Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4241157907', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-105', 'title': 'Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells', 'display_name': 'Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells', 'publication_year': 2019, 'publication_date': '2019-07-01', 'ids': {'openalex': 'https://openalex.org/W4241157907', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-105'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-105', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101243758', 'display_name': 'Kumar Sanjiv', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Kumar Sanjiv', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067442100', 'display_name': 'Helge Gad', 'orcid': 'https://orcid.org/0000-0001-6530-1443'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Helge gad', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042397070', 'display_name': 'Sean G. Rudd', 'orcid': 'https://orcid.org/0000-0002-4368-3855'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Sean G. Rudd', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076348386', 'display_name': 'Oliver Mortusewicz', 'orcid': 'https://orcid.org/0000-0002-4290-4994'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Oliver Mortusewicz', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001510553', 'display_name': 'Ailine Stolz', 'orcid': 'https://orcid.org/0000-0002-8357-8160'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ailine Stolz', 'raw_affiliation_strings': ['2Institute of Molecular Oncology, Göttingen, Germany.'], 'affiliations': [{'raw_affiliation_string': '2Institute of Molecular Oncology, Göttingen, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045958181', 'display_name': 'Nuno Amaral', 'orcid': 'https://orcid.org/0000-0003-2501-1403'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Nuno Amaral', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032510295', 'display_name': 'Lars Brautigham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Lars Brautigham', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028192514', 'display_name': 'Linda Pudelko', 'orcid': 'https://orcid.org/0009-0007-2201-6475'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Linda Pudelko', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039438134', 'display_name': 'Christina Kalderén', 'orcid': 'https://orcid.org/0000-0001-7004-7048'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Christina Kaldéren', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003918697', 'display_name': 'Ann‐Sofie Jemth', 'orcid': 'https://orcid.org/0000-0002-7550-1833'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ann-Sofie Jemth', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085546344', 'display_name': 'Ingrid Almlöf', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ingrid Almlöf', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013277256', 'display_name': 'Torkild Visnes', 'orcid': 'https://orcid.org/0000-0003-1047-988X'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Torkild Visnes', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027062405', 'display_name': 'Niklas Schultz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Niklas Schultz', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049913121', 'display_name': 'Johan Boström', 'orcid': 'https://orcid.org/0000-0001-5252-4023'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Johan Boström', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006061477', 'display_name': 'José Manuel Calderón‐Montaño', 'orcid': 'https://orcid.org/0000-0001-6845-797X'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'José Manuel Calderon Montano1', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013569942', 'display_name': 'Anna Hagenkort', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Anna Hagenkort', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086261240', 'display_name': 'Petra Groth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Petra Groth', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011443121', 'display_name': 'Camilla Göktürk', 'orcid': 'https://orcid.org/0000-0002-6272-9927'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Camilla Gokturk', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046790715', 'display_name': 'Tobias Koolmeister', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Tobias Koolmeister', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034169956', 'display_name': 'Prasad B. Wakchaure', 'orcid': 'https://orcid.org/0000-0003-2828-4642'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Prasad Wakchaure', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016071108', 'display_name': 'Evert Homan', 'orcid': 'https://orcid.org/0000-0002-9057-1848'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Evert Homan', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009315904', 'display_name': 'Mikael Altun', 'orcid': 'https://orcid.org/0000-0002-6937-6124'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Mikael Altun', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077916796', 'display_name': 'Cecilia Jylhä', 'orcid': 'https://orcid.org/0000-0002-6964-2517'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Cecilia Ström', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075556991', 'display_name': 'Martin Scobie', 'orcid': 'https://orcid.org/0000-0002-7073-8495'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Martin Scobie', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013651038', 'display_name': 'Holger Bastians', 'orcid': 'https://orcid.org/0000-0001-7915-3648'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Holger Bastians', 'raw_affiliation_strings': ['2Institute of Molecular Oncology, Göttingen, Germany.'], 'affiliations': [{'raw_affiliation_string': '2Institute of Molecular Oncology, Göttingen, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053492421', 'display_name': 'Ulrika Warpman Berglund', 'orcid': 'https://orcid.org/0000-0002-6372-1396'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ulrika Warpman Berglund', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029296072', 'display_name': 'Thomas Helleday', 'orcid': 'https://orcid.org/0000-0002-7384-092X'}, 'institutions': [{'id': 'https://openalex.org/I4210102984', 'display_name': 'Svenska Örtmedicinska Institute', 'ror': 'https://ror.org/018yv7m63', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210102984']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Helleday', 'raw_affiliation_strings': ['1Karolinska Institutet, Solna, Sweden;'], 'affiliations': [{'raw_affiliation_string': '1Karolinska Institutet, Solna, Sweden;', 'institution_ids': ['https://openalex.org/I4210102984', 'https://openalex.org/I28166907']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.119, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.498068, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 62, 'max': 70}, 'biblio': {'volume': '79', 'issue': '13_Supplement', 'first_page': '105', 'last_page': '105'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 0.9062, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 0.9062, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11440', 'display_name': 'Click Chemistry in Chemical Biology and Drug Development', 'score': 0.9037, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/molecular-motors', 'display_name': 'Molecular Motors', 'score': 0.458947}], 'concepts': [{'id': 'https://openalex.org/C93304396', 'wikidata': 'https://www.wikidata.org/wiki/Q14763008', 'display_name': 'Mitosis', 'level': 2, 'score': 0.76031256}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.6170999}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.56988937}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.56640595}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.55894446}, {'id': 'https://openalex.org/C512185932', 'wikidata': 'https://www.wikidata.org/wiki/Q28745', 'display_name': 'Nucleotide', 'level': 3, 'score': 0.537979}, {'id': 'https://openalex.org/C84425145', 'wikidata': 'https://www.wikidata.org/wiki/Q422492', 'display_name': 'Tubulin', 'level': 3, 'score': 0.5300006}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.50956106}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.45422673}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45174125}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.41239613}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.37331456}, {'id': 'https://openalex.org/C20418707', 'wikidata': 'https://www.wikidata.org/wiki/Q189933', 'display_name': 'Microtubule', 'level': 2, 'score': 0.36403495}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.35899693}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32889265}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16818383}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13431627}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-105', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4313640443', 'https://openalex.org/W3165382431', 'https://openalex.org/W3163690654', 'https://openalex.org/W2528453622', 'https://openalex.org/W2415662583', 'https://openalex.org/W2405887049', 'https://openalex.org/W2079310684', 'https://openalex.org/W2024145976', 'https://openalex.org/W2020008420', 'https://openalex.org/W1901412126'], 'abstract_inverted_index': {'Abstract': [0], 'MTH1': [1, 16, 32, 58, 82, 93, 101, 157, 182, 203, 305], 'prevents': [2], 'incorporation': [3, 143, 164, 235], 'of': [4, 43, 57, 144, 165, 177, 193, 215, 236, 320], 'oxidized': [5, 44], 'deoxynucleoside': [6], 'triphosphates': [7], '(e.g.,': [8], '8-oxodGTP)': [9], 'into': [10, 147, 168, 239], 'DNA.': [11, 47], 'Earlier': [12], 'we': [13, 52, 80, 122, 153], 'demonstrated': [14], 'that': [15, 90, 107, 124, 155], 'inhibitors': [17, 33, 94, 158, 183], 'TH588': [18, 108, 125], 'and': [19, 74, 78, 104, 109, 126, 135, 142, 162, 190, 225, 228], 'TH1579': [20, 110, 127], 'possesses': [21], 'anti-cancer': [22], 'activity': [23, 233], 'in': [24, 46, 59, 67, 71, 85, 116, 149, 223, 314], 'various': [25], 'tumour': [26], 'types,': [27], 'while': [28], 'other': [29], 'structurally': [30, 91], 'distinct': [31, 92], 'failed': [34], 'to': [35, 98, 220, 241, 309], 'kill': [36, 128, 242], 'cancer': [37, 72, 129, 185, 243, 315], 'cells': [38, 73, 130, 186, 316], 'or': [39], 'elevate': [40], 'the': [41, 100, 321], 'levels': [42], 'nucleotides': [45, 146, 167, 238], 'In': [48, 180], 'our': [49, 120], 'current': [50], 'study,': [51], 'found': [53, 154], 'a': [54, 132, 188, 197], 'novel': [55], 'function': [56], 'mitosis,': [60, 77], 'as': [61], 'it': [62], 'plays': [63], 'an': [64, 221], 'important': [65], 'role': [66], 'correct': [68], 'spindle': [69], 'assembly': [70], 'progression': [75, 308], 'through': [76, 212], 'furthermore,': [79], 'demonstrate': [81, 106], 'binds': [83], 'tubulin': [84, 102, 114], 'vivo.': [86], 'We': [87], 'also': [88, 105, 211], 'observed': [89], 'display': [95], 'differential': [96], 'abilities': [97], 'break': [99], 'interaction,': [103], 'can': [111, 159], 'directly': [112], 'inhibit': [113], 'polymerisation': [115], 'vitro.': [117], 'Consistent': [118], 'with': [119, 174], 'results,': [121], 'establish': [123], 'by': [131, 201], 'mitosis-dependent': [133], 'mechanism': [134, 192], 'implicate': [136], 'reactive': [137], 'oxygen': [138], 'species': [139], '(ROS)': [140], 'accumulation': [141], 'oxidised': [145, 166], 'DNA': [148, 169, 240, 312], 'this': [150], 'process.': [151], 'Furthermore,': [152], 'non-cytotoxic': [156], 'become': [160], 'cytotoxic': [161], 'increase': [163, 222], 'when': [170], 'they': [171], 'are': [172], 'combined': [173], 'sub-therapeutic': [175], 'concentrations': [176], 'mitotic': [178, 198, 208, 307], 'inhibitors.': [179], 'conclusion,': [181], 'killing': [184], 'have': [187], 'unique': [189], 'complex': [191], 'action:': [194], '(1)': [195], 'causing': [196, 234], 'arrest,': [199], 'induced': [200], 'targeting': [202], 'which': [204], 'is': [205], 'required': [206], 'for': [207, 324], 'progression,': [209], 'but': [210], 'direct': [213], 'inhibition': [214], 'microtubule': [216], 'polymerisation,': [217], 'in-turn': [218], 'leading': [219], 'ROS': [224], 'likely': [226], '8-oxodGTP': [227], '(2)': [229], 'MTH1-dependent': [230], '8-oxodGTPase': [231], 'inhibitory': [232], 'damaged': [237], 'cells.': [244], 'Citation': [245], 'Format:': [246], 'Kumar': [247], 'Sanjiv,': [248], 'Helge': [249], 'gad,': [250], 'Sean': [251], 'G.': [252], 'Rudd,': [253], 'Oliver': [254], 'Mortusewicz,': [255], 'Ailine': [256], 'Stolz,': [257], 'Nuno': [258], 'Amaral,': [259], 'Lars': [260], 'Brautigham,': [261], 'Linda': [262], 'Pudelko,': [263], 'Christina': [264], 'Kaldéren,': [265], 'Ann-Sofie': [266], 'Jemth,': [267], 'Ingrid': [268], 'Almlöf,': [269], 'Torkild': [270], 'Visnes,': [271], 'Niklas': [272], 'Schultz,': [273], 'Johan': [274], 'Boström,': [275], 'José': [276], 'Manuel': [277], 'Calderon': [278], 'Montano1,': [279], 'Anna': [280], 'Hagenkort,': [281], 'Petra': [282], 'Groth,': [283], 'Camilla': [284], 'Gokturk,': [285], 'Tobias': [286], 'Koolmeister,': [287], 'Prasad': [288], 'Wakchaure,': [289], 'Evert': [290], 'Homan,': [291], 'Mikael': [292], 'Altun,': [293], 'Cecilia': [294], 'Ström,': [295], 'Martin': [296], 'Scobie,': [297], 'Holger': [298], 'Bastians,': [299], 'Ulrika': [300], 'Warpman': [301], 'Berglund,': [302], 'Thomas': [303], 'Helleday.': [304], 'promotes': [306], 'avoid': [310], 'oxidative': [311], 'damage': [313], '[abstract].': [317], 'In:': [318], 'Proceedings': [319], 'American': [322], 'Association': [323], 'Cancer': [325, 339], 'Research': [326], 'Annual': [327], 'Meeting': [328], '2019;': [329], '2019': [330], 'Mar': [331], '29-Apr': [332], '3;': [333], 'Atlanta,': [334], 'GA.': [335], 'Philadelphia': [336], '(PA):': [337], 'AACR;': [338], 'Res': [340], '2019;79(13': [341], 'Suppl):Abstract': [342], 'nr': [343], '105.': [344]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4241157907', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-09-11T04:13:14.209063', 'created_date': '2022-05-12'}