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'Diabetic': [6], 'Heart': [7], 'from': [8], 'Ischemia/': [9], '周期G0期にある細胞を特異的に標識できるマウスなどを開発し幹細胞のそのものの性質から幹細胞を検出する新しいシ': [10], 'ステムの開発を行っている.これらの性質を用いて,当講座ではいくつかの新しい幹細胞を同定した.これらについて': [11], '解析中である.': [12], '2)幹細胞培養法の開発': [13], '幹細胞の性質を解析する上で,最もパワフルな方法は': [14], 'in': [15, 21], 'vivo': [16], 'で幹細胞を蛍光標識し,それをlive': [17], 'で観察する事である.しかしながら,体表からのアクセスの容易度に依存して,生体内での幹細胞を直接観察する事は': [18], '難しく,組織を固定した上で切片上にて観察するという方法が取られる.しかしながら,それらはスナップショットで': [19], 'あり,同一の幹細胞を経時的に観察する事はできない.次に考えられる方法としては,幹細胞を': [20], 'vitro': [22], 'にて培養する方': [23], '法であるが,一般的に幹細胞は単独で存在すると幹細胞の性質を保ったまま維持する事は難しく,周囲のニッチを形成': [24], 'する細胞集団をいっしょに培養する事が必要と想像されてきた.近年そうしたorgan': [25], 'culture': [26], 'が消化管上皮細胞を中心に成': [27], '功例が報告されてきている.当講座も上記で単離された幹細胞について培養法を開発して解析中である.': [28], '3)マウス腸幹細胞の解析と大腸がんの発症機序の解明哺乳類の小腸上皮細胞は約': [29], '5日の間に細胞代謝回転(turnover)し': [30], 'て全て入れ替わると言われており生体内で最も細胞代謝回転の早い臓器の一つである.腸の': [31], 'crypt': [32], 'には腸幹細胞が存在し': [33], 'て複数種類の上皮細胞(吸収上皮細胞,内分泌細胞,Goblet細胞': [34], 'Paneth細胞など)を供給していると考えられている.当': [35], '講座ではこれまでに開発した新しいマルチカラー細胞系譜解析法(誘導可能マルチカラーモサイクマウス(レインボー': [36], 'マウス)にて腸上皮細胞の維持機構の解析を行って来た.一方大腸に発生する悪性腫瘍の多くは腸上皮に発生するアテ': [37], 'ノーマ(良性腫瘍)に由来し,そのアテノーマは': [38], 'Wnt情報伝達経路の抑制因子である': [39], 'Apc遺伝子の異常に起因する事が知': [40], 'られている.正常幹細胞の維持機構かApc異常マウスにおいてどのように破綻を来すのか解析を進めている.': [41], '4)各種成体組織幹細胞の疾患発症への関与の解析と新しい分子標的療法の開発ある疾患の原因細胞を可溶化型阻害蛋白': [42], '質による治療の試みは関節リウマチにおける可溶化型': [43], 'TNF': [44], '受容体など既に実用化され劇的な効果を挙げている.しかし': [45], 'ながら組織特異的成体幹細胞およびそれに由来するがん幹細胞に関する同様の試みはあまり進んでいない.当講座では': [46]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4243152566', 'counts_by_year': [], 'updated_date': '2024-09-15T04:45:00.241111', 'created_date': '2022-05-12'}