentsand data were analyzed with Rho Spearman. The resultshowed that 82% of respondents washed their hands with soap after handling poultry but only 5% ofrespondents used mask when contacting with poultry. Chickens were kept by respondents most. The cagelocation near to the house accounted for 71%, most of respondents cleaned the cage routinely but there were11% of respondents who did not keep their poultry into the cage. All respondents revealed that the poultrywere not vaccinated periodically. It was about 37.3% of respondents burned dead poultry, and 55.2% and 22.4% buried and throw away to the river respectively. They disagreed with stamping out accounted for 48% andonly 16% of respondents agreed to sell their unhealthy poultry. No respondents informed to the authority ofsub-village when suddent death of the chickens was found. Respondent’s knowledge, attitude and practicewere suffient in preventing Avian Influenza and there was significant correlation between knowledge, attitudeand practice (P<0,05).