Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4244346637', 'doi': 'https://doi.org/10.1002/1097-0215(20001101)88:3<342::aid-ijc4>3.3.co;2-9', 'title': 'Acetaldehyde production by non‐pathogenic Neisseria in human oral microflora: Implications for carcinogenesis in upper aerodigestive tract', 'display_name': 'Acetaldehyde production by non‐pathogenic Neisseria in human oral microflora: Implications for carcinogenesis in upper aerodigestive tract', 'publication_year': 2000, 'publication_date': '2000-11-01', 'ids': {'openalex': 'https://openalex.org/W4244346637', 'doi': 'https://doi.org/10.1002/1097-0215(20001101)88:3<342::aid-ijc4>3.3.co;2-9'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/1097-0215(20001101)88:3<342::aid-ijc4>3.3.co;2-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5382288', 'display_name': 'International Journal of Cancer', 'issn_l': '0020-7136', 'issn': ['0020-7136', '1097-0215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022854492', 'display_name': 'Manabu Muto', 'orcid': 'https://orcid.org/0000-0002-3127-8203'}, 'institutions': [{'id': 'https://openalex.org/I4210145079', 'display_name': 'National Cancer Center Hospital East', 'ror': 'https://ror.org/03rm3gk43', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145079']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Manabu Muto', 'raw_affiliation_strings': ['Department of Gastrointestinal Oncology and Gastroenterology, National Cancer Center Hospital East, Kashiwa, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastrointestinal Oncology and Gastroenterology, National Cancer Center Hospital East, Kashiwa, Japan', 'institution_ids': ['https://openalex.org/I4210145079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077100536', 'display_name': 'Yoshiaki Hitomi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145079', 'display_name': 'National Cancer Center Hospital East', 'ror': 'https://ror.org/03rm3gk43', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145079']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yoshiaki Hitomi', 'raw_affiliation_strings': ['Investigative Treatment Division, National Cancer Center Research Institute East, Kashiwa, Japan'], 'affiliations': [{'raw_affiliation_string': 'Investigative Treatment Division, National Cancer Center Research Institute East, Kashiwa, Japan', 'institution_ids': ['https://openalex.org/I4210145079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024904484', 'display_name': 'Atsushi Ohtsu', 'orcid': 'https://orcid.org/0000-0003-1329-0628'}, 'institutions': [{'id': 'https://openalex.org/I4210145079', 'display_name': 'National Cancer Center Hospital East', 'ror': 'https://ror.org/03rm3gk43', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145079']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Atsushi Ohtsu', 'raw_affiliation_strings': ['Department of Gastrointestinal Oncology and Gastroenterology, National Cancer Center Hospital East, Kashiwa, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastrointestinal Oncology and Gastroenterology, National Cancer Center Hospital East, Kashiwa, Japan', 'institution_ids': ['https://openalex.org/I4210145079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038815138', 'display_name': 'Hiroyuki Shimada', 'orcid': 'https://orcid.org/0000-0001-8111-6440'}, 'institutions': [{'id': 'https://openalex.org/I4210145079', 'display_name': 'National Cancer Center Hospital East', 'ror': 'https://ror.org/03rm3gk43', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145079']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Hiroyuki Shimada', 'raw_affiliation_strings': ['Clinical Laboratory, National Cancer Center Hospital East, Kashiwa, Japan'], 'affiliations': [{'raw_affiliation_string': 'Clinical Laboratory, National Cancer Center Hospital East, Kashiwa, Japan', 'institution_ids': ['https://openalex.org/I4210145079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081230135', 'display_name': 'Yukiko Kashiwase', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139656', 'display_name': 'SRL (Japan)', 'ror': 'https://ror.org/04gcg0n58', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210139656']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yukiko Kashiwase', 'raw_affiliation_strings': ['Department of Biochemistry, SRL Inc., Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, SRL Inc., Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210139656']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103449013', 'display_name': 'Hiroki Sasaki', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Hiroki Sasaki', 'raw_affiliation_strings': ['Genetics Division, National Cancer Center Research Institute, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Genetics Division, National Cancer Center Research Institute, Tokyo, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040419736', 'display_name': 'S. Yoshida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145079', 'display_name': 'National Cancer Center Hospital East', 'ror': 'https://ror.org/03rm3gk43', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145079']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Sigeaki Yoshida', 'raw_affiliation_strings': ['Department of Gastrointestinal Oncology and Gastroenterology, National Cancer Center Hospital East, Kashiwa, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastrointestinal Oncology and Gastroenterology, National Cancer Center Hospital East, Kashiwa, Japan', 'institution_ids': ['https://openalex.org/I4210145079']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028717780', 'display_name': 'Hiroyasu Esumi', 'orcid': 'https://orcid.org/0000-0001-9522-2957'}, 'institutions': [{'id': 'https://openalex.org/I4210145079', 'display_name': 'National Cancer Center Hospital East', 'ror': 'https://ror.org/03rm3gk43', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145079']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Hiroyasu Esumi', 'raw_affiliation_strings': ['Investigative Treatment Division, National Cancer Center Research Institute East, Kashiwa, Japan'], 'affiliations': [{'raw_affiliation_string': 'Investigative Treatment Division, National Cancer Center Research Institute East, Kashiwa, Japan', 'institution_ids': ['https://openalex.org/I4210145079']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5022854492', 'https://openalex.org/A5077100536', 'https://openalex.org/A5024904484', 'https://openalex.org/A5038815138', 'https://openalex.org/A5081230135', 'https://openalex.org/A5103449013', 'https://openalex.org/A5040419736', 'https://openalex.org/A5028717780'], 'corresponding_institution_ids': ['https://openalex.org/I4210145079', 'https://openalex.org/I4210145079', 'https://openalex.org/I4210145079', 'https://openalex.org/I4210145079', 'https://openalex.org/I4210139656', 'https://openalex.org/I4210145079', 'https://openalex.org/I4210145079'], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.196, 'has_fulltext': False, 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.566831, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 80}, 'biblio': {'volume': '88', 'issue': '3', 'first_page': '342', 'last_page': '350'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11521', 'display_name': "Diagnosis and Management of Sjögren's Syndrome", 'score': 0.9836, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11521', 'display_name': "Diagnosis and Management of Sjögren's Syndrome", 'score': 0.9836, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10307', 'display_name': 'Epidemiology and Treatment of Head and Neck Cancer', 'score': 0.9835, 'subfield': {'id': 'https://openalex.org/subfields/2733', 'display_name': 'Otorhinolaryngology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11207', 'display_name': 'Pathogenesis and Treatment of Alcoholic Liver Disease', 'score': 0.9739, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neisseria', 'display_name': 'Neisseria', 'score': 0.5188552}, {'id': 'https://openalex.org/keywords/metabolism', 'display_name': 'Metabolism', 'score': 0.455691}], 'concepts': [{'id': 'https://openalex.org/C2777595113', 'wikidata': 'https://www.wikidata.org/wiki/Q61457', 'display_name': 'Acetaldehyde', 'level': 3, 'score': 0.9429344}, {'id': 'https://openalex.org/C114246631', 'wikidata': 'https://www.wikidata.org/wiki/Q187661', 'display_name': 'Carcinogen', 'level': 2, 'score': 0.7868682}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.67104715}, {'id': 'https://openalex.org/C2777344606', 'wikidata': 'https://www.wikidata.org/wiki/Q410754', 'display_name': 'Alcohol dehydrogenase', 'level': 3, 'score': 0.6641275}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5466781}, {'id': 'https://openalex.org/C2777954195', 'wikidata': 'https://www.wikidata.org/wiki/Q132209', 'display_name': 'Neisseria', 'level': 3, 'score': 0.5188552}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.5159624}, {'id': 'https://openalex.org/C2780161600', 'wikidata': 'https://www.wikidata.org/wiki/Q153', 'display_name': 'Ethanol', 'level': 2, 'score': 0.47018898}, {'id': 'https://openalex.org/C2781066024', 'wikidata': 'https://www.wikidata.org/wiki/Q156', 'display_name': 'Alcohol', 'level': 2, 'score': 0.46727788}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.4396597}, {'id': 'https://openalex.org/C193230392', 'wikidata': 'https://www.wikidata.org/wiki/Q1663054', 'display_name': 'Ingestion', 'level': 2, 'score': 0.4346764}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.42793733}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3756112}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22718576}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.113550305}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/1097-0215(20001101)88:3<342::aid-ijc4>3.3.co;2-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5382288', 'display_name': 'International Journal of Cancer', 'issn_l': '0020-7136', 'issn': ['0020-7136', '1097-0215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.83, 'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2992512058', 'https://openalex.org/W26328854', 'https://openalex.org/W2401829271', 'https://openalex.org/W2129004583', 'https://openalex.org/W2083207745', 'https://openalex.org/W2005293706', 'https://openalex.org/W2004016943', 'https://openalex.org/W1982023842', 'https://openalex.org/W1963888894', 'https://openalex.org/W156950731'], 'abstract_inverted_index': {'International': [0], 'Journal': [1], 'of': [2, 35, 47, 95, 135, 169, 215, 227, 275, 315, 349, 413, 423, 436, 447, 478, 505, 522, 529, 562, 598, 607, 630, 668, 709, 722, 728, 742, 752, 808, 815, 863, 869, 872, 920, 929, 959, 963, 1000, 1007, 1042, 1093, 1125, 1156, 1165, 1177, 1182, 1200, 1288, 1325, 1343, 1353, 1358, 1364, 1444, 1458, 1472, 1485, 1491, 1515, 1522, 1533, 1536, 1599, 1602, 1634, 1650, 1653, 1727, 1732, 1745, 1769, 1839, 1938, 1944, 1960, 1988, 2015, 2164, 2167, 2185, 2191, 2198, 2203, 2214, 2228, 2240, 2275, 2297, 2311, 2319, 2329, 2345, 2364, 2374, 2384, 2393, 2409, 2421, 2428, 2487, 2492, 2562, 2569, 2579, 2699, 2709, 2722, 2739, 2760, 2883, 2894, 2905, 2992, 2999, 3003, 3011, 3021, 3051, 3059, 3094, 3113, 3146, 3154, 3160, 3218, 3220, 3250, 3272, 3282, 3287, 3300, 3334, 3353, 3399, 3414, 3422, 3445, 3453, 3458, 3471, 3478, 3512, 3530, 3535, 3566, 3580, 3648, 3666, 3709, 3734, 3784, 3790, 3796, 3815, 3818, 3834, 3854, 3860, 3870, 3877, 3888, 3900, 3918, 3945, 3954, 3961, 3965, 3987, 3992, 4023, 4065, 4083, 4091, 4114, 4158, 4176, 4182, 4199, 4211, 4266, 4341, 4384, 4394, 4449, 4484, 4527, 4578, 4601, 4672, 4681, 4701, 4733, 4737, 4764, 4777, 4793, 4865, 4904, 4945, 5025, 5032, 5057, 5090, 5094, 5111, 5129, 5228, 5308, 5334, 5342, 5374, 5403, 5407, 5454, 5464, 5514, 5592, 5663, 5694], 'CancerVolume': [3], '88,': [4], 'Issue': [5], '3': [6, 1415, 2158, 2886, 3219, 3477, 3579, 4941], 'p.': [7], '342-350': [8, 5717], 'CarcinogenesisFree': [9], 'Access': [10], 'Acetaldehyde': [11, 1338, 2581, 2654, 2697, 2752], 'production': [12, 504, 871, 923, 1006, 1179, 1339, 1342, 1465, 1905, 1927, 2582, 2655, 2698, 2729, 2745, 2753, 3817, 3917, 3970, 4265, 4280, 5152, 5190], 'by': [13, 68, 88, 110, 128, 144, 162, 184, 204, 248, 268, 290, 308, 324, 342, 364, 384, 493, 585, 677, 735, 855, 1047, 1122, 1162, 1194, 1223, 1330, 1349, 1818, 1833, 1906, 1935, 2172, 2306, 2633, 2656, 2688, 2754, 2911, 2921, 2959, 3169, 3678, 3702, 3714, 4026, 4130, 4281, 4402, 4796, 4804, 4868, 4876, 5153, 5191, 5338], 'non-pathogenic': [14, 4358], 'Neisseria': [15, 552, 610, 1094, 1858, 1969, 1989, 2242, 2400, 2493, 2584, 2612, 2657, 2898, 2960, 2974, 3052, 3063, 3147, 3277, 3301, 3322, 3335, 3385, 3400, 3428, 3472, 3567, 3587, 3624, 3649, 3928, 3955, 3980, 4027, 4051, 4131, 4200, 4212, 4230, 4466, 4516], 'in': [16, 23, 484, 524, 531, 570, 603, 612, 640, 643, 675, 785, 796, 798, 818, 832, 852, 874, 877, 887, 894, 1004, 1137, 1212, 1227, 1229, 1249, 1380, 1392, 1446, 1497, 1539, 1551, 1588, 1751, 1806, 1810, 1823, 1917, 1971, 1996, 2010, 2024, 2262, 2590, 2609, 2620, 2627, 2644, 2648, 2694, 2937, 2983, 3015, 3042, 3103, 3109, 3118, 3179, 3193, 3226, 3257, 3285, 3305, 3339, 3348, 3389, 3404, 3425, 3476, 3517, 3578, 3615, 3650, 3685, 3704, 3731, 3777, 3820, 3823, 3843, 3890, 3902, 3920, 3930, 3977, 3982, 4005, 4036, 4052, 4085, 4179, 4201, 4213, 4234, 4298, 4307, 4424, 4445, 4459, 4467, 4517, 4530, 4540, 4569, 4648, 4741, 4761, 4823, 4970, 4973, 4996, 5199, 5224, 5278, 5412, 5456, 5461, 5466, 5479, 5483, 5519, 5546, 5628, 5665, 5701], 'human': [17, 533, 548, 644, 676, 888, 950, 986, 1016, 1029, 1540, 1733, 1811, 2180, 3180, 3355, 3518, 3693, 3844, 4351, 4971, 5064], 'oral': [18, 535, 549, 600, 614, 930, 951, 987, 1001, 1017, 1030, 1541, 1734, 1752, 1812, 1856, 1973, 1999, 2181, 2985, 3181, 3194, 3252, 3356, 3426, 3459, 3519, 3537, 3652, 3933, 4054, 4143, 4177, 4203, 4215, 4286, 4316, 4352, 4386, 4396, 4437, 4468, 4500, 4519, 4651, 4683, 4739, 4946, 5158, 5276, 5310, 5457], 'microflora:': [19, 3228], 'Implications': [20], 'for': [21, 65, 85, 107, 125, 141, 159, 181, 201, 245, 265, 287, 305, 321, 339, 361, 381, 476, 518, 666, 1259, 1276, 1283, 1321, 1405, 1772, 1951, 1956, 2288, 2293, 2299, 2321, 2397, 2405, 2927, 3075, 3671, 3774, 3851, 3896, 3915, 4040, 4046, 4060, 4073, 4252, 4312, 4482, 4555, 4567, 4581, 4590], 'carcinogenesis': [22, 642, 876, 3684, 3776, 3822, 4426], 'upper': [24, 480, 5034, 5583], 'aerodigestive': [25, 481, 5584], 'tract': [26, 482, 4821, 5036, 5585], 'Manabu': [27, 31, 207, 211], 'Muto,': [28, 208], 'Corresponding': [29, 209], 'Author': [30, 210], 'Muto': [32, 212], '[email protected]': [33, 213], 'Department': [34, 94, 134, 168, 214, 274, 314, 348], 'Gastrointestinal': [36, 48, 96, 170, 216, 228, 276, 350], 'Oncology': [37, 49, 97, 171, 217, 229, 277, 351], 'and': [38, 50, 98, 172, 218, 230, 278, 352, 411, 415, 427, 434, 453, 558, 633, 672, 725, 789, 801, 812, 826, 829, 858, 891, 977, 1038, 1050, 1072, 1101, 1113, 1148, 1188, 1245, 1279, 1314, 1376, 1433, 1460, 1530, 1583, 1591, 1605, 1639, 1659, 1669, 1718, 1780, 1785, 1870, 1932, 2251, 2266, 2272, 2290, 2301, 2314, 2342, 2361, 2389, 2412, 2624, 2966, 3026, 3097, 3203, 3231, 3241, 3265, 3366, 3409, 3416, 3550, 3557, 3707, 3717, 3726, 3762, 3798, 4067, 4145, 4195, 4259, 4318, 4332, 4359, 4412, 4502, 4552, 4558, 4584, 4587, 4603, 4615, 4641, 4646, 4652, 4667, 4675, 4685, 4696, 4704, 4707, 4713, 4728, 4756, 4798, 4817, 4854, 4861, 4870, 4906, 4936, 4943, 4948, 4961, 4990, 5003, 5021, 5030, 5052, 5059, 5063, 5082, 5147, 5182, 5219, 5245, 5270, 5275, 5282, 5299, 5306, 5312, 5330, 5368, 5399, 5406, 5430, 5434, 5449, 5458, 5463, 5482, 5505, 5517, 5537, 5542, 5575, 5581, 5587, 5620, 5625, 5658, 5697], 'Gastroenterology,': [39, 51, 99, 173, 219, 231, 279, 353, 4767, 5522], 'National': [40, 52, 77, 100, 118, 152, 174, 193, 220, 232, 257, 280, 298, 332, 354, 373], 'Cancer': [41, 53, 78, 101, 119, 153, 175, 194, 221, 233, 258, 281, 299, 333, 355, 374, 648, 4617, 4655, 4743, 4838, 4953, 5040, 5549], 'Center': [42, 54, 79, 102, 120, 154, 176, 195, 222, 234, 259, 282, 300, 334, 356, 375], 'Hospital': [43, 55, 103, 121, 177, 223, 235, 283, 301, 357], 'East,': [44, 56, 82, 104, 122, 178, 198, 224, 236, 262, 284, 302, 358, 378], 'Kashiwa,': [45, 83, 105, 123, 179, 199, 225, 263, 285, 303, 359, 379], 'JapanDepartment': [46, 226], '6-5-1': [57, 237], 'Kashiwanoha,': [58, 238], 'Kashiwa': [59, 239], '277-8577,': [60, 240], 'Chiba,': [61, 241], 'Japan.': [62, 242], 'Fax:': [63, 243], '+81-471-31-4724Search': [64, 244], 'more': [66, 86, 108, 126, 142, 160, 182, 202, 246, 266, 288, 306, 322, 340, 362, 382, 578, 1679, 1861, 1897, 2681, 3076, 3279, 3430, 4125], 'papers': [67, 87, 109, 127, 143, 161, 183, 203, 247, 267, 289, 307, 323, 341, 363, 383], 'this': [69, 89, 111, 129, 145, 163, 185, 205, 249, 269, 291, 309, 325, 343, 365, 385, 448, 623, 1691, 2919, 3185, 3390, 3484, 3778, 4504], 'authorYoshiaki': [70, 250], 'Hitomi,': [71, 251], 'Yoshiaki': [72, 252], 'Hitomi': [73, 253], 'Investigative': [74, 190, 254, 370], 'Treatment': [75, 191, 255, 371], 'Division,': [76, 151, 192, 256, 331, 372], 'Research': [80, 155, 196, 260, 335, 376], 'Institute': [81, 197, 261, 377], 'JapanSearch': [84, 106, 124, 140, 158, 180, 200, 264, 286, 304, 320, 338, 360, 380], 'authorAtsushi': [90, 270], 'Ohtsu,': [91, 271], 'Atsushi': [92, 272], 'Ohtsu': [93, 273], 'authorHiroyuki': [112, 292], 'Shimada,': [113, 293], 'Hiroyuki': [114, 294], 'Shimada': [115, 295], 'Clinical': [116, 296], 'Laboratory,': [117, 297], 'authorYukiko': [130, 310], 'Kashiwase,': [131, 311], 'Yukiko': [132, 312], 'Kashiwase': [133, 313], 'Biochemistry,': [136, 316], 'SRL': [137, 317], 'Inc.,': [138, 318], 'Tokyo,': [139, 157, 319, 337], 'authorHiroki': [146, 326], 'Sasaki,': [147, 327], 'Hiroki': [148, 328], 'Sasaki': [149, 329, 4566], 'Genetics': [150, 330], 'Institute,': [156, 336], 'authorSigeaki': [164, 344], 'Yoshida,': [165, 345], 'Sigeaki': [166, 346], 'Yoshida': [167, 347, 4586], 'authorHiroyasu': [186, 366], 'Esumi,': [187, 367], 'Hiroyasu': [188, 368], 'Esumi': [189, 369], 'author': [206, 386], 'First': [387], 'published:': [388], '17': [389], 'October': [390], '2000': [391, 652], 'https://doi.org/10.1002/1097-0215(20001101)88:3<342::AID-IJC4>3.0.CO;2-ICitations:': [392], '109AboutSectionsPDF': [393], 'ToolsRequest': [394], 'permissionExport': [395], 'citationAdd': [396], 'to': [397, 419, 442, 574, 770, 850, 927, 967, 979, 1084, 1519, 1690, 1884, 2004, 2223, 2309, 2668, 2725, 2914, 2963, 2978, 3105, 3263, 3525, 3543, 3571, 3573, 3699, 3737, 3771, 3973, 3984, 4002, 4031, 4127, 4361, 4419, 4443, 4447, 4493, 4507, 4532, 4563, 4650, 4710, 4826, 4832, 5096, 5115, 5133, 5336, 5410], 'favoritesTrack': [398], 'citation': [399], 'ShareShare': [400], 'Give': [401], 'accessShare': [402, 405], 'full': [403], 'text': [404], 'full-text': [406, 421, 445], 'accessPlease': [407], 'review': [408], 'our': [409, 514, 964, 3561, 3923, 4186, 4365, 4512], 'Terms': [410, 433], 'Conditions': [412, 435, 1404], 'Use': [414], 'check': [416], 'box': [417], 'below': [418, 441], 'share': [420, 443], 'version': [422, 446], 'article.I': [424], 'have': [425, 466, 717, 745, 974, 1975, 2902, 3687, 4078, 4416], 'read': [426], 'accept': [428], 'the': [429, 439, 479, 488, 509, 519, 527, 532, 542, 547, 595, 599, 669, 673, 707, 712, 720, 726, 740, 749, 793, 816, 853, 866, 878, 922, 969, 985, 993, 997, 1028, 1067, 1085, 1157, 1163, 1225, 1264, 1289, 1292, 1326, 1332, 1335, 1354, 1393, 1469, 1611, 1626, 1635, 1645, 1743, 1789, 1807, 1824, 1850, 1855, 1903, 1913, 1918, 1957, 1972, 1985, 1997, 2211, 2225, 2241, 2291, 2327, 2349, 2394, 2398, 2498, 2598, 2610, 2615, 2628, 2645, 2710, 2743, 2956, 2976, 2984, 2996, 3008, 3012, 3016, 3057, 3085, 3092, 3161, 3189, 3221, 3251, 3258, 3273, 3297, 3306, 3327, 3354, 3380, 3469, 3527, 3533, 3536, 3563, 3651, 3667, 3675, 3692, 3705, 3710, 3765, 3775, 3787, 3831, 3845, 3848, 3857, 3861, 3871, 3874, 3885, 3897, 3916, 3931, 3943, 3948, 3951, 3978, 3997, 4021, 4033, 4047, 4053, 4081, 4089, 4122, 4156, 4180, 4202, 4209, 4214, 4237, 4263, 4276, 4310, 4313, 4339, 4362, 4367, 4381, 4385, 4392, 4395, 4436, 4440, 4478, 4485, 4499, 4518, 4575, 4682, 4738, 4762, 4967, 5033, 5088, 5091, 5109, 5112, 5127, 5130, 5195, 5251, 5309, 5588], 'Wiley': [430], 'Online': [431], 'Library': [432], 'UseShareable': [437], 'LinkUse': [438], 'link': [440, 3736], 'a': [444, 459, 472, 500, 627, 662, 757, 957, 1207, 1269, 1381, 1447, 1476, 1480, 1574, 1754, 1797, 1941, 2378, 2591, 2649, 3065, 3100, 3323, 3396, 3405, 3616, 3636, 3655, 3759, 4041, 4058, 4061, 4071, 4173, 4231, 4523, 4537, 5375], 'article': [449], 'with': [450, 566, 1268, 1296, 1361, 1526, 1632, 1829, 2326, 2337, 2358, 2371, 2484, 2576, 2588, 2638, 2717, 2757, 3056, 3068, 3464, 3547, 3868, 4149, 4155, 4220, 4255, 4275, 4285, 4322, 5157, 5250, 5280], 'your': [451], 'friends': [452], 'colleagues.': [454], 'Learn': [455], 'more.Copy': [456], 'URL': [457], 'Share': [458], 'linkShare': [460], 'onFacebookTwitterLinkedInRedditWechat': [461], 'Abstract': [462], 'Many': [463], 'epidemiological': [464, 679], 'studies': [465, 680, 716, 4077], 'identified': [467, 545, 955, 1608, 1624, 3236, 3663], 'chronic': [468, 3680, 4150], 'alcohol': [469, 494, 592, 656, 710, 737, 1667, 1746, 3088, 3681, 4151, 4323, 4335, 4374, 4676, 4703, 4711, 4797, 4869, 5187, 5304, 5416, 5455, 5510], 'consumption': [470, 657, 738, 3660, 3682, 4336], 'as': [471, 499, 661, 756, 765, 956, 1033, 1175, 1408, 1451, 1625, 1687, 1867, 2377, 3167, 3654, 3664, 4132, 4134, 4407], 'significant': [473, 560, 663, 3668, 4524], 'risk': [474, 664, 741, 3669, 3789, 4082, 4340, 4480, 4604, 4907, 4944, 5093, 5114, 5132], 'factor': [475, 665, 4481], 'cancer': [477, 667, 744, 3792, 4320, 4483, 4736, 5223, 5307, 5460, 5478, 5541, 5586, 5700], '(UAT)': [483], 'human.': [485], 'Although': [486, 609, 844, 3628], 'acetaldehyde,': [487, 2614, 3735, 3878, 5644], 'first': [489, 750, 3006, 4048], 'metabolite': [490, 751], 'from': [491, 546, 949, 982, 1015, 1027, 1334, 1479, 1560, 1854, 1877, 2002, 2157, 2179, 2348, 2597, 2659, 2941, 2981, 3199, 3342, 3360, 4000, 4268, 4283, 5155], 'ethanol': [492, 569, 846, 983, 994, 1147, 1248, 1375, 1461, 1492, 1728, 1771, 1830, 1931, 1952, 2186, 2589, 2733, 2740, 2761, 2982, 2993, 3022, 3040, 3114, 3454, 3466, 3513, 3531, 3642, 3695, 3855, 3901, 3946, 4999, 5335], 'dehydrogenase': [495, 1112, 1115, 1847, 2891, 4940], '(ADH),': [496], 'is': [497, 616, 754, 847, 1982, 2287, 2961, 3696, 3712, 3758, 4138, 4476, 4491], 'regarded': [498, 755], 'carcinogen,': [501], 'how': [502, 4495], 'systemic': [503, 3732, 3766, 3782, 4135], 'acetaldehyde': [506, 523, 563, 576, 632, 809, 851, 873, 882, 914, 981, 1341, 1390, 1464, 2594, 2625, 2642, 2728, 2744, 2895, 2910, 2957, 2980, 3700, 3711, 3757, 3785, 3819, 3889, 3919, 3962, 3969, 3993, 4024, 4066, 4128, 4267, 4279, 4529, 4591, 4827, 4994, 5026, 5151, 5189, 5337, 5411, 5664], 'particularly': [507], 'affects': [508, 4498], 'UAT': [510, 713, 743, 819, 3672, 3686, 3738, 3791, 3862, 4037, 4086, 4123, 4159, 4183, 4319, 4342, 4425, 4441, 4460, 4486, 4508, 4544], 'remains': [511, 3809, 4470], 'unclear.': [512], 'In': [513, 3270, 3691, 3922, 4185, 4364, 4510, 5185], 'study,': [515, 3924, 4187, 4366], 'we': [516, 538, 589, 1693, 2216, 3005, 3187, 3925, 4188, 4559], 'searched': [517], 'regional': [520, 628, 3832, 4264, 4525], 'source': [521, 629, 958, 3876, 4064, 4526], 'UAT,': [525, 3824], 'especially': [526, 4117], 'involvement': [528, 868, 3814], 'bacteria': [530, 1044, 1445, 1852, 2608, 2706, 2756, 3096, 3223, 3424, 5193], 'normal': [534, 613, 1998, 3227, 3932, 5196], 'microflora.': [536, 988, 3357, 3427, 3460, 3538, 4204, 4387], 'Here': [537], 'demonstrate': [539, 2224], 'that,': [540], 'among': [541, 984, 1814, 3432, 4345, 5314], 'bacterial': [543, 596, 931, 947, 971, 998, 1133, 1158, 1183, 1202, 1345, 1356, 1486, 1517, 1537, 1553, 1730, 1749, 1808, 1825, 2016, 2230, 2276, 2330, 2395, 2700, 3116, 3191, 3260, 3456, 3515, 3910, 4253, 4382], 'species': [544, 948, 1970, 3911], 'cavity,': [550, 1031, 4287, 5159], 'genus': [551, 1627, 1636, 1646, 1655, 2385, 2399, 2611, 3162], 'had': [553, 1912, 2244, 2254, 3935], 'extremely': [554, 3937], 'high': [555, 1977, 2964, 3000, 3034, 3039, 3938], 'ADH': [556, 856, 975, 1118, 1171, 1187, 1219, 1309, 1915, 1946, 1978, 1986, 2013, 2020, 2165, 2189, 2201, 2212, 2226, 2246, 2265, 2271, 2289, 2300, 2313, 2322, 2376, 2382, 2509, 2965, 3001, 3035, 3703, 3826, 3858, 3939, 4257, 4582], 'activity': [557, 976, 1119, 1172, 1196, 1220, 1848, 1916, 1987, 2166, 2190, 2202, 2220, 2268, 2282, 2403, 2499, 2506, 2892, 2924, 2933, 2949, 3002, 3827, 3859, 4258], 'produced': [559, 584, 1859, 2613, 2687, 4025, 4129], 'amounts': [561, 2328, 3960], 'when': [564, 4038], 'cultured': [565, 786, 2619], 'medium': [567, 1524, 2639, 3017], 'containing': [568, 1144, 1232, 1273, 1304, 1372, 2640, 3018], 'vitro.': [571, 4974], 'The': [572, 961, 1040, 1170, 1218, 1340, 1389, 1441, 1456, 1568, 1648, 1792, 1949, 2285, 2295, 2317, 2879, 3048, 3205, 3248, 3451, 4106, 4350, 5452], 'ability': [573, 978, 2977], 'produce': [575, 980, 2979, 3957], 'was': [577, 966, 1045, 1120, 1135, 1160, 1173, 1221, 1294, 1328, 1347, 1385, 1396, 1449, 1475, 1495, 1558, 1570, 1586, 1623, 1630, 1656, 1672, 1757, 1794, 1841, 1928, 1933, 1953, 1990, 2176, 2369, 2595, 2680, 2935, 3046, 3073, 3148, 3164, 3207, 3290, 3302, 3369, 3429, 3612, 3847, 3864, 4292], 'than': [579, 582, 1680, 1863, 1898, 1902, 2682, 2685, 3077, 3280, 3292, 3435, 3963, 4295], '100-fold': [580, 2683], 'higher': [581, 1901, 2684, 3304, 4256, 4294], 'that': [583, 622, 1911, 1968, 1984, 2238, 2686, 2897, 2955, 2973, 3031, 3087, 3159, 3316, 3641, 3724, 3842, 3869, 3884, 3927, 4050, 4080, 4141, 4208, 4225, 4245, 4278, 4296, 4370, 4391, 4435, 4515], 'any': [586, 2257, 2514, 2689, 2938], 'other': [587, 1864, 2690, 3069, 3875, 3966, 4403], 'genera': [588, 1865, 3261], 'studied.': [590, 1740], 'Furthermore,': [591, 1980], 'ingestion': [593, 995, 3089, 3643], 'influences': [594], 'composition': [597, 999, 1538, 1554, 1731, 1750, 1809, 1826, 3178, 3192, 3249, 3352, 3457, 3516, 3534, 4383, 4393], 'microflora,': [601, 1002, 1753, 1857, 3195], 'resulting': [602, 1003], 'an': [604, 637, 2218, 2402, 2505, 2923, 3170, 3610, 3936, 4190, 4196, 4421], 'increased': [605, 3468, 3569, 4197, 4217], 'proportion': [606, 3470, 4198, 4210], 'Neisseria.': [608, 1039, 1628, 3106, 3449], 'present': [611, 3225, 3929], 'microflora': [615, 952, 1018, 1542, 1735, 1813, 1920, 1974, 3182, 3253, 3444, 3520, 3653, 3934, 4055, 4178, 4216, 4353, 4397, 4438, 4469, 4501, 4520, 5405], 'generally': [617, 3224], 'non-pathogenic,': [618], 'these': [619, 913, 1695, 3638, 4450], 'findings': [620, 3522, 4170], 'suggest': [621, 865, 1967, 2972, 4172, 4224, 4390], 'microbe': [624], 'can': [625, 3956], 'be': [626, 928, 3337, 3402, 3772, 3893, 4029, 4057, 4070, 4243, 4399, 4433, 4522], 'carcinogenic': [631, 1008, 4528, 4598, 4901, 5092, 5113, 5131], 'thus': [634, 3098, 4260], 'potentially': [635], 'play': [636, 4420], 'important': [638, 4063, 4422], 'role': [639, 708, 4175, 4423, 5341, 5453], 'alcohol-related': [641, 875, 3821, 4543, 5060], 'UAT.': [645, 879, 3903], 'Int.': [646, 4687, 5232, 5468, 5486, 5704], 'J.': [647, 4688, 4837, 4951, 5038, 5070, 5233, 5255, 5386, 5418, 5469, 5487, 5705], '88:342–350,': [649], '2000.': [650], '©': [651], 'Wiley-Liss,': [653], 'Inc.': [654], 'Chronic': [655], 'has': [658, 767, 884, 924, 953, 2975, 3661, 3721, 3768, 4355], 'been': [659, 746, 768, 885, 925, 954, 3662, 3689, 3722, 3769, 4356, 4417], 'claimed': [660], 'oropharynx,': [670], 'larynx': [671], 'esophagus': [674], 'many': [678], '(IARC,': [681, 759, 820, 4008, 4487], '1988;': [682, 686, 3804, 4097], 'Blot': [683], 'et': [684, 690, 694, 698, 702, 782, 823, 837, 841, 897, 901, 905, 909, 934, 938, 942, 1167, 1509, 1922, 3741, 3745, 3749, 3753, 3802, 3806, 3838, 3880, 4014, 4095, 4099, 4103, 4162, 4166, 4301, 4325, 4329, 4428], 'al.,': [685, 691, 695, 699, 703, 763, 783, 824, 838, 842, 898, 902, 906, 910, 935, 939, 943, 1510, 1923, 3742, 3746, 3750, 3754, 3803, 3807, 4015, 4096, 4100, 4104, 4163, 4167, 4302, 4326, 4330, 4429], 'Blot,': [687, 4612, 4623, 4925], '1992;': [688, 696], 'Talamini': [689], '1990;': [692, 4164, 4327], 'Boffetta': [693], 'Mashberg': [697], '1993;': [700], 'Bundgaard': [701], '1995).': [704], 'When': [705, 2583, 3811], 'investigating': [706], 'on': [711, 719, 1206, 1463, 1666, 1729, 1748, 1796, 1930, 2188, 2200, 2497, 2727, 2742, 3115, 3209, 3238, 3371, 3379, 3455, 3514, 3532, 4088, 4542, 4678, 5027, 5087, 5108, 5126], 'carcinogenesis,': [714], 'most': [715, 3708], 'concentrated': [718], 'type': [721, 5693], 'alcoholic': [723, 4092, 4115, 4799, 4871, 5230, 5695], 'beverage': [724, 5696], 'amount': [727], 'daily': [729, 4248], 'intake.': [730], 'However,': [731, 945, 3674, 3780, 3836, 3904, 4472], 'no': [732, 946], 'conclusive': [733], 'mechanisms': [734, 3677], 'which': [736, 973, 1023, 1474, 1546, 2908, 3215, 3679, 3729, 4415], 'increases': [739, 3786, 4338], 'elucidated.': [747], 'Acetaldehyde,': [748], 'ethanol,': [753, 2641, 3157, 3549], 'carcinogen': [758], '1985;': [760, 821, 4009], 'Feron': [761, 840], 'et.': [762], '1991),': [764], 'it': [766, 1981, 2913, 3289, 4241], 'shown': [769], 'induce': [771], 'chromosomal': [772], 'aberration': [773], '(Dellarco,': [774], '1998),': [775], 'micronuclei': [776], 'and/or': [777], 'sister': [778], 'chromatid': [779], 'exchanges': [780, 4795, 4867], '(Feron': [781], '1983)': [784], 'mammalian': [787], 'cells': [788, 4035], 'gene': [790], 'mutations': [791], 'at': [792, 1127, 1152, 1216, 1257, 1281, 1387, 1488, 1594, 1762, 1992, 2027, 2734, 2746, 2749, 2762, 2884, 2989, 3575, 3996, 4966], 'hprt': [794, 4968], 'locus': [795, 4969], 'lymphocytes': [797, 4972], 'vivo': [799, 3104, 4235], '(He': [800], 'Lambert,': [802, 4962], '1990).': [803], 'Moreover,': [804, 3941], 'inhalation': [805], 'or': [806, 1499, 2704, 2901, 3912, 4247, 4289, 4830, 4834, 5161], 'drinking': [807, 1668, 1678, 3264, 3319, 4194, 4227, 4249, 4647, 4677], 'causes': [810], 'hyperplastic': [811], 'dysplastic': [813], 'changes': [814, 1822], 'mucosa': [817, 1103, 1882, 2051, 2127, 2444, 2529, 2777, 2853, 3143, 3863, 4124, 4442], 'Homann': [822, 904, 941, 3879], '1997b)': [825], 'induces': [827], 'nasal': [828], 'laryngeal': [830, 4288], 'carcinomas': [831], 'experimental': [833], 'animal': [834], 'models': [835], '(Wountersen': [836], '1986;': [839, 903, 940], '1982).': [843], 'ingested': [845, 4269, 4533], 'mainly': [848, 3701], 'oxidized': [849, 3698], 'liver': [854, 3797, 3846, 4702], '(Bosron': [857, 3716], 'Li,': [859, 3718, 4697, 5499], '1986),': [860, 4488], 'several': [861], 'lines': [862], 'evidence': [864], 'possible': [867, 3813, 4174, 4244, 4434], 'local': [870, 3816], 'For': [880, 1286], 'example,': [881], 'formation': [883, 3887], 'reported': [886, 1677, 3723, 3841, 4079], 'mouth': [889, 1755, 1790, 3462], 'washings': [890, 893], 'bronchopulmonary': [892, 5339], 'vitro': [895, 5186], '(Pikkarainen': [896, 933], '1981;': [899, 936], 'Miyakawa': [900, 937], '1997a;': [907], 'Jokelainen': [908], '1996).': [911, 1924, 4303], 'Since': [912, 3756, 3989], 'productions': [915, 1875], 'were': [916, 1024, 1191, 1204, 1266, 1319, 1407, 1466, 1565, 1607, 1685, 1739, 1777, 1816, 1831, 1896, 2278, 2304, 2335, 2356, 2482, 2494, 2574, 2586, 2618, 2631, 3053, 3235, 3364, 3541, 3553, 3994], 'reduced': [917], 'after': [918, 1788, 1827, 3152, 3558, 4218, 4801, 4873, 4998, 5415], 'use': [919], 'antibiotics,': [921], 'suggested': [926], 'origin': [932], '1997a).': [944], 'acetaldehyde.': [960, 1009, 1307, 3835, 4778], 'aim': [962], 'study': [965, 4732], 'determine': [968, 2605, 3908], 'specific': [970, 1195], 'strains,': [972], 'We': [989, 1019, 1088, 2917, 3029, 4205, 4547, 4572], 'further': [990, 2209, 2604, 4206, 4489], 'assessed': [991, 1348], 'whether': [992, 2606, 4503], 'influenced': [996, 4380], 'enhanced': [1005], 'MATERIAL': [1010], 'AND': [1011], 'METHODS': [1012], 'Bacterial': [1013, 1493, 2987, 3177, 3233, 3351], 'isolation': [1014], 'isolated': [1020, 1026, 1043, 1851, 2178, 2616, 3013, 3952], 'representative': [1021, 3423, 3979], 'bacteria,': [1022, 3070], 'commonly': [1025], 'such': [1032, 1866, 3635, 4406], 'Streptococcus': [1034, 1604, 3163, 3230, 3415], 'milleri,': [1035], 'Stomatococcus,': [1036], 'Branhamella': [1037, 1869], 'identification': [1041, 1053, 1061, 1651, 3368], 'performed': [1046, 3370], 'gram': [1048, 3239], 'staining': [1049, 3240], 'established': [1051, 1091], 'biochemical': [1052], 'kits:': [1054], 'Rapid': [1055], 'ID': [1056, 1071, 1076], '32': [1057], 'Strep': [1058], 'API': [1059], 'system': [1060, 5380], 'kits': [1062], '(Bio-Merieux': [1063], 'Vitek,': [1064], 'Hazelwood,': [1065], 'MO),': [1066], 'BBL': [1068, 1073], 'CRYSTAL': [1069, 1074], 'N/H': [1070], 'Gram/Positive': [1075], 'systems': [1077, 1505], '(Becton': [1078, 1506, 1580], 'Dickinson,': [1079], 'Franklin': [1080], 'Lakes,': [1081], 'NJ)': [1082], 'according': [1083, 3262], "manufacturer's": [1086], 'instructions.': [1087], 'also': [1089, 1192, 1673, 2510, 3829, 4139, 4377, 4477], 'examined': [1090, 3188], 'strains': [1092, 1853, 2243, 2617, 3014, 3913, 3953, 4254], '(N.': [1095, 1881, 1890, 2665, 2674], 'subflava': [1096, 1891, 1962, 2041, 2056, 2061, 2066, 2071, 2076, 2081, 2086, 2091, 2102, 2107, 2112, 2117, 2122, 2169, 2193, 2205, 2351, 2434, 2449, 2454, 2459, 2464, 2469, 2519, 2534, 2539, 2544, 2549, 2554, 2675, 2712, 2767, 2782, 2787, 2792, 2797, 2802, 2807, 2812, 2817, 2828, 2833, 2838, 2843, 2848, 3128, 3133], 'ATCC-49275,': [1097], 'N.': [1098, 1102, 1961, 2040, 2045, 2050, 2055, 2060, 2065, 2070, 2075, 2080, 2085, 2090, 2101, 2106, 2111, 2116, 2121, 2126, 2168, 2192, 2204, 2350, 2433, 2438, 2443, 2448, 2453, 2458, 2463, 2468, 2518, 2523, 2528, 2533, 2538, 2543, 2548, 2553, 2711, 2766, 2771, 2776, 2781, 2786, 2791, 2796, 2801, 2806, 2811, 2816, 2827, 2832, 2837, 2842, 2847, 2852, 3127, 3132, 3137, 3142, 4579], 'sicca': [1099, 2046, 2439, 2524, 2666, 2772, 3138], 'ATCC-29256,': [1100], 'ATCC-19696;': [1104], 'American': [1105], 'Type': [1106], 'Culture': [1107], 'Collection,': [1108], 'Rockville,': [1109], 'MD).': [1110], 'Alcohol': [1111, 1846, 3659, 4614, 4939, 5121, 5164, 5201, 5344, 5433], 'aldehyde': [1114, 4705, 5511, 5543, 5589, 5626], 'activities': [1116, 1190, 2014, 2021, 2213, 2227, 2274, 2303, 2323, 2383, 2491, 4583, 5518], 'Microbial': [1117, 2019], 'determined': [1121, 1161, 1193, 1397, 1467, 1496, 2279], 'measuring': [1123], 'absorbency': [1124], 'NADH': [1126, 1178, 1862, 1874, 1904, 1926], '340': [1128], 'nm': [1129], 'wavelength': [1130], 'spectrophotometrically.': [1131], 'Crude': [1132], 'lysate': [1134, 2939], 'incubated': [1136, 1295, 1386, 2587], '83': [1138], 'mM': [1139, 1146, 1150, 1234, 1237, 1242, 1251, 1298, 1366, 1374, 1378, 1532, 1937, 1955, 2732, 2759, 3061, 3156, 3986], 'glycine': [1140, 2025], 'buffer': [1141, 1215, 1254, 1301, 1369, 2026], '(pH': [1142, 1255, 1302, 1370], '11.0)': [1143], '20': [1145, 1954, 3078, 4783], '10': [1149, 1362, 2372, 2419, 2567], 'NAD': [1151], '37°C.': [1153, 1388, 1595, 2735, 2750, 2763], 'Protein': [1154, 5248], 'concentration': [1155, 1391, 1462, 2187, 3833], 'lysates': [1159, 1203, 2277, 2331, 2396, 2585, 2701], 'method': [1164, 2236, 2926], 'Lowry': [1166], 'al.': [1168, 3839, 3881], '(1951).': [1169, 5261], 'calculated': [1174], 'nanomoles': [1176], 'per': [1180, 1185, 1683], 'mg': [1181], 'protein': [1184, 1889], 'min.': [1186, 1285], 'ALDH': [1189, 1290, 1315, 2267, 2273, 2302, 2490, 2503, 2906, 2928, 2932, 2946, 2968], 'gel': [1197, 1211, 1226, 1293, 2221, 2235, 2283, 2925], 'methods.': [1198, 2284], 'Aliquots': [1199], 'fresh': [1201], 'electrophoresed': [1205], '5%': [1208, 1589], 'native': [1209], 'polyacrylamide': [1210], '1×': [1213], 'TBE': [1214], '4°C.': [1217], 'localized': [1222], 'incubating': [1224], 'situ': [1228], 'reaction': [1230, 1336, 2599], 'buffer,': [1231], '3.6': [1233, 1377], 'β-NAD,': [1235], '0.95': [1236], 'MTT': [1238], '(3-[4,5-dimethylthyazol-2-y]-2,5-diphenyltetrazolium': [1239], 'bromide),': [1240], '0.1': [1241, 2362], 'Meldola': [1243], 'blue': [1244], '1.5': [1246, 1305], 'M': [1247, 1306], '100': [1250, 1297, 1365], 'sodium': [1252, 1367], 'pyrophosphate': [1253, 1368], '8.8)': [1256], '37°C': [1258], '1': [1260, 2360, 2426], 'hr.': [1261], 'After': [1262, 1596], 'incubating,': [1263], 'gels': [1265], 'fixed': [1267], '5:5:1': [1270], 'methanol-water-acetate': [1271], 'solution': [1272], '8%': [1274], 'glycerol': [1275], '5': [1277, 1760, 1763, 3479, 3581], 'min': [1278, 1764], 'dried': [1280], '80°C': [1282], '40': [1284, 1439, 4001], 'detection': [1287], 'activity,': [1291, 2907, 3036], 'potassium': [1299], 'phosphate': [1300], '7.4)': [1303], 'Yeast': [1308, 2508], '(Sigma,': [1310], 'St.': [1311], 'Louis,': [1312], 'MO)': [1313], '(Biogenesis,': [1316], 'Poole,': [1317], 'UK)': [1318], 'used': [1320], 'positive': [1322, 2379], 'controls.': [1323], 'Specificity': [1324], 'reactions': [1327], 'validated': [1329], 'omitting': [1331], 'substrates': [1333], 'buffer.': [1337], 'each': [1344, 1584, 1654], 'strain': [1346, 1471, 1959, 2171, 2175, 2714], 'mixing': [1350], '0.2': [1351, 1513], 'ml': [1352, 1363, 1514, 1521, 1768], 'intact': [1355, 2755], 'suspension': [1357], 'overnight': [1359, 1516], 'culture': [1360, 1504, 1518, 2622, 3043, 3949, 4006, 5379], '7.0)': [1371], '200': [1373, 1529, 2731, 2758, 3060, 3155, 3985], 'β-NAD': [1379], 'closed': [1382, 2592], 'vial.': [1383], 'This': [1384, 1925, 2174, 2953, 3045, 4044, 4271, 4535], 'head': [1394, 5281], 'space': [1395, 2630, 2647], 'using': [1398, 1468, 1610, 1766, 2281, 2730, 3196, 5381], 'gas': [1399, 1435, 2634], 'chromatography': [1400], '(HITACHI,': [1401], 'Hitachi,': [1402], 'Japan).': [1403], 'analysis': [1406, 4490], 'follows:': [1409], 'Porapack': [1410], 'Q': [1411], '60/80': [1412], 'glass': [1413], 'column,': [1414], 'mm': [1416], '×': [1417], '2': [1418, 3629], 'm;': [1419], 'detector,': [1420], 'flame': [1421], 'ionization': [1422], 'detector;': [1423], 'injection': [1424], 'temperature,': [1425, 1428, 1431], '200°C;': [1426, 1432], 'column': [1427], '150°C;': [1429], 'detector': [1430], 'carrier': [1434], '(He)': [1436], 'flow': [1437], 'rate,': [1438], 'ml/min.': [1440], 'actual': [1442], 'number': [1443], 'vial': [1448], 'expressed': [1450], 'colony': [1452, 1617, 3243, 3367], 'forming': [1453], 'units': [1454], '(CFU).': [1455], 'effects': [1457, 1726, 1744, 3511, 3529, 3991, 4113], 'pH': [1459, 1993, 2028, 2199, 2723, 2747], '98001': [1470, 1958, 2170, 2194, 2206, 2352, 2713], 'Neisseria,': [1473, 1603, 2215, 2386, 2942, 3004, 3032, 3229], 'clinical': [1477, 2036, 5372], 'isolate': [1478], '26-year-old': [1481], 'healthy': [1482, 1566, 1737, 3200, 3274, 3362], 'female.': [1483], 'Analysis': [1484, 1535], 'growth': [1487, 1494, 2988, 3009, 3049, 3072, 3093, 3101, 3117, 3217, 3324, 4232], 'various': [1489, 2990, 3019], 'concentrations': [1490, 2626, 2741, 2991, 3020, 3041, 3998], 'anaerobic': [1498, 3027], 'aerobic': [1500, 3025, 5192], 'BACTEC': [1501], '9120': [1502], 'automatic': [1503], 'Dickinson)': [1507, 1581], '(Nolte': [1508], '1993),': [1511], 'adding': [1512], '50': [1520, 1767, 1899], 'liquid': [1523, 3119], 'supplemented': [1525], '0,': [1527, 1781], '100,': [1528], '500': [1531], 'ethanol.': [1534, 2718, 3062, 3988, 4221, 4270, 4534], 'A': [1543, 1614, 1837, 3461, 4774], 'tongue': [1544, 3197, 3551, 3584, 3619], 'swab,': [1545], 'showed': [1547, 2237, 2401, 2504, 2947, 3064, 3254, 4189], 'low': [1548, 2903, 2967, 3866], 'sampling': [1549], 'variation': [1550], 'relative': [1552, 3190, 3298, 3564, 3646, 3788], '(data': [1555, 1662, 3245], 'not': [1556, 1663, 2495, 2512, 3149, 3246, 3613, 3633, 3688, 3794, 3907, 4109, 4371], 'shown),': [1557], 'obtained': [1559, 2347, 3341], '51': [1561, 3361], 'volunteers.': [1562], 'All': [1563, 2392], 'subjects': [1564], 'adults.': [1567], 'swab': [1569, 3206], 'directly': [1571], 'streaked': [1572, 1795], 'onto': [1573], 'non-selective': [1575, 1798, 3210, 3372], 'sheep': [1576, 1799, 3211, 3373, 3381], 'blood': [1577, 1800, 3212, 3374, 3382, 5378], 'agar': [1578, 1801, 3213, 3375, 3383], 'plate': [1579, 1585], 'immediately,': [1582], 'placed': [1587], 'O2': [1590], '7%': [1592], 'CO2': [1593], '24': [1597], 'hr': [1598, 1787, 3079, 3475, 3577], 'incubation,': [1600], 'colonies': [1601, 1633, 1643, 3234, 3333, 3398, 3413], 'Stomatococcus': [1606, 1871, 3417], 'morphologically': [1609], 'following': [1612], 'criteria.': [1613], 'yellowish': [1615], 'rough-rimmed': [1616], 'having': [1618, 3033], 'smooth': [1619], '(or': [1620], 'mucoid)': [1621], 'surface': [1622], 'Alpha-hemolysis': [1629], 'found': [1631, 1995, 4297], 'Streptococcus.': [1637], 'Grayish': [1638], 'relatively': [1640], 'large': [1641], 'mucoid': [1642], 'characterized': [1644], 'Stomatococcus.': [1647, 3232], 'accuracy': [1649], 'rates': [1652, 3050], '100%,': [1657], '100%': [1658], '90.5%,': [1660], 'respectively': [1661], 'shown).': [1664, 3247], 'Information': [1665], 'cigarette': [1670, 4378, 4474, 4496], 'smoking': [1671, 1713, 3266, 4379, 4463, 4475, 4497, 4674], 'obtained.': [1674], 'Volunteers': [1675], 'who': [1676], 'one': [1681, 3665, 3894], 'day': [1682], 'week': [1684], 'classified': [1686], 'drinkers.': [1688], 'According': [1689], 'information,': [1692], 'divided': [1694], 'volunteers': [1696, 1738, 3363, 3480, 3540, 3582, 3631], 'into': [1697, 3947], '4': [1698, 1784], 'groups:': [1699], '1.': [1700], 'non-drinker': [1701], 'non-smoker': [1702], '(n': [1703, 1709, 1715, 1722], '=': [1704, 1710, 1716, 1723, 3310, 3438, 3488, 3491, 3495, 3498, 3502, 3505, 3592, 3595, 3601, 3607], '18);': [1705], '2.': [1706], 'non-smoking': [1707, 3275, 3307, 3391, 3433, 4346, 5480], 'drinker': [1708, 1714, 3392], '15);': [1711], '3.': [1712], '10);': [1717], '4.': [1719], 'non-drinking': [1720, 5484], 'smoker': [1721, 3406], '8).': [1724], 'Short-term': [1725, 1821, 3510], 'Six': [1736], 'To': [1741, 2208, 2603, 2994, 3183, 3560], 'assess': [1742], 'exposure': [1747], 'rinse': [1756, 3463, 3544], 'carried': [1758], 'out': [1759], 'times': [1761, 1900], 'intervals,': [1765], '10%': [1770, 3293, 3465, 3548], '30': [1773], 'sec.': [1774], 'Tongue': [1775, 3358], 'swabs': [1776, 3198, 3340, 3359, 3482, 3552, 3585, 3620], 'collected': [1778, 3554], 'before': [1779, 3556], '1,': [1782], '2,': [1783], '6': [1786, 3474, 3576], 'rinse.': [1791], 'specimen': [1793], 'plate.': [1802], 'Statistical': [1803], 'analyses': [1804], 'Differences': [1805], 'groups': [1815], 'analyzed': [1817, 2632, 3007], 'Kruskal-Wallis': [1819, 3312, 3440], 'test.': [1820, 1836], 'mouth-washing': [1828], 'estimated': [1832], 'linear': [1834, 3507], 'regression': [1835, 3508], 'p-value': [1838], '<0.05': [1840], 'considered': [1842, 3770, 4357, 4418], 'statistically': [1843], 'significant.': [1844], 'RESULTS': [1845], 'Among': [1849], 'significantly': [1860, 1976, 3303, 3568, 3958, 4293], 'Streptococcus,': [1868], '(Fig.': [1872, 1893, 1909, 1947, 1963, 2006, 2232, 2258, 2601, 2652, 2677, 2929, 2951, 3080, 3268, 3294, 3344, 3588, 3625], '1a).': [1873, 1894], 'ranged': [1876], '117.3': [1878], '±': [1879, 1886, 2155, 2661, 2670, 2881], '3.7': [1880], 'ATCC19696)': [1883], '1,522.7': [1885], '10.7': [1887], 'nmol/min/mg': [1888], '9903683)': [1892, 2676], 'These': [1895, 1965, 2970, 3082, 3521, 4169, 4222, 4388, 4453], 'E.': [1907, 2145, 2150, 2252, 2387, 2410, 2473, 2871, 2876], 'coli': [1908, 2146, 2151, 2253, 2388, 2411, 2474, 2872, 2877], '1a)': [1910], 'highest': [1914], 'colonic': [1919, 5197], '(Jokelainen': [1921, 4300], 'dependent': [1929], 'inhibited': [1934], '6.25': [1936, 2341], '4-methylpyrazol': [1939], '(4-MP),': [1940], 'competitive': [1942], 'inhibitor': [1943], 'NAD-linked': [1945], '1b).': [1948], 'Km': [1950], '1c).': [1964], 'results': [1966, 2971, 3083, 3639, 4223, 4305, 4368, 4513], 'activity.': [1979, 3940], 'noteworthy': [1983], 'observed': [1991, 2936, 3614, 3995], 'values': [1994, 2154], 'environment,': [2000], 'ranging': [2001, 3999], '7.0': [2003], '11.0': [2005], '1d).': [2007], 'Figure': [2008, 2260, 2692, 3107, 3346], '1Open': [2009], 'figure': [2011, 2263, 2695, 3110, 3349], 'viewerPowerPoint': [2012, 2264, 2696, 3111, 3350], 'lysates.': [2017], '(a)': [2018, 2270, 3377], 'measured': [2022], 'spectrophotometrically': [2023], '11.0.': [2029], 'Lanes': [2030, 2333, 2354, 2480, 2572], '1–3:': [2031], 'ATCC': [2032], 'strains;': [2033], 'lanes': [2034], '4–24:': [2035], 'isolates.': [2037], 'Lane': [2038, 2367, 2417, 2516, 2764, 3121], '1:': [2039, 2418, 2517, 2765, 3122], 'ATCC49275;': [2042, 2435, 2520, 2768, 3129], 'lane': [2043, 2048, 2053, 2058, 2063, 2068, 2073, 2078, 2083, 2088, 2093, 2096, 2099, 2104, 2109, 2114, 2119, 2124, 2129, 2134, 2139, 2143, 2148, 2424, 2431, 2436, 2441, 2446, 2451, 2456, 2461, 2466, 2471, 2476, 2521, 2526, 2531, 2536, 2541, 2546, 2551, 2556, 2559, 2565, 2769, 2774, 2779, 2784, 2789, 2794, 2799, 2804, 2809, 2814, 2819, 2822, 2825, 2830, 2835, 2840, 2845, 2850, 2855, 2860, 2865, 2869, 2874, 3125, 3130, 3135, 3140], '2:': [2044, 2425, 2522, 2770, 3126], 'ATCC29256;': [2047, 2440, 2525, 2773, 3139], '3:': [2049, 2432, 2527, 2775, 3131], 'ATCC19696;': [2052, 2445, 2530, 2778], '4:': [2054, 2437, 2532, 2780, 3136], '98001;': [2057, 2450, 2535, 2783, 3134], '5:': [2059, 2442, 2537, 2785, 3141], '99471;': [2062, 2455, 2540, 2788], '6:': [2064, 2447, 2542, 2790], '99476;': [2067, 2460, 2545, 2793], '7:': [2069, 2452, 2547, 2795], '99493;': [2072, 2465, 2550, 2798], '8:': [2074, 2457, 2552, 2800], '99498;': [2077, 2138, 2470, 2555, 2803, 2864], '9:': [2079, 2462, 2557, 2805], '99a;': [2082, 2808], '10:': [2084, 2467, 2810], '99ta;': [2087, 2813], '11:': [2089, 2472, 2566, 2815], '99mu;': [2092, 2818], '12:': [2094, 2477, 2820], '99mi;': [2095, 2821], '13:': [2097, 2823], '9903683;': [2098, 2824], '14:': [2100, 2826], '9904068;': [2103, 2829], '15:': [2105, 2831], '9904347;': [2108, 2834], '16:': [2110, 2836], '99475;': [2113, 2839], '17:': [2115, 2841], '99477;': [2118, 2844], '18:': [2120, 2846], '99496;': [2123, 2849], '19:': [2125, 2851], '7893752;': [2128, 2854], '20:': [2130, 2856], 'B.': [2131, 2857], 'catarrharis': [2132, 2858], '99718;': [2133, 2859], '21:': [2135, 2861], 'S.': [2136, 2141, 2249, 2390, 2413, 2478, 2862, 2867, 3123, 4565, 4585, 5448], 'mucilanginosus': [2137, 2863], '22:': [2140, 2866], 'constellatus;': [2142, 2868, 3124], '23:': [2144, 2870], '99658;': [2147, 2475, 2873], '24:': [2149, 2875], '99603.': [2152, 2878], 'Average': [2153], 'SD': [2156, 2882], 'experiments': [2159], 'are': [2160, 2888, 4108, 4153], 'shown.': [2161, 2889], '(b)': [2162, 2381, 3420], 'Suppression': [2163], '4-methylpyrazol.': [2173], 'clinically': [2177], 'cavity.': [2182, 2986], '(c)': [2183, 2489, 3450], 'Effect': [2184], 'strain.': [2195, 2207, 2353], '(d)': [2196], 'Effects': [2197, 2721, 2738, 3112, 5024], 'confirm': [2210], 'developed': [2217], 'ADH-specific': [2219], 'technique': [2222], 'fractionated': [2229], 'proteins': [2231, 2346], '2a).': [2233, 2930], 'Activity': [2234], 'all': [2239, 3271], 'strong': [2245, 4118], 'activities,': [2247], 'while': [2248, 2407, 2501, 2943, 3158, 3284, 3394], 'constellatus': [2250, 2414], 'little': [2255], 'if': [2256], '2b).': [2259], '2Open': [2261], 'gels.': [2269], 'semiquantitatively': [2280], 'top': [2286], 'bottom': [2292], 'ALDH.': [2294, 2366], 'intensity': [2296, 2318], 'bands': [2298, 2320, 2950], 'quantified': [2305], 'comparing': [2307], 'them': [2308], 'those': [2310, 2408, 3795, 3964], 'yeast': [2312, 2365, 2375, 2422, 2429, 2502, 2563, 2570, 2945], 'ALDH,': [2315], 'respectively.': [2316, 3419], 'corresponded': [2324], 'closely': [2325], 'added.': [2332], '1–5': [2334], 'loaded': [2336, 2357, 2370, 2483, 2575], '50,': [2338], '25,': [2339, 5073], '12.5,': [2340], '2.5': [2343], 'μg': [2344, 2486, 2578], '6–8': [2355], '10,': [2359, 5348], 'U': [2363, 2373, 2420, 2427, 2561, 2568], '9': [2368], 'control.': [2380], 'constellatus.': [2391, 2479], 'band': [2404, 2934], 'ADH,': [2406], 'did': [2415, 2511, 3632, 3906], 'not.': [2416], 'ADH;': [2423, 2430], '3–12': [2481], '25': [2485, 2577], 'proteins.': [2488, 2580], 'detected': [2496, 3338, 3403], 'gel,': [2500], 'band.': [2507, 2515], 'show': [2513, 3634, 4369], 'mock,': [2558], '10:10': [2560], 'ALDH;': [2564], 'ADH.': [2571], '1–8': [2573], 'vial,': [2593], 'liberated': [2596], 'mixture': [2600], '3a,c).': [2602], 'living': [2607, 2705], 'air-tight': [2621], 'vials,': [2623], 'air': [2629, 2646, 5414], 'chromatography.': [2635], 'During': [2636], 'incubation': [2637, 2716], 'accumulated': [2643], 'time-dependent': [2650], 'manner': [2651], '3b,d).': [2653], 'varied': [2658], '174.9': [2660], '39.4': [2662], 'nmol/min/1011': [2663, 2672], 'CFU': [2664, 2673, 3976], 'ATCC29256)': [2667], '23,050.4': [2669], '1,624.7': [2671], '3e).': [2678], 'It': [2679, 3314, 3720, 4137, 4431], 'bacteria.': [2691, 3329, 3485, 4239, 5343], '3Open': [2693], '(a,': [2702, 2719], 'c)': [2703], '(b,': [2707], 'd)': [2708, 2737], 'during': [2715], 'b)': [2720], '(7.0': [2724], '10.8)': [2726], '(c,': [2736], '7': [2748], '(e)': [2751], 'means': [2880], 'least': [2885], 'determinations': [2887], 'Aldehyde': [2890], 'Accumulation': [2893], 'suggests': [2896, 4045], 'might': [2899, 4028, 4069, 4171, 4250, 4306, 4455, 4464], 'lack': [2900], 'levels': [2904, 4995], 'eliminates': [2909], 'oxidizing': [2912], 'acetic': [2915], 'acid.': [2916], 'tested': [2918], 'possibility': [2920, 3086, 4272], 'developing': [2922], 'No': [2931], 'prepared': [2940], 'control': [2944], 'intense': [2948], '2c).': [2952], 'indicates': [2954, 3174], 'accumulation': [2958, 3733, 3783, 4022], 'due': [2962], 'activities.': [2969], 'elucidate': [2995], 'biological': [2997], 'significance': [2998], 'rate': [3010], 'under': [3023], 'both': [3024], 'conditions.': [3028], 'hypothesized': [3030], 'could': [3037, 3320, 3336, 3401, 3892, 4228, 4242, 4261, 4398, 4432, 4521], 'tolerate': [3038], 'medium.': [3044], 'confirmed:': [3047], 'unaffected,': [3054], 'even': [3055, 3151, 3317, 4344], 'addition': [3058, 3153, 3944], 'marked': [3066], 'contrast': [3067], 'whose': [3071, 3481, 3583, 3618], 'retarded': [3074], '4).': [3081], 'raise': [3084], 'may': [3090, 3644, 3828, 4056, 4120, 4505], 'suppress': [3091], 'ADH-negative': [3095, 3328, 4238], 'give': [3099], 'advantage': [3102, 3325, 4233], '4Open': [3108], 'culture.': [3120], 'ATCC19696.': [3144], 'Growth': [3145], 'delayed': [3150, 3165], 'significantly,': [3166], 'indicated': [3168], 'arrow.': [3171], 'Vertical': [3172], 'axis': [3173], 'fluorescent': [3175], 'units.': [3176], 'address': [3184], 'question,': [3186], 'volunteer': [3201], 'drinkers': [3202, 3308, 3434, 4347, 5481], 'non-drinkers.': [3204, 5467], 'plated': [3208], 'plates,': [3214], 'allowed': [3216], 'major': [3222, 3849, 4479], 'based': [3237], 'characteristic': [3242], 'morphology': [3244], 'interesting': [3255], 'differences': [3256], 'predominating': [3259], 'habits': [3267], '5a).': [3269], 'drinkers,': [3276], 'constituted': [3278], '20%': [3281], 'colonies,': [3283], '50%': [3286], 'non-drinker/non-smokers': [3288, 3436], 'less': [3291], '5b).': [3295, 3345], 'Statistically,': [3296], 'ratio': [3299], '(p': [3309, 3437], '0.0008,': [3311, 3439], 'test).': [3313, 3441, 3509], 'appears': [3315], 'social': [3318, 4193], 'provide': [3321, 4229, 4456], 'over': [3326, 3473, 4236], 'Interestingly,': [3330], 'very': [3331, 3622, 3760, 3865, 4062], 'few': [3332, 3397, 3448, 3623], 'smokers': [3343, 3446], '5Open': [3347], 'obtained,': [3365], 'plates.': [3376, 3384], 'Colonies': [3378], '(black': [3386], 'arrow)': [3387], 'predominated': [3388], '(A1),': [3393], 'only': [3395, 4372], '(A2).': [3407], 'Black': [3408], 'white': [3410], 'arrowheads': [3411], 'indicate': [3412, 3640, 4514], 'genera,': [3418], 'Composition': [3421], 'prevalent': [3431], 'By': [3442], 'contrast,': [3443], 'contained': [3447, 3586, 3621], 'effect': [3452, 3899, 4671], 'progressively': [3467, 3570], 'contain': [3483], '(e2:': [3486], 'β': [3487, 3494, 3501, 3591, 3598, 3604], '2.95%/hr,': [3489, 3593], 'p': [3490, 3497, 3504, 3594, 3600, 3606], '0.0005;': [3492, 3596], 've4:': [3493, 3597], '5.82%/hr,': [3496], '0.0031;': [3499, 3602], 've5:': [3500, 3603], '4.24%/hr,': [3503], '0.0423,': [3506], 'led': [3523], 'us': [3524], 'examine': [3526], 'direct': [3528, 4112], 'Healthy': [3539], 'asked': [3542], 'their': [3545, 4708], 'mouths': [3546], 'sequentially': [3555], 'rinsing.': [3559], 'surprise,': [3562], 'counts': [3565, 3647], '2-': [3572], '10-fold': [3574], '5c,': [3589, 3626], 've2:': [3590], '=5.82%/hr,': [3599], '=4.24%/hr,': [3605], '0.0423).': [3608], 'Such': [3609], 'increase': [3611, 3645], 'person': [3617], 've6).': [3627], 'remaining': [3630], 'change,': [3637], 'short-term': [3656], 'effect.': [3657], 'DISCUSSION': [3658], 'factors': [3670], 'cancers.': [3673, 4950], 'exact': [3676], 'stimulates': [3683], 'known.': [3690], 'body,': [3694], 'primarily': [3697], 'liver,': [3706], 'eliminated': [3713], 'ALDH2': [3715, 3727], '1986).': [3719, 5119], 'ADH3': [3725], 'polymorphisms,': [3728], 'result': [3730], 'cancers': [3739, 3800, 4084, 4160, 4291, 4343, 5624], '(Harty': [3740], '1997;': [3743, 4101], 'Yokoyama': [3744, 3748], '1996a,b,': [3747], '1998;': [3751, 4011], 'Hori': [3752], '1997).': [3755], 'organ-toxic': [3761], 'reactive': [3763], 'compound,': [3764], 'acetaldehydemia': [3767], 'responsible': [3773, 3914], 'region.': [3779], 'why': [3781, 4333], 'but': [3793, 4111, 4376], 'breast': [3799], '(Blot': [3801, 4094], 'Seitz': [3805], '1998)': [3808], 'unknown.': [3810, 4471], 'considering': [3812], 'mucosal': [3825], 'influence': [3830], 'Yin': [3837], '(1997)': [3840], 'site': [3850], 'first-pass': [3852], 'metabolism': [3853, 4712], 'because': [3856], 'compared': [3867], 'liver.': [3872], 'As': [3873], '(1997a)': [3882], 'proposed': [3883], 'microbial': [3886], 'saliva': [3891, 4997], 'explanation': [3895], 'tumor-promoting': [3898], 'they': [3905], 'distinct': [3909], 'saliva.': [3921], 'demonstrated': [3926, 4207], 'upon': [3942], 'medium,': [3950], 'larger': [3959], 'genera.': [3967], 'Their': [3968], 'reached': [3971], 'up': [3972], '23': [3974], 'μmol/min/1011': [3975], 'isolates': [3981], 'response': [3983, 4446, 4531], 'mutagenic': [3990], '1,000': [4003], 'μM': [4004], 'cell': [4007, 4735, 5028, 5067], 'Dellarco,': [4010, 4772], 'De': [4012, 4785, 4848, 4856, 4889], 'Raat': [4013], '1983;': [4016], 'World': [4017, 5636, 5646], 'Health': [4018, 5637, 5647], 'Organization,': [4019, 5648], '1995),': [4020], 'sufficient': [4030], 'affect': [4032], 'epithelial': [4034], 'exposed': [4039, 4825], 'long': [4042], 'time.': [4043], 'time': [4049], 'candidate': [4059], 'thereby': [4068], 'modifier': [4072], 'ethanol-related': [4074], 'cancer.': [4075, 4184, 4616, 4654, 4766, 5163, 5284, 5435], 'Previous': [4076], 'depends': [4087], 'types': [4090], 'beverages': [4093, 4800, 4872], 'Launoy': [4098], 'Zambon': [4102], '2000).': [4105], 'reasons': [4107, 4311], 'clear,': [4110], 'beverages,': [4116], 'alcohol,': [4119], 'make': [4121], 'sensitive': [4126], 'well': [4133], 'metabolism.': [4136], 'known': [4140], 'poor': [4142], 'hygiene': [4144, 4317, 5277], 'dental': [4146], 'status,': [4147], 'along': [4148, 4321], 'consumption,': [4152], 'associated': [4154], 'development': [4157, 4181], '(Talamini': [4161, 4324], 'Maier': [4165, 4328], '1993).': [4168], 'association': [4191, 4314], 'between': [4192, 4315], 'mouthwash': [4219], 'habitual': [4226, 4373], 'Accordingly,': [4240], 'heavy': [4246, 4334], 'select': [4251], 'enhance': [4262], 'seems': [4273], 'consistent': [4274], 'fact': [4277], 'mouth-washings': [4282], 'patients': [4284, 5156, 5279], 'pharyngeal': [4290, 4653, 4949, 5162, 5459], 'controls': [4299], 'Our': [4304], 'part': [4308], 'explain': [4309], '1993)': [4331], 'sharply': [4337], '(Tuyns,': [4348], '1983).': [4349], 'usually': [4354], 'beneficial': [4360], 'host.': [4363], 'intake': [4375], 'evidences': [4389], 'dramatically': [4400], 'changed': [4401], 'environmental': [4404, 4451], 'factors,': [4405], 'chemical': [4408], 'irritants,': [4409], 'pollutants,': [4410], 'foods': [4411], 'food': [4413], 'additives,': [4414], '(Chang': [4427], '1992).': [4430], 'predisposed': [4439], 'malignancy': [4444], 'some': [4448], 'factors.': [4452], 'ideas': [4454], 'new': [4457, 4538], 'implications': [4458], 'carcinogenesis.': [4461, 4509, 4545], 'Why': [4462], 'eradicate': [4465], 'since': [4473], 'necessary': [4492], 'understand': [4494], 'contribute': [4506], 'summary,': [4511], 'opens': [4536], 'perspective': [4539], 'research': [4541], 'Acknowledgements': [4546], 'thank': [4548], 'Drs.': [4549], 'T.': [4550], 'Ogura': [4551], 'M.': [4553, 5051, 5269, 5536, 5574], 'Salaspuro': [4554], 'helpful': [4556], 'suggestions,': [4557], 'express': [4560], 'special': [4561], 'thanks': [4562], 'Dr.': [4564], 'assistance': [4568, 4577], 'statistic': [4570], 'analysis.': [4571], 'gratefully': [4573], 'acknowledge': [4574], 'technical': [4576], 'Tsuji': [4580], 'K.': [4588, 5020, 5619], 'Tatenuma': [4589], 'measurement.': [4592], 'REFERENCES': [4593], 'Bladeren,': [4594], 'P.J.,': [4595, 4898], 'Aldehydes:': [4596, 4899], 'occurrence,': [4597, 4900], 'potential,': [4599, 4902], 'mechanism': [4600, 4903], 'action': [4602, 4905], 'assessment.': [4605, 4908], 'Mutat.': [4606, 4779, 4807, 4879, 4909], 'Res.,': [4607, 4618, 4656, 4780, 4808, 4880, 4910, 5167, 5204, 5347], '259,': [4608, 4911], '363-': [4609, 4912], '385': [4610], '(1991).': [4611, 4914], 'W.J.,': [4613, 4624, 4926], '52,': [4619, 4690], '2119-': [4620], '2123': [4621], '(1992).': [4622, 4693, 4771], 'McLaughlin,': [4625], 'J.K.,': [4626], 'Winn,': [4627, 4921], 'D.M.,': [4628, 4922], 'Austin,': [4629], 'D.F.,': [4630], 'Greenberg,': [4631], 'R.S.,': [4632], 'Preston-Martin,': [4633], 'S.,': [4634, 4753, 5363, 5446, 5534, 5566, 5568, 5615, 5687, 5691], 'Bernstein,': [4635], 'L.,': [4636, 4669, 5301, 5451, 5683, 5689], 'Schoenberg,': [4637], 'J.B.,': [4638], 'Stemhagen,': [4639], 'A.': [4640, 4816, 5657], 'Fraumeni': [4642], 'J.F.': [4643, 4934], 'Jr.,': [4644], 'Smoking': [4645], 'relation': [4649], '48,': [4657], '3282-': [4658], '3287': [4659], '(1988).': [4660], 'Boffetta,': [4661, 5295], 'P.,': [4662, 5014, 5296, 5676], 'Mashberg,': [4663, 5293], 'A.,': [4664, 5175, 5267, 5294, 5528, 5558, 5601], 'Winkelmann,': [4665], 'R.': [4666, 4989, 5181, 5298], 'Garfinkel,': [4668, 5300], 'Carcinogenic': [4670], 'tobacco': [4673, 5465], 'anatomic': [4679], 'sites': [4680], 'cavity': [4684, 4740, 4947, 5311], 'oropharynx.': [4686], 'Cancer,': [4689, 5234, 5317, 5470, 5488, 5595, 5706], '530-': [4691], '533': [4692], 'Bosron,': [4694], 'W.F.': [4695], 'T.K.,': [4698], 'Genetic': [4699, 5055], 'polymorphism': [4700], 'dehydrogenases': [4706], 'relationship': [4709], 'alcoholism.': [4714], 'Hepatology,': [4715], '6,': [4716, 4746], '502-': [4717], '510': [4718], '(1986).': [4719, 5351, 5674], 'Bundgaard,': [4720], 'T.,': [4721, 5016, 5018, 5049, 5179, 5530, 5532, 5560, 5562, 5603, 5605, 5607], 'Wildt,': [4722], 'J.,': [4723, 5216, 5265], 'Frydenberg,': [4724], 'M.,': [4725, 4992, 5023, 5149, 5184, 5221], 'Elbrond,': [4726], 'O.': [4727], 'Nielsen,': [4729], 'J.E.,': [4730], 'Case-control': [4731], 'squamous': [4734, 5066], 'Denmark.': [4742], 'Causes': [4744], 'Control,': [4745], '57-': [4747, 4979], '67': [4748], '(1995).': [4749], 'Chang,': [4750, 5326], 'F.,': [4751, 4850, 4891, 5370], 'Syrjanen,': [4752, 4757], 'Wang,': [4754], 'L.': [4755], 'K.,': [4758, 4987, 5140, 5173, 5570, 5572, 5609, 5617], 'Infectious': [4759], 'agents': [4760], 'etiology': [4763], 'esophageal': [4765, 5065, 5580], '103,': [4768], '1336-': [4769], '1348': [4770], 'V.L.,': [4773], 'mutagenicity': [4775], 'assessment': [4776], '195,': [4781], '1-': [4782], '(1998).': [4784, 5442, 5635], 'Raat,': [4786, 4857], 'W.K.,': [4787, 4858], 'Davis,': [4788, 4859], 'P.B.,': [4789], 'Bakker,': [4790, 4862], 'G.L.,': [4791, 4863], 'Induction': [4792, 4864], 'sisterchromatid': [4794], 'metabolic': [4802, 4874], 'activation': [4803, 4875], 'rat-liver': [4805, 4877], 'homogenate.': [4806, 4878], '124,': [4809, 4881], '85-': [4810, 4882], '90': [4811, 4883], '(1983).': [4812, 4884, 5492], 'Feron,': [4813, 4885, 5659], 'V.J.,': [4814, 4886, 5660], 'Kruysse,': [4815], 'Woutersen,': [4818, 4892, 5651], 'R.A.,': [4819, 4893, 5652], 'Respiratory': [4820], 'tumors': [4822], 'hamsters': [4824], 'vapour': [4828], 'alone': [4829], 'simultaneously': [4831], 'benzo[a]pyrene': [4833], 'diethylnitrosamin.': [4835], 'Europ.': [4836], 'Clin.': [4839, 5071, 5165, 5202, 5345, 5387, 5420], 'Oncol.,': [4840], '18,': [4841, 5007], '13-': [4842], '31': [4843], '(1982).': [4844], 'Feron,V.J.,': [4845], 'Til,': [4846, 4887], 'H.P.,': [4847, 4888], 'Vrijer,': [4849, 4890], 'Woutersen,R.A.,': [4851], 'Cassee,': [4852, 4894], 'F.R.': [4853], 'Van': [4855, 5655], 'P.B.': [4860], 'sister-chromatid': [4866], 'F.R.,': [4895], 'Van,': [4896], 'Bladeren': [4897], '85': [4913], 'Harty,': [4915], 'L.C.,': [4916], 'Caporaso,': [4917], 'N.E.,': [4918, 5214], 'Hayes,': [4919], 'R.B.,': [4920], 'Bravo-Otero,': [4923], 'E.,': [4924, 5142, 5325, 5396, 5685], 'Kleinman,': [4927], 'D.V.,': [4928], 'Brown,': [4929], 'L.M.,': [4930, 5654], 'Armenian,': [4931], 'H.K.,': [4932, 5427], 'Fraumeni,': [4933], 'Jr.': [4935], 'Shields,': [4937], 'P.G.,': [4938], 'genotype': [4942, 5591], 'Nat.': [4952, 5039], 'Inst.,': [4954, 5041], '89,': [4955, 5042], '1698-': [4956], '1705': [4957], '(1997).': [4958, 5076, 5238, 5526], 'He,': [4959], 'S.M.': [4960], 'B.,': [4963], 'Acetaldehyde-induced': [4964], 'mutation': [4965], 'Environ.': [4975], 'mol.': [4976], 'Mutagenesis,': [4977], '16,': [4978], '63': [4980], '(1990).': [4981, 5474], 'Homann,': [4982, 5011], 'N.,': [4983, 5012], 'Jousimies-Somer,': [4984, 5176], 'H.,': [4985, 5047, 5177, 5263, 5323, 5539, 5564, 5577, 5611, 5622], 'Jokelainen,': [4986, 5019, 5139, 5172], 'Heine,': [4988, 5180], 'Salaspuro,': [4991, 5022, 5148, 5183], 'High': [4993], 'consumption:': [5000], 'methodological': [5001], 'aspects': [5002], 'pathogenetic': [5004], 'implications.': [5005], 'Carcinogenesis,': [5006, 5631], '1739-': [5008], '1743': [5009], '(1997a).': [5010], 'Parkkarinen,': [5013], 'Koivisto,': [5015], 'Nosova,': [5017, 5178], 'regeneration': [5029], 'differentiation': [5031], 'gastrointestinal': [5035], 'mucosa.': [5037], '1692-': [5043], '1697': [5044], '(1997b).': [5045], 'Hori,': [5046], 'Kawano,': [5048], 'Endo,': [5050], 'Yuasa,': [5053], 'Y.,': [5054, 5613], 'polymorphisms': [5056], 'tobacco-': [5058], 'metabolizing': [5061], 'enzymes': [5062], 'carcinoma': [5068], 'susceptibility.': [5069], 'Gastroenterol.,': [5072], '568-': [5074], '575': [5075], 'IARC,': [5077, 5099, 5102, 5120, 5136], 'Allyl': [5078], 'compounds,': [5079], 'aldehydes,': [5080], 'epoxides': [5081], 'peroxides.': [5083], 'In:': [5084, 5105, 5123, 5640], 'IARC': [5085, 5106, 5124], 'monographs': [5086, 5107, 5125], 'evaluation': [5089, 5110, 5128, 5373], 'chemicals': [5095], 'humans,': [5097, 5116, 5134], '36,': [5098], 'Lyon': [5100, 5118, 5137], '1985).': [5101, 5650], 'Tobacco': [5103, 5302], 'smoking.': [5104], '38,': [5117], 'drinking.': [5122, 5417], '44,': [5135], '1988).': [5138], 'Heikkonen,': [5141], 'Roine,': [5143], 'R.,': [5144, 5444], 'Lehtonen,': [5145], 'H.': [5146], 'Increased': [5150], 'mouthwashings': [5154], 'laryngeal,': [5160], 'Exp.': [5166, 5203, 5346], '20,': [5168, 5205], '1206-': [5169], '1210': [5170], '(1996).': [5171, 5208], 'Siitonen,': [5174], 'dehydrogenase-mediated': [5188], 'representing': [5194], 'flora': [5198], 'man.': [5200], '967-': [5206], '972': [5207], 'Launoy,': [5209], 'G.,': [5210], 'Milan,': [5211], 'C.,': [5212, 5680], 'Day,': [5213], 'Faivre,': [5215], 'Pienkowski,': [5217], 'P.': [5218, 5398], 'Gignoux,': [5220], 'Oesophageal': [5222, 5477], 'France:': [5225], 'potential': [5226], 'importance': [5227], 'hot': [5229], 'drinks.': [5231], '71,': [5235], '917-': [5236], '923': [5237], 'Lowry,': [5239], 'O.H.,': [5240], 'Rosenbrough,': [5241], 'N.J.,': [5242], 'Farr,': [5243], 'A.L.': [5244], 'Randall,': [5246], 'R.J.,': [5247], 'measurement': [5249], 'folin': [5252], 'phenol': [5253], 'reagent.': [5254], 'Biol.': [5256], 'Chem.,': [5257], '193,': [5258], '262-': [5259], '275': [5260], 'Maier,': [5262], 'Zoller,': [5264], 'Herrmann,': [5266], 'Kreiss,': [5268], 'Heller,': [5271], 'W.D.,': [5272], 'Dental': [5273], 'status': [5274], 'neck': [5283], 'Otolaryngol.': [5285], 'Head': [5286], 'Neck': [5287], 'Surg.,': [5288], '108,': [5289], '655-': [5290], '661': [5291], '(1993).': [5292, 5321, 5392], 'Winkelman,': [5297], 'smoking,': [5303], 'drinking,': [5305], 'oropharynx': [5313, 5404], 'U.S.': [5315], 'veterans.': [5316], '72,': [5318], '1369-': [5319], '1275': [5320], 'Miyakawa,': [5322], 'Baraona,': [5324, 5395], 'J.C.,': [5327], 'Lesser,': [5328], 'M.D.': [5329], 'Lieber,': [5331, 5400], 'C.S.,': [5332, 5401], 'Oxidation': [5333], 'washings:': [5340], '517-': [5349], '520': [5350], 'Nolte,': [5352], 'F.S.,': [5353], 'Williams,': [5354], 'J.M.,': [5355], 'Jerris,': [5356], 'R.C.,': [5357], 'Morello,': [5358], 'J.A.,': [5359], 'Leitch,': [5360], 'C.D.,': [5361], 'Matushek,': [5362], 'Schwabe,': [5364], 'L.D.,': [5365], 'Dorigan,': [5366], 'F.': [5367], 'Kocka,': [5369], 'Multicenter': [5371], 'continuous': [5376], 'monitoring': [5377], 'fluorescent-sensor': [5382], 'technology': [5383], '(BACTEC': [5384], '9240).': [5385], 'Microbiol.,': [5388], '31,': [5389], '552-': [5390], '557': [5391], 'Pikkarainen,': [5393], 'P.H.,': [5394], 'Jauhonen,': [5397], 'Contribution': [5402], 'lung': [5408], 'microsomes': [5409], 'expired': [5413], 'Lab.': [5419], 'Med.,': [5421], '97,': [5422], '631-': [5423], '636': [5424], '(1981).': [5425], 'Seitz,': [5426], 'Poschl,': [5428], 'G.': [5429], 'Simanowski,': [5431], 'U.A.,': [5432], 'Recent': [5436], 'Dev.': [5437], 'Alcohol,': [5438], '14,': [5439], '67-': [5440], '95': [5441], 'Talamini,': [5443], 'Franceschi,': [5445, 5690], 'Barra,': [5447], 'Vecchia,': [5450, 5679], 'non-smokers,': [5462], '46,': [5471], '391-': [5472], '393': [5473], 'Tuyns,': [5475], 'A.J.,': [5476], 'smokers.': [5485], '32,': [5489], '443-': [5490], '444': [5491], 'Yin,': [5493], 'S-J.,': [5494], 'Liao,': [5495], 'C-S.,': [5496], 'Wu,': [5497], 'C-W.,': [5498], 'T-T.,': [5500], 'Chen,': [5501], 'L-L.,': [5502], 'Lai,': [5503], 'C-L.': [5504], 'Tsao,': [5506], 'T-Y.,': [5507], 'Human': [5508], 'stomach': [5509], 'dehydrogenases:': [5512], 'comparison': [5513], 'expression': [5515], 'pattern': [5516], 'alimentary': [5520], 'tract.': [5521], '112,': [5523], '766-': [5524], '775': [5525], 'Yokoyama,': [5527, 5557, 5600, 5606], 'Muramatsu,': [5529, 5559, 5602], 'Ohmori,': [5531, 5561, 5604], 'Higuchi,': [5533, 5565, 5614], 'Hayashida,': [5535], 'Ishii,': [5538, 5576, 5621], 'Esophageal': [5540], 'dehydrogenase-2': [5544, 5590, 5627], 'genotypes': [5545], 'Japanese': [5547, 5593, 5629], 'males.': [5548], 'Epidemiol.': [5550], 'Biomark.': [5551], 'Prev.,': [5552], '5,': [5553], '99-': [5554], '102': [5555], '(1996a).': [5556], 'Makuuchi,': [5563], 'Matsushita,': [5567], 'Yoshino,': [5569], 'Maruyama,': [5571, 5616], 'Nakano,': [5573], 'Multiple': [5578], 'primary': [5579], 'concurrent': [5582], 'alcoholics.': [5594, 5630], '77,': [5596], '1986-': [5597], '1990': [5598], '(1996b).': [5599], 'Okuyama,': [5608], 'Takahashi,': [5610], 'Hasegawa,': [5612], 'Shirakura,': [5618], 'Alcohol-related': [5623], '19,': [5632], '1383-': [5633], '1387': [5634], 'Organization.': [5638], 'Acetaldehyde.': [5639], 'Environmental': [5641], 'health': [5642], 'criteria,': [5643], '167,': [5645], 'Geneva': [5649], 'Aplleman,': [5653], 'Garderen-Hoetmer,': [5656], 'Inhalation': [5661], 'toxicity': [5662], 'rat.': [5666], 'III.': [5667], 'Carcinogenicity': [5668], 'study.': [5669], 'Toxicology,': [5670], '41,': [5671], '213-': [5672], '231': [5673], 'Zambon,': [5675], 'Talaminir,': [5677], 'L.A.,': [5678], 'Dal': [5681], 'Maso,': [5682], 'Negri,': [5684], 'Tognazzo,': [5686], 'Simonato,': [5688], 'Smoking,': [5692], 'squamous-cell': [5698], 'oesophageal': [5699], 'northern': [5702], 'Italy.': [5703], '86,': [5707], '144-': [5708], '149': [5709], '(2000).': [5710], 'Citing': [5711], 'Literature': [5712], 'Volume88,': [5713], 'Issue31': [5714], 'November': [5715], '2000Pages': [5716], 'FiguresReferencesRelatedInformation': [5718]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4244346637', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-19T17:33:46.253329', 'created_date': '2022-05-12'}