Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4244226712', 'doi': 'https://doi.org/10.1213/00000539-200004000-00008', 'title': 'Anticoagulation for Cardiac Surgery in Patients Receiving Preoperative Heparin: Use of the High-Dose Thrombin Time', 'display_name': 'Anticoagulation for Cardiac Surgery in Patients Receiving Preoperative Heparin: Use of the High-Dose Thrombin Time', 'publication_year': 2000, 'publication_date': '2000-04-01', 'ids': {'openalex': 'https://openalex.org/W4244226712', 'doi': 'https://doi.org/10.1213/00000539-200004000-00008'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1213/00000539-200004000-00008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104698359', 'display_name': 'Anesthesia & Analgesia', 'issn_l': '0003-2999', 'issn': ['0003-2999', '1526-7598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029110974', 'display_name': 'Linda Shore‐Lesserson', 'orcid': 'https://orcid.org/0000-0002-1138-6098'}, 'institutions': [{'id': 'https://openalex.org/I4210095266', 'display_name': 'Mount Sinai Medical Center', 'ror': 'https://ror.org/00wgjpw02', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210095266']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Linda Shore-Lesserson', 'raw_affiliation_strings': ['Department of Anesthesiology, Mount Sinai Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Mount Sinai Medical Center', 'institution_ids': ['https://openalex.org/I4210095266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065737121', 'display_name': 'Heather E. Manspeizer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Heather E. Manspeizer', 'raw_affiliation_strings': ['Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057178011', 'display_name': 'Maria Bolastig', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210095266', 'display_name': 'Mount Sinai Medical Center', 'ror': 'https://ror.org/00wgjpw02', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210095266']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Maria Bolastig', 'raw_affiliation_strings': ['Department of Anesthesiology, Mount Sinai Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Mount Sinai Medical Center', 'institution_ids': ['https://openalex.org/I4210095266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108236079', 'display_name': 'Donna Harrington', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210095266', 'display_name': 'Mount Sinai Medical Center', 'ror': 'https://ror.org/00wgjpw02', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210095266']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Donna Harrington', 'raw_affiliation_strings': ['Department of Anesthesiology, Mount Sinai Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Mount Sinai Medical Center', 'institution_ids': ['https://openalex.org/I4210095266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023219541', 'display_name': 'Frances Vela-Cantos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210095266', 'display_name': 'Mount Sinai Medical Center', 'ror': 'https://ror.org/00wgjpw02', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210095266']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Frances Vela-Cantos', 'raw_affiliation_strings': ['Department of Anesthesiology, Mount Sinai Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Mount Sinai Medical Center', 'institution_ids': ['https://openalex.org/I4210095266']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027928376', 'display_name': 'Marietta DePerio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210095266', 'display_name': 'Mount Sinai Medical Center', 'ror': 'https://ror.org/00wgjpw02', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210095266']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Marietta DePerio', 'raw_affiliation_strings': ['Department of Anesthesiology, Mount Sinai Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Mount Sinai Medical Center', 'institution_ids': ['https://openalex.org/I4210095266']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5029110974', 'https://openalex.org/A5057178011', 'https://openalex.org/A5108236079', 'https://openalex.org/A5023219541', 'https://openalex.org/A5027928376'], 'corresponding_institution_ids': ['https://openalex.org/I4210095266', 'https://openalex.org/I4210095266', 'https://openalex.org/I4210095266', 'https://openalex.org/I4210095266', 'https://openalex.org/I4210095266'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.065, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.850816, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '90', 'issue': '4', 'first_page': '813', 'last_page': '818'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10292', 'display_name': 'Acute Myocardial Infarction Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10292', 'display_name': 'Acute Myocardial Infarction Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11055', 'display_name': 'Cardiac and Coronary Surgery Techniques', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10285', 'display_name': 'Venous Thromboembolism Diagnosis and Management', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2724', 'display_name': 'Internal Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/activated-clotting-time', 'display_name': 'Activated clotting time', 'score': 0.92237234}, {'id': 'https://openalex.org/keywords/thrombin-time', 'display_name': 'Thrombin time', 'score': 0.42468578}], 'concepts': [{'id': 'https://openalex.org/C2777987278', 'wikidata': 'https://www.wikidata.org/wiki/Q4677454', 'display_name': 'Activated clotting time', 'level': 3, 'score': 0.92237234}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.91192603}, {'id': 'https://openalex.org/C2777557582', 'wikidata': 'https://www.wikidata.org/wiki/Q190016', 'display_name': 'Heparin', 'level': 2, 'score': 0.88897705}, {'id': 'https://openalex.org/C2778881276', 'wikidata': 'https://www.wikidata.org/wiki/Q552304', 'display_name': 'Cardiopulmonary bypass', 'level': 2, 'score': 0.7055188}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.65614223}, {'id': 'https://openalex.org/C2780835560', 'wikidata': 'https://www.wikidata.org/wiki/Q5449573', 'display_name': 'Protamine', 'level': 3, 'score': 0.64770705}, {'id': 'https://openalex.org/C2777292125', 'wikidata': 'https://www.wikidata.org/wiki/Q409166', 'display_name': 'Thrombin', 'level': 3, 'score': 0.61868775}, {'id': 'https://openalex.org/C54173615', 'wikidata': 'https://www.wikidata.org/wiki/Q27205', 'display_name': 'Fibrin', 'level': 2, 'score': 0.59813017}, {'id': 'https://openalex.org/C2779026020', 'wikidata': 'https://www.wikidata.org/wiki/Q416336', 'display_name': 'Antithrombin', 'level': 3, 'score': 0.5651028}, {'id': 'https://openalex.org/C2778205648', 'wikidata': 'https://www.wikidata.org/wiki/Q215118', 'display_name': 'Anticoagulant', 'level': 2, 'score': 0.45252082}, {'id': 'https://openalex.org/C2780077467', 'wikidata': 'https://www.wikidata.org/wiki/Q2520736', 'display_name': 'Thrombin time', 'level': 4, 'score': 0.42468578}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.3670252}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.25919467}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2106987}, {'id': 'https://openalex.org/C2778261982', 'wikidata': 'https://www.wikidata.org/wiki/Q1755136', 'display_name': 'Partial thromboplastin time', 'level': 3, 'score': 0.083343774}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.06567061}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1213/00000539-200004000-00008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104698359', 'display_name': 'Anesthesia & Analgesia', 'issn_l': '0003-2999', 'issn': ['0003-2999', '1526-7598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.83, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1483075567', 'https://openalex.org/W1813018921', 'https://openalex.org/W192624987', 'https://openalex.org/W1994460021', 'https://openalex.org/W1994749331', 'https://openalex.org/W1996999357', 'https://openalex.org/W2005489000', 'https://openalex.org/W2057646315', 'https://openalex.org/W2066401415', 'https://openalex.org/W2073825098', 'https://openalex.org/W2086744615', 'https://openalex.org/W2107177738', 'https://openalex.org/W2136629589', 'https://openalex.org/W2395374849', 'https://openalex.org/W30189465', 'https://openalex.org/W4243346534', 'https://openalex.org/W4251635256', 'https://openalex.org/W4293355324'], 'related_works': ['https://openalex.org/W96823224', 'https://openalex.org/W4386743610', 'https://openalex.org/W4385346020', 'https://openalex.org/W2516483145', 'https://openalex.org/W2414219585', 'https://openalex.org/W2411561722', 'https://openalex.org/W2205160479', 'https://openalex.org/W2029364688', 'https://openalex.org/W2025086308', 'https://openalex.org/W178231999'], 'abstract_inverted_index': {'Patients': [0], 'receiving': [1, 22, 30, 189, 218, 237, 252], 'heparin': [2, 13, 24, 31, 190, 239, 254, 271], 'infusions': [3], 'have': [4], 'an': [5], 'attenuated': [6], 'activated': [7, 244, 289], 'clotting': [8, 245, 290], 'time': [9, 40, 70, 246, 279, 291], '(ACT)': [10], 'response': [11, 196, 247], 'to': [12, 27, 36, 197, 248, 260, 282], 'given': [14], 'for': [15, 211, 233, 264], 'cardiopulmonary': [16, 265], 'bypass': [17], '(CPB).': [18], 'We': [19], 'compared': [20], 'patients': [21, 51, 188, 217, 236, 251, 295], 'preoperative': [23, 219, 238, 253], '(Group': [25], 'H)': [26], 'those': [28, 115], 'not': [29, 126, 139, 157, 185, 274], '(REF': [32], 'group)': [33, 57], 'with': [34], 'respect': [35], 'ACT,': [37], 'high-dose': [38, 277], 'thrombin': [39, 45, 180, 278], '(HiTT),': [41], 'and': [42, 64, 78, 87, 93, 99, 110, 135, 152, 173, 182, 203, 228, 285], 'markers': [43], 'of': [44, 74, 148, 201, 208, 231], 'generation': [46], 'during': [47, 85, 174], 'CPB.': [48, 175], 'Sixty-five': [49], 'consecutive': [50], '(33': [52], 'Group': [53, 108, 169], 'H,': [54], '32': [55], 'REF': [56, 118], 'undergoing': [58], 'elective': [59], 'CPB': [60, 212, 234], 'were': [61, 66, 81, 97, 111, 138], 'evaluated.': [62], 'ACT': [63, 101, 167, 195, 202], 'HiTT': [65, 123, 221], 'measured': [67, 98], 'at': [68, 83, 161], 'multiple': [69], 'points.': [71], 'Plasma': [72, 146], 'levels': [73, 147], 'thrombin-antithrombin': [75, 149], 'III': [76, 150], 'complex': [77], 'fibrin': [79, 153], 'monomer': [80, 154], 'determined': [82], 'baseline,': [84], 'CPB,': [86], 'after': [88, 103, 171], 'protamine': [89], 'administration.': [90], 'Transfusion': [91], 'requirements': [92, 137], 'postoperative': [94], 'blood': [95], 'loss': [96, 134], 'compared.': [100], 'values': [102, 124, 206], 'heparinization': [104, 172], 'increased': [105], 'less': [106], 'in': [107, 116, 168, 187, 216, 235, 250, 293], 'H': [109, 170], 'significantly': [112, 128, 140], 'lower': [113, 166, 288], 'than': [114], 'the': [117, 130, 143, 204], 'group': [119], '(P': [120], '<': [121], '0.01).': [122], 'did': [125, 156], 'differ': [127, 158], 'between': [129, 142, 159], 'two': [131, 144], 'groups.': [132, 145], 'Blood': [133], 'transfusion': [136], 'different': [141], 'complexes': [151], 'also': [155], 'groups': [160], 'any': [162], 'time,': [163], 'despite': [164, 192], 'a': [165, 193, 226, 287], 'Our': [176], 'data': [177, 268], 'suggest': [178, 269], 'that': [179, 270, 286], 'formation': [181], 'activity': [183], 'are': [184, 213], 'enhanced': [186], 'therapy,': [191, 255], 'diminished': [194, 243], 'heparin.': [198, 220], 'The': [199, 242], 'utility': [200], 'threshold': [205], 'indicative': [207], 'adequate': [209, 262], 'anticoagulation': [210, 232, 263, 284], 'relatively': [214], 'undefined': [215], 'should': [222], 'be': [223, 297], 'investigated': [224], 'as': [225], 'safe': [227], 'accurate': [229], 'monitor': [230, 283], 'therapy.': [240], 'Implications:': [241], 'heparin,': [249], 'poses': [256], 'difficulties': [257], 'when': [258, 276], 'attempting': [259], 'provide': [261], 'bypass.': [266], 'Current': [267], 'resistance': [272], 'is': [273, 280], 'observed': [275], 'used': [281], 'value': [292], 'these': [294], 'may': [296], 'safe.': [298]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4244226712', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-15T19:22:42.960444', 'created_date': '2022-05-12'}