Title: Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. I. In vivo test for compounds requiring metabolic activation
Abstract: An in vivo system has been devised in which chemical mutagen-carcinogens injected into an animal induced sister chromatid exchanges that can be observed when the animal's peripheral lymphocytes are subsequently cultured and then stained with the FPG tecnique. Chemicals requiring metabolic activation, as well as those that do not, produce significant increases in SCE frequency one day after exposure. The frequency then returns to control level within two weeks. This in vivo system is a highly sensitive assay for the ability of chemical agents to damage chromosomes.
Publication Year: 1976
Publication Date: 1976-12-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 132
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