Publication Information

{'id': 'https://openalex.org/W4240987545', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs18-1385', 'title': 'Abstract 1385: Prognostic and predictive utility of copy number variations (CNVs) in circulating tumor DNA (ctDNA) from metastatic castration-resistant prostate cancer (mCRPC) patients', 'display_name': 'Abstract 1385: Prognostic and predictive utility of copy number variations (CNVs) in circulating tumor DNA (ctDNA) from metastatic castration-resistant prostate cancer (mCRPC) patients', 'publication_year': 2019, 'publication_date': '2019-07-01', 'ids': {'openalex': 'https://openalex.org/W4240987545', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs18-1385'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs18-1385', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306506411', 'display_name': 'Clinical Research (Excluding Clinical Trials)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'proceedings-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071985773', 'display_name': 'Heidi Fettke', 'orcid': 'https://orcid.org/0000-0002-5784-3338'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Heidi Fettke', 'raw_affiliation_strings': ['Monash University, Melbourne, Australia'], 'affiliations': [{'raw_affiliation_string': 'Monash University, Melbourne, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089420153', 'display_name': 'Edmond M. 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[4, 20, 44, 95, 163, 227, 271, 308, 323], 'routine': [5], 'metastatic': [6, 385], 'tissue': [7], 'biopsy': [8], 'in': [9, 58, 68, 87, 98, 153, 225, 254, 303, 332, 379], 'mCRPC,': [10, 69], 'the': [11, 48, 145, 298, 395], 'identification': [12], 'of': [13, 53, 210, 301, 306, 313, 319, 374, 394], 'prognostic': [14], 'and': [15, 25, 92, 126, 135, 178, 216, 237, 281, 315, 317, 329, 371], 'predictive': [16, 372], 'biomarkers': [17], 'for': [18, 398], 'treatment': [19], 'androgen-receptor': [21], 'signalling': [22], 'inhibitors': [23], '(ARSI)': [24], 'chemotherapy': [26, 106, 115, 328], 'remains': [27], 'an': [28, 78, 292], 'unmet': [29], 'clinical': [30, 96, 325], 'need.': [31], 'Plasma': [32, 123, 140], 'circulating': [33, 380], 'tumor': [34, 381], 'DNA': [35, 137, 382], '(ctDNA)': [36, 383], 'has': [37, 60], 'emerged': [38], 'as': [39], 'a': [40, 65, 333], 'promising': [41], 'minimally-invasive': [42], 'tool': [43], 'which': [45, 70, 149], 'interrogate': [47], 'cancer': [49, 155, 388], 'genome.': [50], 'However,': [51], 'detection': [52, 300], 'copy': [54, 266, 375], 'number': [55, 267, 311, 376], 'variations': [56, 377], '(CNVs)': [57, 378], 'ctDNA': [59, 88, 305], 'proved': [61], 'challenging.': [62], 'This': [63], 'poses': [64], 'major': [66], 'problem': [67], 'commonly': [71], 'harbours': [72], 'pathogenic': [73], 'CNVs.': [74], 'Here': [75], 'we': [76, 296], 'use': [77], 'ultra-sensitive': [79, 293], 'next-generation': [80], 'sequencing': [81], '(NGS)': [82], 'assay': [83], 'identify': [85], 'CNVs': [86, 157, 204, 302], 'from': [89, 158, 384], 'mCRPC': [90, 110], 'patients': [91, 111, 226, 307, 390], 'correlate': [93], 'findings': [94], 'outcomes': [97, 326], 'men': [99], 'commencing': [100, 112], 'ARSI': [101, 113], '(abiraterone': [102], 'or': [103, 105, 108, 114], 'enzalutamide)': [104], '(docetaxel': [107], 'cabazitaxel).Methods:': [109], 'were': [116, 132, 142, 161, 195, 205, 251, 321], 'prospectively': [117], 'recruited': [118], 'at': [119], 'two': [120], 'Australian': [121], 'centers.': [122], 'was': [124, 184, 223, 269], 'collected': [125], 'platelet': [127], 'poor': [128], 'plasma': [129, 304], '(PPP)': [130], 'fractions': [131], 'processed': [133], 'uniformly': [134], 'cell-free': [136], '(cfDNA)': [138], 'extracted.': [139], 'samples': [141, 194], 'analysed': [143], 'using': [144], 'PredicineLITE': [146], 'NGS': [147, 294], 'assay,': [148, 295], 'reports': [150], 'genomic': [151], 'alterations': [152], '90': [154], 'genes.': [156], 'this': [159], 'cohort': [160, 335], 'correlated': [162], 'PSA': [164, 170, 248], 'response': [165, 249], 'rate': [166], "(Fisher's": [167], 'exact': [168], 'test),': [169], 'progression-free': [171, 175], 'survival': [172, 176, 180], '(PSA-PFS),': [173], 'clinical/radiographic': [174], '(clinical/rPFS),': [177], 'overall': [179], '(OS).Results:': [181], 'Median': [182], 'follow-up': [183], '19.85': [185], 'months': [186], '(mo)': [187], '(IQR': [188], '12.5-23.0).': [189], 'In': [190, 263], 'total,': [191], '32': [192], 'pre-treatment': [193], 'analyzed': [196], '(7': [197], 'chemotherapy,': [198], '25': [199], 'ARSI).': [200], 'The': [201], 'most': [202], 'common': [203], 'PTEN': [206, 228, 314], 'loss': [207, 213, 229, 239, 256], '(n=12,': [208, 219], '38%': [209], 'cohort),': [211], 'RB1': [212, 238, 255], '(n=5,': [214], '16%)': [215], 'AR': [217, 265, 320], 'gain': [218, 268], '38%).': [220], 'Notably,': [221], 'OS': [222, 283], 'decreased': [224, 272], '(median': [230, 240, 274, 284], '9.7': [231, 285], 'mo': [232, 242, 276, 286], 'vs.': [233, 243, 259, 277, 287], 'not': [234, 288], 'reached;': [235, 289], 'p=0.03)': [236], '7.1': [241], '17.1': [244], 'mo;': [245, 279], 'p=0.1),': [246], 'while': [247], 'rates': [250], 'also': [252], 'lower': [253], '(1/5,': [257], '20%': [258], '19/27,': [260], '71%;': [261], 'p=0.053).': [262], 'addition,': [264], 'associated': [270, 322], 'clinical/rPFS': [273], '3.4': [275], '10.7': [278], 'p=0.05)': [280], 'inferior': [282], 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