Title: THE USE OF NONTRADITIONAL ASSAYS IN AN INTEGRATED ENVIRONMENTAL ASSESSMENT OF CONTAMINATED GROUND WATER
Abstract: Environmental Toxicology and ChemistryVolume 16, Issue 9 p. 1816-1820 Environmental Chemistry The use of nontraditional assays in an integrated environmental assessment of contaminated ground water† Lorraine E. Twerdok, Corresponding Author Lorraine E. Twerdok Geo-Centers, Inc., Building 568, Fort Detrick, Maryland 21702, USAGeo-Centers, Inc., Building 568, Fort Detrick, Maryland 21702, USASearch for more papers by this authorDennis T. Burton, Dennis T. Burton Wye Research and Education Center University of Maryland, P.O. Box 169 Queenstown Maryland 21658 USASearch for more papers by this authorHenry S. Gardner, Henry S. Gardner U.S. Army Biomedical Research and Development Laboratory, Building 568, Fort Detrick, Maryland 21702Search for more papers by this authorTommy R. Shedd, Tommy R. Shedd U.S. Army Biomedical Research and Development Laboratory, Building 568, Fort Detrick, Maryland 21702Search for more papers by this authorMarilyn J. Wolfe, Marilyn J. Wolfe Experimental Pathology Laboratories, P.O. Box 474, Herndon, Virginia, USASearch for more papers by this author Lorraine E. Twerdok, Corresponding Author Lorraine E. Twerdok Geo-Centers, Inc., Building 568, Fort Detrick, Maryland 21702, USAGeo-Centers, Inc., Building 568, Fort Detrick, Maryland 21702, USASearch for more papers by this authorDennis T. Burton, Dennis T. Burton Wye Research and Education Center University of Maryland, P.O. Box 169 Queenstown Maryland 21658 USASearch for more papers by this authorHenry S. Gardner, Henry S. Gardner U.S. Army Biomedical Research and Development Laboratory, Building 568, Fort Detrick, Maryland 21702Search for more papers by this authorTommy R. Shedd, Tommy R. Shedd U.S. Army Biomedical Research and Development Laboratory, Building 568, Fort Detrick, Maryland 21702Search for more papers by this authorMarilyn J. Wolfe, Marilyn J. Wolfe Experimental Pathology Laboratories, P.O. Box 474, Herndon, Virginia, USASearch for more papers by this author First published: 26 October 2009 https://doi.org/10.1002/etc.5620160908Citations: 8 † Presented at the 15th Annual Meeting, Society of Environmental Toxicology and Chemistry, Denver, Colorado, USA, October 30–No-vember 3, 1994. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The toxic potential of ground water contaminated with several probable carcinogenic heavy metals and halogenated solvents was evaluated using an integrated environmental assessment approach. A number of assays, which included acute toxicity, short-term chronic toxicity, genotoxicity, developmental toxicity and carcinogenicity, were used to assist in a hazard assessment. Comprehensive analytical chemistry was performed throughout the 9-month exposure to document the chemical characteristics of the ground water. An initiation-promotion protocol using a non-neoplastic concentration of diethylnitrosamine as an initiator in a 9-month chronic exposure of Japanese medaka (Oryzias latipes) was used to evaluate potential carcinogenicity of the ground water. The fish were exposed to groundwater concentrations of 1% and 10% ground water by volume. No significant lesions were found in the Japanese medaka exposed to groundwater concentrations at 1% or 10% ground water by volume. Likewise, no genotoxicity, developmental toxicity, acute toxicity or short-term chronic toxicity, were found at concentrations of ≤10% ground water by volume. The negative results obtained in this study show that the potential hazard posed by low concentrations of a complex mixture containing suspect carcinogens may not be manifested at environmentally relevant concentrations. Citing Literature Volume16, Issue9September 1997Pages 1816-1820 RelatedInformation
Publication Year: 1997
Publication Date: 1997-01-01
Language: en
Type: article
Indexed In: ['crossref']
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